LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation

Cell Death and Disease

Volumn 3, Issue 4, 2012, Pages

  Malek, M ^a,b,c   Guillaumot, P ^a,b,c   Huber, A L ^a,b,c   Lebeau, J ^a,b,c   Petrilli V ^a,b,c   Kfoury, A ^a,b,c   Mikaelian, I ^a,b,c   Renno, T ^a,b,c   Manie S N ^a,b,c  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

^c CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

Author keywords

Apoptosis; LAMTOR1; Lysosomes; p53; ROS

Indexed keywords

CATHEPSIN B; LAMTOR1 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CARRIER PROTEIN; MTOR PROTEIN, HUMAN; P27RF RHO PROTEIN, HUMAN; P27RF-RHO PROTEIN, HUMAN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CATABOLISM; CELL ACTIVATION; CELL CYCLE ARREST; CELL MATURATION; CELL MIGRATION; CELL STRUCTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; CELL CYCLE CHECKPOINT; ENZYMOLOGY; GENETICS; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CARRIER PROTEINS; CATHEPSIN B; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; HUMANS; LYSOSOMES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862061588     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.39     Document Type: Article

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