N,N-diethyldithiocarbamate produces copper accumulation, lipid peroxidation, and myelin injury in rat peripheral nerve

Toxicological Sciences

Volumn 81, Issue 1, 2004, Pages 160-171

  Tonkin, Elizabeth G ^a   Valentine, Holly L ^a   Milatovic, Dejan M ^b   Valentine, William M ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Copper; Demyelination; Disulfiram; Dithiocarbamate; Isoprostanes; Lipid peroxidation; Myelin

Indexed keywords

COPPER; DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; ISOPROSTANE; ISOPROSTANE DERIVATIVE; METAL;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; ATOMIC EMISSION SPECTROMETRY; AUTOMETALLOGRAPHY; BRAIN LEVEL; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; GAS CHROMATOGRAPHY; LIPID PEROXIDATION; LIVER LEVEL; MASS SPECTROMETRY; MICROSCOPY; MYELIN SHEATH; NONHUMAN; OSMOTIC PUMP; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PERIPHERAL NERVE INJURY; RAT;

ALCOHOL DETERRENTS; ANIMALS; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPPER; DIET; DISULFIRAM; DITIOCARB; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HISTOCYTOCHEMISTRY; ISOPROSTANES; LIPID PEROXIDATION; LIVER; LIVER FUNCTION TESTS; MALE; MUSCLE, SKELETAL; MYELIN SHEATH; NEUROMUSCULAR JUNCTION; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; SILVER STAINING; SPECTROPHOTOMETRY, ATOMIC; TISSUE DISTRIBUTION; WEIGHT GAIN;

ANIMALIA;

EID: 4444223239     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh190     Document Type: Article

References (40)

1. Aaseth, J., Soli, N. E., and Forre, O. (1979). Increased brain uptake of copper and zinc in mice caused by diethyldithiocarbamate. Acta Pharmacol. Toxicol. 45, 41-44.
2. Allain, P., and Krari, N. (1991). Diethyldithiocarbamate, copper and neurological disorders. Life Sci. 48, 291-299.
3. Allain, P., and Krari, N. (1993). Diethyldithiocarbamate and brain copper. Res. Commun. Chem. Pathol. Pharmacol. 80, 105-112.
4. Ansbacher, L. E., Bosch, E. P., and Cancilla, P. A. (1982). Disulfiram neuropathy: A neurofilamentous distal axonopathy. Neurology 32, 424-428.
5. Bouldin, T. W., Hall, C. D., and Krigman, M. R. (1980). Pathology of disulfiram neuropathy. Neuropath. Appl. Neurobiol. 6, 155-160.
6. Bremner, I. (1998). Manifestations of copper excess. Am. J. Clin. Nutr. 67(S), 1069S-1073S.
7. Chen, S. H., Liu, S. H., Liang, Y. C., Lin, J. K., and Lin-Shiau, S. Y. (2000). Death signaling pathway induced by pyrrolidine dithiocarbamate-Cu(2+) complex in the cultured rat cortical astrocytes. Glia 31, 249-261.
8. Danscher, G. (1984). Autometallography. A new technique for light and electron microscopic visualization of metals in biological tissues (gold, silver, metal sulphides and metal selenides). Histochemistry 81, 331-335.
9. Delmaestro, E., and Trombetta, L. D. (1995). The effects of disulfiram on the hippocampus and cerebellum of the rat brain: A study of oxidative stress. Toxicol. Lett. 75, 235-243.
10. Edington, N., and Howell, J. M. (1966). Changes in the nervous system of rabbits following the adminstration of sodium diethyldithiocarbamate. Nature 210, 1060-1061.
11. Erve, J. C. L., Jensen, O. N., Valentine, H. S., Amarnath, V., and Valentine, W. M. (2000). Disulfiram generates a stable N,N-Diethylcarbamoyl adduct on Cys-125 of rat hemoglobin β-chains in vivo. Chem. Res. Toxicol. 13, 237-244.
12. Gessner, P. K., and Gessner, T. (1992). Disulfiram and Its Metabolite DEDC. Chapman & Hall, London.
13. Haywood, S., Loughran, M., and Batt, R. M. (1985). Copper toxicosis and tolerance in the rat. III. Intracellular localization of copper in the liver and kidney. Exp. Mol. Pathol. 43, 209-219.
14. Heikkila, R. E., Cabbat, F. S., and Cohen, G. (1976). In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate. J. Biol. Chem. 251, 2182-2185.
15. Ho, B. T., Knan, M. M., Major, L. F., Fang, V. S., and Estevez, V. S. (1985). Trace elements and disulfiram. In Metal Ions in Neurology and Psychiatry (S. Gabay, J. Harris, and B. T. Ho, Eds.), Vol. 15, pp. 139-149. Alan R. Liss, Inc., New York.
16. Howell, J. M., Ishmael, J., Ewbank, R., and Blakemore, W. F. (1970). Changes in the central nervous system of lambs following the administration of sodium diethydithiocarbamate. Acta neuropathol. 15, 197-207.
17. Iwata, H., Watanabe, K., Miichi, H., and Matsui, Y. (1970). Accumulation of copper in the central nervous system on prolonged administration of sodium diethyldithiocarbamate to rats. Pharmacol. Res. Commun. 2, 213-220.
18. Johansson, B. (1992). A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr. Scand. 86, 15-26.
19. Johansson, B., and Stankiewicz, Z. (1985). Bis-(diethyldithiocarbamato) copper complex: A new metabolite of disulfiram? Biochem. Pharmacol. 34, 2989-2991.
20. Johnson, D. J., Graham, D. G., Amarnath, V., Amarnath, K., and Valentine, W. M. (1998). Release of carbon disulfide is a contributing mechanism in the axonopathy produced by N,N-diethyldithiocarbamate. Toxicol. Appl. Pharmacol. 148, 288-296.
21. Koutensky, J., Eybl, V., Koutenska, M., Sykora, J., and Mertl, F. (1971). Influence of sodium diethyldithiocarbamate on the toxicity and distribution of copper in mice. Eur. J. Pharmacol. 14, 389-392.
22. Lakomaa, E. L., Sato, S., Goldberg, A. M., and Frazier, J. M. (1982). The effect of sodium diethyldithiocarbamate treatment on copper and zinc concentrations in rat brain. Toxicol. Appl. Pharmacol. 65, 286-290.
23. Meyer, O. A., Tilson, H. A., Byrd, W. C., and Riley, M. T. (1979). A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. Neurobehav. Toxicol. 1, 233-236.
24. Moore, K. (1969). Effects of disulfiram and diethyldithiocarbamate on spontaneous locomotor activity and brain catecholamine levels in mice. Biochem. Pharmacol. 18, 1627-1634.
25. Morell, P., and Toews, A. D. (1996). Schwann cells as targets for neurotoxicants. Neurotoxicology 17, 685-696.
26. Mur, J. (1964). Analytische Reagenzstoffe im neuropathologishcen Versuch. Confin. Neurol. 24, 235-236.
27. Orrenius, S., Nobel, C. S., van den Dobbelsteen, D. J., Burkitt, M. J., and Slater, A. F. (1996). Dithiocarbamates and the redox regulation of cell death. Biochem. Soc. Trans. 24, 1032-1038.
28. Reich, E. E., Markesbery, W. R., Roberts, L. J., Swift, L. L., Morrow, J. D., and Montine, T. J. (2001). Brain regional quantification of F-ring and D/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Amer. J. Pathol. 158, 293-297.
29. 2-isoprosatnes as an index of oxidative stress in vivo. Free Rad. Biol. Med. 28, 505-513.
30. Ross, J. F., Switzer, R. C., Poston, M. R., and Lawhorn, G. T. (1996). Distribution of bismuth in the brain after intraperitoneal dosing of bismuth subnitrate in mice: Implications for routes of entry of xenobiotic metals into the brain. Brain Res. 725, 137-154.
31. Sato, M., Sugiyama, T., Daimon, T., and Iijima, K. (1994). Histochemical evidence for abnormal copper distribution in the central nervous system of LEC mutant rat. Neurosci. Lett. 171, 97-100.
32. Strausak, D., Mercer, J. F., Dieter, H. H., Stremmel, W., and Multhaup, G. (2001). Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases. Brain Res. Bull. 55, 175-185.
33. Szerdahelyi, P., and Kasa, P. (1986). Histochemical demonstration of copper in normal rat brain and spinal cord. Evidence of localization in glial cells. Histochem. 85, 341-347.
34. Szerdalheyi, P., and Kasa, P. (1987). Regional differences in the uptake of exogenous copper into rat brain after acute treatment with sodium diethyldithiocarbamate. Histocheistry 86, 627-632.
35. Tietz, N. W. (1976). Blood gases and electrolytes. In Fundamentals of Clinical Chemistry (N. W. Tieztz, Ed.), pp. 930-932. W.B. Saunders Co., Philadelphia.
36. Tiffany-Castiflioni, E., and Qian, Y. (2001). Astroglia as metal depots: Molecular mechanisms for metal accumulation, storage and release. Neurotoxicology 22, 577-592.
37. Tonkin, E. G., Erve, J. C. L., Amarnath, K., and Valentine, W. A (2000). Disulfiram produces a non-carbon disulfide-dependent schwannopathy in the rat. J. Neuropathol. Exp. Neurol. 59, 786-797.
38. Tonkin, E. G., Valentine, H. L., Zimmerman, L. J., and Valentine, W. M. (2003). Parenteral N,N-diethyldithiocarbamate produces segmental demyelination in the rat that is not dependent on cysteine carbamylation. Toxicol. Appl. Pharmacol. 189, 139-150.
39. Weiss, B., Cory-Slechta, D. A., and Cox, C. (1990). Modification of lead distribution by diethyldithiocarbamate. Fund. Appl. Toxicol. 15, 791-799.
40. Wilson, A., and Trombetta, L. D. (1999). The protective effects of zinc on diethyldithiocarbamate cytotoxicity on rat astrocytes in vitro. Toxicol. Lett. 105, 129-140.