Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics

Drug Metabolism and Disposition

Volumn 43, Issue 3, 2015, Pages 367-374

  Wang, Li ^a   Prasad, Bhagwat ^a   Salphati, Laurent ^b   Chu, Xiaoyan ^c   Gupta, Anshul ^d   Hop, Cornelis E C A ^b   Evers, Raymond ^c   Unadkat, Jashvant D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Departments of Pharmacokinetics and Drug Metabolism   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT EXPORT PUMP; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; ORGANIC CATION TRANSPORTER 1; SODIUM BILE ACID COTRANSPORTER; CARRIER PROTEIN; PROTEOME;

ADOLESCENT; ADULT; AGED; ANIMAL TISSUE; ARTICLE; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER CELL; MALE; NONHUMAN; POPULATION ABUNDANCE; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT; SPECIES DIFFERENCE; SPECIES DIVERSITY; TANDEM MASS SPECTROMETRY; ANIMAL; CRYOPRESERVATION; DOG; HAPLORHINI; LIVER; MACACA FASCICULARIS; METABOLISM; MIDDLE AGED; PROCEDURES; SPRAGUE DAWLEY RAT; WISTAR RAT; YOUNG ADULT;

CANIS FAMILIARIS; MACACA FASCICULARIS; RATTUS; RATTUS NORVEGICUS;

ADOLESCENT; ADULT; AGED; ANIMALS; CHILD; CRYOPRESERVATION; DOGS; FEMALE; HAPLORHINI; HEPATOCYTES; HUMANS; LIVER; MACACA FASCICULARIS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; PROTEOME; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; YOUNG ADULT;

EID: 84921808980     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.061580     Document Type: Article

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