S-Allylcysteine inhibits tumour progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer

British Journal of Nutrition

Volumn 108, Issue 1, 2012, Pages 28-38

  Pai, Man Hui ^a   Kuo, Yueh Hsiung ^b   Chiang, En Pei Isabel ^c   Tang, Feng Yao ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Cyclo oxygenase 2; Human oral cancer cells; Osteopontin; S Allylcysteine; Vimentin

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLINE; CYCLOOXYGENASE 2; DNA GLYCOSYLTRANSFERASE; I KAPPA B ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYLPURINE DNA GLYCOSYLTRANSFERASE; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S ALLYLCYSTEINE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; EPITHELIAL MESENCHYMAL TRANSITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; MOUTH CANCER; NONHUMAN; PROTEIN EXPRESSION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYCLIN D1; CYSTEINE; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, NUDE; MOUTH NEOPLASMS; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NF-KAPPA B; OSTEOPONTIN; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; STAINING AND LABELING;

ALLIUM SATIVUM; MAMMALIA; MUS;

EID: 84863643531     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511005307     Document Type: Article

References (48)

1. Kademani D (2007) Oral cancer. Mayo Clin Proc 82, 878-887. (Pubitemid 47015470)
2. Devoll RE, Li W, Woods KV, et al. (1999) Osteopontin (OPN) distribution in premalignant and malignant lesions of oral epithelium and expression in cell lines derived from squamous cell carcinoma of the oral cavity. J Oral Pathol Med 28, 97-101. (Pubitemid 29101029)
3. Rittling SR & Chambers AF (2004) Role of osteopontin in tumour progression. Br J Cancer 90, 1877-1881. (Pubitemid 38746324)
4. Wai PY & Kuo PC (2008) Osteopontin: regulation in tumor metastasis. Cancer Metastasis Rev 27, 103-118.
5. Das R, Mahabeleshwar GH & Kundu GC (2003) Osteopontin stimulates cell motility and nuclear factor kappaB-mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells. J Biol Chem 278, 28593-28606. (Pubitemid 36935765)
6. Fresno Vara JA, Casado E, de Castro J, et al. (2004) PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30, 193-204.
7. Robertson BW, Bonsal L & Chellaiah MA (2010) Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells. Mol Cancer 9, 260.
8. Nicholson KM & Anderson NG (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14, 381-395. (Pubitemid 34214843)
9. Vivanco I & Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2, 489-501. (Pubitemid 37328931)
10. Bai D, Ueno L & Vogt PK (2009) Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int J Cancer 125, 2863-2870.
11. Sawhney M, Rohatgi N, Kaur J, et al. (2007) Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. Int J Cancer 120, 2545-2556. (Pubitemid 46651274)
12. Brown JR & DuBois RN (2004) Cyclooxygenase as a target in lung cancer. Clin Cancer Res 10, 4266s-4269s. (Pubitemid 38812460)
13. Tamatani T, Azuma M, Motegi K, et al. (2007) Cepharanthinenhanced radiosensitivity through the inhibition of radiationinduced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells. Int J Oncol 31, 761-768.
14. McCubrey JA, Steelman LS, Chappell WH, et al. (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773, 1263-1284. (Pubitemid 47125967)
15. Jayasurya R, Francis G, Kannan S, et al. (2004) p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma. Int J Cancer 109, 710-716. (Pubitemid 38405618)
16. Todd R, Hinds PW, Munger K, et al. (2002) Cell cycle dysregulation in oral cancer. Crit Rev Oral Biol Med 13, 51-61. (Pubitemid 34792760)
17. Sartor M, Steingrimsdottir H, Elamin F, et al. (1999) Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines. Br J Cancer 80, 79-86. (Pubitemid 29210092)
18. Dohadwala M, Wang G, Heinrich E, et al. (2010) The role of ZEB1 in the inflammation-induced promotion of EMT in HNSCC. Otolaryngol Head Neck Surg 142, 753-759.
19. Jang TJ, Jeon KH & Jung KH (2009) Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. Yonsei Med J 50, 818-824.
20. Chang JY, Wright JM & Svoboda KK (2007) Signal transduction pathways involved in epithelial-mesenchymal transition in oral cancer compared with other cancers. Cells Tissues Organs 185, 40-47. (Pubitemid 46956841)
21. Hong KO, Kim JH, Hong JS, et al. (2009) Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells. J Exp Clin Cancer Res 28, 28.
22. Thomas GJ & Speight PM (2001) Cell adhesion molecules and oral cancer. Crit Rev Oral Biol Med 12, 479-498. (Pubitemid 34037727)
23. Neal CL, McKeithen D & Odero-Marah VA (2011) Snail negatively regulates cell adhesion to extracellular matrix and integrin expression via the MAPK pathway in prostate cancer cells. Cell Adh Migr 5, 249-257.
24. Conacci-Sorrell M, Simcha I, Ben Yedidia T, et al. (2003) Autoregulation of E-cadherin expression by cadherincadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 163, 847-857. (Pubitemid 37517891)
25. Matsuzaki H, Shima K, Muramatsu T, et al. (2007) Osteopontin as biomarker in early invasion by squamous cell carcinoma in tongue. J Oral Pathol Med 36, 30-34. (Pubitemid 44973985)
26. Muramatsu T, Shima K, Ohta K, et al. (2005) Inhibition of osteopontin expression and function in oral cancer cell lines by antisense oligonucleotides. Cancer Lett 217, 87-95. (Pubitemid 39642869)
27. Sharma C, Kaur J, Shishodia S, et al. (2006) Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. Toxicology 228, 1-15. (Pubitemid 44548099)
28. Nystrom ML, McCulloch D, Weinreb PH, et al. (2006) Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion. Cancer Res 66, 10833-10842. (Pubitemid 44876979)
29. Cerda SR, Turk PW, Thor AD, et al. (1998) Altered expression of the DNA repair protein. N-methylpurine-DNA glycosylase (MPG) in breast cancer. FEBS Lett 431, 12-18. (Pubitemid 28330843)
30. Bessho T, Roy R, Yamamoto K, et al. (1993) Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase. Proc Natl Acad Sci USA 90, 8901-8904. (Pubitemid 23306418)
31. Fleischauer AT & Arab L (2001) Garlic and cancer: a critical review of the epidemiologic literature. J Nutr 131, 1032S-1040S. (Pubitemid 32197292)
32. Hsing AW, Chokkalingam AP, Gao YT, et al. (2002) Allium vegetables and risk of prostate cancer: a population-based study. J Natl Cancer Inst 94, 1648-1651. (Pubitemid 35378731)
33. Thomson M & Ali M (2003) Garlic [Allium sativum[: a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets 3, 67-81. (Pubitemid 36119422)
34. Hosono T, Fukao T, Ogihara J, et al. (2005) Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of betatubulin. J Biol Chem 280, 41487-41493. (Pubitemid 41832209)
35. Jo HJ, Song JD, Kim KM, et al. (2008) Diallyl disulfide induces reversible G2/M phase arrest on a p53-independent mechanism in human colon cancer HCT-116 cells. Oncol Rep 19, 275-280. (Pubitemid 351176161)
36. Xiao D, Lew KL, Kim YA, et al. (2006) Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction. Clin Cancer Res 12, 6836-6843. (Pubitemid 44876854)
37. Arunkumar A, Vijayababu MR, Srinivasan N, et al. (2006) Garlic compound, diallyl disulfide induces cell cycle arrest in prostate cancer cell line PC-3. Mol Cell Biochem 288, 107-113. (Pubitemid 44314445)
38. Yang JS, Kok LF, Lin YH, et al. (2006) Diallyl disulfide inhibits WEHI-3 leukemia cells in vivo. Anticancer Res 26, 219-225.
39. Tanaka S, Haruma K, Yoshihara M, et al. (2006) Aged garlic extract has potential suppressive effect on colorectal adenomas in humans. J Nutr 136, 821S-826S. (Pubitemid 43363785)
40. Chu Q, Lee DT, Tsao SW, et al. (2007) S-allylcysteine, a water-soluble garlic derivative, suppresses the growth of a human androgen-independent prostate cancer xenograft, CWR22R, under in vivo conditions. BJU Int 99, 925-932. (Pubitemid 46439548)
41. Gapter LA, Yuin OZ & Ng KY (2008) S-Allylcysteine reduces breast tumor cell adhesion and invasion. Biochem Biophys Res Commun 367, 446-451.
42. Tang FY, Chiang EP, Chung JG, et al. (2009) S-allylcysteine modulates the expression of E-cadherin and inhibits the malignant progression of human oral cancer. J Nutr Biochem 20, 1013-1020.
43. Katsuki T, Hirata K, Ishikawa H, et al. (2006) Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. J Nutr 136, 847S-851S. (Pubitemid 43363790)
44. Sundaresan S & Subramanian P (2008) Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine. Mol Cell Biochem 310, 209-214.
45. Tang FY, Chiang EP & Pai MH (2010) Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model. J Agric Food Chem 58, 11156-11164.
46. Nagae S, Ushijima M, Hatono S, et al. (1994) Pharmacokinetics of the garlic compound S-allylcysteine. Planta Med 60, 214-217. (Pubitemid 24207711)
47. Amagase H, Petesch BL, Matsuura H, et al. (2001) Intake of garlic and its bioactive components. J Nutr 131, 955S-962S. (Pubitemid 32194988)
48. Raimondi AR, Molinolo A & Gutkind JS (2009) Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res 69, 4159-4166.