The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells

Biochemical Pharmacology

Volumn 91, Issue 4, 2015, Pages 510-521

  Pabois, Angélique ^a,b,c   Devallière, Julie ^a,b,c   Quillard, Thibaut ^a,b,c   Coulon, Flora ^a,b,c   Gérard, Nathalie ^a,b,c   Laboisse, Christian ^b,c   Toquet, Claire ^b,c   Charreau, Béatrice ^a,b,c  

^a Centre National de la Recherche Scientifique   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE NANTES   (France)

Author keywords

ADAM10; Endothelial cells; Inflammation; Notch pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADAM10 ENDOPEPTIDASE; DELTA LIKE LIGAND 4 PROTEIN; DISINTEGRIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA SECRETASE; HEY1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NOTCH RECEPTOR; NOTCH2 RECEPTOR; PROTEIN; RNA; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; DLL4 PROTEIN, HUMAN; MEMBRANE PROTEIN; SECRETASE; SIGNAL PEPTIDE;

ARTICLE; CELL ACTIVATION; CELL CONTACT; CELL ISOLATION; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STABLE EXPRESSION; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-6; MEMBRANE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH;

EID: 84921667819     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.08.007     Document Type: Article

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