Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways

Journal of Virology

Volumn 89, Issue 4, 2015, Pages 2287-2300

  Liu, Yinghui ^a   Li, Jianhua ^a   Chen, Jieliang ^a   Li, Yaming ^a   Wang, Weixia ^a   Du, Xiaoting ^a   Song, Wuhui ^a   Zhang, Wen ^a   Lin, Li ^a   Yuan, Zhenghong ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYCLIC AMP; DNA DIRECTED DNA POLYMERASE; INTERFERON REGULATORY FACTOR 3; RIBONUCLEASE H; STING PROTEIN; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; CATALYSIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; HEPATITIS B VIRUS; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOMODULATION; IMMUNOPRECIPITATION; MEMBRANE PERMEABILITY; NONHUMAN; PLASMID; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; QUORUM SENSING; SIGNAL TRANSDUCTION; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; CELL LINE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE EVASION; IMMUNOLOGY; LIVER CELL; METABOLISM; PHYSIOLOGY; PROTEIN ANALYSIS; VIROLOGY;

DNA VIRUSES; HEPATITIS B VIRUS;

CELL LINE; DNA, VIRAL; HEPATITIS B VIRUS; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; INTERFERON-BETA; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; UBIQUITINATION;

EID: 84921638462     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02760-14     Document Type: Article

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