메뉴 건너뛰기




Volumn 29, Issue 1, 2014, Pages 17-24

Interplay between hepatitis B virus and the innate immune responses: Implications for new therapeutic strategies

Author keywords

antiviral approaches; HBV; innate immunity; interferon; viral evasion

Indexed keywords

HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; IMMUNOTHERAPY;

EID: 84895076131     PISSN: 16740769     EISSN: 1995820X     Source Type: Journal    
DOI: 10.1007/s12250-014-3412-3     Document Type: Review
Times cited : (18)

References (66)
  • 1
    • 84856514985 scopus 로고    scopus 로고
    • IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome
    • 1:CAS:528:DC%2BC38XitVemu7Y%3D 3266786 22251702 10.1172/JCI58847
    • Belloni L, Allweiss L, Guerrieri F, Pediconi N, Volz T, Pollicino T, Petersen J, Raimondo G, Dandri M, and Levrero M. 2012. IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome. J Clin Invest, 122: 529-537.
    • (2012) J Clin Invest , vol.122 , pp. 529-537
    • Belloni, L.1    Allweiss, L.2    Guerrieri, F.3    Pediconi, N.4    Volz, T.5    Pollicino, T.6    Petersen, J.7    Raimondo, G.8    Dandri, M.9    Levrero, M.10
  • 2
    • 84868702241 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in chronic hepatitis B virus infections: Towards restoration of immune control of viral infection
    • 1:CAS:528:DC%2BC3sXktFOhtw%3D%3D 22157327 10.1136/gutjnl-2011-301073
    • Bertoletti A and Ferrari C. 2012. Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection. Gut, 61: 1754-1764.
    • (2012) Gut , vol.61 , pp. 1754-1764
    • Bertoletti, A.1    Ferrari, C.2
  • 3
    • 84869118771 scopus 로고    scopus 로고
    • The innate immune response to hepatitis B virus infection: Implications for pathogenesis and therapy
    • 1:CAS:528:DC%2BC38XhslCkt7jE 23072881 10.1016/j.antiviral.2012.10.001
    • Chang J, Block T M, and Guo J T. 2012. The innate immune response to hepatitis B virus infection: implications for pathogenesis and therapy. Antiviral Res, 96: 405-413.
    • (2012) Antiviral Res , vol.96 , pp. 405-413
    • Chang, J.1    Block, T.M.2    Guo, J.T.3
  • 4
    • 84895908706 scopus 로고    scopus 로고
    • An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases
    • Chen J, Zhang W, Lin J, Wang F, Wu M, Chen C, Zheng Y, Peng X, Li J, and Yuan Z. 2013. An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases. Mol Ther. doi:10.1038/mt.2013.212.
    • (2013) Mol Ther
    • Chen, J.1    Zhang, W.2    Lin, J.3    Wang, F.4    Wu, M.5    Chen, C.6    Zheng, Y.7    Peng, X.8    Li, J.9    Yuan, Z.10
  • 5
    • 84873311551 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase impairs interferon-alpha-induced STA T activation through inhibition of importin-alpha5 and protein kinase C-delta
    • 1:CAS:528:DC%2BC3sXit1Wgtrw%3D 22996189 10.1002/hep.26064
    • Chen J, Wu M, Zhang X, Zhang W, Zhang Z, Chen L, He J, Zheng Y, Chen C, Wang F, Hu Y, Zhou X, Wang C, Xu Y, Lu M, and Yuan Z. 2013. Hepatitis B virus polymerase impairs interferon-alpha-induced STA T activation through inhibition of importin-alpha5 and protein kinase C-delta. Hepatology, 57: 470-482.
    • (2013) Hepatology , vol.57 , pp. 470-482
    • Chen, J.1    Wu, M.2    Zhang, X.3    Zhang, W.4    Zhang, Z.5    Chen, L.6    He, J.7    Zheng, Y.8    Chen, C.9    Wang, F.10    Hu, Y.11    Zhou, X.12    Wang, C.13    Xu, Y.14    Lu, M.15    Yuan, Z.16
  • 6
    • 38049161918 scopus 로고    scopus 로고
    • RNAi for treating hepatitis B viral infection
    • 1:CAS:528:DC%2BD1cXkslShtA%3D%3D 2217617 18074201 10.1007/s11095-007- 9504-0
    • Chen Y, Cheng G, and Mahato R I. 2008. RNAi for treating hepatitis B viral infection. Pharm Res, 25: 72-86.
    • (2008) Pharm Res , vol.25 , pp. 72-86
    • Chen, Y.1    Cheng, G.2    Mahato, R.I.3
  • 7
    • 49149128080 scopus 로고    scopus 로고
    • Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
    • 1:CAS:528:DC%2BD1cXhtVShtr3K 18565796 10.1016/j.clim.2008.04.006
    • Chen Z, Cheng Y, Xu Y, Liao J, Zhang X, Hu Y, Zhang Q, Wang J, Zhang Z, Shen F, and Yuan Z. 2008. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol, 128: 400-408.
    • (2008) Clin Immunol , vol.128 , pp. 400-408
    • Chen, Z.1    Cheng, Y.2    Xu, Y.3    Liao, J.4    Zhang, X.5    Hu, Y.6    Zhang, Q.7    Wang, J.8    Zhang, Z.9    Shen, F.10    Yuan, Z.11
  • 8
    • 23444438877 scopus 로고    scopus 로고
    • Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1
    • 1:CAS:528:DC%2BD2MXntVCku70%3D 15963597 10.1016/j.jhep.2005.02.033
    • Cheng J, Imanishi H, Morisaki H, Liu W, Nakamura H, Morisaki T, and Hada T. 2005. Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1. J Hepatol, 43: 465-471.
    • (2005) J Hepatol , vol.43 , pp. 465-471
    • Cheng, J.1    Imanishi, H.2    Morisaki, H.3    Liu, W.4    Nakamura, H.5    Morisaki, T.6    Hada, T.7
  • 9
    • 33845770748 scopus 로고    scopus 로고
    • Inhibition of alpha interferon signaling by hepatitis B virus
    • 1:CAS:528:DC%2BD28XhtlCgu7rE 1797249 17065208 10.1128/JVI.01292-06
    • Christen V, Duong F, Bernsmeier C, Sun D, Nassal M, and Heim M H. 2007. Inhibition of alpha interferon signaling by hepatitis B virus. J Virol, 81: 159-165.
    • (2007) J Virol , vol.81 , pp. 159-165
    • Christen, V.1    Duong, F.2    Bernsmeier, C.3    Sun, D.4    Nassal, M.5    Heim, M.H.6
  • 10
    • 23844455909 scopus 로고    scopus 로고
    • Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2
    • 1:CAS:528:DC%2BD2MXos1Ghs78%3D 16116207
    • Cooper A, Tal G, Lider O, and Shaul Y. 2005. Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2. J Immunol, 175: 3165-3176.
    • (2005) J Immunol , vol.175 , pp. 3165-3176
    • Cooper, A.1    Tal, G.2    Lider, O.3    Shaul, Y.4
  • 11
    • 77952011493 scopus 로고    scopus 로고
    • Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs
    • 1:CAS:528:DC%2BC3cXhvFOisr0%3D 20160705 10.1038/mt.2010.20
    • Cradick T J, Keck K, Bradshaw S, Jamieson A C, and McCaffrey A P. 2010. Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Mol Ther, 18: 947-954.
    • (2010) Mol Ther , vol.18 , pp. 947-954
    • Cradick, T.J.1    Keck, K.2    Bradshaw, S.3    Jamieson, A.C.4    McCaffrey, A.P.5
  • 13
    • 80051526424 scopus 로고    scopus 로고
    • 5′ Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice
    • 1:CAS:528:DC%2BC3MXpvFOqtb8%3D 21684282 10.1053/j.gastro.2011.05.001
    • Ebert G, Poeck H, Lucifora J, Baschuk N, Esser K, Esposito I, Hartmann G, and Protzer U. 2011. 5′ Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice. Gastroenterology, 141: 696-706, 706 e691-693.
    • (2011) Gastroenterology , vol.141 , pp. 696-706
    • Ebert, G.1    Poeck, H.2    Lucifora, J.3    Baschuk, N.4    Esser, K.5    Esposito, I.6    Hartmann, G.7    Protzer, U.8
  • 14
    • 0043169550 scopus 로고    scopus 로고
    • Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins
    • 1:CAS:528:DC%2BD3sXlvF2gsLY%3D 12867637 10.1099/vir.0.18966-0
    • Fernandez M, Quiroga J A, and Carreno V. 2003. Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins. J Gen Virol, 84: 2073-2082.
    • (2003) J Gen Virol , vol.84 , pp. 2073-2082
    • Fernandez, M.1    Quiroga, J.A.2    Carreno, V.3
  • 16
    • 0025906989 scopus 로고
    • Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA
    • 1:CAS:528:DyaK3MXitVGgsb4%3D 51345 1707174 10.1073/pnas.88.7.2888
    • Foster G R, Ackrill A M, Goldin R D, Kerr I M, Thomas H C, and Stark G R. 1991. Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA. Proc Natl Acad Sci U S A, 88: 2888-2892.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2888-2892
    • Foster, G.R.1    Ackrill, A.M.2    Goldin, R.D.3    Kerr, I.M.4    Thomas, H.C.5    Stark, G.R.6
  • 17
    • 0035123448 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein
    • 1:CAS:528:DC%2BD3MXhsFWiurw%3D 115893 11222692 10.1128/JVI.75.6.2684- 2691.2001
    • Gordien E, Rosmorduc O, Peltekian C, Garreau F, Brechot C, and Kremsdorf D. 2001. Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein. J Virol, 75: 2684-2691.
    • (2001) J Virol , vol.75 , pp. 2684-2691
    • Gordien, E.1    Rosmorduc, O.2    Peltekian, C.3    Garreau, F.4    Brechot, C.5    Kremsdorf, D.6
  • 19
    • 0033617583 scopus 로고    scopus 로고
    • Viral clearance without destruction of infected cells during acute HBV infection
    • 1:CAS:528:DyaK1MXivVKqsLk%3D 10221919 10.1126/science.284.5415.825
    • Guidotti L G, Rochford R, Chung J, Shapiro M, Purcell R, and Chisari F V. 1999. Viral clearance without destruction of infected cells during acute HBV infection. Science, 284: 825-829.
    • (1999) Science , vol.284 , pp. 825-829
    • Guidotti, L.G.1    Rochford, R.2    Chung, J.3    Shapiro, M.4    Purcell, R.5    Chisari, F.V.6
  • 20
    • 0036187835 scopus 로고    scopus 로고
    • Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice
    • 1:CAS:528:DC%2BD38XitV2rtbk%3D 135990 11861827 10.1128/JVI.76.6.2617- 2621.2002
    • Guidotti L G, Morris A, Mendez H, Koch R, Silverman R H, Williams B R, and Chisari F V. 2002. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. J Virol, 76: 2617-2621.
    • (2002) J Virol , vol.76 , pp. 2617-2621
    • Guidotti, L.G.1    Morris, A.2    Mendez, H.3    Koch, R.4    Silverman, R.H.5    Williams, B.R.6    Chisari, F.V.7
  • 21
    • 58149517671 scopus 로고    scopus 로고
    • Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells
    • 1:CAS:528:DC%2BD1MXotlCmt70%3D 2612386 18971270 10.1128/JVI.02008-08
    • Guo H, Jiang D, Ma D, Chang J, Dougherty A M, Cuconati A, Block T M, and Guo J T. 2009. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J Virol, 83: 847-858.
    • (2009) J Virol , vol.83 , pp. 847-858
    • Guo, H.1    Jiang, D.2    Ma, D.3    Chang, J.4    Dougherty, A.M.5    Cuconati, A.6    Block, T.M.7    Guo, J.T.8
  • 22
    • 50149117189 scopus 로고    scopus 로고
    • Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus
    • 1:CAS:528:DC%2BD1cXhtVClt7%2FN 2519695 18596101 10.1128/JVI.01022-08
    • Guy C S, Mulrooney-Cousins P M, Churchill N D, and Michalak T I. 2008. Intrahepatic expression of genes affiliated with innate and adaptive immune responses immediately after invasion and during acute infection with woodchuck hepadnavirus. J Virol, 82: 8579-8591.
    • (2008) J Virol , vol.82 , pp. 8579-8591
    • Guy, C.S.1    Mulrooney-Cousins, P.M.2    Churchill, N.D.3    Michalak, T.I.4
  • 23
    • 82955201589 scopus 로고    scopus 로고
    • Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition
    • 1:CAS:528:DC%2BC3MXhs1Oqur%2FI 3234243 22174754 10.1371/journal.pone. 0027931
    • Han Q, Zhang C, Zhang J, and Tian Z. 2011. Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition. PLoS One, 6: e27931.
    • (2011) PLoS One , vol.6 , pp. 27931
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 24
    • 80053330165 scopus 로고    scopus 로고
    • Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner
    • 1:CAS:528:DC%2BC3MXht1amtbzN 21721030 10.1002/hep.24505
    • Han Q, Zhang C, Zhang J, and Tian Z. 2011. Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner. Hepatology, 54: 1179-1189.
    • (2011) Hepatology , vol.54 , pp. 1179-1189
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 25
    • 84872378173 scopus 로고    scopus 로고
    • The role of innate immunity in HBV infection
    • 1:CAS:528:DC%2BC3sXnt12msA%3D%3D 22814721 10.1007/s00281-012-0331-y
    • Han Q, Zhang C, Zhang J, and Tian Z. 2013. The role of innate immunity in HBV infection. Semin Immunopathol, 35: 23-38.
    • (2013) Semin Immunopathol , vol.35 , pp. 23-38
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 27
    • 18744399291 scopus 로고    scopus 로고
    • Toll-like receptor signaling inhibits hepatitis B virus replication in vivo
    • 1:CAS:528:DC%2BD2MXksFKgtr0%3D 1112123 15890966 10.1128/JVI.79.11.7269- 7272.2005
    • Isogawa M, Robek M D, Furuichi Y, and Chisari F V. 2005. Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol, 79: 7269-7272.
    • (2005) J Virol , vol.79 , pp. 7269-7272
    • Isogawa, M.1    Robek, M.D.2    Furuichi, Y.3    Chisari, F.V.4
  • 29
    • 78650645590 scopus 로고    scopus 로고
    • Hepatitis B Virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon
    • 3020017 21068253 10.1128/JVI.01825-10
    • Kumar M, Jung S Y, Hodgson A J, Madden C R, Qin J, and Slagle B L. 2011. Hepatitis B Virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol, 85: 987-995.
    • (2011) J Virol , vol.85 , pp. 987-995
    • Kumar, M.1    Jung, S.Y.2    Hodgson, A.J.3    Madden, C.R.4    Qin, J.5    Slagle, B.L.6
  • 30
    • 79955672370 scopus 로고    scopus 로고
    • Hepatitis B therapy
    • 1:CAS:528:DC%2BC3MXlsFKit7o%3D 21423260
    • Kwon H, and Lok A S. 2011. Hepatitis B therapy. Nat Rev Gastroenterol Hepatol, 8: 275-284.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 275-284
    • Kwon, H.1    Lok, A.S.2
  • 31
    • 84879601220 scopus 로고    scopus 로고
    • Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance
    • 1:CAS:528:DC%2BC3sXhtVaju7vL 23447417 10.1002/hep.26339
    • Lan P, Zhang C, Han Q, Zhang J, and Tian Z. 2013. Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. Hepatology, 58: 73-85.
    • (2013) Hepatology , vol.58 , pp. 73-85
    • Lan, P.1    Zhang, C.2    Han, Q.3    Zhang, J.4    Tian, Z.5
  • 33
    • 80052444371 scopus 로고    scopus 로고
    • The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway
    • 1:CAS:528:DC%2BC3MXhtF2hurnN 21334391 10.1016/j.jhep.2010.12.042
    • Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, and Mansell A. 2011. The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway. J Hepatol, 55: 762-769.
    • (2011) J Hepatol , vol.55 , pp. 762-769
    • Lang, T.1    Lo, C.2    Skinner, N.3    Locarnini, S.4    Visvanathan, K.5    Mansell, A.6
  • 34
    • 77953295897 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of pre-S/S RNAs
    • 1:CAS:528:DC%2BC3cXptVehtbw%3D 2903248 20410269 10.1128/JVI.00236-10
    • Li J, Lin S, Chen Q, Peng L, Zhai J, Liu Y, and Yuan Z. 2010. Inhibition of hepatitis B virus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of pre-S/S RNAs. J Virol, 84: 6387-6399.
    • (2010) J Virol , vol.84 , pp. 6387-6399
    • Li, J.1    Lin, S.2    Chen, Q.3    Peng, L.4    Zhai, J.5    Liu, Y.6    Yuan, Z.7
  • 35
    • 84880797948 scopus 로고    scopus 로고
    • Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity
    • 1:CAS:528:DC%2BC3sXhtVKgsr3K 23832071 10.1038/ni.2647
    • Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, and Yuan Z. 2013. Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity. Nat Immunol, 14: 793-803.
    • (2013) Nat Immunol , vol.14 , pp. 793-803
    • Li, J.1    Liu, K.2    Liu, Y.3    Xu, Y.4    Zhang, F.5    Yang, H.6    Liu, J.7    Pan, T.8    Chen, J.9    Wu, M.10    Zhou, X.11    Yuan, Z.12
  • 36
    • 84884247557 scopus 로고    scopus 로고
    • Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication
    • 1:CAS:528:DC%2BC3sXhsVWrsr7E 23926323 10.4049/jimmunol.1300512
    • Lu H L, and Liao F. 2013. Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication. J Immunol, 191: 3264-3276.
    • (2013) J Immunol , vol.191 , pp. 3264-3276
    • Lu, H.L.1    Liao, F.2
  • 37
    • 73449093499 scopus 로고    scopus 로고
    • Control of hepatitis B virus replication by innate response of HepaRG cells
    • 10.1002/hep.23230
    • Lucifora J, Durantel D, Testoni B, Hantz O, Levrero M, and Zoulim F. 2009. Control of hepatitis B virus replication by innate response of HepaRG cells. Hepatology, 51: 63-72.
    • (2009) Hepatology , vol.51 , pp. 63-72
    • Lucifora, J.1    Durantel, D.2    Testoni, B.3    Hantz, O.4    Levrero, M.5    Zoulim, F.6
  • 39
    • 84884747041 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein
    • 1:CAS:528:DC%2BC3sXht1GitL7I 3708887 23853601 10.1371/journal.ppat. 1003494
    • Mao R, Nie H, Cai D, Zhang J, Liu H, Yan R, Cuconati A, Block T M, Guo J T, and Guo H. 2013. Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein. PLoS Pathog, 9: e1003494.
    • (2013) PLoS Pathog , vol.9 , pp. 1003494
    • Mao, R.1    Nie, H.2    Cai, D.3    Zhang, J.4    Liu, H.5    Yan, R.6    Cuconati, A.7    Block, T.M.8    Guo, J.T.9    Guo, H.10
  • 40
    • 42649145816 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus gene expression and replication by endoribonuclease-prepared siRNA
    • 1:CAS:528:DC%2BD1cXlslGntLs%3D 18378325 10.1016/j.jviromet.2008.02.008
    • Meng Z, Xu Y, Wu J, Tian Y, Kemper T, Bleekmann B, Roggendorf M, Yang D, and Lu M. 2008. Inhibition of hepatitis B virus gene expression and replication by endoribonuclease-prepared siRNA. J Virol Methods, 150: 27-33.
    • (2008) J Virol Methods , vol.150 , pp. 27-33
    • Meng, Z.1    Xu, Y.2    Wu, J.3    Tian, Y.4    Kemper, T.5    Bleekmann, B.6    Roggendorf, M.7    Yang, D.8    Lu, M.9
  • 41
    • 0025202950 scopus 로고
    • Impaired lipopolysaccharide-inducible tumor necrosis factor production in vitro by peripheral blood monocytes of patients with viral hepatitis
    • 1:STN:280:DyaK3M%2FjtlGqtw%3D%3D 2121637 10.1002/hep.1840120507
    • Muller C, and Zielinski C C. 1990. Impaired lipopolysaccharide-inducible tumor necrosis factor production in vitro by peripheral blood monocytes of patients with viral hepatitis. Hepatology, 12: 1118-1124.
    • (1990) Hepatology , vol.12 , pp. 1118-1124
    • Muller, C.1    Zielinski, C.C.2
  • 42
    • 34247635482 scopus 로고    scopus 로고
    • Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G
    • 1:CAS:528:DC%2BD2sXkvFChs7k%3D 1900192 17314171 10.1128/JVI.02510-06
    • Nguyen D H, Gummuluru S, and Hu J. 2007. Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G. J Virol, 81: 4465-4472.
    • (2007) J Virol , vol.81 , pp. 4465-4472
    • Nguyen, D.H.1    Gummuluru, S.2    Hu, J.3
  • 43
    • 46049093989 scopus 로고    scopus 로고
    • Hepatitis B virus-cell interactions and pathogenesis
    • 1:CAS:528:DC%2BD1cXotFyrtr0%3D 18302164 10.1002/jcp.21416
    • Nguyen D H, Ludgate L, and Hu J. 2008. Hepatitis B virus-cell interactions and pathogenesis. J Cell Physiol, 216: 289-294.
    • (2008) J Cell Physiol , vol.216 , pp. 289-294
    • Nguyen, D.H.1    Ludgate, L.2    Hu, J.3
  • 44
    • 58149299723 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen impairs myeloid dendritic cell function: A possible immune escape mechanism of hepatitis B virus
    • 1:CAS:528:DC%2BD1MXhsVCitrc%3D 18624732 10.1111/j.1365-2567.2008.02896.x
    • Op den Brouw M L, Binda R S, van Roosmalen M H, Protzer U, Janssen H L, van der Molen R G, and Woltman A M. 2009. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus. Immunology, 126: 280-289.
    • (2009) Immunology , vol.126 , pp. 280-289
    • Op Den Brouw, M.L.1    Binda, R.S.2    Van Roosmalen, M.H.3    Protzer, U.4    Janssen, H.L.5    Van Der Molen, R.G.6    Woltman, A.M.7
  • 45
    • 77952300032 scopus 로고    scopus 로고
    • Lambda and alpha interferons inhibit hepatitis B virus replication through a common molecular mechanism but with different in vivo activities
    • 1:CAS:528:DC%2BC3cXlsFajtbo%3D 2864496 20303135 10.1016/j.virol.2010.02. 022
    • Pagliaccetti N E, Chu E N, Bolen C R, Kleinstein S H, and Robek M D. 2010. Lambda and alpha interferons inhibit hepatitis B virus replication through a common molecular mechanism but with different in vivo activities. Virology, 401: 197-206.
    • (2010) Virology , vol.401 , pp. 197-206
    • Pagliaccetti, N.E.1    Chu, E.N.2    Bolen, C.R.3    Kleinstein, S.H.4    Robek, M.D.5
  • 46
    • 84857623630 scopus 로고    scopus 로고
    • Living in the liver: Hepatic infections
    • 1:CAS:528:DC%2BC38XislynsL0%3D 22362353 10.1038/nri3169
    • Protzer U, Maini M K, and Knolle P A. 2012. Living in the liver: hepatic infections. Nat Rev Immunol, 12: 201-213.
    • (2012) Nat Rev Immunol , vol.12 , pp. 201-213
    • Protzer, U.1    Maini, M.K.2    Knolle, P.A.3
  • 47
    • 0344631691 scopus 로고    scopus 로고
    • Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells
    • 1:CAS:528:DyaK1MXnvFansr4%3D 10580575 10.1016/S0168-8278(99)80279-7
    • Rang A, Gunther S, and Will H. 1999. Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells. J Hepatol, 31: 791-799.
    • (1999) J Hepatol , vol.31 , pp. 791-799
    • Rang, A.1    Gunther, S.2    Will, H.3
  • 48
    • 84874418555 scopus 로고    scopus 로고
    • New insights into how HBV manipulates the innate immune response to establish acute and persistent infection
    • 1:CAS:528:DC%2BC3sXnt12qu7Y%3D 23363957 10.3851/IMP2542
    • Revill P, and Yuan Z. 2013. New insights into how HBV manipulates the innate immune response to establish acute and persistent infection. Antivir Ther, 18: 1-15.
    • (2013) Antivir Ther , vol.18 , pp. 1-15
    • Revill, P.1    Yuan, Z.2
  • 49
    • 14744276042 scopus 로고    scopus 로고
    • Lambda interferon inhibits hepatitis B and C virus replication
    • 1:CAS:528:DC%2BD2MXit1ehtr0%3D 1075734 15731279 10.1128/JVI.79.6.3851- 3854.2005
    • Robek M D, Boyd B S, and Chisari F V. 2005. Lambda interferon inhibits hepatitis B and C virus replication. J Virol, 79: 3851-3854.
    • (2005) J Virol , vol.79 , pp. 3851-3854
    • Robek, M.D.1    Boyd, B.S.2    Chisari, F.V.3
  • 50
    • 1642308939 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication by APOBEC3G
    • 15031497 10.1126/science.1092066
    • Turelli P, Mangeat B, Jost S, Vianin S, and Trono D. 2004. Inhibition of hepatitis B virus replication by APOBEC3G. Science, 303: 1829.
    • (2004) Science , vol.303 , pp. 1829
    • Turelli, P.1    Mangeat, B.2    Jost, S.3    Vianin, S.4    Trono, D.5
  • 53
    • 77955381494 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: Implications for immune evasion
    • 2904777 20657822 10.1371/journal.ppat.1000986
    • Wang H, and Ryu W S. 2010. Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion. PLoS Pathog, 6: e1000986.
    • (2010) PLoS Pathog , vol.6 , pp. 1000986
    • Wang, H.1    Ryu, W.S.2
  • 55
    • 84877820210 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation
    • 1:CAS:528:DC%2BC3sXmvFyqt7k%3D 23585678 10.4049/jimmunol.1201625
    • Wang S, Chen Z, Hu C, Qian F, Cheng Y, Wu M, Shi B, Chen J, Hu Y, and Yuan Z. 2013. Hepatitis B virus surface antigen selectively inhibits TLR2 ligand-induced IL-12 production in monocytes/macrophages by interfering with JNK activation. J Immunol, 190: 5142-5151.
    • (2013) J Immunol , vol.190 , pp. 5142-5151
    • Wang, S.1    Chen, Z.2    Hu, C.3    Qian, F.4    Cheng, Y.5    Wu, M.6    Shi, B.7    Chen, J.8    Hu, Y.9    Yuan, Z.10
  • 57
    • 2342588229 scopus 로고    scopus 로고
    • Genomic analysis of the host response to hepatitis B virus infection
    • 1:CAS:528:DC%2BD2cXjvVyhsr8%3D 404103 15100412 10.1073/pnas.0401771101
    • Wieland S, Thimme R, Purcell R H, and Chisari F V. 2004. Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci U S A, 101: 6669-6674.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6669-6674
    • Wieland, S.1    Thimme, R.2    Purcell, R.H.3    Chisari, F.V.4
  • 58
    • 0033998463 scopus 로고    scopus 로고
    • Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice
    • 1:CAS:528:DC%2BD3cXislGrurk%3D 111931 10756029 10.1128/JVI.74.9.4165- 4173.2000
    • Wieland S F, Guidotti L G, and Chisari F V. 2000. Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J Virol, 74: 4165-4173.
    • (2000) J Virol , vol.74 , pp. 4165-4173
    • Wieland, S.F.1    Guidotti, L.G.2    Chisari, F.V.3
  • 61
    • 67650435788 scopus 로고    scopus 로고
    • HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells
    • 1:CAS:528:DC%2BD1MXos1Omu7s%3D 19501403 10.1016/j.molimm.2009.04.031
    • Xu Y, Hu Y, Shi B, Zhang X, Wang J, Zhang Z, Shen F, Zhang Q, Sun S, and Yuan Z. 2009. HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells. Mol Immunol, 46: 2640-2646.
    • (2009) Mol Immunol , vol.46 , pp. 2640-2646
    • Xu, Y.1    Hu, Y.2    Shi, B.3    Zhang, X.4    Wang, J.5    Zhang, Z.6    Shen, F.7    Zhang, Q.8    Sun, S.9    Yuan, Z.10
  • 62
    • 77955290279 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3
    • 1:CAS:528:DC%2BC3cXhtVCrsrfK 20375222 10.1099/vir.0.020552-0
    • Yu S, Chen J, Wu M, Chen H, and Yuan Z. 2010. Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J Gen Virol, 91: 2080-2090.
    • (2010) J Gen Virol , vol.91 , pp. 2080-2090
    • Yu, S.1    Chen, J.2    Wu, M.3    Chen, H.4    Yuan, Z.5
  • 65
    • 49149097044 scopus 로고    scopus 로고
    • Zinc finger proteins designed to specifically target duck hepatitis B virus covalently closed circular DNA inhibit viral transcription in tissue culture
    • 1:CAS:528:DC%2BD1cXpsVOqurg%3D 2519588 18524822 10.1128/JVI.00366-08
    • Zimmerman K A, Fischer K P, Joyce M A, and Tyrrell D L. 2008. Zinc finger proteins designed to specifically target duck hepatitis B virus covalently closed circular DNA inhibit viral transcription in tissue culture. J Virol, 82: 8013-8021.
    • (2008) J Virol , vol.82 , pp. 8013-8021
    • Zimmerman, K.A.1    Fischer, K.P.2    Joyce, M.A.3    Tyrrell, D.L.4
  • 66
    • 84867411012 scopus 로고    scopus 로고
    • Are novel combination therapies needed for chronic hepatitis B?
    • 1:CAS:528:DC%2BC38Xhs12gtLrP 22999818 10.1016/j.antiviral.2012.09.006
    • Zoulim F. 2012. Are novel combination therapies needed for chronic hepatitis B? Antiviral Res, 96: 256-259.
    • (2012) Antiviral Res , vol.96 , pp. 256-259
    • Zoulim, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.