메뉴 건너뛰기




Volumn 19, Issue 1, 2015, Pages 1-10

The role of the small GTPase Rab31 in cancer

Author keywords

Cancer; Membrane traffic; Mucin1; Rab31

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; RAB PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 84921599178     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12403     Document Type: Article
Times cited : (51)

References (132)
  • 2
    • 68049105101 scopus 로고    scopus 로고
    • Rab GTPases as coordinators of vesicle traffic
    • Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol. 2009; 10: 513-25.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 513-525
    • Stenmark, H.1
  • 3
    • 84870204151 scopus 로고    scopus 로고
    • The Rab family of proteins: 25 years on
    • Kelly EE, Horgan CP, Goud B, et al. The Rab family of proteins: 25 years on. Biochem Soc Trans. 2012; 40: 1337-47.
    • (2012) Biochem Soc Trans , vol.40 , pp. 1337-1347
    • Kelly, E.E.1    Horgan, C.P.2    Goud, B.3
  • 4
    • 84856710398 scopus 로고    scopus 로고
    • The Ras protein superfamily: evolutionary tree and role of conserved amino acids
    • Rojas AM, Fuentes G, Rausell A, et al. The Ras protein superfamily: evolutionary tree and role of conserved amino acids. J Cell Biol. 2012; 196: 189-201.
    • (2012) J Cell Biol , vol.196 , pp. 189-201
    • Rojas, A.M.1    Fuentes, G.2    Rausell, A.3
  • 5
    • 3142585284 scopus 로고    scopus 로고
    • Controlling the location and activation of Rab GTPases
    • Seabra MC, Wasmeier C. Controlling the location and activation of Rab GTPases. Curr Opin Cell Biol. 2004; 16: 451-7.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 451-457
    • Seabra, M.C.1    Wasmeier, C.2
  • 6
    • 8444243363 scopus 로고    scopus 로고
    • Targeting Rab GTPases to distinct membrane compartments
    • Pfeffer S, Aivazian D. Targeting Rab GTPases to distinct membrane compartments. Nat Rev Mol Cell Biol. 2004; 5: 886-96.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 886-896
    • Pfeffer, S.1    Aivazian, D.2
  • 7
    • 78751656754 scopus 로고    scopus 로고
    • Role of Rab GTPases in membrane traffic and cell physiology
    • Hutagalung AH, Novick PJ. Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev. 2011; 91: 119-49.
    • (2011) Physiol Rev , vol.91 , pp. 119-149
    • Hutagalung, A.H.1    Novick, P.J.2
  • 9
    • 78751705518 scopus 로고    scopus 로고
    • GTPases involved in vesicular trafficking: structures and mechanisms
    • Itzen A, Goody RS. GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol. 2011; 22: 48-56.
    • (2011) Semin Cell Dev Biol , vol.22 , pp. 48-56
    • Itzen, A.1    Goody, R.S.2
  • 10
    • 0029126327 scopus 로고
    • Rab GDP dissociation inhibitor: putting rab GTPases in the right place
    • Pfeffer SR, Dirac-Svejstrup AB, Soldati T. Rab GDP dissociation inhibitor: putting rab GTPases in the right place. J Biol Chem. 1995; 270: 17057-9.
    • (1995) J Biol Chem , vol.270 , pp. 17057-17059
    • Pfeffer, S.R.1    Dirac-Svejstrup, A.B.2    Soldati, T.3
  • 11
    • 0030051303 scopus 로고    scopus 로고
    • Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein
    • Shen F, Seabra MC. Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein. J Biol Chem. 1996; 271: 3692-8.
    • (1996) J Biol Chem , vol.271 , pp. 3692-3698
    • Shen, F.1    Seabra, M.C.2
  • 12
    • 0038247888 scopus 로고    scopus 로고
    • Membrane targeting of Rab GTPases is influenced by the prenylation motif
    • Gomes AQ, Ali BR, Ramalho JS, et al. Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell. 2003; 14: 1882-99.
    • (2003) Mol Biol Cell , vol.14 , pp. 1882-1899
    • Gomes, A.Q.1    Ali, B.R.2    Ramalho, J.S.3
  • 13
    • 23844449034 scopus 로고    scopus 로고
    • Targeting of Rab GTPases to cellular membranes
    • Ali BR, Seabra MC. Targeting of Rab GTPases to cellular membranes. Biochem Soc Trans. 2005; 33: 652-6.
    • (2005) Biochem Soc Trans , vol.33 , pp. 652-656
    • Ali, B.R.1    Seabra, M.C.2
  • 15
    • 84874366009 scopus 로고    scopus 로고
    • RabGEFs are a major determinant for specific Rab membrane targeting
    • Blümer J, Rey J, Dehmelt L, et al. RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol. 2013; 200: 287-300.
    • (2013) J Cell Biol , vol.200 , pp. 287-300
    • Blümer, J.1    Rey, J.2    Dehmelt, L.3
  • 16
    • 77958487311 scopus 로고    scopus 로고
    • TRAPP complexes in membrane traffic: convergence through a common Rab
    • Barrowman J, Bhandari D, Reinisch K, et al. TRAPP complexes in membrane traffic: convergence through a common Rab. Nat Rev Mol Cell Biol. 2010; 11: 759-63.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 759-763
    • Barrowman, J.1    Bhandari, D.2    Reinisch, K.3
  • 17
  • 18
    • 33751269381 scopus 로고    scopus 로고
    • Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis
    • Novick P, Medkova M, Dong G, et al. Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis. Biochem Soc Trans. 2006; 34: 683-6.
    • (2006) Biochem Soc Trans , vol.34 , pp. 683-686
    • Novick, P.1    Medkova, M.2    Dong, G.3
  • 19
    • 84879768677 scopus 로고    scopus 로고
    • Rab GTPases-cargo direct interactions: fine modulators of intracellular trafficking
    • Aloisi AL, Bucci C. Rab GTPases-cargo direct interactions: fine modulators of intracellular trafficking. Histol Histopathol. 2013; 28: 839-49.
    • (2013) Histol Histopathol , vol.28 , pp. 839-849
    • Aloisi, A.L.1    Bucci, C.2
  • 20
    • 79952424287 scopus 로고    scopus 로고
    • TBC proteins: GAPs for mammalian small GTPase Rab?
    • Fukuda M. TBC proteins: GAPs for mammalian small GTPase Rab? Biosci Rep. 2011; 31: 159-68.
    • (2011) Biosci Rep , vol.31 , pp. 159-168
    • Fukuda, M.1
  • 21
    • 0037371509 scopus 로고    scopus 로고
    • Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy
    • Verhoeven K, De Jonghe P, Coen K, et al. Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy. Am J Hum Genet. 2003; 72: 722-7.
    • (2003) Am J Hum Genet , vol.72 , pp. 722-727
    • Verhoeven, K.1    De Jonghe, P.2    Coen, K.3
  • 22
    • 39549098329 scopus 로고    scopus 로고
    • Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease
    • Spinosa MR, Progida C, De Luca A, et al. Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci. 2008; 28: 1640-8.
    • (2008) J Neurosci , vol.28 , pp. 1640-1648
    • Spinosa, M.R.1    Progida, C.2    De Luca, A.3
  • 23
    • 79953728451 scopus 로고    scopus 로고
    • Loss-of-function mutations in RAB18 cause Warburg micro syndrome
    • Bem D, Yoshimura SI, Nunes-Bastos R, et al. Loss-of-function mutations in RAB18 cause Warburg micro syndrome. Am J Hum Genet. 2011; 88: 499-507.
    • (2011) Am J Hum Genet , vol.88 , pp. 499-507
    • Bem, D.1    Yoshimura, S.I.2    Nunes-Bastos, R.3
  • 24
    • 84890310034 scopus 로고    scopus 로고
    • Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans
    • Liegel RP, Handley MT, Ronchetti A, et al. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet. 2013; 93: 1001-14.
    • (2013) Am J Hum Genet , vol.93 , pp. 1001-1014
    • Liegel, R.P.1    Handley, M.T.2    Ronchetti, A.3
  • 25
    • 34250009169 scopus 로고    scopus 로고
    • RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity
    • Jenkins D, Seelow D, Jehee FS, et al. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Am J Hum Genet. 2007; 80: 1162-70.
    • (2007) Am J Hum Genet , vol.80 , pp. 1162-1170
    • Jenkins, D.1    Seelow, D.2    Jehee, F.S.3
  • 26
    • 79952763789 scopus 로고    scopus 로고
    • Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay
    • Jenkins D, Baynam G, De Catte L, et al. Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay. Hum Mutat. 2011; 32: E2069-78.
    • (2011) Hum Mutat , vol.32 , pp. E2069-E2078
    • Jenkins, D.1    Baynam, G.2    De Catte, L.3
  • 27
    • 0036073806 scopus 로고    scopus 로고
    • Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome
    • Barral DC, Ramalho JS, Anders R, et al. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest. 2002; 110: 247-57.
    • (2002) J Clin Invest , vol.110 , pp. 247-257
    • Barral, D.C.1    Ramalho, J.S.2    Anders, R.3
  • 28
    • 76249116225 scopus 로고    scopus 로고
    • Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly
    • Giannandrea M, Bianchi V, Mignogna ML, et al. Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly. Am J Hum Genet. 2010; 86: 185-95.
    • (2010) Am J Hum Genet , vol.86 , pp. 185-195
    • Giannandrea, M.1    Bianchi, V.2    Mignogna, M.L.3
  • 29
    • 1842556755 scopus 로고    scopus 로고
    • The rat Ruby (R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain
    • Oiso N, Riddle SR, Serikawa T, et al. The rat Ruby (R) locus is Rab38: identical mutations in Fawn-hooded and Tester-Moriyama rats derived from an ancestral Long Evans rat sub-strain. Mamm Genome. 2004; 15: 307-14.
    • (2004) Mamm Genome , vol.15 , pp. 307-314
    • Oiso, N.1    Riddle, S.R.2    Serikawa, T.3
  • 30
    • 84869491973 scopus 로고    scopus 로고
    • BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor
    • Gerondopoulos A, Langemeyer L, Liang JR, et al. BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor. Curr Biol. 2012; 22: 2135-9.
    • (2012) Curr Biol , vol.22 , pp. 2135-2139
    • Gerondopoulos, A.1    Langemeyer, L.2    Liang, J.R.3
  • 32
    • 79957963356 scopus 로고    scopus 로고
    • Rabs, SNAREs and α-synuclein-membrane trafficking defects in synucleinopathies
    • Chua CEL, Tang BL. Rabs, SNAREs and α-synuclein-membrane trafficking defects in synucleinopathies. Brain Res Rev. 2011; 67: 268-81.
    • (2011) Brain Res Rev , vol.67 , pp. 268-281
    • Chua, C.E.L.1    Tang, B.L.2
  • 33
    • 84909965921 scopus 로고    scopus 로고
    • RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions
    • S0149-7634(14)00003-7
    • D'Adamo P, Masetti M, Bianchi V, et al. RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. Neurosci Biobehav Rev. 2014; pii: S0149-7634(14)00003-7.
    • (2014) Neurosci Biobehav Rev , pp. S0149-S7634
    • D'Adamo, P.1    Masetti, M.2    Bianchi, V.3
  • 34
    • 84883249554 scopus 로고    scopus 로고
    • Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders
    • Krzewski K, Cullinane AR. Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders. Exp Cell Res. 2013; 319: 2360-7.
    • (2013) Exp Cell Res , vol.319 , pp. 2360-2367
    • Krzewski, K.1    Cullinane, A.R.2
  • 35
    • 62749117198 scopus 로고    scopus 로고
    • Emerging roles for Rab family GTPases in human cancer
    • Chia WJ, Tang BL. Emerging roles for Rab family GTPases in human cancer. Biochim Biophys Acta. 2009; 1795: 110-6.
    • (2009) Biochim Biophys Acta , vol.1795 , pp. 110-116
    • Chia, W.J.1    Tang, B.L.2
  • 36
    • 84870196513 scopus 로고    scopus 로고
    • Novel functions for Rab GTPases in multiple aspects of tumour progression
    • Recchi C, Seabra MC. Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans. 2012; 40: 1398-403.
    • (2012) Biochem Soc Trans , vol.40 , pp. 1398-1403
    • Recchi, C.1    Seabra, M.C.2
  • 37
    • 20344395864 scopus 로고    scopus 로고
    • Aberrant expression of RAB1A in human tongue cancer
    • Shimada K, Uzawa K, Kato M, et al. Aberrant expression of RAB1A in human tongue cancer. Br J Cancer. 2005; 92: 1915-21.
    • (2005) Br J Cancer , vol.92 , pp. 1915-1921
    • Shimada, K.1    Uzawa, K.2    Kato, M.3
  • 38
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado H, Alečković M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012; 18: 883-91.
    • (2012) Nat Med , vol.18 , pp. 883-891
    • Peinado, H.1    Alečković, M.2    Lavotshkin, S.3
  • 39
    • 0026631462 scopus 로고
    • Overexpression of the ras-related rab2 gene product in peripheral blood mononuclear cells from patients with hematological and solid neoplasms
    • Culine S, Honoré N, Tavitian A, et al. Overexpression of the ras-related rab2 gene product in peripheral blood mononuclear cells from patients with hematological and solid neoplasms. Cancer Res. 1992; 52: 3083-8.
    • (1992) Cancer Res , vol.52 , pp. 3083-3088
    • Culine, S.1    Honoré, N.2    Tavitian, A.3
  • 40
    • 0028232778 scopus 로고
    • A small GTP-binding protein is frequently overexpressed in peripheral blood mononuclear cells from patients with solid tumours
    • Culine S, Honore N, Closson V, et al. A small GTP-binding protein is frequently overexpressed in peripheral blood mononuclear cells from patients with solid tumours. Eur J Cancer. 1994; 30A: 670-4.
    • (1994) Eur J Cancer , vol.30 A , pp. 670-674
    • Culine, S.1    Honore, N.2    Closson, V.3
  • 41
    • 79958136035 scopus 로고    scopus 로고
    • Rab5 in the regulation of cell motility and invasion
    • Torres VA, Stupack DG. Rab5 in the regulation of cell motility and invasion. Curr Protein Pept Sci. 2011; 12: 43-51.
    • (2011) Curr Protein Pept Sci , vol.12 , pp. 43-51
    • Torres, V.A.1    Stupack, D.G.2
  • 42
    • 84883306115 scopus 로고    scopus 로고
    • Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells
    • Mendoza P, Ortiz R, Díaz J, et al. Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells. J Cell Sci. 2013; 126: 3835-47.
    • (2013) J Cell Sci , vol.126 , pp. 3835-3847
    • Mendoza, P.1    Ortiz, R.2    Díaz, J.3
  • 43
    • 0032797695 scopus 로고    scopus 로고
    • Differential expression of RAB5A in human lung adenocarcinoma cells with different metastasis potential
    • Yu L, Hui-chen F, Chen Y, et al. Differential expression of RAB5A in human lung adenocarcinoma cells with different metastasis potential. Clin Exp Metastasis. 1999; 17: 213-9.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 213-219
    • Yu, L.1    Hui-chen, F.2    Chen, Y.3
  • 44
    • 0037062499 scopus 로고    scopus 로고
    • The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production
    • Croizet-Berger K, Daumerie C, Couvreur M, et al. The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production. Proc Natl Acad Sci USA. 2002; 99: 8277-82.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8277-8282
    • Croizet-Berger, K.1    Daumerie, C.2    Couvreur, M.3
  • 45
    • 34548649469 scopus 로고    scopus 로고
    • Expression of Rab5a in hepatocellular carcinoma: possible involvement in epidermal growth factor signaling
    • Fukui K, Tamura S, Wada A, et al. Expression of Rab5a in hepatocellular carcinoma: possible involvement in epidermal growth factor signaling. Hepatol Res. 2007; 37: 957-65.
    • (2007) Hepatol Res , vol.37 , pp. 957-965
    • Fukui, K.1    Tamura, S.2    Wada, A.3
  • 46
    • 77954169426 scopus 로고    scopus 로고
    • Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1-related epidermal growth factor signaling pathway
    • Zhao Z, Liu XF, Wu HC, et al. Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1-related epidermal growth factor signaling pathway. Cancer Sci. 2010; 101: 1454-62.
    • (2010) Cancer Sci , vol.101 , pp. 1454-1462
    • Zhao, Z.1    Liu, X.F.2    Wu, H.C.3
  • 47
    • 84863749351 scopus 로고    scopus 로고
    • Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
    • Onodera Y, Nam JM, Hashimoto A, et al. Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion. J Cell Biol. 2012; 197: 983-96.
    • (2012) J Cell Biol , vol.197 , pp. 983-996
    • Onodera, Y.1    Nam, J.M.2    Hashimoto, A.3
  • 48
    • 84895552825 scopus 로고    scopus 로고
    • Supporting a role for the GTPase Rab7 in prostate cancer progression
    • Steffan JJ, Dykes SS, Coleman DT, et al. Supporting a role for the GTPase Rab7 in prostate cancer progression. PLoS ONE. 2014; 9: e87882.
    • (2014) PLoS ONE , vol.9
    • Steffan, J.J.1    Dykes, S.S.2    Coleman, D.T.3
  • 49
    • 33244496908 scopus 로고    scopus 로고
    • Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma
    • Amillet JM, Ferbus D, Real FX, et al. Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. Hum Pathol. 2006; 37: 256-63.
    • (2006) Hum Pathol , vol.37 , pp. 256-263
    • Amillet, J.M.1    Ferbus, D.2    Real, F.X.3
  • 50
    • 78649777296 scopus 로고    scopus 로고
    • The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia
    • Hackenbeck T, Huber R, Schietke R, et al. The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia. Biochim Biophys Acta. 2011; 1813: 1-3.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1-3
    • Hackenbeck, T.1    Huber, R.2    Schietke, R.3
  • 51
    • 34047116394 scopus 로고    scopus 로고
    • Rab23 is a potential biological target for treating hepatocellular carcinoma
    • Liu YJ, Wang Q, Li W, et al. Rab23 is a potential biological target for treating hepatocellular carcinoma. World J Gastroenterol. 2007; 13: 1010-7.
    • (2007) World J Gastroenterol , vol.13 , pp. 1010-1017
    • Liu, Y.J.1    Wang, Q.2    Li, W.3
  • 52
    • 49649127726 scopus 로고    scopus 로고
    • Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer
    • Hou Q, Wu YH, Grabsch H, et al. Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. Cancer Res. 2008; 68: 4623-30.
    • (2008) Cancer Res , vol.68 , pp. 4623-4630
    • Hou, Q.1    Wu, Y.H.2    Grabsch, H.3
  • 53
    • 78649960338 scopus 로고    scopus 로고
    • The secretory small GTPase Rab27B as a marker for breast cancer progression
    • Hendrix A, Braems G, Bracke M, et al. The secretory small GTPase Rab27B as a marker for breast cancer progression. Oncotarget. 2010; 1: 304-8.
    • (2010) Oncotarget , vol.1 , pp. 304-308
    • Hendrix, A.1    Braems, G.2    Bracke, M.3
  • 54
    • 77953691801 scopus 로고    scopus 로고
    • Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis
    • Hendrix A, Maynard D, Pauwels P, et al. Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst. 2010; 102: 866-80.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 866-880
    • Hendrix, A.1    Maynard, D.2    Pauwels, P.3
  • 55
    • 84870337000 scopus 로고    scopus 로고
    • Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis
    • Zhang JX, Huang XX, Cai MB, et al. Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis. J Transl Med. 2012; 10: 242.
    • (2012) J Transl Med , vol.10 , pp. 242
    • Zhang, J.X.1    Huang, X.X.2    Cai, M.B.3
  • 57
    • 0027160730 scopus 로고
    • Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung
    • Goldenring JR, Shen KR, Vaughan HD, et al. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem. 1993; 268: 18419-22.
    • (1993) J Biol Chem , vol.268 , pp. 18419-18422
    • Goldenring, J.R.1    Shen, K.R.2    Vaughan, H.D.3
  • 58
    • 0032951298 scopus 로고    scopus 로고
    • Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells
    • Casanova JE, Wang X, Kumar R, et al. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 1999; 10: 47-61.
    • (1999) Mol Biol Cell , vol.10 , pp. 47-61
    • Casanova, J.E.1    Wang, X.2    Kumar, R.3
  • 59
    • 9144271680 scopus 로고    scopus 로고
    • The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
    • Cheng KW, Lahad JP, Kuo WL, et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med. 2004; 10: 1251-6.
    • (2004) Nat Med , vol.10 , pp. 1251-1256
    • Cheng, K.W.1    Lahad, J.P.2    Kuo, W.L.3
  • 60
    • 77951912503 scopus 로고    scopus 로고
    • Tumor suppressor function of Rab25 in triple-negative breast cancer
    • Cheng JM, Volk L, Janaki DKM, et al. Tumor suppressor function of Rab25 in triple-negative breast cancer. Int J Cancer. 2010; 126: 2799-812.
    • (2010) Int J Cancer , vol.126 , pp. 2799-2812
    • Cheng, J.M.1    Volk, L.2    Janaki, D.K.M.3
  • 61
    • 84869228632 scopus 로고    scopus 로고
    • Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma
    • Tong M, Chan KW, Bao JYJ, et al. Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma. Cancer Res. 2012; 72: 6024-35.
    • (2012) Cancer Res , vol.72 , pp. 6024-6035
    • Tong, M.1    Chan, K.W.2    Bao, J.Y.J.3
  • 62
    • 84885142254 scopus 로고    scopus 로고
    • Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling
    • Zhang J, Wei J, Lu J, et al. Overexpression of Rab25 contributes to metastasis of bladder cancer through induction of epithelial-mesenchymal transition and activation of Akt/GSK-3β/Snail signaling. Carcinogenesis. 2013; 34: 2401-8.
    • (2013) Carcinogenesis , vol.34 , pp. 2401-2408
    • Zhang, J.1    Wei, J.2    Lu, J.3
  • 63
    • 84875169465 scopus 로고    scopus 로고
    • Rab25 regulates invasion and metastasis in head and neck cancer
    • Amornphimoltham P, Rechache K, Thompson J, et al. Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res. 2013; 19: 1375-88.
    • (2013) Clin Cancer Res , vol.19 , pp. 1375-1388
    • Amornphimoltham, P.1    Rechache, K.2    Thompson, J.3
  • 64
    • 68849084073 scopus 로고    scopus 로고
    • RCP is a human breast cancer-promoting gene with Ras-activating function
    • Zhang J, Liu X, Datta A, et al. RCP is a human breast cancer-promoting gene with Ras-activating function. J Clin Invest. 2009; 119: 2171-83.
    • (2009) J Clin Invest , vol.119 , pp. 2171-2183
    • Zhang, J.1    Liu, X.2    Datta, A.3
  • 65
    • 77954633914 scopus 로고    scopus 로고
    • Is Rab25 a tumor promoter or suppressor-context dependency on RCP status?
    • Tang BL. Is Rab25 a tumor promoter or suppressor-context dependency on RCP status? Tumour Biol. 2010; 31: 359-61.
    • (2010) Tumour Biol , vol.31 , pp. 359-361
    • Tang, B.L.1
  • 66
    • 53849140404 scopus 로고    scopus 로고
    • Identification of novel neuroendocrine-specific tumour genes
    • Hofsli E, Wheeler TE, Langaas M, et al. Identification of novel neuroendocrine-specific tumour genes. Br J Cancer. 2008; 99: 1330-9.
    • (2008) Br J Cancer , vol.99 , pp. 1330-1339
    • Hofsli, E.1    Wheeler, T.E.2    Langaas, M.3
  • 67
    • 0033991914 scopus 로고    scopus 로고
    • Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2
    • Zhou J, Fogelgren B, Wang Z, et al. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Gene. 2000; 241: 133-41.
    • (2000) Gene , vol.241 , pp. 133-141
    • Zhou, J.1    Fogelgren, B.2    Wang, Z.3
  • 68
    • 59249084437 scopus 로고    scopus 로고
    • Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer
    • Wu CY, Tseng RC, Hsu HS, et al. Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer. Lung Cancer. 2009; 63: 360-7.
    • (2009) Lung Cancer , vol.63 , pp. 360-367
    • Wu, C.Y.1    Tseng, R.C.2    Hsu, H.S.3
  • 69
    • 84884211455 scopus 로고    scopus 로고
    • Inhibition of autophagy and tumor growth in colon cancer by miR-502
    • Zhai H, Song B, Xu X, et al. Inhibition of autophagy and tumor growth in colon cancer by miR-502. Oncogene. 2013; 32: 1570-9.
    • (2013) Oncogene , vol.32 , pp. 1570-1579
    • Zhai, H.1    Song, B.2    Xu, X.3
  • 70
    • 77955239270 scopus 로고    scopus 로고
    • Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites
    • Zoppino FCM, Militello RD, Slavin I, et al. Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites. Traffic. 2010; 11: 1246-61.
    • (2010) Traffic , vol.11 , pp. 1246-1261
    • Zoppino, F.C.M.1    Militello, R.D.2    Slavin, I.3
  • 71
    • 79958288052 scopus 로고    scopus 로고
    • MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14)
    • Wang R, Wang ZX, Yang JS, et al. MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene. 2011; 30: 2644-58.
    • (2011) Oncogene , vol.30 , pp. 2644-2658
    • Wang, R.1    Wang, Z.X.2    Yang, J.S.3
  • 72
    • 80053165340 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer
    • Tanaka T, Arai M, Wu S, et al. Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer. Oncol Rep. 2011; 26: 1329-35.
    • (2011) Oncol Rep , vol.26 , pp. 1329-1335
    • Tanaka, T.1    Arai, M.2    Wu, S.3
  • 73
    • 84892571117 scopus 로고    scopus 로고
    • miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family
    • Ye F, Tang H, Liu Q, et al. miR-200b as a prognostic factor in breast cancer targets multiple members of RAB family. J Transl Med. 2014; 12: 17.
    • (2014) J Transl Med , vol.12 , pp. 17
    • Ye, F.1    Tang, H.2    Liu, Q.3
  • 74
    • 84892936699 scopus 로고    scopus 로고
    • miR-200b as a prognostic factor targets multiple members of RAB family in glioma
    • Liu Q, Tang H, Liu X, et al. miR-200b as a prognostic factor targets multiple members of RAB family in glioma. Med Oncol. 2014; 31: 859.
    • (2014) Med Oncol , vol.31 , pp. 859
    • Liu, Q.1    Tang, H.2    Liu, X.3
  • 76
    • 33947597433 scopus 로고    scopus 로고
    • MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway
    • Bravo-Cordero JJ, Marrero-Diaz R, Megías D, et al. MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway. EMBO J. 2007; 26: 1499-510.
    • (2007) EMBO J , vol.26 , pp. 1499-1510
    • Bravo-Cordero, J.J.1    Marrero-Diaz, R.2    Megías, D.3
  • 77
    • 34848816931 scopus 로고    scopus 로고
    • Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
    • Caswell PT, Spence HJ, Parsons M, et al. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell. 2007; 13: 496-510.
    • (2007) Dev Cell , vol.13 , pp. 496-510
    • Caswell, P.T.1    Spence, H.J.2    Parsons, M.3
  • 78
    • 53749092962 scopus 로고    scopus 로고
    • Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments
    • Caswell PT, Chan M, Lindsay AJ, et al. Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol. 2008; 183: 143-55.
    • (2008) J Cell Biol , vol.183 , pp. 143-155
    • Caswell, P.T.1    Chan, M.2    Lindsay, A.J.3
  • 79
    • 84855966245 scopus 로고    scopus 로고
    • Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression
    • Dozynkiewicz MA, Jamieson NB, Macpherson I, et al. Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell. 2012; 22: 131-45.
    • (2012) Dev Cell , vol.22 , pp. 131-145
    • Dozynkiewicz, M.A.1    Jamieson, N.B.2    Macpherson, I.3
  • 80
    • 0030603226 scopus 로고    scopus 로고
    • Molecular cloning of two novel rab genes from human melanocytes
    • Chen D, Guo J, Miki T, et al. Molecular cloning of two novel rab genes from human melanocytes. Gene. 1996; 174: 129-34.
    • (1996) Gene , vol.174 , pp. 129-134
    • Chen, D.1    Guo, J.2    Miki, T.3
  • 81
    • 0036156128 scopus 로고    scopus 로고
    • Molecular cloning, bacterial expression and properties of Rab31 and Rab32
    • Bao X, Faris AE, Jang EK, et al. Molecular cloning, bacterial expression and properties of Rab31 and Rab32. Eur J Biochem. 2002; 269: 259-71.
    • (2002) Eur J Biochem , vol.269 , pp. 259-271
    • Bao, X.1    Faris, A.E.2    Jang, E.K.3
  • 82
    • 0035892625 scopus 로고    scopus 로고
    • Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments
    • Rodriguez-Gabin AG, Cammer M, Almazan G, et al. Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments. J Neurosci Res. 2001; 66: 1149-60.
    • (2001) J Neurosci Res , vol.66 , pp. 1149-1160
    • Rodriguez-Gabin, A.G.1    Cammer, M.2    Almazan, G.3
  • 83
    • 34547798526 scopus 로고    scopus 로고
    • Rab22B's role in trans-Golgi network membrane dynamics
    • Ng EL, Wang Y, Tang BL. Rab22B's role in trans-Golgi network membrane dynamics. Biochem Biophys Res Commun. 2007; 361: 751-7.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 751-757
    • Ng, E.L.1    Wang, Y.2    Tang, B.L.3
  • 84
    • 80055078598 scopus 로고    scopus 로고
    • Thousands of rab GTPases for the cell biologist
    • Diekmann Y, Seixas E, Gouw M, et al. Thousands of rab GTPases for the cell biologist. PLoS Comput Biol. 2011; 7: e1002217.
    • (2011) PLoS Comput Biol , vol.7 , pp. e1002217
    • Diekmann, Y.1    Seixas, E.2    Gouw, M.3
  • 85
    • 84865378898 scopus 로고    scopus 로고
    • Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis
    • Klöpper TH, Kienle N, Fasshauer D, et al. Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis. BMC Biol. 2012; 10: 71.
    • (2012) BMC Biol , vol.10 , pp. 71
    • Klöpper, T.H.1    Kienle, N.2    Fasshauer, D.3
  • 86
    • 67349204760 scopus 로고    scopus 로고
    • Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31
    • Rodriguez-Gabin AG, Yin X, Si Q, et al. Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31. Exp Cell Res. 2009; 315: 2215-30.
    • (2009) Exp Cell Res , vol.315 , pp. 2215-2230
    • Rodriguez-Gabin, A.G.1    Yin, X.2    Si, Q.3
  • 87
    • 73949156303 scopus 로고    scopus 로고
    • Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors
    • Rodriguez-Gabin AG, Ortiz E, Demoliner K, et al. Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors. J Neurosci Res. 2010; 88: 589-604.
    • (2010) J Neurosci Res , vol.88 , pp. 589-604
    • Rodriguez-Gabin, A.G.1    Ortiz, E.2    Demoliner, K.3
  • 88
    • 70449724727 scopus 로고    scopus 로고
    • Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells
    • Ng EL, Ng JJ, Liang F, et al. Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells. J Cell Physiol. 2009; 221: 716-28.
    • (2009) J Cell Physiol , vol.221 , pp. 716-728
    • Ng, E.L.1    Ng, J.J.2    Liang, F.3
  • 89
    • 84870350433 scopus 로고    scopus 로고
    • Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase
    • King GJ, Stöckli J, Hu SH, et al. Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. J Biol Chem. 2012; 287: 40996-1006.
    • (2012) J Biol Chem , vol.287 , pp. 40996-41006
    • King, G.J.1    Stöckli, J.2    Hu, S.H.3
  • 90
    • 33845572827 scopus 로고    scopus 로고
    • Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes
    • Lodhi IJ, Chiang SH, Chang L, et al. Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 2007; 5: 59-72.
    • (2007) Cell Metab , vol.5 , pp. 59-72
    • Lodhi, I.J.1    Chiang, S.H.2    Chang, L.3
  • 91
    • 79959892930 scopus 로고    scopus 로고
    • Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31
    • Kajiho H, Sakurai K, Minoda T, et al. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. J Biol Chem. 2011; 286: 24364-73.
    • (2011) J Biol Chem , vol.286 , pp. 24364-24373
    • Kajiho, H.1    Sakurai, K.2    Minoda, T.3
  • 92
    • 34248666981 scopus 로고    scopus 로고
    • Gene expression signature of estrogen receptor alpha status in breast cancer
    • Abba MC, Hu Y, Sun H, et al. Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genom. 2005; 6: 37.
    • (2005) BMC Genom , vol.6 , pp. 37
    • Abba, M.C.1    Hu, Y.2    Sun, H.3
  • 93
    • 0037391933 scopus 로고    scopus 로고
    • Identification of a novel urokinase receptor splice variant and its prognostic relevance in breast cancer
    • Luther T, Kotzsch M, Meye A, et al. Identification of a novel urokinase receptor splice variant and its prognostic relevance in breast cancer. Thromb Haemost. 2003; 89: 705-17.
    • (2003) Thromb Haemost , vol.89 , pp. 705-717
    • Luther, T.1    Kotzsch, M.2    Meye, A.3
  • 94
    • 27744522730 scopus 로고    scopus 로고
    • Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer
    • Kotzsch M, Farthmann J, Meye A, et al. Prognostic relevance of uPAR-del4/5 and TIMP-3 mRNA expression levels in breast cancer. Eur J Cancer. 2005; 41: 2760-8.
    • (2005) Eur J Cancer , vol.41 , pp. 2760-2768
    • Kotzsch, M.1    Farthmann, J.2    Meye, A.3
  • 95
    • 79958277643 scopus 로고    scopus 로고
    • Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo
    • Sato S, Kopitz C, Grismayer B, et al. Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo. Breast Cancer Res Treat. 2011; 127: 649-57.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 649-657
    • Sato, S.1    Kopitz, C.2    Grismayer, B.3
  • 96
    • 48149112465 scopus 로고    scopus 로고
    • Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor
    • Kotzsch M, Sieuwerts AM, Grosser M, et al. Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor. Breast Cancer Res Treat. 2008; 111: 229-40.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 229-240
    • Kotzsch, M.1    Sieuwerts, A.M.2    Grosser, M.3
  • 97
    • 80053626698 scopus 로고    scopus 로고
    • mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer
    • Kotzsch M, Dorn J, Doetzer K, et al. mRNA expression levels of the biological factors uPAR, uPAR-del4/5, and rab31, displaying prognostic value in breast cancer, are not clinically relevant in advanced ovarian cancer. Biol Chem. 2011; 392: 1047-51.
    • (2011) Biol Chem , vol.392 , pp. 1047-1051
    • Kotzsch, M.1    Dorn, J.2    Doetzer, K.3
  • 98
    • 62849099323 scopus 로고    scopus 로고
    • Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells
    • Yim EK, Tong SY, Ho EM, et al. Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells. Oncol Rep. 2009; 21: 549-57.
    • (2009) Oncol Rep , vol.21 , pp. 549-557
    • Yim, E.K.1    Tong, S.Y.2    Ho, E.M.3
  • 99
    • 79957967092 scopus 로고    scopus 로고
    • Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival
    • Serão NVL, Delfino KR, Southey BR, et al. Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival. BMC Med Genom. 2011; 4: 49.
    • (2011) BMC Med Genom , vol.4 , pp. 49
    • Serão, N.V.L.1    Delfino, K.R.2    Southey, B.R.3
  • 100
    • 84878517297 scopus 로고    scopus 로고
    • Reverse engineering of modified genes by bayesian network analysis defines molecular determinants critical to the development of glioblastoma
    • Kunkle BW, Yoo C, Roy D. Reverse engineering of modified genes by bayesian network analysis defines molecular determinants critical to the development of glioblastoma. PLoS ONE. 2013; 8: e64140.
    • (2013) PLoS ONE , vol.8 , pp. e64140
    • Kunkle, B.W.1    Yoo, C.2    Roy, D.3
  • 101
    • 79959957496 scopus 로고    scopus 로고
    • Role of RNA binding protein HuR in ductal carcinoma in situ of the breast
    • Heinonen M, Hemmes A, Salmenkivi K, et al. Role of RNA binding protein HuR in ductal carcinoma in situ of the breast. J Pathol. 2011; 224: 529-39.
    • (2011) J Pathol , vol.224 , pp. 529-539
    • Heinonen, M.1    Hemmes, A.2    Salmenkivi, K.3
  • 102
    • 84877922071 scopus 로고    scopus 로고
    • Mechanisms coordinating ELAV/Hu mRNA regulons
    • Simone LE, Keene JD. Mechanisms coordinating ELAV/Hu mRNA regulons. Curr Opin Genet Dev. 2013; 23: 35-43.
    • (2013) Curr Opin Genet Dev , vol.23 , pp. 35-43
    • Simone, L.E.1    Keene, J.D.2
  • 103
    • 20144389216 scopus 로고    scopus 로고
    • Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma
    • Heinonen M, Bono P, Narko K, et al. Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res. 2005; 65: 2157-61.
    • (2005) Cancer Res , vol.65 , pp. 2157-2161
    • Heinonen, M.1    Bono, P.2    Narko, K.3
  • 104
    • 37249017962 scopus 로고    scopus 로고
    • Prognostic role of HuR in hereditary breast cancer
    • Heinonen M, Fagerholm R, Aaltonen K, et al. Prognostic role of HuR in hereditary breast cancer. Clin Cancer Res. 2007; 13: 6959-63.
    • (2007) Clin Cancer Res , vol.13 , pp. 6959-6963
    • Heinonen, M.1    Fagerholm, R.2    Aaltonen, K.3
  • 105
    • 84863632693 scopus 로고    scopus 로고
    • Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells
    • Jin C, Rajabi H, Pitroda S, et al. Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS ONE. 2012; 7: e39432.
    • (2012) PLoS ONE , vol.7 , pp. e39432
    • Jin, C.1    Rajabi, H.2    Pitroda, S.3
  • 106
    • 25144504517 scopus 로고    scopus 로고
    • Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer
    • Rakha EA, Boyce RWG, Abd El-Rehim D, et al. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. 2005; 18: 1295-304.
    • (2005) Mod Pathol , vol.18 , pp. 1295-1304
    • Rakha, E.A.1    Boyce, R.W.G.2    Abd El-Rehim, D.3
  • 107
    • 84874743726 scopus 로고    scopus 로고
    • MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches
    • Kufe DW. MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches. Oncogene. 2013; 32: 1073-81.
    • (2013) Oncogene , vol.32 , pp. 1073-1081
    • Kufe, D.W.1
  • 108
    • 11144235167 scopus 로고    scopus 로고
    • MUC1 membrane trafficking is modulated by multiple interactions
    • Kinlough CL, Poland PA, Bruns JB, et al. MUC1 membrane trafficking is modulated by multiple interactions. J Biol Chem. 2004; 279: 53071-7.
    • (2004) J Biol Chem , vol.279 , pp. 53071-53077
    • Kinlough, C.L.1    Poland, P.A.2    Bruns, J.B.3
  • 109
    • 34547092962 scopus 로고    scopus 로고
    • Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62
    • Leng Y, Cao C, Ren J, et al. Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62. J Biol Chem. 2007; 282: 19321-30.
    • (2007) J Biol Chem , vol.282 , pp. 19321-19330
    • Leng, Y.1    Cao, C.2    Ren, J.3
  • 110
    • 30744474431 scopus 로고    scopus 로고
    • MUC1 oncoprotein stabilizes and activates estrogen receptor alpha
    • Wei X, Xu H, Kufe D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Mol Cell. 2006; 21: 295-305.
    • (2006) Mol Cell , vol.21 , pp. 295-305
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 111
    • 79951904086 scopus 로고    scopus 로고
    • MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop
    • Ahmad R, Rajabi H, Kosugi M, et al. MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci Signal. 2011; 4: ra9.
    • (2011) Sci Signal , vol.4 , pp. ra9
    • Ahmad, R.1    Rajabi, H.2    Kosugi, M.3
  • 112
    • 84865281929 scopus 로고    scopus 로고
    • Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells
    • Grismayer B, Sölch S, Seubert B, et al. Rab31 expression levels modulate tumor-relevant characteristics of breast cancer cells. Mol Cancer. 2012; 11: 62.
    • (2012) Mol Cancer , vol.11 , pp. 62
    • Grismayer, B.1    Sölch, S.2    Seubert, B.3
  • 113
    • 0141640857 scopus 로고    scopus 로고
    • Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    • Tran H, Maurer F, Nagamine Y. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol. 2003; 23: 7177-88.
    • (2003) Mol Cell Biol , vol.23 , pp. 7177-7188
    • Tran, H.1    Maurer, F.2    Nagamine, Y.3
  • 114
    • 24644441893 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator system and breast cancer
    • Han B, Nakamura M, Mori I, et al. Urokinase-type plasminogen activator system and breast cancer. Oncol Rep. 2005; 14: 105-12.
    • (2005) Oncol Rep , vol.14 , pp. 105-112
    • Han, B.1    Nakamura, M.2    Mori, I.3
  • 116
    • 45849105938 scopus 로고    scopus 로고
    • The urokinase receptor and integrins in cancer progression
    • Tang CH, Wei Y. The urokinase receptor and integrins in cancer progression. Cell Mol Life Sci. 2008; 65: 1916-32.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1916-1932
    • Tang, C.H.1    Wei, Y.2
  • 117
    • 84869459789 scopus 로고    scopus 로고
    • Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes
    • Grismayer B, Sato S, Kopitz C, et al. Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes. Biol Chem. 2012; 393: 1449-55.
    • (2012) Biol Chem , vol.393 , pp. 1449-1455
    • Grismayer, B.1    Sato, S.2    Kopitz, C.3
  • 118
    • 15144361572 scopus 로고    scopus 로고
    • Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction
    • Nykjaer A, Christensen EI, Vorum H, et al. Mannose 6-phosphate/insulin-like growth factor-II receptor targets the urokinase receptor to lysosomes via a novel binding interaction. J Cell Biol. 1998; 141: 815-28.
    • (1998) J Cell Biol , vol.141 , pp. 815-828
    • Nykjaer, A.1    Christensen, E.I.2    Vorum, H.3
  • 119
    • 0038419654 scopus 로고    scopus 로고
    • Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR
    • Kreiling JL, Byrd JC, Deisz RJ, et al. Binding of urokinase-type plasminogen activator receptor (uPAR) to the mannose 6-phosphate/insulin-like growth factor II receptor: contrasting interactions of full-length and soluble forms of uPAR. J Biol Chem. 2003; 278: 20628-37.
    • (2003) J Biol Chem , vol.278 , pp. 20628-20637
    • Kreiling, J.L.1    Byrd, J.C.2    Deisz, R.J.3
  • 120
    • 0041850346 scopus 로고    scopus 로고
    • Human DF3/MUC1 carcinoma-associated protein functions as an oncogene
    • Li Y, Liu D, Chen D, et al. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene. 2003; 22: 6107-10.
    • (2003) Oncogene , vol.22 , pp. 6107-6110
    • Li, Y.1    Liu, D.2    Chen, D.3
  • 121
    • 84896140889 scopus 로고    scopus 로고
    • MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter
    • Gnemmi V, Bouillez A, Gaudelot K, et al. MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter. Cancer Lett. 2014; 346: 225-36.
    • (2014) Cancer Lett , vol.346 , pp. 225-236
    • Gnemmi, V.1    Bouillez, A.2    Gaudelot, K.3
  • 122
    • 70149111064 scopus 로고    scopus 로고
    • MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor
    • Ahmad R, Raina D, Joshi MD, et al. MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. Cancer Res. 2009; 69: 7013-21.
    • (2009) Cancer Res , vol.69 , pp. 7013-7021
    • Ahmad, R.1    Raina, D.2    Joshi, M.D.3
  • 123
    • 0035929643 scopus 로고    scopus 로고
    • The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin
    • Li Y, Ren J, Yu W, et al. The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001; 276: 35239-42.
    • (2001) J Biol Chem , vol.276 , pp. 35239-35242
    • Li, Y.1    Ren, J.2    Yu, W.3
  • 124
    • 33947224631 scopus 로고    scopus 로고
    • MUC1 is a novel regulator of ErbB1 receptor trafficking
    • Pochampalli MR, el Bejjani RM, Schroeder JA. MUC1 is a novel regulator of ErbB1 receptor trafficking. Oncogene. 2007; 26: 1693-701.
    • (2007) Oncogene , vol.26 , pp. 1693-1701
    • Pochampalli, M.R.1    el Bejjani, R.M.2    Schroeder, J.A.3
  • 125
    • 84863156123 scopus 로고    scopus 로고
    • Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88
    • Kato K, Lillehoj EP, Park YS, et al. Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. J Immunol. 2012; 188: 2014-22.
    • (2012) J Immunol , vol.188 , pp. 2014-2022
    • Kato, K.1    Lillehoj, E.P.2    Park, Y.S.3
  • 126
    • 67649419014 scopus 로고    scopus 로고
    • MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation
    • Yin L, Kharbanda S, Kufe D. MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation. Int J Oncol. 2009; 34: 1691-9.
    • (2009) Int J Oncol , vol.34 , pp. 1691-1699
    • Yin, L.1    Kharbanda, S.2    Kufe, D.3
  • 127
    • 84865293335 scopus 로고    scopus 로고
    • MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
    • Chaika NV, Gebregiworgis T, Lewallen ME, et al. MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proc Natl Acad Sci USA. 2012; 109: 13787-92.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 13787-13792
    • Chaika, N.V.1    Gebregiworgis, T.2    Lewallen, M.E.3
  • 128
    • 84899767249 scopus 로고    scopus 로고
    • Engagement of the small GTPase Rab31 and its effector, early endosome antigen 1, is important for trafficking of ligand-bound epidermal growth factor receptor from early to late endosome
    • Chua CEL, Tang BL. Engagement of the small GTPase Rab31 and its effector, early endosome antigen 1, is important for trafficking of ligand-bound epidermal growth factor receptor from early to late endosome. J Biol Chem. 2014; 289: 12375-89.
    • (2014) J Biol Chem , vol.289 , pp. 12375-12389
    • Chua, C.E.L.1    Tang, B.L.2
  • 129
    • 34547132827 scopus 로고    scopus 로고
    • GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor
    • Su X, Kong C, Stahl PD. GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor. J Biol Chem. 2007; 282: 21278-84.
    • (2007) J Biol Chem , vol.282 , pp. 21278-21284
    • Su, X.1    Kong, C.2    Stahl, P.D.3
  • 130
    • 0034468132 scopus 로고    scopus 로고
    • Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
    • Stern DF. Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Res. 2000; 2: 176-83.
    • (2000) Breast Cancer Res , vol.2 , pp. 176-183
    • Stern, D.F.1
  • 131
    • 74949110711 scopus 로고    scopus 로고
    • Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol. 2010; 28: 357-60.
    • (2010) J Clin Oncol , vol.28 , pp. 357-360
    • Jackman, D.1    Pao, W.2    Riely, G.J.3
  • 132
    • 84875860054 scopus 로고    scopus 로고
    • Mechanisms of resistance to EGFR targeted therapies
    • Hrustanovic G, Lee BJ, Bivona TG. Mechanisms of resistance to EGFR targeted therapies. Cancer Biol Ther. 2013; 14: 304-14.
    • (2013) Cancer Biol Ther , vol.14 , pp. 304-314
    • Hrustanovic, G.1    Lee, B.J.2    Bivona, T.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.