MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13787-13792

  Chaika, Nina V ^a   Gebregiworgis, Teklab ^b   Lewallen, Michelle E ^a   Purohit, Vinee ^a,c   Radhakrishnan, Prakash ^a   Liu, Xiang ^a   Zhang, Bo ^b   Mehla, Kamiya ^a   Brown, Roger B ^a   Caffrey, Thomas ^a   Yu, Fang ^a   Johnson, Keith R ^a,c,d   Powers, Robert ^b   Hollingsworth, Michael A ^a,c   Singh, Pankaj K ^a,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

2 Ketoglutarate; Cancer metabolism; Glutamine accumulation; Pentose phosphate pathway

Indexed keywords

GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; MUCIN 1; PROTEIN P300;

ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVATION; ENZYME STABILITY; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; IN VIVO STUDY; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOSE; GLUTAMINE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KETOGLUTARIC ACIDS; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MUCIN-1; P300-CBP TRANSCRIPTION FACTORS; PANCREATIC NEOPLASMS; PENTOSE PHOSPHATE PATHWAY; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION;

EID: 84865293335     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203339109     Document Type: Article

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