MUC1 is a novel regulator of ErbB1 receptor trafficking

Oncogene

Volumn 26, Issue 12, 2007, Pages 1693-1701

  Pochampalli, M R ^a   Bejjani, R M El ^a   Schroeder, J A ^a  

^a University of Arizona   (United States)

Author keywords

Breast cancer; ErbB1; MUC1; Phosphorylation; Ubiquitination

Indexed keywords

CELL SURFACE RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; MEMBRANE PROTEIN; MUCIN 1;

ARTICLE; BIOTINYLATION; BREAST CANCER; BREAST EPITHELIUM; CELL PROTECTION; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA INTERFERENCE; UBIQUITINATION;

BASE SEQUENCE; CA-15-3 ANTIGEN; CELL LINE, TUMOR; DNA PRIMERS; EPIDERMAL GROWTH FACTOR; HUMANS; PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR, EPIDERMAL GROWTH FACTOR; UBIQUITIN;

EID: 33947224631     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209976     Document Type: Article

References (37)

1. Alroy I, Yarden Y. (1997). The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 410: 83-86.
2. Bivona TG, Philips MR. (2003). Ras pathway signaling on endomembranes. Curr Opin Cell Biol 15: 136-142.
3. Brummelkamp TR, Bernards R, Agami R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
4. Carpenter G. (2000). The EGF receptor: a nexus for trafficking and signaling. Bioessays 22: 697-707.
5. Gendler SJ. (2001). MUC1, the renaissance molecule. J Mammary Gland Biol Neoplasia 6: 339-353.
6. Haj FG, Verveer PJ, Squire A, Neel BG, Bastiaens PI. (2002). Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum. Science 295: 1708-1711.
7. Hanisch FG, Muller S. (2000). MUC1: the polymorphic appearance of a human mucin. Glycobiology 10: 439-449.
8. Hilkens J, Vos HL, Wesseling J, Boer M, Storm J, van der Valk S et al. (1995). Is episialin/MUC1 involved in breast cancer progression? Cancer Lett 90: 27-33.
9. Ishizawar R, Parsons SJ. (2004). c-Src and cooperating partners in human cancer. Cancer Cell 6: 209-214.
10. Kowanetz K, Husnjak K, Holler D, KowanetzM, Soubeyran P, Hirsch D et al. (2004). CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors. Mol Biol Cell 15: 3155-3166.
11. Kuwada SK, Lund KA, Li XF, Cliften P, Amsler K, Opresko LK et al. (1998). Differential signaling and regulation of apical vs basolateral EGFR in polarised epithelial cells. Am J Physiol 275: C1419-C1428.
12. Lan MS, Batra SK, Qi WN, Metzgar RS, Hollingsworth MA. (1990). Cloning and sequencing of a human pancreatic tumor mucin cDNA. J Biol Chem 265: 15294-15299.
13. Lee FT, Mountain AJ, Kelly MP, Hall C, Rigopoulos A, Johns TG et al. (2005). Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A″-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478. Clin Cancer Res 11: 7080s-7086s.
14. Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I et al. (1999). Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 4: 1029-1040.
15. Levkowitz G, Waterman H, Zamir E, Kam Z, Oved S, Langdon WY et al. (1998). c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 12: 3663-3674.
16. Li X, Wang L, Nunes DP, Troxler RF, Offner GD. (2005). Suppression of MUC1 synthesis down regulates expression of the epidermal growth factor receptor. Cancer Biol Ther 4: 968-973.
17. Li Y, Kuwahara H, Ren J, Wen G, Kufe D. (2001a). The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem 276: 6061-6064.
18. Li Y, Liu D, Chen D, Kharbanda S, Kufe D. (2003). Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 22: 6107-6110.
19. Li Y, Ren J, Yu W, Li Q, Kuwahara H, Yin L et al. (2001b). The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem 276: 35239-35242.
20. Litvinov SV, Hilkens J. (1993). The epithelial sialomucin, episialin, is sialylated during recycling. J Biol Chem 268: 21364-21371.
21. McDermott KM, Crocker PR, Harris A, Burdick MD, Hinoda Y, Hayashi T et al. (2001). Over expression of MUC1 reconfigures the binding properties of tumor cells. Int J Cancer 94: 783-791.
22. Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. (1999). ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J Biol Chem 274: 17209-17218.
23. Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE. (1998). ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerisation partner. Mol Cell Biol 18: 5042-5051.
24. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, Tarnawski AS. (2002). Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8: 289-293.
25. Puertollano R, Bonifacino JS. (2004). Interactions of GGA3 with the ubiquitin sorting machinery. Nat Cell Biol 6: 244-251.
26. Reinheckel T, Hagemann S, Dollwet-Mack S, Martinez E, Lohmuller T, Zlatkovic G et al. (2005). The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. J Cell Sci 118: 3387-3395.
27. Ren J, Agata N, Chen D, Li Y, Yu WH, Huang L et al. (2004). Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell 5: 163-175.
28. Schroeder JA, Lee DC. (1997). Transgenic mice reveal roles for TGFalpha and EGF receptor in mammary gland development and neoplasia. J Mammary Gland Biol Neoplasia 2: 119-129.
29. Schroeder JA, Masri AA, Adriance MC, Tessier JC, Kotlarczyk KL, Thompson MC et al. (2004). MUC1 over expression results in mammary gland tumorigenesis and prolonged alveolar differentiation. Oncogene 23: 5739-5747.
30. Schroeder JA, Thompson MC, Gardner MM, Gendler SJ. (2001). Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem 276: 13057-13064.
31. Shtiegman K, Yarden Y. (2003). The role of ubiquitylation in signaling by growth factors: implications to cancer. Semin Cancer Biol 13: 29-40.
32. Strachan L, Murison JG, Prestidge RL, Sleeman MA, Watson JD, Kumble KD. (2001). Cloning and biological activity of epigen, a novel member of the epidermal growth factor superfamily. J Biol Chem 276: 18265-18271.
33. Thien CB, Walker F, Langdon WY. (2001). RING finger mutations that abolish c-Cbl-directed polyubiquitination and down regulation of the EGF receptor are insufficient for cell transformation. Mol Cell 7: 355-365.
34. Wang Y, Pennock S, Chen X, Wang Z. (2002). Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol Cell Biol 22: 7279-7290.
35. Waterman H, Yarden Y. (2001). Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases. FEBS Lett 490: 142-152.
36. Yan Q, Hunt PR, Frelin L, Vida TA, Pevsner J, Bean AJ. (2005). mVps24p functions in EGF receptor sorting/trafficking from the early endosome. Exp Cell Res 304: 265-273.
37. Zotter S, Hageman PC, Lossnitzer A, Mooi WJ, Hilgers J. (1988). Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev 11-12: 55-101.