Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via a rho kinase-dependent mechanism

Hypertension

Volumn 65, Issue 2, 2015, Pages 345-351

  Michael De Silva, T ^a   Ketsawatsomkron, Pimonrat ^a   Pelham, Christopher ^a   Sigmund, Curt D ^a   Faraci, Frank M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b Veterans Affairs Healthcare System   (United States)

Author keywords

cerebral arteries; cerebrovascular circulation; potassium channels; protein kinase C

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RHO KINASE; BKCA PROTEIN, MOUSE; DEOXYCORTICOSTERONE ACETATE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA PROTEIN, MOUSE; SODIUM CHLORIDE; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ARTERY LIGATION; ARTICLE; BLOOD VESSEL TONE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; MIDDLE CEREBRAL ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESISTANCE BLOOD VESSEL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE TONE; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; DEFICIENCY; DOMINANT GENE; DRUG EFFECTS; ENZYME INDUCTION; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETICS; HYPERTENSION; KNOCKOUT MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; VASOCONSTRICTION;

ANIMALS; CEREBROVASCULAR CIRCULATION; DESOXYCORTICOSTERONE ACETATE; ENZYME INDUCTION; GENE EXPRESSION PROFILING; GENES, DOMINANT; HYPERTENSION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MICE; MICE, KNOCKOUT; MIDDLE CEREBRAL ARTERY; MUSCLE, SMOOTH, VASCULAR; PPAR GAMMA; RHO GTP-BINDING PROTEINS; RHO-ASSOCIATED KINASES; SODIUM CHLORIDE; TETRAETHYLAMMONIUM; VASOCONSTRICTION;

EID: 84921598861     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04541     Document Type: Article

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