Therapeutic potential of pharmacologically targeting arteriolar myogenic tone

Trends in Pharmacological Sciences

Volumn 30, Issue 7, 2009, Pages 363-374

  Hill, Michael A ^a   Meininger, Gerald A ^a   Davis, Michael J ^a   Laher, Ismail ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CALCIUM ION; CELL ADHESION MOLECULE; FIBRONECTIN; INTEGRIN; PROTEIN KINASE C; SODIUM ION; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; VOLTAGE GATED CALCIUM CHANNEL;

ARTERIOLAR MYOGENIC TONE; CALCIUM TRANSPORT; CHANNEL GATING; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE FUNCTION; HEART DEPOLARIZATION; HUMAN; INTESTINE PRESSURE; MECHANOTRANSDUCTION; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE TONE; VASCULAR DISEASE; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ANIMALS; ARTERIOLES; DRUG DELIVERY SYSTEMS; HUMANS; MUSCLE, SMOOTH, VASCULAR; PHARMACEUTICAL PREPARATIONS; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATION;

EID: 67649390994     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2009.04.008     Document Type: Review

References (117)

1. In: Davis M.J., et al. (Ed). Local Regulation of Microvascular Perfusion (2008), Academic Press
2. Meininger G.A., and Faber J.E. Adrenergic facilitation of myogenic response in skeletal muscle arterioles. Am. J. Physiol. 260 (1991) H1424-H1432
3. Meininger G.A., and Trzeciakowski J.P. Combined effects of autoregulation and vasoconstrictors on hindquarters vascular resistance. Am. J. Physiol. 258 (1990) H1032-H1041
4. Davis M.J., and Hill M.A. Signaling mechanisms underlying the vascular myogenic response. Physiol. Rev. 79 (1999) 387-423
5. Welsh D.G., et al. Swelling-activated cation channels mediate depolarization of rat cerebrovascular smooth muscle by hyposmolarity and intravascular pressure. J. Physiol. 527 (2000) 139-148
6. Wu X., and Davis M.J. Characterization of stretch-activated cation current in coronary smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 280 (2001) H1751-H1761
7. McCarron J.G., et al. Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries. J. Physiol. 498 (1997) 371-379
8. 1 integrin requires signaling between focal adhesion proteins. J. Biol. Chem. 276 (2001) 30285-30292
9. Gui P., et al. Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways. J. Biol. Chem. 281 (2006) 14015-14025
10. + channels in rabbit myogenic cerebral arteries. Am. J. Physiol. 269 (1995) H348-H355
11. 2+ signaling. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H1326-H1334
12. Davis M.J., et al. Stretch-activated single-channel and whole cell currents in vascular smooth muscle cells. Am. J. Physiol. 262 (1992) C1083-C1088
13. + channels: a functional unit for regulating arterial tone. Acta Physiol. Scand. 164 (1998) 577-587
14. Christensen A.P., and Corey D.P. TRP channels in mechanosensation: direct or indirect activation?. Nat. Rev. Neurosci. 8 (2007) 510-521
15. Sharif-Naeini R., et al. TRP channels and mechanosensory transduction: insights into the arterial myogenic response. Pflugers Arch. 456 (2008) 529-540
16. Clapham D.E., et al. The TRP ion channel family. Nat. Rev. Neurosci. 2 (2001) 387-396
17. Dietrich A., et al. Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn Schmiedebergs Arch. Pharmacol. 371 (2005) 257-265
18. Welsh D.G., et al. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ. Res. 90 (2002) 248-250
19. Earley S., et al. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ. Res. 95 (2004) 922-929
20. Earley S., et al. Protein kinase C regulates vascular myogenic tone through activation of TRPM4. Am. J. Physiol. Heart Circ. Physiol. 292 (2007) H2613-H2622
21. Dietrich A., et al. Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1. Pflugers Arch. 455 (2007) 465-477
22. Dietrich A., et al. Increased vascular smooth muscle contractility in TRPC6-/- mice. Mol. Cell. Biol. 25 (2005) 6980-6989
23. Reading S.A., et al. TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H2055-H2061
24. Gottlieb P., et al. Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Arch. 455 (2008) 1097-1103
25. Fronius M., and Clauss W.G. Mechano-sensitivity of ENaC: may the (shear) force be with you. Pflugers Arch. 455 (2008) 775-785
26. + channels are activated by laminar shear stress. J. Biol. Chem. 279 (2004) 4120-4126
27. + channel proteins: components of a vascular mechanosensor. Hypertension 44 (2004) 643-648
28. Jernigan N.L., and Drummond H.A. Vascular ENaC proteins are required for renal myogenic constriction. Am. J. Physiol. Renal Physiol. 289 (2005) F891-F901
29. Jernigan N.L., and Drummond H.A. Myogenic vasoconstriction in mouse renal interlobar arteries: role of endogenous β and γENaC. Am. J. Physiol. Renal Physiol. 291 (2006) F1184-F1191
30. - cotransporter on myogenic and angiotensin II responses of the rat afferent arteriole. Am. J. Physiol. Renal Physiol. 292 (2007) F999-F1006
31. Gannon K.P., et al. Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice. Am. J. Physiol. Heart Circ. Physiol. 294 (2008) H1793-H1803
32. Jernigan N.L., et al. Dietary salt enhances benzamil-sensitive component of myogenic constriction in mesenteric arteries. Am. J. Physiol. 294 (2008) H409-H420
33. 3 integrin mediates arteriolar vasodilation in response to RGD peptides. Circ. Res. 79 (1996) 821-826
34. 2+]i induced by RGD-containing peptide. Am. J. Physiol. 272 (1997) H2065-H2070
35. Hein T.W., et al. Integrin-binding peptides containing RGD produce coronary arteriolar dilation via cyclooxygenase activation. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H2378-H2384
36. Martinez-Lemus L.A., et al. αvβ3- and α5β1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H322-H329
37. + (BK) channels by α5β1 integrin activation in arteriolar smooth muscle. J. Physiol. 586 (2008) 1699-1713
38. Drummond H.A., et al. A new trick for an old dogma: ENaC proteins as mechanotransducers in vascular smooth muscle. Physiology 23 (2008) 23-31
39. Sun Z., et al. Extracellular matrix-specific focal adhesions in vascular smooth muscle produce mechanically active adhesion sites. Am. J. Physiol. Cell Physiol. 295 (2008) C268-C278
40. Cipolla M.J., and Osol G. Vascular smooth muscle actin cytoskeleton in cerebral artery forced dilatation. Stroke 29 (1998) 1223-1228
41. Flavahan N.A., et al. Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechanosensitive arteriolar constriction. Am. J. Physiol. Heart Circ. Physiol. 288 (2005) H660-H669
42. Na S., et al. Time-dependent changes in smooth muscle cell stiffness and focal adhesion area in response to cyclic equibiaxial stretch. Ann. Biomed. Eng. 36 (2008) 369-380
43. Lagaud G., et al. Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H2177-H2186
44. Earley S., et al. Disruption of smooth muscle gap junctions attenuates myogenic vasoconstriction of mesenteric resistance arteries. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H2677-H2686
45. Jackson T.Y., et al. Cadherins play a role in arteriolar myogenic responsiveness. FASEB J (2008)
46. Martinez-Lemus L.A., et al. Acute mechanoadaptation of vascular smooth muscle cells in response to continuous arteriolar vasoconstriction: implications for functional remodeling. FASEB J. 18 (2004) 708-710
47. Lucchesi, P.A. et al. (2004) Involvement of metalloproteinases 2/9 in epidermal growth factor receptor transactivation in pressure-induced myogenic tone in mouse mesenteric resistance arteries. Circulation 110, 3587-3593.
48. Su J., et al. Mice lacking the gene encoding for MMP-9 and resistance artery reactivity. Biochem. Biophys. Res. Commun. 349 (2006) 1177-1181
49. Belin de Chantemele E.J., et al. Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries. Arterioscler. Thromb. Vasc. Biol. 28 (2008) 2216-2224
50. Hill M.A., and Meininger G.A. Calcium entry and myogenic phenomena in skeletal muscle arterioles. Am. J. Physiol. 267 (1994) H1085-H1092
51. Loutzenhiser R., et al. Renal myogenic response: kinetic attributes and physiological role. Circ. Res. 90 (2002) 1316-1324
52. q-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 27 (2008) 3092-3103
53. Gudi S., et al. Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 2515-2519
54. Yatani A., and Brown A.M. Rapid β-adrenergic modulation of cardiac calcium channel currents by a fast G protein pathway. Science 245 (1989) 71-74
55. 2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc. Res. 77 (2008) 8-18
56. 2+ sensitization in rabbit smooth muscle. J. Physiol. 546 (2003) 879-889
57. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol. Rev. 83 (2003) 1325-1358
58. Hill M.A., et al. Calcium dependence of indolactam-mediated contractions in resistance vessels. J. Pharmacol. Exp. Ther. 276 (1996) 867-874
59. Shiraishi M., et al. A highly sensitive method for quantification of myosin light chain phosphorylation by capillary isoelectric focusing with laser-induced fluorescence detection. Electrophoresis 26 (2005) 571-580
60. Takeya K., et al. A highly sensitive technique to measure myosin regulatory light chain phosphorylation: the first quantification in renal arterioles. Am. J. Physiol. Renal Physiol. 294 (2008) F1487-F1492
61. 2+ sensitization owing to Rho kinase-dependent phosphorylation of MYPT1-T855 contributes to myogenic control of arterial diameter. J. Physiol (2009). http://jp.physoc.org 10.1113/jphysiol.2008.168252
62. Somlyo A.P., and Somlyo A.V. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J. Physiol. 522 (2000) 177-185
63. Tang D.D., and Anfinogenova Y. Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J. Cardiovasc. Pharmacol. Ther. 13 (2008) 130-140
64. Laporte R., et al. Pharmacological modulation of sarcoplasmic reticulum function in smooth muscle. Pharmacol. Rev. 56 (2004) 439-513
65. 2+ stores in smooth muscle. J. Biol. Chem. 283 (2008) 7206-7218
66. 2+ signaling in cerebral artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 281 (2001) C439-C448
67. 2+-activated K+ channels in arteriolar muscle cells. Am. J. Physiol. 274 (1998) H27-H34
68. 1-subunit. J. Physiol. DOI: 10.1113/jphysiol.2009.169920 (http://jp.physoc.org)
69. 2+ sparks in mouse airway smooth muscle. J. Gen. Physiol. 132 (2008) 145-160
70. 2+ waves in cremaster muscle arterioles. FASEB J (2009)
71. i in myogenic reactivity and arteriolar tone. Am. J. Physiol. 269 (1995) H1590-H1596
72. 2+ and myosin phosphorylation during myogenic and norepinephrine-induced arteriolar constriction. J. Vasc. Res. 37 (2000) 556-567
73. Roman R.J., et al. Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm. Neurol. Res. 28 (2006) 738-749
74. 2+ sparks and their function in human cerebral arteries. Stroke 33 (2002) 802-808
75. 2+ channels. Acta Neurochir. Suppl. 104 (2008) 95-98
76. Shirao S., et al. Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. Cerebrovasc. Dis. 26 (2008) 30-37
77. 2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ. Res. 101 (2007) 493-502
78. Harris A.K., et al. Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 (2008) R1213-R1219
79. Ahn D.S., et al. Enhanced stretch-induced myogenic tone in the basilar artery of spontaneously hypertensive rats. J. Vasc. Res. 44 (2007) 182-191
80. Choy J.C., et al. Coxsackievirus B3 infection compromises endothelial-dependent vasodilation of coronary resistance arteries. J. Cardiovasc. Pharmacol. 43 (2004) 39-47
81. Petersen H.H., et al. Coronary artery myogenic response in a genetic model of hypertrophic cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H2244-H2249
82. 1-adrenergic vasoconstriction in aging female rats. Am. J. Hypertens. 21 (2008) 685-690
83. Broughton B.R., et al. Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries. Am. J. Physiol. Lung Cell. Mol. Physiol. 294 (2008) L797-L806
84. Raffai G., et al. Does long-term experimental antiorthostasis lead to cardiovascular deconditioning in the rat?. Physiol. Res. 58 (2008) 57-67
85. Otsuka T., et al. Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina. Coron. Artery Dis. 19 (2008) 105-110
86. Lagaud G., et al. Pressure-dependent myogenic constriction of cerebral arteries occurs independently of voltage-dependent activation. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H2187-H2195
87. Shimokawa H., and Rashid M. Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol. Sci. 28 (2007) 296-302
88. Miyata N., and Roman R.J. Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J. Smooth Muscle Res. 41 (2005) 175-193
89. Maroto R., et al. TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat. Cell Biol. 7 (2005) 179-185
90. Drummond H.A., et al. Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis. Hypertension 51 (2008) 1265-1271
91. Nelson M.T., et al. Relaxation of arterial smooth muscle by calcium sparks. Science 270 (1995) 633-637
92. Jaggar J.H., et al. Calcium sparks in smooth muscle. Am. J. Physiol. Cell Physiol. 278 (2000) C235-C256
93. 2+ sparks in intact cerebral arteries. Am. J. Physiol. 274 (1998) C1755-C1761
94. Chen T.T., et al. Key role of Kv1 channels in vasoregulation. Circ. Res. 99 (2006) 53-60
95. Bryan Jr. R.M., et al. Evidence for two-pore domain potassium channels in rat cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H770-H780
96. Blondeau N., et al. Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. Circ. Res. 101 (2007) 176-184
97. 2P channel TREK-1. Eur. Biophys. J. 38 (2009) 293-303
98. Nelson M.T., et al. Chloride channel blockers inhibit myogenic tone in rat cerebral arteries. J. Physiol. 502 (1997) 259-264
99. Doughty J.M., and Langton P.D. Measurement of chloride flux associated with the myogenic response in rat cerebral arteries. J. Physiol. 534 (2001) 753-761
100. 2+ influx in cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 282 (2002) H1410-H1420
101. Schiffers P.M., et al. Altered flow-induced arterial remodeling in vimentin-deficient mice. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 611-616
102. Loufrani L., et al. Selective microvascular dysfunction in mice lacking the gene encoding for desmin. FASEB J. 16 (2002) 117-119
103. 2+ spark coupling in murine arterial smooth muscle cells. Am. J. Physiol. 290 (2006) H2309-H2319
104. Potocnik S.J., et al. Membrane cholesterol depletion with β-cyclodextrin impairs pressure-induced contraction and calcium signalling in isolated skeletal muscle arterioles. J. Vasc. Res. 44 (2007) 292-302
105. Dubroca C., et al. RhoA activation and interaction with Caveolin-1 are critical for pressure-induced myogenic tone in rat mesenteric resistance arteries. Cardiovasc. Res. 73 (2007) 190-197
106. Narayanan J., et al. Pressurization of isolated renal arteries increases inositol trisphosphate and diacylglycerol. Am. J. Physiol. 266 (1994) H1840-H1845
107. Hill M.A., et al. Evidence for protein kinase C involvement in arteriolar myogenic reactivity. Am. J. Physiol. 259 (1990) H1586-H1594
108. Osol G., et al. Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation. Circ. Res. 68 (1991) 359-367
109. Massett M.P., et al. Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonists. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H2282-H2287
110. Murphy T.V., et al. Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H1047-H1056
111. Spurrell B.E., et al. Intraluminal pressure stimulates MAPK phosphorylation in arterioles: temporal dissociation from myogenic contractile response. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H1764-H1773
112. Nowicki P.T., et al. Redox signaling of the arteriolar myogenic response. Circ. Res. 89 (2001) 114-116
113. 2+ sensitivity in vascular smooth muscle. J. Smooth Muscle Res. 40 (2004) 219-236
114. Murthy K.S. Signaling for contraction and relaxation in smooth muscle of the gut. Annu. Rev. Physiol. 68 (2006) 345-374
115. 2+ signaling pathways underlying myogenic reactivity. J. Appl. Physiol. 91 (2001) 973-983
116. 2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J. Physiol. 508 (1998) 199-209
117. 2+ entry in cannulated and pressurized skeletal muscle arterioles. Br. J. Pharmacol. 134 (2001) 247-256