Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1- phosphate signaling

Circulation

Volumn 126, Issue 2, 2012, Pages 196-206

  Yang, Jingli ^a   Hossein Noyan Ashraf, M ^a,c   Meissner, Anja ^a   Voigtlaender Bolz, Julia ^a,b,d,e   Kroetsch, Jeffrey T ^a   Foltz, Warren ^f   Jaffray, David ^f   Kapoor, Amita ^a   Momen, Abdul ^c   Heximer, Scott P ^a,b   Zhang, Hangjun ^a   Van Eede, Matthijs ^a,g   Henkelman, R Mark ^a,g   Matthews, Stephen G ^a   Lidington, Darcy ^a,b,d   Husain, Mansoor ^a,b,c   Bolz, Steffen Sebastian ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e ST MICHAEL'S HOSPITAL   (Canada)

^f PRINCESS MARGARET HOSPITAL   (Canada)

^g Toronto Centre for Phenogenomics   (Canada)

Author keywords

cerebrovascular circulation; myocardial infarction; signal transduction; sphingosine kinase; vasomotor system

Indexed keywords

ETANERCEPT; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN FUNCTION; CONTROLLED STUDY; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POSTERIOR CEREBRAL ARTERY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; CEREBRAL ARTERIES; HEART FAILURE; IMMUNOGLOBULIN G; LYSOPHOSPHOLIPIDS; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; MUSCLE DEVELOPMENT; MUSCLE, SMOOTH, VASCULAR; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; RECEPTORS, TUMOR NECROSIS FACTOR; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; SPHINGOSINE; TUMOR NECROSIS FACTOR-ALPHA; VASOCONSTRICTION;

EID: 84863795499     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.039644     Document Type: Article

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