Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 352, Issue 3, 2015, Pages 455-461

  Koh, Seong Joon ^a   Kim, Ji Won ^a   Kim, Byeong Gwan ^a   Lee, Kook Lae ^a   Chun, Jaeyoung ^b   Kim, Joo Sung ^a,b  

^a Seoul National University Boramae Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 12; CCAAT ENHANCER BINDING PROTEIN; FEXOFENADINE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; INTERLEUKIN 10; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; TERFENADINE;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CELL STIMULATION; CHRONIC INFLAMMATION; COLITIS; COLO205 CELL LINE; CONTROLLED STUDY; DIGESTIVE TRACT PARAMETERS; DISEASE ACTIVITY; DISEASE SEVERITY; DRUG EFFECT; DRUG SCREENING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HCT116 CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INTESTINE EPITHELIUM CELL; MALE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CHRONIC DISEASE; DRUG EFFECTS; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; COLITIS; ENDOPLASMIC RETICULUM STRESS; FEMALE; HCT116 CELLS; HUMANS; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; TERFENADINE;

EID: 84921510432     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.217844     Document Type: Article

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