Evidence for Altered Regulation of IκBα Degradation in Human Colonic Epithelial Cells

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 226-234

  Jobin, Christian ^a   Haskill, Stephen ^a,b   Mayer, Lloyd ^c   Panja, Asit ^c   Sartor, R Balfour ^a,d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c MOUNT SINAI MEDICAL CENTER   (United States)

^d IL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 8; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ARTICLE; BIOSYNTHESIS; CELL LINE; COLON; CYTOLOGY; DRUG ANTAGONISM; EPITHELIUM; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PHOSPHORYLATION;

CELL LINE, TRANSFORMED; COLON; DNA-BINDING PROTEINS; EPITHELIUM; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-1; INTERLEUKIN-8; NF-KAPPA B; PHOSPHORYLATION;

EID: 0030636792     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Baeuerle, P. A., and T. Henkle. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
2. Grilli, M., J. S. Chui, and M. J. Lenardo. 1993. NF-κB and Rel participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 153:1.
3. Fan, C.-M., and T. Maniatis. 1991. Generation of p50 subunit of NF-κB by processing of p105 through an ATP-dependent pathway. Nature 354:395.
4. Gilmore, T. D., and P. J. Morin. 1993. The IκB protein: members of a multifunctional family. Trends Genet. 9:427.
5. Thanos, D., and T. Maniatis. 1995. NF-κB: A lesson in family values. Cell 80:529.
6. Beg, A. A., T. S. Finco, P. V. Nantermet, and A. S. Baldwin. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκBα: a mechanism for NF-κB activation. Mol. Cell. Biol. 13:3301.
7. Henkel, T., T. Machleidt, I. Alkalay, M. Kronke, Y. Ben-Neriah, and P. A. Baeuerle. 1993. Rapid proteolysis of IκB-α is necessary for activation of transcriptional factor NF-κB. Nature 365:182.
8. Chen, Z. J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by novel ubiquitination-dependent protein kinase activity. Cell 84:853.
9. Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773.
10. Scherer, D. C., J. A. Brockman, Z. Chen, T. Maniatis, and D. W. Ballard. 1995. Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc. Natl. Acad. Sci. USA 92:11259.
11. Li, C.-C. H., R.-M. Dai, and D. L. Longo. 1995. Inactivation of NF-κB inhibitor IκBα: ubiquitin-dependent proteolysis and its degradation product. Biochem. Biophys. Res. Commun. 215:292.
12. Sun, S.-C., P. A. Ganchi, D. W. Ballard, and W. C. Greene. 1993. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259:1912.
13. McCall, R. D., S. Haskill, E. M. Zimmermann, P. K. Lund, R. C. Thompson, and R. B. Sartor. 1994. Tissue interleukin 1 and interleukin-1 receptor antagonist expression in enterocolitis in resistant and susceptible rats. Gastroenterology 106:960.
14. Panja, A., A. Barone, and L. Mayer. 1994. Stimulation of lamina propria lymphocytes by intestinal epithelial cells. J. Exp. Med. 179:943.
15. Panja, A., E. Siden, and L. Mayer. 1995. Synthesis and regulation of accessory/ proinflammatory cytokines by intestinal epithelial cells. J. Clin. Immunol. 100:298.
16. Haskill, S., A. A. Beg, S. M. Tompkins, J. S. Morris, A. D. Yurochko, A. Sampson-Johannes, K. Mondal, P. Ralph, and A. S. Baldwin. 1991. Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity. Cell 65:1281.
17. Kunsch, C., R. K. Lang, C. A. Rosen, and M. Frances Shannon. 1994. Synergistic transcriptional activation of the IL-8 gene by NF-κB (relA) and NF-IL-6. J. Immunol. 153:153.
18. Beg, A. A., S. M. Ruben, R. I. Scheinman, S. Haskill, C. A. Rosen, and A. S. Baldwin. 1992. IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention. Genes Dev. 6:1899.
19. Galang, C. K., C. J. Der, and C. A. Hauser. 1994. Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene 9:2913.
20. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463.
21. Eckmann, L., H. J. Jung, C. Schürer-maly, A. Panja, E. Morzycka-Wroblewska, and M. J. Kagnoff. 1993. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology 105:1689.
22. Lin, Y.-C., K. Brown, and U. Siebenlist. 1995. Activation of NF-κB requires proteolysis of the inhibitor IκB-α: signal-induced phosphorylation of IκB-α alone does not release active NF-κB. Proc. Natl. Acad. Sci. USA 92:552.
23. Miyamoto, S., M. Maki, M. J. Schmitt, M. Hatanaka, and I. M. Verma. 1994. Tumor necrosis factor a-induced phosphorylation of IκBα is a signal for its degradation but not dissociation from NF-κB. Proc. Natl. Acad. Sci. USA 91:12740.
24. Figueiredo-Pereira, M. E., N. Banik, and S. Wilk. 1994. Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain. J. Neurochem. 62:1989.
25. Sartor, R. B. 1995. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol. Clin. North Am. 24:475.
26. Jung, H. C., L. Eckmann, S.-K. Yang, A. Panja, J. Fierer, E. Morzycka-Wroblewska, and M. F. Kagnoff. 1995. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 95:55.
27. Lofquist, A. K., K. Mondal, J. S. Morris, and J. S. Haskill. 1995. Transcription-independent turnover of IκBα during monocyte adherence: implication for a translational component regulating IκBα/MAD-3 mRNA levels. Mol. Cell. Biol. 15:1737.
28. Herrero, J. A., P. Mathew, and C. V. Paya. 1995. LMP-1 activates NF-κB by targeting the inhibitory molecule IκBα. J. Virol. 69:2168.
29. Thompson, J. E., R. J. Phillips, H. Erdument-Bromage, P. Tempst, and S. Ghosh. 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573.
30. Hellerbrand, C., C. Jobin, R. B. Sartor, and D. A. Brenner. 1996. NF-κB mediates cytokine induced expression of ICAM-1 in IEC-6 cells. Gastroenterology 110:A329.
31. Baeuerle, P. A. 1991. The inducible transcription activator NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63.