Peptidoglycan-mediated IL-8 expression in human alveolar type II epithelial cells requires lipid raft formation and MAPK activation

Molecular Immunology

Volumn 45, Issue 6, 2008, Pages 1665-1673

  Cheon, In Su ^a,b,c   Woo, Sang Su ^a   Kang, Seok Seong ^a,b   Im, Jintaek ^a   Yun, Cheol Heui ^b   Chung, Dae Kyun ^d,e   Park, Dong Ki ^f   Han, Seung Hyun ^a,b,c  

^a School of Dentistry   (South Korea)

^b Seoul National University   (South Korea)

^c International Vaccine Institute   (South Korea)

^d Kyung Hee University   (South Korea)

^e RNA Inc   (South Korea)

^f Konkuk University   (South Korea)

Author keywords

A549; Epithelial cells; IL 8; MAP kinase; Peptidoglycan; Signaling; Staphylococcus aureus; Transcription factor

Indexed keywords

CD14 ANTIGEN; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NYSTATIN; PEPTIDOGLYCAN; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; ATTENUATION; CELL LINE; DNA BINDING; DOSE RESPONSE; ENZYME ACTIVATION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; LIPID RAFT; LUNG ALVEOLUS CELL TYPE 2; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS;

ANTIGENS, CD14; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-8; MEMBRANE MICRODOMAINS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PEPTIDOGLYCAN; PROTEIN KINASE C; PULMONARY ALVEOLI; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION FACTOR AP-1;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 38949161530     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.10.001     Document Type: Article

References (48)

1. Blanchard E., Belouzard S., Goueslain L., Wakita T., Dubuisson J., Wychowski C., and Rouille Y. Hepatitis C virus entry depends on clathrin-mediated endocytosis. J. Virol. 80 (2006) 6964-6972
2. D'Angio C.T., LoMonaco M.B., Johnston C.J., Reed C.K., and Finkelstein J.N. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am. J. Physiol. Lung Cell. Mol. Physiol. 286 (2004) L30-L36
3. Davis R.J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268 (1993) 14553-14556
4. Di Guglielmo G.M., Le Roy C., Goodfellow A.F., and Wrana J.L. Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. Nat. Cell Biol. 5 (2003) 410-421
5. Dykstra M., Cherukuri A., Sohn H.W., Tzeng S.J., and Pierce S.K. Location is everything: lipid rafts and immune cell signaling. Annu. Rev. Immunol. 21 (2003) 457-481
6. Fehrenbach H. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir. Res. 2 (2001) 33-46
7. Fragaki K., Kileztky C., Trentesaux C., Zahm J.M., Bajolet O., Johnson M., and Puchelle E. Downregulation by a long-acting beta2-adrenergic receptor agonist and corticosteroid of Staphylococcus aureus-induced airway epithelial inflammatory mediator production. Am. J. Physiol. Lung Cell. Mol. Physiol. 291 (2006) L11-L18
8. Frevel M.A., Bakheet T., Silva A.M., Hissong J.G., Khabar K.S., and Williams B.R. p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts. Mol. Cell. Biol. 23 (2003) 425-436
9. Gillespie S.H., and Balakrishnan I. Pathogenesis of pneumococcal infection. J. Med. Microbiol. 49 (2000) 1057-1067
10. Girardin S.E., Boneca I.G., Viala J., Chamaillard M., Labigne A., Thomas G., Philpott D.J., and Sansonetti P.J. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278 (2003) 8869-8872
11. Hadley J.S., Wang J.E., Foster S.J., Thiemermann C., and Hinds C.J. Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, Toll-like receptor 2 (TLR2), and TLR4 in human blood: possible implications for priming of lipopolysaccharide signaling. Infect. Immun. 73 (2005) 7613-7619
12. Han S.H., Jeon Y.J., Yea S.S., and Yang K.H. Suppression of the interleukin-2 gene expression by aflatoxin B1 is mediated through the down-regulation of the NF-AT and AP-1 transcription factors. Toxicol. Lett. 108 (1999) 1-10
13. Hattar K., Grandel U., Moeller A., Fink L., Iglhaut J., Hartung T., Morath S., Seeger W., Grimminger F., and Sibelius U. Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14-dependent, Toll-like-receptor-independent mechanism: autocrine role of tumor necrosis factor-[alpha] in mediating LTA-induced interleukin-8 generation. Crit. Care Med. 34 (2006) 835-841
14. Hattor Y., Kasai K., Akimoto K., and Thiemermann C. Induction of NO synthesis by lipoteichoic acid from Staphylococcus aureus in J774 macrophages: involvement of a CD14-dependent pathway. Biochem. Biophys. Res. Commun. 233 (1997) 375-379
15. Hessle C.C., Andersson B., and Wold A.E. Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes. Cytokine 30 (2005) 311-318
16. Heyer G., Saba S., Adamo R., Rush W., Soong G., Cheung A., and Prince A. Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect. Immun. 70 (2002) 127-133
17. Hoffmann E., Dittrich-Breiholz O., Holtmann H., and Kracht M. Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 72 (2002) 847-855
18. Holz R.W. The effects of the polyene antibiotics nystatin and amphotericin B on thin lipid membranes. Ann. NY Acad. Sci. 235 (1974) 469-479
19. Krivan H.C., Roberts D.D., and Ginsburg V. Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 6157-6161
20. Kufer T.A., Banks D.J., and Philpott D.J. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci. 1072 (2006) 19-27
21. Kumar A., Zhang J., and Yu F.S. Innate immune response of corneal epithelial cells to Staphylococcus aureus infection: role of peptidoglycan in stimulating proinflammatory cytokine secretion. Invest. Ophthalmol. Vis. Sci. 45 (2004) 3513-3522
22. Kuroki Y., Takahashi M., and Nishitani C. Pulmonary collectins in innate immunity of the lung. Cell. Microbiol. (2007)
23. Machen T.E. Innate immune response in CF airway epithelia: hyperinflammatory?. Am. J. Physiol. Cell Physiol. 291 (2006) C218-C230
24. Mayer A.K., Muehmer M., Mages J., Gueinzius K., Hess C., Heeg K., Bals R., Lang R., and Dalpke A.H. Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J. Immunol. 178 (2007) 3134-3142
25. McNamara N., Khong A., McKemy D., Caterina M., Boyer J., Julius D., and Basbaum C. ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 9086-9091
26. Mukaida N., Morita M., Ishikawa Y., Rice N., Okamoto S., Kasahara T., and Matsushima K. Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin-8 gene repression. J. Biol. Chem. 269 (1994) 13289-13295
27. Nadesalingam J., Dodds A.W., Reid K.B., and Palaniyar N. Mannose-binding lectin recognizes peptidoglycan via the N-acetyl glucosamine moiety, and inhibits ligand-induced proinflammatory effect and promotes chemokine production by macrophages. J. Immunol. 175 (2005) 1785-1794
28. Palaniyar N., Nadesalingam J., and Reid K.B. Pulmonary innate immune proteins and receptors that interact with Gram-positive bacterial ligands. Immunobiology 205 (2002) 575-594
29. Patterson A.M., Schmutz C., Davis S., Gardner L., Ashton B.A., and Middleton J. Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium. Arthritis Res. 4 (2002) 209-214
30. Plumb J.A., Milroy R., and Kaye S.B. Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res. 49 (1989) 4435-4440
31. Rietschel E.T., Schletter J., Weidemann B., El-Samalouti V., Mattern T., Zahringer U., Seydel U., Brade H., Flad H.D., Kusumoto S., Gupta D., Dziarski R., and Ulmer A.J. Lipopolysaccharide and peptidoglycan: CD14-dependent bacterial inducers of inflammation. Microb. Drug Resist. 4 (1998) 37-44
32. Rogan M.P., Geraghty P., Greene C.M., O'Neill S.J., Taggart C.C., and McElvaney N.G. Antimicrobial proteins and polypeptides in pulmonary innate defence. Respir. Res. 7 (2006) 29
33. Schulz C., Farkas L., Wolf K., Kratzel K., Eissner G., and Pfeifer M. Differences in LPS-induced activation of bronchial epithelial cells (BEAS-2B) and type II-like pneumocytes (A-549). Scand. J. Immunol. 56 (2002) 294-302
34. Schwandner R., Dziarski R., Wesche H., Rothe M., and Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274 (1999) 17406-17409
35. Smart E.J., Graf G.A., McNiven M.A., Sessa W.C., Engelman J.A., Scherer P.E., Okamoto T., and Lisanti M.P. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19 (1999) 7289-7304
36. Standiford T.J., Kunkel S.L., Basha M.A., Chensue S.W., Lynch III J.P., Toews G.B., Westwick J., and Strieter R.M. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J. Clin. Invest. 86 (1990) 1945-1953
37. Stoddart A., Dykstra M.L., Brown B.K., Song W., Pierce S.K., and Brodsky F.M. Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization. Immunity 17 (2002) 451-462
38. Strober W., Murray P.J., Kitani A., and Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 6 (2006) 9-20
39. Tebo J., Der S., Frevel M., Khabar K.S., Williams B.R., and Hamilton T.A. Heterogeneity in control of mRNA stability by AU-rich elements. J. Biol. Chem. 278 (2003) 12085-12093
40. Travassos L.H., Girardin S.E., Philpott D.J., Blanot D., Nahori M.A., Werts C., and Boneca I.G. Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep. 5 (2004) 1000-1006
41. Triantafilou M., Miyake K., Golenbock D.T., and Triantafilou K. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J. Cell Sci. 115 (2002) 2603-2611
42. Tsutsumi-Ishii Y., and Nagaoka I. Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J. Immunol. 170 (2003) 4226-4236
43. Wang J.E., Jorgensen P.F., Almlof M., Thiemermann C., Foster S.J., Aasen A.O., and Solberg R. Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model. Infect. Immun. 68 (2000) 3965-3970
44. Wang J.E., Dahle M.K., McDonald M., Foster S.J., Aasen A.O., and Thiemermann C. Peptidoglycan and lipoteichoic acid in gram-positive bacterial sepsis: receptors, signal transduction, biological effects, and synergism. Shock 20 (2003) 402-414
45. Wang J.E., Dahle M.K., Yndestad A., Bauer I., McDonald M.C., Aukrust P., Foster S.J., Bauer M., Aasen A.O., and Thiemermann C. Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. Crit. Care Med. 32 (2004) 546-552
46. Weidemann B., Brade H., Rietschel E.T., Dziarski R., Bazil V., Kusumoto S., Flad H.D., and Ulmer A.J. Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures. Infect. Immun. 62 (1994) 4709-4715
47. Weidemann B., Schletter J., Dziarski R., Kusumoto S., Stelter F., Rietschel E.T., Flad H.D., and Ulmer A.J. Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes. Infect. Immun. 65 (1997) 858-864
48. Wilsie L.C., Gonzales A.M., and Orlando R.A. Syndecan-1 mediates internalization of apoE-VLDL through a low-density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway. Lipids Health Dis. 5 (2006) 23