Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides

Journal of Medicinal Chemistry

Volumn 58, Issue 2, 2015, Pages 1012-1018

  Tochowicz, Anna ^a   Santucci, Matteo ^b   Saxena, Puneet ^b   Guaitoli, Giambattista ^b,c   Trande, Matteo ^b   Finer Moore, Janet ^a   Stroud, Robert M ^a   Costi, Maria P ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ANTINEOPLASTIC AGENT; DIMER; MUTANT PROTEIN; THYMIDYLATE SYNTHASE; ENZYME INHIBITOR;

ALLOSTERISM; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG PROTEIN BINDING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; HUMAN; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALANINE; ALLOSTERIC REGULATION; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MUTAGENESIS, SITE-DIRECTED; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE;

EID: 84921510043     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5011176     Document Type: Article

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