Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 2, 2009, Pages 418-423

  Edward Martucci, W ^a   Udier Blagovic, Marina ^b   Atreya, Chloe ^a   Babatunde, Oladapo ^a   Vargo, Melissa A ^a   Jorgensen, William L ^b   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Allosteric; Cryptosporidium hominis; DHFR; Glide; Non active site; Virtual screen

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FLAVINE MONONUCLEOTIDE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

ALLOSTERISM; ARTICLE; CRYPTOSPORIDIUM HOMINIS; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RESEARCH; DRUG SELECTIVITY; DRUG TARGETING; ENZYME SUBUNIT;

ALLOSTERIC SITE; ANIMALS; CATALYTIC DOMAIN; CRYPTOSPORIDIUM; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; TETRAHYDROFOLATE DEHYDROGENASE;

CRYPTOSPORIDIUM HOMINIS; PROTOZOA;

EID: 57749085324     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.054     Document Type: Article

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