Amino acid modified xanthone derivatives: Novel, highly promising membrane-active antimicrobials for multidrug-resistant gram-positive bacterial infections

Journal of Medicinal Chemistry

Volumn 58, Issue 2, 2015, Pages 739-752

  Koh, Jun Jie ^a,b   Lin, Shuimu ^a,c   Aung, Thet Tun ^a   Lim, Fanghui ^a   Zou, Hanxun ^a,c   Bai, Yang ^a,f   Li, Jianguo ^a,d   Lin, Huifen ^a   Pang, Li Mei ^a   Koh, Wee Luan ^a   Salleh, Shuhaida Mohamed ^a   Lakshminarayanan, Rajamani ^a,e   Zhou, Lei ^a,e   Qiu, Shengxiang ^h   Pervushin, Konstantin ^f   Verma, Chandra ^a,d,f,g   Tan, Donald T H ^b   Cao, Derong ^c   Liu, Shouping ^a,c,e   Beuerman, Roger W ^a,e  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^d BIOINFORMATICS INSTITUTE   (Singapore)

^e DUKE NUS MEDICAL SCHOOL   (Singapore)

^f NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^g NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^h SOUTH CHINA INSTITUTE OF BOTANY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; DAPTOMYCIN; DIMETHYL 2,2' [[2,2' [(1 HYDROXY 7 METHOXY 2,8 BIS(3 METHYLBUT 2 EN 1 YL) 9 OXO 9H XANTHENE 3,6 DIYL]BIS(OXY)]BIS(ACETYL)]BIS(AZANEDIYL)]BIS(5 GUANIDINOPENTANOATE; DIMETHYL 2,2' [[2,2' [[2,2' [(1 HYDROXY 7 METHOXY 2,8 BIS(3 METHYLBUT 2 EN 1 YL) 9 OXO 9H XANTHENE 3,6 DIYL]BIS(OXY)]BIS(ACETYL)]BIS(AZANEDIYL)]BIS(5 GUANIDINOPENTANOATE); UNCLASSIFIED DRUG; VANCOMYCIN; XANTHONE DERIVATIVE; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIAL MEMBRANE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; GRAM POSITIVE BACTERIUM; GRAM POSITIVE INFECTION; HUMAN; HYDROPHOBICITY; KERATITIS; LIPOPHILICITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR DYNAMICS; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RABBIT; STAPHYLOCOCCUS AUREUS; STATIC ELECTRICITY; VANCOMYCIN RESISTANT ENTEROCOCCUS; WOUND HEALING; ANIMAL; CELL MEMBRANE; DRUG EFFECTS; GRAM-POSITIVE BACTERIAL INFECTIONS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACIDS; ANIMALS; ANTI-BACTERIAL AGENTS; CELL MEMBRANE; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GRAM-POSITIVE BACTERIAL INFECTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICROBIAL SENSITIVITY TESTS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; UNILAMELLAR LIPOSOMES; XANTHONES;

EID: 84921495327     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501285x     Document Type: Article

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