In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers

European Journal of Pharmacology

Volumn 732, Issue 1, 2014, Pages 86-95

  Zhang, Wei ^a,b   Parniak, Michael A ^c   Sarafianos, Stefan G ^d   Empey, Philip E ^b   Rohan, Lisa C ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d University of Missouri   (United States)

Author keywords

Bidirectional flux; Caco 2; EFdA; MDCKII; PGP1

Indexed keywords

4' ETHYNYL 2 FLUORO 2' DEOXYADENOSINE; CALCEIN; IVERMECTIN; MULTIDRUG RESISTANCE PROTEIN 1; QUINIDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; 4'-ETHYNYL-2-FLUORO-2'-DEOXYADENOSINE; DEOXYADENOSINE DERIVATIVE; FLUORESCENT DYE; ISOQUINOLINE DERIVATIVE; LUCIFER YELLOW;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; IN VITRO STUDY; MDCK CELL; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; ANIMAL; CACO 2 CELL LINE; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DOG; DRUG EFFECTS; HUMAN; MDCK CELL LINE;

ANIMALS; CACO-2 CELLS; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DEOXYADENOSINES; DOGS; FLUORESCENT DYES; HUMANS; ISOQUINOLINES; MADIN DARBY CANINE KIDNEY CELLS; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 84921433817     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.03.022     Document Type: Article

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