The effect of hyperosmosis on paracellular permeability in caco-2 cell monolayers

Bioscience, Biotechnology and Biochemistry

Volumn 73, Issue 2, 2009, Pages 328-334

  Inokuchi, Hitoshi ^a   Takei, Takuto ^a   Aikawa, Katsuyoshi ^a   Shimizu, Makoto ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Caco 2 cell; Hyperosmosis; Paracellular permeability; Tight junction

Indexed keywords

CACO-2 CELL; HYDROPHILIC COMPOUNDS; HYPEROSMOSIS; INTERCELLULAR SPACES; INTESTINAL EPITHELIUMS; ORAL ABSORPTIONS; OSMOTIC PRESSURES; PARACELLULAR PERMEABILITY; PARACELLULAR TRANSPORTS; SIGNIFICANT FACTORS; TEST SOLUTIONS; TIGHT JUNCTION; TRANSEPITHELIAL ELECTRICAL RESISTANCES;

AMINES; AMINO ACIDS; ELECTRON ENERGY LEVELS; LIVING SYSTEMS STUDIES; MODULATION; MONOLAYERS; ORGANIC ACIDS; OSMOSIS; SODIUM; SODIUM CHLORIDE;

CAPILLARITY;

DIFRUCTOSE ANHYDRIDE III; DISACCHARIDE; GLUTAMIC ACID DERIVATIVE; ISOQUINOLINE DERIVATIVE; LUCIFER YELLOW; MANNITOL; PALMITOYLCARNITINE; RAFFINOSE; SODIUM CHLORIDE;

ANIMAL; ARTICLE; CELL STRAIN CACO 2; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; HUMAN; IMPEDANCE; METABOLISM; OSMOSIS; PERMEABILITY; TIGHT JUNCTION;

ANIMALS; CACO-2 CELLS; DISACCHARIDES; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; GLUTAMATES; HUMANS; ISOQUINOLINES; MANNITOL; OSMOSIS; PALMITOYLCARNITINE; PERMEABILITY; RAFFINOSE; SODIUM CHLORIDE; TIGHT JUNCTIONS;

EID: 65249152459     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80538     Document Type: Article

References (34)

1. Anderson, J. M., and Van Itallie, C. M., Tight junctions and the molecular basis for regulation of paracellular permeability. Am. J. Physiol., 269, G467-G475 (1995).
2. Lutz, K. L., and Siahaan, T. J., Molecular structure of the apical junction complex and its contribution to the paracellular barrier. J. Pharm. Sci., 86, 977-984 (1997).
3. Noach, A. B., Sakai, M., Blom-Roosemalen, M. C, de Jonge, H. R., de Boer, A. G., and Breimer, D. D., Effect of anisotonic conditions on the transport of hydrophilic model compounds across monolayers of human colonic cell lines. J. Pharmacol. Exp. Ther., 270, 1373-1380 (1994).
4. Perez, M., Barber, A., and Ponz, F., Effect of osmolality on the epithelial paracellular permeability in rat jejunum. Rev. Esp. Fisiol, 52, 103-112(1996).
5. Parisi, M., Pisam, M., Calamita, G., Gobin, R., Toriano, R., and Bourguet, J., Water pathways across a reconstituted epithelial barrier formed by Caco-2 cells: effects of medium hyper-tonicity. J. Membr. Biol, 143, 237-245 (1995).
6. Hubert, A., Cauliez, B., Chedeville, A., Husson, A., and Lavoinne, A., Osmotic stress, a proinflammatory signal in Caco-2 cells. Biochimie, 86, 533-541 (2004).
7. Madara, J. L., and Pappenheimer, J. R., Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol, 100, 149-164 (1987).
8. Atisook, K., Carlson, S., and Madara, J. L., Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia. Am. J. Physiol, 258, C77-C85 (1990).
9. Madara, J. L., and Carlson, S., Supraphysiologic L-tryptophan elicits cytoskeletal and macromolecular permeability alterations in hamster small intestinal epithelium in vitro. J. Clin. Invest., 87, 454-462 (1991).
10. Farhadi, A., Banan, A., Fields, J., and Keshavarzian, A., Intestinal barrier: an interface between health and disease. J. Gastroenterol. Hepatol, 18, 479-497 (2003).
11. Pinto, M., Robine-Leon, S., Appay, M. D., Kedinger, M., Triadou, N., Dussaulx, E., Lacroix, B., Simon-Assmann, P., Haffen, K., Fogh, J., and Zweibaum, A., Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell, 47, 323-330 (1983).
12. Chantret, I., Rodolosse, A., Barbat, A., Dussaulx, E., Brot-Laroche, E., Zweibaum, A., and Rousset, M., Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation. J. Cell Sci., 107, 213-225 (1994).
13. Hidalgo, I. J., Raub, T. J., and Borchardt, R. T., Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology, 96, 736-749 (1989).
14. Vachon, P. H., and Beaulieu, J. F., Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line. Gastroenterology, 103, 414-423 (1992).
15. Konishi, T., Satsu, H., Hatsugai, Y., Aizawa, K., Inakuma, T., Nagata, S., Sakuda, S. H., Nagasawa, H., and Shimizu, M., Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br. J. Pharmacol, 143, 379-387 (2004).
16. Tsukazaki, M., Satsu, H., Mori, A., Sugita-Konishi, Y., and Shimizu, M., Effects of tributyltin on barrier functions in human intestinal Caco-2 cells. Biochem. Biophys. Res. Commun., 315, 991-997 (2004).
17. Gumbiner, B., Structure, biochemistry, and assembly of epithelial tight junctions. Am. J. Physiol, 253, C749-C758 (1987).
18. Schneeberger, E. E., and Lynch, R. D., Structure, function, and regulation of cellular tight junctions. Am. J. Physiol, 262, L647-L661 (1992).
19. Satsu, H., Miyamoto, Y., and Shimizu, M., Hypertonicity stimulates taurine uptake and transporter gene expression in Caco-2 cells. Biochim. Biophys. Acta, 1419, 89-96 (1999).
20. Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K., and Watson, J. D., "Molecular Biology of the Cell" 2nd ed., Garland, New York, pp. 304-310 (1989).
21. Anderberg, E. K., Lindmark, T., and Artursson, P., Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by paracellular route. Pharm. Res., 10, 857-864 (1993).
22. Liu, D. Z., LeCluyse, E. L., and Thakker, D. R., Dodecylphos-phocholine- mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. J. Pharm. Sci., 88, 1161-1168 (1999).
23. Ballard, S. T., Hunter, J. H., and Taylor, A. E., Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium. Annu. Rev. Nutr., 15, 35-55 (1995).
24. Takeuchi, M., Okura, T., Mori, T., Akita, K., Ohta, T., Ikeda, M., Ikegami, H., and Kurimoto, M., Intracellular production of interleukin-18 in human epithelial-like cell lines is enhanced by hyperosmotic stress in vitro. Cell Tissue Res., 297, 467-473 (1999).
25. Nemeth, Z. H., Deitch, E. A., Szabo, C, and Haskó, G., Hyperosmotic stress induces nuclear factor-kappaB activation and interleukin-8 production in human intestinal epithelial cells. Am. J. Pathol., 161, 987-996 (2002).
26. de Vries, H. E., Blom-Roosemalen, M. C, van Oosten, M., de Boer, A. G., van Berkel, T. J., Breimer, D. D., and Kuiper, J., The influence of cytokines on the integrity of the blood-brain barrier in vitro. J. Neuroimmunol., 64, 37-43 (1996).
27. Hochman, J. H., Fix, J., and LeCluyse, E. L., In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoyl carnitine. J. Pharmacol. Exp. Ther., 269, 813-822 (1994).
28. Suzuki, T., and Hara, H., Various nondigestible saccharides open a paracellular calcium transport pathway with the induction of intracellular calcium signaling in human intestinal Caco-2 cells. J. Nutr., 134, 1935-1941 (2004).
29. Hidalgo, I. J., and Li, J., Carrier-mediated transport and efflux mechanism in Caco-2 cells. Adv. Drug Deliv. Rev., 22, 53-66 (1996).
30. Mordrelle, A., Jullian, E., Costa, C, Cormet-Boyaka, E., Benamouzig, R., Tome, D., and Huneau, J. F., EAAT1 is involved in transport of L-glutamate during differentiation of the Caco-2 cell line. Am. J. Physiol. Gastrointest. Liver Physiol., 279, G366-G373 (2000).
31. +-induced intestinal interstitial hyperosmo-lality and vascular responses during absorptive hyperemia. Am. J. Physiol., 242, H785-H789 (1982).
32. Haljamäe, H., Jodal, M., and Lundgren, O., Countercurrent multiplication of sodium in intestinal villi during absorption of sodium chloride. Acta Physiol. Scand., 89, 580-593 (1973).
33. Hallbäck, D. A., Jodal, M., Mannischeff, M., and Lundgren, O., Tissue osmolality in intestinal villi of four mammals in vivo and in vitro. Acta Physiol. Scand., 143, 271-277 (1991).
34. Sjöqvist, A., and Beeuwkes, R. 3rd, Villous sodium gradient associated with volume absorption in the feline intestine: an electron-microprobe study on freeze-dried tissue. Acta Physiol. Scand, 136, 271-279 (1989).