메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages 2253-2263

Functionalized carbon nanomaterials: Exploring the interactions with Caco-2 cells for potential oral drug delivery

Author keywords

Carbon nanotubes; Fullerenes; Functionalization; P glycoprotein; Paracellular transport

Indexed keywords

CARBOXYLIC ACID; FULLERENE DERIVATIVE; LUCIFER YELLOW; MACROGOL; MULTIDRUG RESISTANCE PROTEIN; PROTEIN ZO1; RHODAMINE 123; SINGLE WALLED NANOTUBE; CARBON NANOTUBE; GLYCOPROTEIN P; ISOQUINOLINE DERIVATIVE; RHODAMINE;

EID: 84867883989     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S23962     Document Type: Article
Times cited : (57)

References (38)
  • 1
    • 77954817236 scopus 로고    scopus 로고
    • Functionalized carbon nanotubes for potential medicinal applications
    • Zhang Y, Bai Y, Yan B. Functionalized carbon nanotubes for potential medicinal applications. Drug Discov Today. 2010;15(11-12):428-435.
    • (2010) Drug Discov Today , vol.15 , Issue.11-12 , pp. 428-435
    • Zhang, Y.1    Bai, Y.2    Yan, B.3
  • 2
    • 0001421410 scopus 로고    scopus 로고
    • Applications of carbon nanotubes
    • Dresselhaus MS, Dresselhaus G, Avouris P, editors, Berlin, Germany: Springer-Verlag
    • Ajayan PM, Zhou OZ. Applications of carbon nanotubes. In: Dresselhaus MS, Dresselhaus G, Avouris P, editors. Carbon Nanotubes: Synthesis, Structure, Properties, and Applications. Berlin, Germany: Springer-Verlag; 2001:391-425.
    • (2001) Carbon Nanotubes: Synthesis, Structure, Properties, and Applications , pp. 391-425
    • Ajayan, P.M.1    Zhou, O.Z.2
  • 3
    • 77449141909 scopus 로고    scopus 로고
    • Biomedical applications of functionalized fullerene-based nanomaterials
    • Partha R, Conyers JL. Biomedical applications of functionalized fullerene-based nanomaterials. Int J Nanomedicine. 2009;4:261-275.
    • (2009) Int J Nanomedicine , vol.4 , pp. 261-275
    • Partha, R.1    Conyers, J.L.2
  • 4
    • 27744504244 scopus 로고    scopus 로고
    • Applications of carbon nanotubes in drug delivery
    • Bianco A, Kostarelos K, Prato M. Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol. 2005;9(6):674-679.
    • (2005) Curr Opin Chem Biol , vol.9 , Issue.6 , pp. 674-679
    • Bianco, A.1    Kostarelos, K.2    Prato, M.3
  • 5
    • 0342819025 scopus 로고
    • Helical microtubules of graphitic carbon
    • Available at
    • Iijima S. Helical microtubules of graphitic carbon. Nature. 1991;354:56-58. Available at: http://www.nature.com/nature/journal/v354/n6348/ abs/354056a0.html.
    • (1991) Nature , vol.354 , pp. 56-58
    • Iijima, S.1
  • 6
    • 1542743726 scopus 로고
    • C60: Buckministerfullerene
    • Available at
    • Kroto HW, Heath JR, O'Brien SC, Curl RF, Smalley RE. C60: Buckministerfullerene. Nature. 1985;318:162-163. Available at: http://www. nature.com/nature/journal/v318/n6042/abs/318162a0.html.
    • (1985) Nature , vol.318 , pp. 162-163
    • Kroto, H.W.1    Heath, J.R.2    O'Brien, S.C.3    Curl, R.F.4    Smalley, R.E.5
  • 7
    • 79952578010 scopus 로고    scopus 로고
    • In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice
    • Yang K, Wan J, Zhang S, Zhang Y, Lee ST, Liu Z. In vivo pharmacokinetics, long-term biodistribution, and toxicology of PEGylated graphene in mice. ACS Nano. 2011;5(1):516-522.
    • (2011) ACS Nano , vol.5 , Issue.1 , pp. 516-522
    • Yang, K.1    Wan, J.2    Zhang, S.3    Zhang, Y.4    Lee, S.T.5    Liu, Z.6
  • 8
    • 77956455985 scopus 로고    scopus 로고
    • Graphene in mice: Ultrahigh in vivo tumor uptake and efficient photothermal therapy
    • Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2010;10(9):3318-3323.
    • (2010) Nano Lett , vol.10 , Issue.9 , pp. 3318-3323
    • Yang, K.1    Zhang, S.2    Zhang, G.3    Sun, X.4    Lee, S.T.5    Liu, Z.6
  • 9
    • 79952586310 scopus 로고    scopus 로고
    • Graphene in biomedicine: Opportunities and challenges
    • Feng L, Liu Z. Graphene in biomedicine: opportunities and challenges. Nanomedicine (Lond). 2011;6(2):317-324.
    • (2011) Nanomedicine (Lond) , vol.6 , Issue.2 , pp. 317-324
    • Feng, L.1    Liu, Z.2
  • 10
    • 80053191375 scopus 로고    scopus 로고
    • Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells
    • Patlolla A, Knighten B, Tchounwou P. Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells. Ethn Dis. 2010;20(1 Suppl 1):S165-S172.
    • (2010) Ethn Dis , vol.20 , Issue.1 SUPPL 1
    • Patlolla, A.1    Knighten, B.2    Tchounwou, P.3
  • 11
    • 61849090369 scopus 로고    scopus 로고
    • Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro
    • Lindberg HK, Falck GC, Suhonen S, et al. Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro. Toxicol Lett. 2009;186(3):166-173.
    • (2009) Toxicol Lett , vol.186 , Issue.3 , pp. 166-173
    • Lindberg, H.K.1    Falck, G.C.2    Suhonen, S.3
  • 12
    • 32044433499 scopus 로고    scopus 로고
    • Effects of fullerenes and single-wall carbon nanotubes on murine and human macrophages
    • Fiorito S, Serafino A, Andreola F, Bernier P. Effects of fullerenes and single-wall carbon nanotubes on murine and human macrophages. Carbon. 2006;44(6):1100-1105.
    • (2006) Carbon , vol.44 , Issue.6 , pp. 1100-1105
    • Fiorito, S.1    Serafino, A.2    Andreola, F.3    Bernier, P.4
  • 13
    • 77952877794 scopus 로고    scopus 로고
    • Multi wall carbon nanotubes induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells
    • Reddy AR, Reddy YN, Krishna DR, Himabindu V. Multi wall carbon nanotubes induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells. Toxicology. 2010;272(1-3):11-16.
    • (2010) Toxicology , vol.272 , Issue.1-3 , pp. 11-16
    • Reddy, A.R.1    Reddy, Y.N.2    Krishna, D.R.3    Himabindu, V.4
  • 14
    • 40349112868 scopus 로고    scopus 로고
    • Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy
    • Liu Z, Davis C, Cai W, He L, Chen X, Dai H. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci U S A. 2008; 105(5):1410-1415.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.5 , pp. 1410-1415
    • Liu, Z.1    Davis, C.2    Cai, W.3    He, L.4    Chen, X.5    Dai, H.6
  • 15
    • 41849126454 scopus 로고    scopus 로고
    • A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice
    • Schipper ML, Nakayama-Ratchford N, Davis CR, et al. A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nat Nanotechnol. 2008;3(4):216-221.
    • (2008) Nat Nanotechnol , vol.3 , Issue.4 , pp. 216-221
    • Schipper, M.L.1    Nakayama-Ratchford, N.2    Davis, C.R.3
  • 16
    • 77950154641 scopus 로고    scopus 로고
    • In vivo behavior of large doses of ultrashort and full-length single-walled carbon nanotubes after oral and intraperitoneal administration to Swiss mice
    • Kolosnjaj-Tabi J, Hartman KB, Boudjemaa S, et al. In vivo behavior of large doses of ultrashort and full-length single-walled carbon nanotubes after oral and intraperitoneal administration to Swiss mice. ACS Nano. 2010;4(3):1481-1492.
    • (2010) ACS Nano , vol.4 , Issue.3 , pp. 1481-1492
    • Kolosnjaj-Tabi, J.1    Hartman, K.B.2    Boudjemaa, S.3
  • 17
    • 46749153312 scopus 로고    scopus 로고
    • Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study
    • Poland CA, Duffin R, Kinloch I, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3(7):423-428.
    • (2008) Nat Nanotechnol , vol.3 , Issue.7 , pp. 423-428
    • Poland, C.A.1    Duffin, R.2    Kinloch, I.3
  • 18
    • 40349113411 scopus 로고    scopus 로고
    • Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
    • Takagi A, Hirose A, Nishimura T, et al. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci. 2008;33(1):105-116.
    • (2008) J Toxicol Sci , vol.33 , Issue.1 , pp. 105-116
    • Takagi, A.1    Hirose, A.2    Nishimura, T.3
  • 19
    • 0031885845 scopus 로고    scopus 로고
    • Acute and subacute toxicity study of water-soluble polyalkylsulfonated C-60 in rats
    • Chen HHC, Yu C, Ueng TH, et al. Acute and subacute toxicity study of water-soluble polyalkylsulfonated C-60 in rats. Toxicol Pathol. 1998; 26(1):143-151.
    • (1998) Toxicol Pathol , vol.26 , Issue.1 , pp. 143-151
    • Chen, H.H.C.1    Yu, C.2    Ueng, T.H.3
  • 20
    • 79751474332 scopus 로고    scopus 로고
    • Maternal exposure to multi-wall carbon nanotubes does not induce embryo-fetal developmental toxicity in rats
    • Lim JH, Kim SH, Shin IS, et al. Maternal exposure to multi-wall carbon nanotubes does not induce embryo-fetal developmental toxicity in rats. Birth Defects Res B Dev Reprod Toxicol. 2011;92(1):69-76.
    • (2011) Birth Defects Res B Dev Reprod Toxicol , vol.92 , Issue.1 , pp. 69-76
    • Lim, J.H.1    Kim, S.H.2    Shin, I.S.3
  • 21
    • 33745742443 scopus 로고    scopus 로고
    • Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis
    • Mori T, Takada H, Ito S, Matsubayashi K, Miwa N, Sawaguchi T. Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology. 2006;225(1):48-54.
    • (2006) Toxicology , vol.225 , Issue.1 , pp. 48-54
    • Mori, T.1    Takada, H.2    Ito, S.3    Matsubayashi, K.4    Miwa, N.5    Sawaguchi, T.6
  • 22
    • 7544226477 scopus 로고    scopus 로고
    • The differential cytotoxicity of water-soluble fullerenes
    • Sayes CM, Fortner JD, Guo W, et al. The differential cytotoxicity of water-soluble fullerenes. Nano Lett. 2004;4(10):1881-1887.
    • (2004) Nano Lett , vol.4 , Issue.10 , pp. 1881-1887
    • Sayes, C.M.1    Fortner, J.D.2    Guo, W.3
  • 23
    • 0025189818 scopus 로고
    • Transport and permeability properties of human Caco-2 Cells - an in vitro model of the intestinal epithelial-cell barrier
    • Wilson G, Hassan IF, Dix CJ, et al. Transport and permeability properties of human Caco-2 Cells - an in vitro model of the intestinal epithelial-cell barrier. J Control Release. 1990;11(1-3):25-40.
    • (1990) J Control Release , vol.11 , Issue.1-3 , pp. 25-40
    • Wilson, G.1    Hassan, I.F.2    Dix, C.J.3
  • 24
    • 0024593744 scopus 로고
    • Characterization of the humancolon carcinoma cell-Line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the humancolon carcinoma cell-Line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology. 1989;96(3):736-749.
    • (1989) Gastroenterology , vol.96 , Issue.3 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 25
    • 0025132942 scopus 로고
    • Caco-2 Cell monolayers as a model for drug transport across the intestinal mucosa
    • Hilgers AR, Conradi RA, Burton PS. Caco-2 Cell monolayers as a model for drug transport across the intestinal mucosa. Pharmaceut Res. 1990; 7(9):902-910.
    • (1990) Pharmaceut Res , vol.7 , Issue.9 , pp. 902-910
    • Hilgers, A.R.1    Conradi, R.A.2    Burton, P.S.3
  • 26
    • 35348866826 scopus 로고    scopus 로고
    • The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction
    • Belyanskaya L, Manser P, Spohn P, Bruinink A, Wick P. The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction. Carbon. 2007;45(13):2643-2648.
    • (2007) Carbon , vol.45 , Issue.13 , pp. 2643-2648
    • Belyanskaya, L.1    Manser, P.2    Spohn, P.3    Bruinink, A.4    Wick, P.5
  • 27
    • 33745741441 scopus 로고    scopus 로고
    • Oops they did it again! Carbon nanotubes hoax scientists in viability assays
    • Worle-Knirsch JM, Pulskamp K, Krug HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett. 2006;6(6):1261-1268.
    • (2006) Nano Lett , vol.6 , Issue.6 , pp. 1261-1268
    • Worle-Knirsch, J.M.1    Pulskamp, K.2    Krug, H.F.3
  • 28
    • 0036849724 scopus 로고    scopus 로고
    • Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by Caco-2 cells using low molecular weight methoxypolyethylene glycolblock- polycaprolactone diblock copolymers
    • Zastre J, Jackson J, Bajwa M, Liggins R, Iqbal F, Burt H. Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by Caco-2 cells using low molecular weight methoxypolyethylene glycolblock- polycaprolactone diblock copolymers. Eur J Pharm Biopharm. 2002;54(3):299-309.
    • (2002) Eur J Pharm Biopharm , vol.54 , Issue.3 , pp. 299-309
    • Zastre, J.1    Jackson, J.2    Bajwa, M.3    Liggins, R.4    Iqbal, F.5    Burt, H.6
  • 29
    • 33344459216 scopus 로고    scopus 로고
    • Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers
    • Collnot EM, Baldes C, Wempe MF, et al. Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release. 2006;111(1-2):35-40.
    • (2006) J Control Release , vol.111 , Issue.1-2 , pp. 35-40
    • Collnot, E.M.1    Baldes, C.2    Wempe, M.F.3
  • 33
    • 0031800878 scopus 로고    scopus 로고
    • Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers
    • Batrakova EV, Han HY, Alakhov V, Miller DW, Kabanov AV. Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm Res. 1998;15(6):850-855.
    • (1998) Pharm Res , vol.15 , Issue.6 , pp. 850-855
    • Batrakova, E.V.1    Han, H.Y.2    Alakhov, V.3    Miller, D.W.4    Kabanov, A.V.5
  • 34
    • 78751703392 scopus 로고    scopus 로고
    • Pulmonary toxicity of carbon nanotubes: A systematic report
    • Kayat J, Gajbhiye V, Tekade RK, Jain NK. Pulmonary toxicity of carbon nanotubes: a systematic report. Nanomedicine. 2011;7(1):40-49.
    • (2011) Nanomedicine , vol.7 , Issue.1 , pp. 40-49
    • Kayat, J.1    Gajbhiye, V.2    Tekade, R.K.3    Jain, N.K.4
  • 35
    • 66349119248 scopus 로고    scopus 로고
    • Oxidatively damaged DNA in rats exposed by oral gavage to C-60 fullerenes and single-walled carbon nanotubes
    • Folkmann JK, Risom L, Jacobsen NR, Wallin H, Loft S, Moller P. Oxidatively damaged DNA in rats exposed by oral gavage to C-60 fullerenes and single-walled carbon nanotubes. Environ Health Persp. 2009;117(5):703-708.
    • (2009) Environ Health Persp , vol.117 , Issue.5 , pp. 703-708
    • Folkmann, J.K.1    Risom, L.2    Jacobsen, N.R.3    Wallin, H.4    Loft, S.5    Moller, P.6
  • 36
    • 58149302547 scopus 로고    scopus 로고
    • Carbon nanotubes toxicology and effects on metabolism and immunological modification in vitro and in vivo
    • Chiaretti M, Mazzanti G, Bosco S, et al. Carbon nanotubes toxicology and effects on metabolism and immunological modification in vitro and in vivo. J Phys Condens Matter. 2008;20:474203.
    • (2008) J Phys Condens Matter , vol.20 , pp. 474203
    • Chiaretti, M.1    Mazzanti, G.2    Bosco, S.3
  • 37
    • 70350736097 scopus 로고    scopus 로고
    • Cytotoxicity of carboxylic acid functionalized single wall carbon nanotubes on the human intestinal cell line Caco-2
    • Jos A, Pichardo S, Puerto M, Sanchez E, Grilo A, Camean AM. Cytotoxicity of carboxylic acid functionalized single wall carbon nanotubes on the human intestinal cell line Caco-2. Toxicol in Vitro. 2009;23(8):1491-1496.
    • (2009) Toxicol In Vitro , vol.23 , Issue.8 , pp. 1491-1496
    • Jos, A.1    Pichardo, S.2    Puerto, M.3    Sanchez, E.4    Grilo, A.5    Camean, A.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.