Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4′-ethynyl-2-fluoro- 2′-deoxyadenosine indicates a low potential for host toxicity

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 3, 2012, Pages 1630-1634

  Sohl, Christal D ^a   Singh, Kamlendra ^b   Kasiviswanathan, Rajesh ^c   Copeland, William C ^c   Mitsuya, Hiroaki ^d,e   Sarafianos, Stefan G ^b   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b University of Missouri   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d KUMAMOTO UNIVERSITY   (Japan)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' ETHYNYL 2 FLUORO 2' DEOXYADENOSINE; DEOXYADENOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DNA INTERACTION; ENZYME SUBSTRATE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; STEADY STATE;

BASE SEQUENCE; DEOXYADENOSINES; DNA-DIRECTED DNA POLYMERASE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; KINETICS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 84857181958     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05729-11     Document Type: Article

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