BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1α contributes to cardiomyopathy in male rats

Toxicology

Volumn 329, Issue , 2015, Pages 21-31

  Jiang, Ying ^a   Xia, Wei ^a   Yang, Jie ^a   Zhu, Yingshuang ^a   Chang, Huailong ^a   Liu, Juan ^a   Huo, Wenqian ^a   Xu, Bing ^a   Chen, Xi ^a   Li, Yuanyuan ^a   Xu, Shunqing ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bisphenol A; Cardiomyopathy; DNA methylation; Mitochondrial dysfunction; PGC 1

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ADENOSINE TRIPHOSPHATE; DNA; MESSENGER RNA; BENZHYDRYL DERIVATIVE; PHENOL DERIVATIVE; PPARGC1A PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CARDIOMEGALY; CARDIOMYOPATHY; CARDIOTOXICITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA METHYLATION; ENZYME RELEASE; GENE EXPRESSION; HEART DISEASE; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; LONG TERM EXPOSURE; MALE; MITOCHONDRIAL GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA GENE; PRIORITY JOURNAL; RAT; REFERENCE VALUE; ANIMAL; BLOOD; BLOOD PRESSURE; DRUG EFFECTS; GENETICS; HEART MUSCLE; METABOLISM; MITOCHONDRION; MUSCLE CELL; PROMOTER REGION; WISTAR RAT;

RATTUS; ZEA MAYS;

ANIMALS; BENZHYDRYL COMPOUNDS; BLOOD PRESSURE; CARDIOMYOPATHIES; DNA METHYLATION; GENES, MITOCHONDRIAL; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MUSCLE CELLS; MYOCARDIUM; MYOCYTES, CARDIAC; PHENOLS; PROMOTER REGIONS, GENETIC; RATS; RATS, WISTAR; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 84921417919     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2015.01.001     Document Type: Article

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