The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 3, 2012, Pages 701-710

  Mitra, Riddhi ^a   Nogee, Daniel P ^a   Zechner, Juliet F ^a   Yea, Kyungmoo ^b   Gierasch, Carrie M ^a   Kovacs, Attila ^a   Medeiros, Denis M ^c   Kelly, Daniel P ^a,b   Duncan, Jennifer G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Cardiomyopathy; Diabetes; Heart failure; Insulin resistance; Metabolism; Mitochondria

Indexed keywords

OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; GENE EXPRESSION; GENE SILENCING; GLUCOSE INTOLERANCE; HEART MITOCHONDRION; HETEROZYGOTE; INSULIN RESISTANCE; LIPID DIET; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; WILD TYPE;

ANIMALS; CELL LINE; FEMALE; GENE EXPRESSION; GLUCOSE; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; OXYGEN CONSUMPTION; SYSTOLE; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS;

EID: 84857626157     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.10.010     Document Type: Article

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