Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1a in a FOXO3-dependent mechanism

Oncotarget

Volumn 6, Issue 1, 2015, Pages 43-55

  Cho, Siyoung ^a   Cho, Miook ^b   Kim, Juewon ^a   Kaeberlein, Matt ^c   Lee, Sang Jun ^a   Suh, Yousin ^b  

^a AmorePacific Corporation   (South Korea)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cardiomyocytes; FOXO3; HIF 1a; Hypoxia reoxygenation; Ischemia reperfusion; Syringaresinol

Indexed keywords

BETA ACTIN; CASPASE 3; CYTOCHROME C; HISTONE H2AX; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BNIP3; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SYRINGARESINOL; TRANSCRIPTION FACTOR FKHRL1; ANTIOXIDANT; CASP3 PROTEIN, RAT; FORKHEAD TRANSCRIPTION FACTOR; FOXO3A PROTEIN, RAT; FURAN DERIVATIVE; HIF1A PROTEIN, RAT; LIGNAN; OXYGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; FLOW CYTOMETRY; HEART MUSCLE CELL; HYPOXIA; ISCHEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; REOXYGENATION; REPERFUSION INJURY; RNA EXTRACTION; ANIMAL; CELL DEATH; CELL HYPOXIA; CELL LINE; CHEMISTRY; CYTOLOGY; FLUORESCENCE MICROSCOPY; HEART MUSCLE; METABOLISM; PATHOLOGY; RAT; UPREGULATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CELL DEATH; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; FURANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGNANS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MYOCARDIUM; MYOCYTES, CARDIAC; OXYGEN; RATS; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84921391894     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2723     Document Type: Article

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