Cancer stem cells: An insight and future perspective

Journal of Cancer Research and Therapeutics

Volumn 10, Issue 4, 2014, Pages 846-852

  Kaur, Sandeep ^a   Singh, Gurdeep ^b   Kaur, Kirandeep ^c  

^a Adesh University   (India)

^b Adesh University   (India)

^c INSTITUTE OF DENTAL STUDIES AND TECHNOLOGIES   (India)

Author keywords

Cancer stem cells; dysregulation; proliferate; self renewal; signaling; tumorigenic

Indexed keywords

INTRINSIC FACTOR; STEM CELL FACTOR;

BRAIN TUMOR; BREAST CANCER; CANCER CELL; CANCER STEM CELL; CELL DIFFERENTIATION; CELL RENEWAL; COLON TUMOR; HEMATOPOIETIC SYSTEM TUMOR; HUMAN; PLASTICITY; REVIEW; TUMOR GROWTH; CARCINOGENESIS; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CARCINOGENESIS; HUMANS; NEOPLASMS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION;

EID: 84921362585     PISSN: 09731482     EISSN: 19984138     Source Type: Journal    
DOI: 10.4103/0973-1482.139264     Document Type: Review

References (46)

1. Wicha MS, Liu S, Dontu G. Cancer stem cells: An old idea-a paradigm shift. Cancer Res 2006;66:1883-90.
2. Sell S. Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 2004;51:1-28.
3. Singh SK, Clarke ID, Hide T, Dirks PB. Cancer stem cells in nervous system tumors. Oncogene 2004;23:7267-73.
4. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 2008;8:755-68.
5. Bajpat S. Cancer stem cells: Identification and target. Available from: http://www.bjcancer.org/-Library/UserFiles/pdf/Cancer%20Stem%20Cells%20-%20Identification%20and%20Targets%20(Wiley,%202008).pdf. [Last accessed on 2014 Jan 10].
6. Clarke MF, Fuller M. Stem cells and cancer: Two faces of eve. Cell 2006;124:1111-5.
7. Al-Hajj M, Becker MW, Wicha M, Weissman I, Clarke MF. Therapeutic implications of cancer stem cells. Curr Opin Genet Dev 2004;14:43-7.
8. Till JE, McCulloch EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961;14:213-22.
9. Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 2002;8:979-86.
10. Pierce GB. Teratocarcinoma: Model for a developmental concept of cancer. Curr Top Dev Biol 1967;2:223-46.
11. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.
12. Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 2004;351:657-67
13. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-37.
14. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994:17;645-48
15. Lotem J, Sachs L. Epigenetics and the plasticity of differentiation in normal and cancer stem cells. Oncogene 2006;25:7663-72.
16. Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 1975;72:3585-9.
17. Brinster RL. Participation of teratocarcinoma cells in mouse embryo development. Cancer Res 1976;36:3412-4.
18. Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004;5:738-43
19. Giangreco A, Groot KR, Janes SM. Lung cancer and lung stem cells: Strange bedfellows Am J Respir Crit Care Med 2007;175:547-53.
20. Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003;100:15178-83.
21. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-31.
22. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, et al. Gastric cancer originating from bone marrow-derived cells. Science 2004;306:1568-71.
23. Li L, Neaves WB. Normal stem cells and cancer stem cells: The niche matters. Cancer Res 2006;66:4553-7.
24. Hochedlinger K, Yamada Y, Beard C, Jaenisch R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005;121:465-77.
25. Watt FM, Hogan BL. Out of Eden: Stem cells and their niches. Science 2000;287:1427-30.
26. Ho AD, Wagner W. The beauty of asymmetry: Asymmetric divisions and self-renewal in the haematopoietic system. Curr Opin Hematol 2007;14:330-6.
27. Scadden DT. The stem-cell niche as an entity of action. Nature 2006;441:1075-9.
28. Ohyama M, Terunuma A, Tock CL, Radonovich MF, Pise-Masison CA, Hopping SB, et al. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest 2006;116:249-60.
29. Bach SP, Renehan AG, Potten CS. Stem cells: The intestinal stem cell as a paradigm. Carcinogenesis 2000;21:469-76.
30. Nichols J, Chambers I, Taga T, Smith A. Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines. Development 2001;128:2333-9.
31. Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, Huls G, et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002;111:251-63.
32. Boiani M, Schöler HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005;6:872-84.
33. Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002;12:432-8.
34. Doucas H, Garcea G, Neal CP, Manson MM, Berry DP. Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance. Eur J Cancer 2005;41:365-79.
35. Kolligs FT, Bommer G, Göke B. Wnt/beta-catenin/tcf signaling: A critical pathway in gastrointestinal tumorigenesis. Digestion 2002;66:131-44.
36. Rask K, Nilsson A, Brännström M, Carlsson P, Hellberg P, Janson PO, et al. Wnt-signalling pathway in ovarian epithelial tumours: Increased expression of beta-catenin and GSK3beta 2003;89:1298-304.
37. Tickle C. Patterning systems-from one end of the limb to the other. Dev Cell 2003;4:449-58.
38. Katano M. Hedgehog signaling pathway as a therapeutic target in breast cancer. Cancer Lett 2005;227:99-104.
39. Sanchez P, Clement V, Ruiz i Altaba A. Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer. Cancer Res 2005;65:2990-2.
40. Hopfer O, Zwahlen D, Fey MF, Aebi S. The Notch pathway in ovarian carcinomas and adenomas. Br J Cancer 2005;93:709-18.
41. Wilson A, Radtke F. Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett 2006;580:2860-8.
42. Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 2005;6:314-22.
43. Ross J, Li L. Recent advances in understanding extrinsic control of hematopoietic stem cell fate. Curr Opin Hematol 2006;13:237-42.
44. Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004;167:215-21.
45. Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004;431:707-12.
46. Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-) p53(-/-) mice. Cancer Cell 2004;6:229-40.