Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation

International Journal of Molecular Sciences

Volumn 16, Issue 1, 2015, Pages 1736-1754

  Li, Kun Cheng ^a   Ho, Yu Ling ^b   Hsieh, Wen Tsong ^c   Huang, Shyh Shyun ^a   Chang, Yuan Shiun ^a,d   Huang, Guan Jhong ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b HUNGKUANG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Acute lung injury; AOEs (antioxidative enzymes); Apigenin 7 glycoside; HO 1 (heme oxygenase 1); Lipopolysaccharide (LPS); MAPK

Indexed keywords

APIGETRIN; BETA ACTIN; CYCLOOXYGENASE 2; CYTOKINE; FLAVONOID; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYELOPEROXIDASE; NITRIC OXIDE; OXIDOREDUCTASE; SUPEROXIDE DISMUTASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; APIGENIN; GLYCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HISTOCHEMISTRY; IC50; INJURY SCALE; LOW DRUG DOSE; LUNG EDEMA; LUNG INJURY SCORE; LUNG LAVAGE; MALE; MOUSE; MURINAE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPPER RESPIRATORY TRACT INFECTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

MUS;

ACUTE LUNG INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS; APIGENIN; CELL LINE; CYTOKINES; DOWN-REGULATION; GLYCOSIDES; LIPOPOLYSACCHARIDES; LUNG; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION;

EID: 84921286171     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16011736     Document Type: Article

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