Chinese prescription kangen-karyu and salviae miltiorrhizae radix improve age-related oxidative stress and inflammatory response through the PI3K/Akt or MAPK pathways

American Journal of Chinese Medicine

Volumn 42, Issue 4, 2014, Pages 987-1005

  Park, Chan Hum ^a   Kim, Dae Hyun ^a   Park, Min Hi ^a   Kim, Mi Kyung ^a   Kim, Nam Deuk ^a   Kim, Cheol Min ^a   Tanaka, Takashi ^b   Yokozawa, Takako ^a,c   Chung, Hae Young ^a   Moon, Hyung Ryong ^a  

^a Pusan National University   (South Korea)

^b NAGASAKI UNIVERSITY   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Aging; Inflammation; Insulin Resistance; Kangen karyu; Oxidative Stress; Renal Damage; Salviae Miltiorrhizae Radix

Indexed keywords

GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; KANGEN KARYU; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SALVIA MILTIORRHIZA EXTRACT; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYCLOOXYGENASE 2; CYTOKINE; I KAPPA B ALPHA; I KAPPA B BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PRESCRIPTION DRUG; PROTECTIVE AGENT; PROTEIN KINASE B INHIBITOR; REACTIVE OXYGEN METABOLITE; SALVIAE MILTIORRHIZAE RADIX; TUMOR NECROSIS FACTOR ALPHA; URINARY TRACT AGENT; AUTACOID; DAN-SHEN ROOT EXTRACT; KANGEN-KARYU;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTHAMUS; CHINESE MEDICINE; CNIDIUM; CONTROLLED STUDY; CYPERUS ROTUNDUS; GLOMERULUS CAPILLARY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PAEONIA LACTIFLORA; PLANT ROOT; PLEIOTROPY; PROTEIN EXPRESSION; RAT; SALVIA MILTIORRHIZA; AGE; AGED; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; CNIDIUM OFFICINALE; CYTOKINE PRODUCTION; ETHNOPHARMACOLOGY; EVIDENCE BASED PRACTICE; EXPERIMENTAL INFLAMMATION; HERBAL MEDICINE; KIDNEY FUNCTION; KIDNEY INJURY; PRESCRIPTION; RENAL PROTECTION; SAFFLOWER; SAUSSUREA; SAUSSUREA LAPPA; SIGNAL TRANSDUCTION; UREA NITROGEN BLOOD LEVEL; ANIMAL; DRUG EFFECTS; GENETICS; INFLAMMATION; KIDNEY; METABOLISM; PHYTOTHERAPY; SPRAGUE DAWLEY RAT;

AGING; ANIMALS; DRUGS, CHINESE HERBAL; INFLAMMATION; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; KIDNEY; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84904362274     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X14500621     Document Type: Article

References (58)

1. Ali, S.F., C.P. LeBel and S.C. Bondy. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology 13: 637-648, 1992.
2. Balbi, A.P.C., E.C.S. Marin, H.D.C. Francescato, R.S. Costa and T.M. Coimbra. MAPK and angiotensin II receptor in kidney of newborn rats from losartan-treated dams. Pediatr. Nephrol. 23: 1433-1444, 2008.
3. Barzilai, N., D.M. Huffman, R.H. Muzumdar and A. Bartke. The critical role of metabolic pathways in aging. Diabetes 61: 1315-1322, 2012.
4. Bonkowski, M.S., J.S. Rocha, M.M. Masternak, K.A. Al Regaiey and A. Bartke. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. USA 103: 7901-7905, 2006.
5. Cadenas, E. and K.J. Davies. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29: 222-230, 2000.
6. Candore, G., C. Caruso, E. Jirillo, T. Magrone and S. Vasto. Low grade inflammation as a common pathogenetic denominator in age-related disease; novel drug targets for anti-ageing strategies and successful ageing achievement. Curr. Pharm. Des. 16: 584-596, 2010.
7. Cheng, H., X. Fan, G.W. Moeckel and R.C. Harris. Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. J. Am. Soc. Nephrol. 22: 1240-1251, 2011.
8. Choudhury, D. and M. Levi. Kidney aging-inevitable or preventable? Nat. Rev. Nephrol. 7: 706-717, 2011.
9. Chung, H.Y., H.J. Kim, K.W. Kim, J.S. Choi and B.P. Yu. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc. Res. Tech. 59: 264-272, 2002.
10. Chung, H.Y., E.K. Lee, Y.J. Choi, J.M. Kim, D.H. Kim, Y. Zou, C.H. Kim, J. Lee, H.S. Kim, N.D. Kim, J.H. Jung and B.P. Yu. Molecular inflammation as an underlying mechanism of the aging process and age-related disease. J. Dent. Res. 90: 830-840, 2011.
11. Corbett, J.A., G. Kwon, T.P. Misko, C.P. Rodi and M.L. McDaniel. Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans. Am. J. Physiol. 267: C48-C54, 1994.
12. Cui, H., Y. Kong and H. Zhang. Oxidative stress, mitochondrial dysfunction, and aging. J. Signal Transduct. 2012: 646354, 2012.
13. Feraille, E., M.L. Carranza, M. Rousselot and H. Favre. Insulin enhances sodium sensitivity of Na-K-ATPase in isolated rat proximal convoluted tubule. Am. J. Physiol. 267: F55F62, 1994.
14. Ford, E.S., W.H. Giles and W.H. Dietz. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA 287: 356-359, 2002.
15. Francescato, H.D.C., R.S. Costa, C. Scavone and T.M. Coimbra. Parthenolide reduces cisplatin-induced renal damage. Toxicology 230: 64-75, 2007.
16. Gao, M., K. Ikeda, T. Noguchi, K. Mori and Y. Yamori. Studies on preventive effect of Kangen-karyu, Chinese herbal medicine, on stroke in SHR-SP. J. Tradit. Med. 18: 245-250, 2001.
17. Harman, D. Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 11: 298-300, 1956.
18. Hissin, P.J. and R.A. Hilf. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74: 214-226, 1976.
19. Holthöfer, H., M. Kretzler, A. Haltia, M.L. Solin, J.W. Taanman, H. Schägger, W. Kriz, D. Ker-jaschki and D. Schlöndorff. Altered gene expression and functions of mitochondria in human nephrotic syndrome. FASEB J. 13: 523-532, 1999.
20. Itzhaki, R.F. and D.M. Gill. A micro-biuret method for estimating proteins. Anal. Biochem. 9: 401-410, 1964.
21. Kakimoto, M., T. Inoguchi, T. Sonta, H.Y. Yu, M. Imamura, T. Etoh, T. Hashimoto and H. Nawata. Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats. Diabetes 51: 1588-1595, 2002.
22. Kalambokis, G.N., A.A. Tsatsoulis and E.V. Tsianos. The edematogenic properties of insulin. Am. J. Kidney Dis. 44: 575-590, 2004.
23. Kim, D.H., J.Y. Kim, B.P. Yu and H.Y. Chung. The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Bioger-ontology 9: 33-47, 2008.
24. Kim, H.Y., T. Okamoto and T. Yokozawa. Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. J. Ethnopharmacol. 124: 263-269, 2009.
25. Kirkwood, T.B. and S.N. Austad. Why do we age? Nature 408: 233-238, 2000.
26. Komatsu, S. Extraction of nuclear proteins. Methods Mol. Biol. 355: 73-77, 2007.
27. Lee, H.J., Y.J. Jeong, T.S. Lee, Y.Y. Park, W.G. Chae, I.K. Chung, H.W. Chang, C.H. Kim, Y.H. Choi, W.J. Kim, S.K. Moon and Y.C. Chang. Moringa fruit inhibits LPS-induced NO/iNOS expression through suppressing the NF-kappa B activation in RAW264.7 cells. Am. J. Chin. Med. 41: 1109-1123, 2013.
28. Lee, J.C., J.T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Heys, S.W. Land Vatter, J.E. Strickler, M.M. Mclaughlin, I.R. Siemens, S.M. Fisher, G.P. Livi, J.R. White, J.L. Adams and P.R. Young. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739-746, 1994.
29. Makino, T., H. Wakushima, T. Okamoto, Y. Okukubo, K. Saito and Y. Kano. Effects of Kangen-karyu on coagulation system and platelet aggregation in mice. Biol. Pharm. Bull. 25: 523-525, 2002.
30. Manna, S.K., A. Mukhopadhyay and B.B. Aggarwal. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-KB, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 164: 6509-6519, 2000.
31. Medeiros, R., R.D. Prediger, G.F. Passos, P. Pandolfo, F.S. Duarte, J.L. Franco, A.L. Dafre, G. Di Giunta, C.P. Figueiredo, R.N. Takahashi, M.M. Campos and J.B. Calixto. Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: Relevance for the behavioral and synaptic deficits induced by amyloid beta protein. J. Neu-rosci. 27: 5394-5404, 2007.
32. Morley, J.E. Diabetes and aging: Epidemiologic overview. Clin. Geriatr. Med. 24: 395-405, 2008.
33. Nishikawa, T., D. Edelstein, X.L. Du, S. Yamagishi, T. Matsumura, Y. Kaneda, M.A. Yorek, D. Beebe, P.J. Oates, H.P. Hammes, I. Giardino and M. Brownlee. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404: 787-790, 2000.
34. Noh, J.S., C.H. Park, H.Y. Kim, Q. Zhao, N. Yamabe, K. Matsumoto and T. Yokozawa. Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J. Pharm. Pharmacol. 63: 111-119, 2011.
35. Nomura, Y., T. Arima, T. Namba, M. Hattori and S. Kadota. Ameliorating effects of dan-shen and its major ingredient calcium/magnesium lithospermate B on cognitive deficiencies in senescence-accelerated mouse. Nihon Yakurigaku Zasshi 1: 142-147, 1997.
36. Okamoto, T., C.H. Park, J.S. Noh, K. Toriizuka, Y. Sei, J.C. Park and T. Yokozawa. Hepato-/reno-protective activity of Chinese prescription Kangen-karyu through inhibition of AGE formation and fibrosis-related protein expression in type 2 diabetes. J. Pharm. Pharmacol. 63: 952-959, 2011.
37. Orchard, T.J., Y.F. Chang, R.E. Ferrell, N. Petro and D.E. Ellis. Nephropathy in type 1 diabetes: A manifestation of insulin resistance and multiple genetic susceptibilities? Further evidence from the Pittsburgh Epidemiology of Diabetes Complication Study. Kidney Int. 62: 963-970, 2002.
38. Pannarale, G., R. Carbone, G. Del Mastro, C. Gallo, V. Gattullo, L. Natalicchio, A. Navarra and A. Tedesco. The aging kidney: Structural changes. J. Nephrol. 15: S37-S40, 2010.
39. Park, C.H., J.S. Noh, T. Okamoto, J.C. Park and T. Yokozawa. Evaluation of effects of Chinese prescription Kangen-karyu on diabetes-induced alterations such as oxidative stress and apo-ptosis in the liver of type 2 diabetic db/db mice. Evid. Based Complement. Alternat. Med. 2012: 143489, 2012.
40. Rahman, K. Studies on free radicals, antioxidants, and co-factors. Clin. Interv. Aging 2: 219-236, 2007.
41. Rangel, E.B., L.A. Moura, M. Franco and A. Pacheco-Silva. Expression of cyclooxygenases during renal allograft rejection. Transplant. Proc. 36: 838-839, 2004.
42. Rangel, E.B., L.A. Moura, M.F. Franco and A. Pacheco-Silva. Up-regulation of cyclooxygenase-2 during acute human renal allograft rejection. Clin. Transplant. 19: 543-550, 2005.
43. Satoh, A., T. Yokozawa, E.J. Cho, T. Okamoto and Y. Sei. Antioxidative effects related to the potential anti-aging properties of the Chinese prescription Kangen-karyu and Carthami Flos in senescence-accelerated mice. Arch. Gerontol. Geriatr. 39: 69-82, 2004.
44. Satoh, A., T. Yokozawa, Y.A. Kim, E.J. Cho, T. Okamoto and Y. Sei. The mechanisms underlying the anti-aging activity of the Chinese prescription Kangen-karyu in hydrogen peroxide-induced human fibroblasts. J. Pharm. Pharmacol. 57: 1335-1343, 2005.
45. Scaduto, R.C., Jr., V.H. Gattone, 2nd., L.W. Grotyohann, J. Wertz and L.F. Martin. Effect of an altered glutathione content on renal ischemic injury. Am. J. Physiol. 255: F911-F921, 1988.
46. Shimizu, M.H., T.M. Coimbra, M. de Araujo, L.F. Menezes and A.C. Seguro. N-acetylcysteine attenuates the progression of chronic renal failure. Kidney Int. 68: 2208-2217, 2005.
47. Solin, M.L., S. Pitkänen, J.W. Taanman and H. Holthöfer. Mitochondrial dysfunction in congenital nephrotic syndrome. Lab. Invest. 80: 1227-1232, 2000.
48. Srinivasan, V., D.W. Spence, S.R. Pandi-Perumal, G.M. Brown and D.P. Cardinali. Melatonin in mitochondrial dysfunction and related disorders. Int. J. Alzheimer's Dis. 2011: 326320, 2011.
49. Takahashi, H. Clinical trial of prescription of Kaketsukao. Clin. J. Chin. Med. 12: 145-151, 1991.
50. Thorn, L.M., C. Forsblom, J. Fagerudd, M.C. Thomas, K. Pettersson-Fernholm, M. Saraheimo, J. Wadén, M. Rönnback, M. Rosengård-Bärlund, C.G. Björkesten, M.R. Taskinen, P.H. Groop and FinnDiane Study Group. Metabolic syndrome in type 1 diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study). Diabetes Care 28: 2019-2024, 2005.
51. Tian, B., J. Liu, P.B. Bitterman and R.J. Bache. Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis. Am. J. Physiol. Heart Circ. Physiol. 283: H1958-H1967, 2002.
52. Tiwari, S., S. Riazi and C.A. Ecelbarger. Insulin's impact on renal sodium transport and blood pressure in health, obesity, and diabetes. Am. J. Physiol. Renal Physiol. 293: F974-F984, 2007.
53. Yamabe, N., H.Y. Kim, K.S. Kang, Q. Zhao, K. Matsumoto and T. Yokozawa. Effect of Chinese prescription Kangen-karyu on lipid metabolism in type 2 diabetic db/db mice. J. Ethno-pharmacol. 129: 299-305, 2010.
54. Yamagata, K., K. Muro, J. Usui, M. Hagiwara, H. Kai, Y. Arakawa, Y. Shimizu, C. Tomida, K. Hirayama, M. Kobayashi and A. Koyama. Mitochondrial DNA mutations in focal segmental glomerulosclerosis lesions. J. Am. Soc. Nephrol. 13: 1816-1823, 2002.
55. Yokozawa, T., E.J. Cho, T. Okamoto and Y. Sei. Effects of the Chinese prescription Kangen-karyu and its crude drug Tanjin on ageing process in rats. J. Pharm. Pharmacol. 58: 1591-1599, 2006a.
56. Yokozawa, T., E.J. Cho, S. Sasaki, T. Okamoto and Y. Sei. The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats. Biol. Pharm. Bull. 29: 760-765, 2006b.
57. Yokozawa, T., H.J. Kim, N. Yamabe, T. Okamoto and E.J. Cho. The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model. J. Pharm. Pharmacol. 59: 1271-1278, 2007.
58. Yu, B.P. and R. Yang. Critical evaluation of free radical theory of aging: A proposal of oxidative stress hypothesis. Ann. N. Y. Acad. Sci. 786: 1-11, 1996.