Chamomile confers protection against hydrogen peroxide-induced toxicity through activation of Nrf2-mediated defense response

Phytotherapy Research

Volumn 27, Issue 1, 2013, Pages 118-125

  Bhaskaran, Natarajan ^a,b   Srivastava, Janmejai K ^c   Shukla, Sanjeev ^a,b   Gupta, Sanjay ^a,b,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c AMITY UNIVERSITY   (India)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

antioxidant defense; chamomile; macrophages; oxidative stress; phase II enzymes

Indexed keywords

CATALASE; CHAMOMILE; ENZYME; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DAMAGE; CELL LEVEL; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL SURVIVAL; CHAMOMILE; HYDROGEN PEROXIDE; MACROPHAGES; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

EID: 84872085168     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4701     Document Type: Article

References (35)

1. Babenko NA, Shakhova EG,. 2006. Effects of chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats. Exp Gerontol 41: 32-39.
2. Bhaskaran N, Shukla S, Srivastava JK, Gupta S,. 2010. Chamomile: an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity. Int J Mol Med 26: 935-940.
3. Bradford MM,. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-54.
4. Cooke MS, Mistry N, Wood C, Herbert KE, Lunec J,. 1997. Immunogenicity of DNA damaged by reactive oxygen species implications for anti-DNA antibodies in lupus. Free Radic Biol Med 22: 151-159.
5. Farinati F, Cardin R, Degan P, et al,. 1998. Oxidative DNA damage accumulation in gastric carcinogenesis. Gut 42: 351-356.
6. Giudice A, Montella M,. 2006. Activation of the Nrf2-ARE signaling pathway: a promising strategy in cancer prevention. Bioessays 28: 169-181.
7. Halliwell B, Aruoma OI,. 1991. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 281: 9-19.
8. Huang HC, Nguyen T, Pickett CB,. 2000. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NFE2- related factor 2. Proc Natl Acad Sci USA 97: 12475-12480.
9. Ishii T, Itoh K, Takahashi S, et al,. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275: 16023-16029.
10. Itoh K, Tong KI, Yamamoto M,. 2004. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36: 1208-1213.
11. Jackson MJ, Papa S, Bolaños J, et al,. 2002. Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Mol Aspects Med 23: 209-285.
12. Jang JS, Piao S, Cha YN, Kim C,. 2009. Taurine chloramine activates Nrf2, Increases HO-1 expression and protects cells from death caused by hydrogen peroxide. J Clin Biochem Nutr 45: 37-43.
13. Kaneko T, Tahara S, Takabayashi F,. 2007. Inhibitory effect of natural coumarin compounds, esculetin and esculin, on oxidative DNA damage and formation of aberrant crypt foci and tumors induced by 1,2-dimethylhydrazine in rat colons. Biol Pharm Bull 30: 2052-2057.
14. Lee KG, Shibamoto T,. 2002. Determination of antioxidant potential of volatile extracts isolated from various herbs and spices. J Agr Food Chem 50: 4947-4952.
15. McKay DL, Blumberg JB,. 2006. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res 20: 519-530.
16. Motohashi H, Yamamoto M,. 2004. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10: 549-556.
17. Nguyen T, Sherrat PJ, Pickett CB,. 2003. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43: 233-260.
18. Paya M, Halliwell B, Hoult JR,. 1992. Interactions of a series of coumarins with reactive oxygen species. Scavenging of superoxide, hypochlorous acid and hydroxyl radicals. Biochem Pharmacol 44: 205-214.
19. Rice-Evans CA, Miller NJ, Paganga G,. 1996. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med 20: 933-56.
20. Rombi M,. 1993. Cento Piante Medicinali; Nuovo Insttuto d'Arti Grafiche: Bergamo, Italy, 63-65.
21. Satoh T, Sakai N, Enokido Y, Uchiyama Y, Hatanaka H,. 1996. Free radical-independent protection by nerve growth factor and Bcl-2 of PC12 cells from hydrogen peroxide-triggered apoptosis. J Biochem 120: 540-546.
22. Shibata N, Glass CK,. 2009. Regulation of macrophage function in inflammation and atherosclerosis. J Lipid Res 50: 277-281.
23. Shukla S, MacLennan GT, Fu P, et al,. 2004. Nuclear factor-κB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. Neoplasia 6: 390-400.
24. Speisky H, Rocco C, Carrasco C, Lissi EA, Lopez-Alarcon C,. 2006. Antioxidant screening of medicinal herbal teas. Phytother Res 20: 462-467.
25. Srivastava JK, Gupta S,. 2007. Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells. J Agric Food Chem 55: 9470-9478.
26. Srivastava JK, Gupta S,. 2009. Health promoting benefits of chamomile in the elderly population. In Complementary and Alternative Therapies in the Aging Population, Watson RR, (eds). Elsevier Inc., Academic Press: San Diego, CA, USA. ISBN: 978-0-12-374228-5
27. Svehliková V, Bennett RN, Mellon FA, et al,. 2004. Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert). Phytochemistry 65: 2323-2332.
28. Tyler VE,. 1993. The Honest Herbal (3rd edn), George F, (ed.). Stickley Co.: Philadelphia.
29. Valko M, Leibfritz D, Moncola J, Cronin MT, Mazura M, Telser J,. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84.
30. Wijeratne SSK, Cuppett SL, Schlegel V,. 2005. Hydrogen peroxide induced oxidative stress damage and antioxidant enzyme response in Caco-2 human colon cells. J Agric Food Chem 53: 8768-8774.
31. Yan ZQ, Hansson GK,. 2007. Innate immunity, macrophage activation, and atherosclerosis. Immunol Rev 219: 187-203.
32. Yoshikawa A, Saito Y, Maruyama K,. 2006. Lignan compounds and 4,4′-dihydroxybiphenyl protect C2C12 cells against damage from oxidative stress. Biochem Biophys Res Commun 344: 394-399.
33. Zhang DD,. 2006. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38: 769-789.
34. Zhang L, Yu H, Sun Y, et al,. 2007. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol 564: 18-25.
35. Zhu H, Jia Z, Mahaney JE, Ross D, Misra HP, Trush MA, Li Y,. 2007. The highly expressed and inducible endogenous NAD(P)H:quinine oxido-reductase1 in cardiovascular cells acts as a potential superoxide scavenger. Cardiovasc Toxicol 7: 202-211.