Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide- induced inflammatory responses in RAW264.7 macrophages

Journal of Ethnopharmacology

Volumn 153, Issue 3, 2014, Pages 846-853

  Hu, Boyang ^a   Zhang, Hai ^a   Meng, Xianli ^a   Wang, Fei ^b   Wang, Ping ^a  

^a CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b CHENGDU INSTITUTE OF BIOLOGY   (China)

Author keywords

Aloe emodin; Anthraquinone; Inflammation; Macrophage; Rhubarb

Indexed keywords

ALOE EMODIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; ANTHRAQUINONE DERIVATIVE; ANTIINFLAMMATORY AGENT; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA; NOS2 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ETHNOPHARMACOLOGY; INFLAMMATION; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; RHEUM;

ALOE; RHEUM RHABARBARUM; RHEUM X HYBRIDUM;

ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS; CELL LINE; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RHEUM; RNA, MESSENGER;

EID: 84900325914     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.03.059     Document Type: Article

References (42)

1. A. Aderem, and R.J. Ulevitch Toll-like receptors in the induction of the innate immune response Nature 406 2000 782 787
2. S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511
3. D. Avni, Y. Glucksam, and T. Zor The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism Biochem. Pharmacol. 83 2012 106 114
4. A.B. Carter The p38 mitogen-activated protein kinase is required for NF-κB-dependent gene expression J. Biol. Chem. 274 1999 30858 30863
5. M. Cheon, T. Yoon, G. Choi, S. Kim, A. Lee, B. Moon, B. Choo, and H. Kim Comparative study of extracts from rhubarb on inflammatory activity in RAW 264.7 cells Korean J. Med. Crop Sci. 17 2009 109 114
6. R.J. Choi, T.M. Ngoc, K. Bae, H.J. Cho, D.D. Kim, J. Chun, S. Khan, and Y.S. Kim Anti-inflammatory properties of anthraquinones and their relationship with the regulation of P-glycoprotein function and expression Eur. J. Pharm. Sci. 48 2013 272 281
7. C.A. Dinarello Proinflammatory cytokines CHEST J. 118 2000 503 508
8. X.L. Fang, Q. Fang, J.J. Luo, and X. Zheng Effects of crude rhubarb on intestinal permeability in septic patients Am. J. Chin. Med. 35 2007 929 936
9. S. Ghosh, and M.S. Hayden New regulators of NF-κB in inflammation Nat. Rev. Immunol. 8 2008 837 848
10. M. Guha, and N. Mackman LPS induction of gene expression in human monocytes Cell Signal. 13 2001 85 94
11. T. Guzik, R. Korbut, and T. Adamek-Guzik Nitric oxide and superoxide in inflammation and immune regulation J. Physiol. Pharmcol. 54 2003 469 487
12. Z.H. He, M.F. He, S.C. Ma, and P.P. But Anti-angiogenic effects of rhubarb and its anthraquinone derivatives J. Ethnopharmacol. 121 2009 313 317
13. P.C. Heinrich, J.V. Castell, and T. Andus Interleukin-6 and the acute phase response Biochem. J. 265 1990 621 636
14. E. Herlaar, and Z. Brown p38 MAPK signalling cascades in inflammatory disease Mol. Med. Today 5 1999 439 447
15. D.W. Hommes Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets Gut 52 2003 144 151
16. Q. Huang, G. Lu, H.M. Shen, M.C. Chung, and C.N. Ong Anti-cancer properties of anthraquinones from rhubarb Med. Res. Rev. 27 2007 609 630
17. X.F. Huang, and J.Z. Chen Obesity, the PI3K/Akt signal pathway and colon cancer Obesity Rev. 10 2009 610 616
18. B. Kaminska MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits Biochim. Biophys. Acta. 1754 2005 253 262
19. S.J. Kao, H.C. Lei, C.T. Kuo, M.S. Chang, B.C. Chen, Y.C. Chang, W.T. Chiu, and C.H. Lin Lipoteichoic acid induces nuclear factor-κB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages Immunology 115 2005 366 374
20. G. Kaplanski, V. Marin, F. Montero-Julian, A. Mantovani, and C. Farnarier IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation Trends. Immunol. 24 2003 25 29
21. S. Kaur, T. Oddos, S. Tucker-Samaras, and D.M. Southall Regulation of DNA repair process by the pro-inflammatory NF-κB pathway Clark Chen, New Research Directions in DNA Repair 2013 InTech Rijeka, Croatia 213 227
22. K. Komatsu, Y. Nagayama, K. Tanaka, Y. Ling, P. Basnet, and M.R. Meselhy Development of a high performance liquid chromatographic method for systematic quantitative analysis of chemical constituents in rhubarb Chem. Pharm. Bull. 54 2006 941 947
23. R. Korhonen, A. Lahti, H. Kankaanranta, and E. Moilanen Nitric oxide production and signaling in inflammation Curr. Drug Targets - Inflamm. Allergy 4 2005 471 479
24. M. Lappas, M. Permezel, and G.E. Rice Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-κB, peroxisomal proliferator-activated receptor-γ and extracellularly regulated kinase 1/2 Endocrinology 146 2005 3334 3342
25. H.L. Li, H.L. Chen, H. Li, K.L. Zhang, X.Y. Chen, X.W. Wang, Q.Y. Kong, and J. Liu Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages Int. J. Mol. Med. 16 2005 41 47
26. Y. Lin, F. Wang, L.J. Yang, Z. Chun, J.K. Bao, and G.L. Zhang Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum Phytochemistry 95 2013 242 251
27. B.L. Ma, Y.M. Ma, D.M. Yan, H. Zhou, R. Shi, T.M. Wang, Y. Yang, C.H. Wang, and N. Zhang Effective constituents in xiexin decoction for anti-inflammation J. Ethnopharmacol. 125 2009 151 156
28. L.V. Madrid, C.Y. Wang, D.C. Guttridge, A.J. Schottelius, A.S. Baldwin, and M.W. Mayo Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB Mol. Cell. Biol. 20 2000 1626 1638
29. B.D. Manning, and L.C. Cantley AKT/PKB signaling: navigating downstream Cell 129 2007 1261 1274
30. J.A. Nick, N.J. Avdi, S.K. Young, L.A. Lehman, P.P. McDonald, S.C. Frasch, M.A. Billstrom, P.M. Henson, G.L. Johnson, and G.S. Worthen Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils J. Clin. Invest. 103 1999 851 858
31. M. Öztürk, F. Aydoǧmuş-Öztürk, M.E. Duru, and G. Topçu Antioxidant activity of stem and root extracts of Rhubarb (Rheum ribes): an edible medicinal plant Food Chem. 103 2007 623 630
32. M.Y. Park, H.J. Kwon, and M.K. Sung Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages Biosci. Biotechnol. Biochem. 73 2009 828 832
33. J. Saklatvala The p38 MAP kinase pathway as a therapeutic target in inflammatory disease Curr. Opin. Pharmacol. 4 2004 372 377
34. N. Schmidt, A. Pautz, J. Art, P. Rauschkolb, M. Jung, G. Erkel, M.B. Goldring, and H. Kleinert Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes Biochem. Pharmacol. 79 2010 722 732
35. State Pharmacopoeia Committee Pharmacopoeia of the Peoples Republic of China, First Div.; China 2010 Chemical Industry Press Beijing 22 23
36. M.J. Sweet, and D.A. Hume Endotoxin signal transduction in macrophages J. Leukoc. Biol. 60 1996 8 26
37. K.J. Tracey The inflammatory reflex Nature 420 2002 853 859
38. P. Viatour, M.P. Merville, V. Bours, and A. Chariot Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation Trends Biochem. Sci. 30 2005 43 52
39. J. Wang, H. Zhao, W. Kong, C. Jin, Y. Zhao, Y. Qu, and X. Xiao Microcalorimetric assay on the antimicrobial property of five hydroxyanthraquinone derivatives in rhubarb (Rheum palmatum L.) to Bifidobacterium adolescentis Phytomedicine 17 2010 684 689
40. L. Yang, Q. Chen, F. Wang, and G. Zhang Antiosteoporotic compounds from seeds of Cuscuta chinensis J. Ethnopharmacol. 135 2011 553 560
41. H. Zheng, J. Hu, Z. Zheng, L. Huang, Y. Chen, J. Zheng, X. Chen, and L. Lv Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway Acta Pharm. Sin. 42 2007 1142
42. B. Zhu, Y. Lin, C.F. Zhu, X.L. Zhu, C.Z. Huang, Y. Lu, X.X. Cheng, and Y.J. Wang Emodin inhibits extracellular matrix synthesis by suppressing p38 and ERK1/2 pathways in TGF-β1-stimulated NRK-49F cells Mol. Med. Rep. 4 2011 505 509