Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors

Journal of Ethnopharmacology

Volumn 162, Issue , 2015, Pages 69-78

  Yu, Xiao Dan ^a   Zheng, Rong Bo ^b   Xie, Jian Hui ^a,d   Su, Ji Yan ^a   Huang, Xiao Qi ^a   Wang, Yong Hong ^c   Zheng, Yi Feng ^a   Mo, Zhi Zhun ^a   Wu, Xiao Li ^a   Wu, Dian Wei ^a   Liang, Ye Er ^a   Zeng, Hui Fang ^a   Su, Zi Ren ^a   Huang, Ping ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b Guangzhou WangLaoJi Pharmaceutical Company Limited   (China)

^c GUANGDONG INSTITUTE OF MICROBIOLOGY   (China)

^d GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

Baicalin; Helicobacter pylori; Molecular docking; Non competitive inhibitior; Scutellarin; Urease

Indexed keywords

ACETOHYDROXAMIC ACID; BAICALIN; BORIC ACID; CYSTEINE; DITHIOTHREITOL; GLUTATHIONE; SCUTELLARIN; SODIUM FLUORIDE; UREASE; UREASE INHIBITOR; APIGENIN; FLAVONOID; GLUCURONIC ACID;

AMMONIA FORMATION; ARTICLE; CATALYSIS; CELL VIABILITY; CYTOTOXICITY; DRUG CONFORMATION; DRUG SCREENING; ENZYME ACTIVITY; HELICOBACTER PYLORI; HYDROGEN BOND; IC50; INHIBITION CONSTANT; INHIBITION KINETICS; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; NONHUMAN; SPECTROPHOTOMETRIC BERTHELOT METHOD; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM;

HELICOBACTER PYLORI; SCUTELLARIA BAICALENSIS;

APIGENIN; CELL LINE; CELL SURVIVAL; FLAVONOIDS; GLUCURONATES; HELICOBACTER PYLORI; HUMANS; MOLECULAR DOCKING SIMULATION; UREASE;

EID: 84921049022     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.12.041     Document Type: Article

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