Synthesis, molecular docking and kinetic properties of β-hydroxy- β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 212-221

  Xiao, Zhu Ping ^a   Peng, Zhi Yun ^a   Dong, Jing Jun ^b   Deng, Rui Cheng ^a   Wang, Xu Dong ^a   Ouyang, Hui ^a   Yang, Pan ^a   He, Juan ^a   Wang, Yuan Feng ^a   Zhu, Man ^a   Peng, Xiao Chun ^a   Peng, Wan Xi ^a,b   Zhu, Hai Liang ^a,c  

^a JISHOU UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY   (China)

Author keywords

A mixture of competitive and uncompetitive mechanism; Helicobacter pylori urease; Hydroxamic acid; Inhibitor

Indexed keywords

3 (2 CHLOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (2 FLUOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (2,3 DICHLOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (3 FLUOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (3,4 DICHLOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (3,5 DICHLORO 2 HYDROXYPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (4 BENZYLOXYPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (4 CHLOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (4 FLUOROPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (5 CHLORO 2 HYDROXYPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 (5 FLUORO 2 METHOXYPHENYL) 3 HYDROXYPROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 (2 METHOXYPHENYL)PROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 (3 HYDROXYPHENYL)PROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 (3 METHOXYPHENYL)PROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 (3 TRIFLUOROMETHYLPHENYL)PROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 (4 METHOXYPHENYL)PROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 (4 TRIFLUOROPHENYL)PROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 PHENYLPROPIONYLHYDROXAMIC ACID; 3 HYDROXY 3 [(4 N,N DIMETHYLAMINO)PHENYL]PROPIONYLHYDROXAMIC ACID; 4 DIMETHYLAMINOPHENYLHYDROXAMIC ACID; ANTIULCER AGENT; BETA HYDROXY BETA PHENYLPROPIONYL HYDROXAMIC ACID; HYDROXAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UREASE; UREASE INHIBITOR;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HELICOBACTER PYLORI; HYDROGEN BOND; IC 50; MOLECULAR DOCKING; REFORMATSKY REACTION; STEREOSPECIFICITY;

A MIXTURE OF COMPETITIVE AND UNCOMPETITIVE MECHANISM; HELICOBACTER PYLORI UREASE; HYDROXAMIC ACID; INHIBITOR;

BINDING, COMPETITIVE; ENZYME ACTIVATION; ENZYME INHIBITORS; HELICOBACTER PYLORI; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; UREASE;

EID: 84884474526     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.047     Document Type: Article

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