Renoprotective effect of red ginseng in gentamicin-induced acute kidney injury

Laboratory Investigation

Volumn 94, Issue 10, 2014, Pages 1147-1160

  Shin, Hyun Soo ^a   Yu, Mina ^a   Kim, Mijin ^a   Choi, Hack Sun ^a   Kang, Duk Hee ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIOXIDANT; CASPASE 3; CASPASE 9; CYTOCHROME C; GENTAMICIN; GINSENG EXTRACT; GLUTATHIONE; MITOCHONDRIAL PROTEIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THYMIDINE; TRITIUM; PLANT EXTRACT;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; ENZYME ACTIVITY; EPITHELIUM CELL; EXPERIMENTAL MODEL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPE; GINSENG; KIDNEY CORTEX; KIDNEY TUBULE CELL; MALE; MITOCHONDRION; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEINURIA; RAT; RENAL PROTECTION; URINARY EXCRETION; ACUTE KIDNEY INJURY; ANIMAL; CELL PROLIFERATION; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG SCREENING; KIDNEY TUBULE; METABOLISM; PANAX; PHYTOTHERAPY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ACUTE KIDNEY INJURY; ANIMALS; APOPTOSIS; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; GENTAMICINS; KIDNEY TUBULES; MALE; NADPH OXIDASE; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84920987297     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.101     Document Type: Article

References (53)

1. Edson RS, Terrell CL. The aminoglycosides. Mayo Clinic Proc 1999;74: 519-528.
2. Gemmell CG, Edwards DI, Fraise AP, et al. Guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK. J Antimicrob Chemother 2006; 57:589-608.
3. Mingeot-Leclercq MP, Tulkens PM. Aminoglycosides: nephrotoxicity. Antimicrob Agents Chemother 1999;43:1003-1012.
4. Humes HD. Aminoglycoside nephrotoxicity. Kidney Int 1988;33: 900-911.
5. Meyer RD. Risk factors and comparisons of clinical nephrotoxicity of aminoglycosides. Am J Med 1986;80:119-125.
6. Lopez-Novoa JM, Quiros Y, Vicente L, et al. New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int 2011;79:33-45.
7. Maldonado PD, Barrera D, Rivero I, et al. Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Free Radic Biol Med 2003;35:317-324.
8. Laurent G, Carlier MB, Rollman B, et al. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin. Biochem Pharmacol 1982;31:3861-3870.
9. Klotman PE, Yarger WE. Reduction of renal blood flow and proximal bicarbonate reabsorption in rats by gentamicin. Kidney Int 1983;24: 638-643.
10. Lee KE, Kim EY, Kim CS, et al. Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells. Biochem Biophys Res Commun 2013;434:527-533.
11. Sha SH, Schacht J. Formation of reactive oxygen species following bioactivation of gentamicin. Free Radic Biol Med 1999;26:341-347.
12. Nakajima T, Hishida A, Kato A. Mechanisms for protective effects of free radical scavengers on gentamicin-mediated nephropathy in rats. Am J Physiol Renal Physiol 1994;266:F425-F431.
13. Liu Z, Li W, Li X, et al. Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J Ethnopharmacol 2013;145:233-240.
14. Kim JH. Cardiovascular diseases and Panax ginseng: a review on molecular mechanisms and medical applications. J Ginseng Res 2012; 36:16-26.
15. Kang S, Min H. Ginseng, the 'Immunity Boost': the effects of Panax ginseng on immune system. J Ginseng Res 2012;36:354-368.
16. Cho IH. Effects of Panax ginseng in neurodegenerative diseases. J Ginseng Res 2012;36:342-353.
17. Yokozawa T, Dong E. Role of ginsenoside-Rd in cisplatin-induced renal injury: special reference to DNA fragmentation. Nephron 2001;89: 433-438.
18. Im GJ, Chang JW, Choi J, et al. Protective effect of Korean red ginseng extract on cisplatin ototoxicity in HEI-OC1 auditory cells. Phytother Res 2010;24:614-621.
19. Lee JH, Cho SH. Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: an atopic dermatitis model. J Ethnopharmacol 2011; 133:810-817.
20. Yu MA, Shin KS, Kim JH, et al. HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium. J Am Soc Nephrol 2009;20:567-581.
21. Ryu ES, Kim MJ, Shin HS, et al. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. Am J Physiol Renal Physiol 2013;304:F471-F480.
22. Rizzi MD, Hirose K. Aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg 2007;15:352-357.
23. Cuzzocrea S, Mazzon E, Dugo L, et al. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacol 2002;450: 67-76.
24. Bledsoe G, Crickman S, Mao J, et al. Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. Nephrol Dial Transplant 2006;21:624-633.
25. Kim WK, Song SY, Oh WK, et al. Wound-healing effect of ginsenoside Rd from leaves of Panax ginseng via cyclic AMP-dependent protein kinase pathway. Eur J Pharmacol 2013;702:285-293.
26. Hong YJ, Kim N, Lee K, et al. Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments. J Ethnopharmacol 2012;144:225-233.
27. Lee DC, Lau AS. Effects of Panax ginseng on tumor necrosis factor-alpha-mediated inflammation: a mini-review. Molecules 2011;16: 2802-2816.
28. Sung H, Jung YS, Cho YK. Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients. Clin Vaccine Immunol 2009;16:1127-1131.
29. Chen Y, Xu Y, Zhu Y, et al. Anti-cancer effects of ginsenoside compound K on pediatric acute myeloid leukemia cells. Cancer Cell Int 2013;13:24-30.
30. Rimar S, Lee-Mengel M, Gillis CN. Pulmonary protective and vasodilator effects of a standardized Panax ginseng preparation following artificial gastric digestion. Pulm Pharmacol 1996;9:205-209.
31. Park JS, Park EM, Kim DH, et al. Anti-inflammatory mechanism of ginseng saponins in activated microglia. J Neuroimmunol 2009;209: 40-49.
32. Keum YS, Park KK, Lee JM, et al. Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Lett 2000;150:41-48.
33. El-Khayat Z, Hussein J, Ramzy T, et al. Antidiabetic antioxidant effect of Panax ginseng. J Med Plants Res 2011;5:4616-4620.
34. Qadir MI, Tahir M, Lone KP, et al. Protective role of ginseng against gentamicin induced changes in kidney of albino mice. J Ayub Med Coll Abbottabad 2011;23:53-57.
35. Lee YK, Chin YW, Choi YH. Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. Food Chem Toxicol 2013;59:153-159.
36. Kalkan Y, Kapakin KA, Kara A, et al. Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate. J Mol Histol 2012;43:603-613.
37. Park S, Yeo M, Jin JH, et al. Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells. Dig Dis Sci 2007;52:973-982.
38. Joo KR, Shin HP, Cha JM, et al. Effect of Korean red ginseng on superoxide dismutase inhibitor-induced pancreatitis in rats: a histo-pathologic and immunohistochemical study. Pancreas 2009;38: 661-666.
39. Dong GZ, Jang EJ, Kang SH, et al. Red ginseng abrogates oxidative stress via mitochondria protection mediated by LKB1-AMPK pathway. BMC Complement Altern Med 2013;13:64-73.
40. Ye R, Zhang X, Kong X, et al. Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia. Neuroscience 2011;178:169-180.
41. Zhang HA, Wang M, Zhou J, et al. Protective effect of ginsenoside against acute renal failure and expression of tyrosine hydroxylase in the locus coeruleus. Physiol Res 2010;59:61-70.
42. Doh KC, Lim SW, Piao SG, et al. Ginseng treatment attenuates chronic cyclosporine nephropathy via reducing oxidative stress in an experimental mouse model. Am J Nephrol 2013;37:421-433.
43. McIlwain DR, Berger T, Mak TW. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol 2013;5:a008656-a008685.
44. Kuwana T, Newmeyer DD. Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 2003;15:691-699.
45. Ojano-Dirain CP, Antonelli PJ. Prevention of gentamicin-induced apoptosis with the mitochondria-targeted antioxidant mitoquinone. Laryngoscope 2012;122:2543-2548.
46. Wang H, Yu P, Gou H, et al. Cardioprotective effects of 20(S)-Ginsenoside Rh2 against doxorubicin-induced cardiotoxicity in vitro and in vivo. Evid Based Complement Alternat Med 2012;2012: 506214-506222.
47. Nag SA, Qin JJ, Wang W, et al. Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationships, and molecular mechanisms of action. Front Pharmacol 2012;3:25-43.
48. Liu WK, Xu SX, Che CT. Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci 2000;67:1297-1306.
49. Ha YW, Ahn KS, Lee JC, et al. Validated quantification for selective cellular uptake of ginsenosides on MCF-7 human breast cancer cells by liquid chromatography-mass spectrometry. Anal Bioanal Chem 2010;396:3017-3025.
50. Lee JI, Ha YW, Choi TW, et al. Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells. Planta Med 2011;77:133-140.
51. Pedraza-Chaverri J, Maldonado PD, Barrera D, et al. Protective effect of diallyl sulfide on oxidative stress and nephrotoxicity induced by gentamicin in rats. Mol Cell Biochem 2003;254:125-130.
52. Naidu MU, Shifow AA, Kumar KV, et al. Ginkgo biloba extract ameliorates gentamicin-induced nephrotoxicity in rats. Phyto-medicine 2000;7:191-197.
53. Ali BH. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research. Food Chem Toxicol 2003;41: 1447-1452.