HGF and BMP-7 ameliorate high glucose-induced epithelial-to-mesenchymal transition of peritoneal mesothelium

Journal of the American Society of Nephrology

Volumn 20, Issue 3, 2009, Pages 567-581

  Yu, Min A ^a   Shin, Kyung Sook ^a   Kim, Jung Hye ^a   Kim, Yong Il ^b   Chung, Soon Sup ^b   Park, Sun Hee ^c   Kim, Yong Lim ^c   Kang, Duk Hee ^a,b  

^a Division of Nephrology   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c Kyungpook National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; CYTOKERATIN; CYTOKINE; FIBRONECTIN; GLUCOSE; OSTEOGENIC PROTEIN 1; RECOMBINANT OSTEOGENIC PROTEIN 1; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL PROTECTION; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; DIALYSATE; DRUG EFFECT; EPITHELIUM CELL; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MESENCHYME CELL; MESOTHELIUM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEAL DIALYSIS; PERITONEAL DISEASE; PERITONEUM FIBROSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT;

EID: 62149135860     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008040424     Document Type: Article

References (49)

1. Davies SJ, Phillips L, Griffiths AM, Russell LH, Naish PF, Russell Gl: What really happens to people on long-term peritoneal dialysis? Kidney int 54: 2207-2217, 1998
2. Krediet RT: The peritoneal membrane in chronic peritoneal dialysis. Kidney Int 55: 341-356, 1999
3. Davies SJ, Phillips L, Naish PF, Russell Gl: Peritoneal glucose exposure and changes in membrane solute transport with time on peritoneal dialysis. J Am Soc Nephrol 12: 1046-1051, 2001
4. Holmes CJ, Faict D: Peritoneal dialysis solution biocompatibility: Definitions and evaluation strategies. Kidney Int Suppl 64: S50-S56, 2003
5. Cendoroglo M, Sundaram S, Jaber BL, Pereira BJ: Effect of glucose concentration, osmolality, and sterilization process of peritoneal dialysis fluids on cytokine production by peripheral blood mononuclear cells and polymorphonuclear cell functions in vitro. Am J Kidney Dis 31: 273-282, 1998
6. Gotloib L, Waisbrut V, Shostak A, Kushnier R: Acute and long-term changes observed in imprints of mouse mesothelium exposed to glucose-enriched, lactated, buffered dialysis solutions. Nephron 70: 466-477, 1995
7. Kang DH, Hong YS, Lim HJ, Choi JH, Han DS, Yoon Kl: High glucose solution and spent dialysate stimulate the synthesis of transforming growth factor-betal of human peritoneal mesothelial cells: Effect of cytokine costimulation. Pent Dial Int 19: 221-230, 1999
8. Ha H, Yu MR, Lee HB: High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells. Kidney Int 59: 463-470, 2001
9. Mandl-Weber S, Cohen CD, Haslinger B, Kretzler M, Sitter T: Vascular endothelial growth factor production and regulation in human peritoneal mesothelial cells. Kidney Int 61: 570-578, 2002
10. Haslinger B, Mandl-Weber S, Sellmayer A, Lederer SR, Sitter T: Effect of high glucose concentration on the synthesis of monocyte chemoat-tractant protein-1 in human peritoneal mesothelial cells: Involvement of protein kinase C. Nephron 87: 346-351, 2001
11. Zheng ZH, Ye RG, Bergstrom J, Lindholm B: Effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein expression of Fas and c-Myc. Adv Perit Dial 16: 31-35, 2000
12. Witowski J, Bender TO, Wisniewska-Elnur J, Ksiazek K, Passlick-Deetjen J, Breborowicz A, Jorres A: Mesothelial toxicity of peritoneal dialysis fluids is related primarily to glucose degradation products, not to glucose per se. Pent Dial Int 23: 381-390, 2003
13. Yanez-Mo M, Lara-Pezzi E, Selgas R, Ramirez-Huesca M, Dominguez-Jimenez C, Jimenez-Heffernan JA, Aguilera A, Sanchez-Tomero JA, Bajo MA, Alvarez V, Castro MA, del Peso G, Cirujeda A, Gamallo C, Sanchez-Madrid F, Lopez-Cabrera M: Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 348: 403-413, 2003
14. Thiery JP: Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746, 2003
15. Kalluri R, Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003
16. Savagner P: Leaving the neighborhood: Molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays 23: 912-923, 2001
17. Boyer B, Valles AM, Edme N: Induction and regulation of epithelial- mesenchymal transitions. Biochem Pharmacol 60: 1091-1099, 2000
18. Yang J, Liu Y: Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol 13: 96-107, 2002
19. Lan HY: Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens 12: 25-29, 2003
20. Michalopoulos G, Houck KA, Dolan ML, Leutteke NC: Control of hepatocyte replication by two serum factors. Cancer Res 44: 4414- 4419, 1984
21. Mizuno S, Kurosawa T, Matsumoto K, Mizuno-Horikawa Y, Okamoto M, Nakamura T: Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J Clin Invest 101: 1827-1834, 1998
22. Urist MR: Bone: Formation by autoinduction. Science 150: 893-899, 1965
23. Zeisberg M: Bone morphogenic protein-7 and the kidney: Current concepts and open questions. Nephrol Dial Transplant 21: 568-573, 2006
24. Matsuo K, Maeda Y, Naiki Y, Matsuoka T, Tamai Y, Yonekawa S, Sakaguchi M, Iwamoto I, Hasegawa H, Matsumoto K, Nakamura T, Kanamaru A: Possible effects of hepatocyte growth factor for the prevention of peritoneal fibrosis. Nephron Exp Nephrol 99: e87-e94, 2005
25. Nakamura S, Niwa T: Pyridoxal phosphate and hepatocyte growth factor prevent dialysate-induced peritoneal damage. J Am Soc Nephrol 16: 144-150, 2005
26. Vargha R, Endemann M, Kratochwill K, Riesenhuber A, Wick N, Krachler AM, Malaga-Dieguez L, Aufricht C: Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents. Nephrol Dial Transplant 21: 2943-2947, 2006
27. Aroeira LS, Aguilera A, Sánchez-Tomero JA, Bajo MA, del Peso G, Jiménez-Heffernan JA, Selgas R, López-Cabrera M: Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: Pathologic significance and potential therapeutic interventions. J Am Soc Nephrol 18: 2004-2013, 2007
28. Del Peso G, Jiménez-Heffernan JA, Bajo MA, Aroeira LS, Aguilera A, Fernández-Perpén A, Cirugeda A, Castro MJ, de Gracia R, Sánchez-Villanueva R, Sánchez-Tomero JA, López-Cabrera M, Selgas R: Epithelial-to-mesenchymal transition of mesothelial cells is an early event during peritoneal dialysis and is associated with high peritoneal transport. Kidney Int Suppl 108: S26-S33, 2008
29. Selgas R, Bajo A, Jimenez-Heffernan JA, Sanchez-Tomero JA, Del Peso G, Aguilera A, Lopez-Cabrera M: Epithelial-to-mesenchymal transition of the mesothelial cell: Its role in the response of the peritoneum to dialysis. Nephrol Dial Transplant 21: ii2-ii7, 2006
30. Margetts PJ, Bonniaud P, Liu L, Hoff CM, Holmes CJ, West-Mays JA, Kelly MM: Transient overexpression of TGF-β1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 16: 425-436, 2005
31. Dokic D, Dettman RW: VCAM-1 inhibits TGF-β stimulated epithelial-mesenchymal transformation by modulating Rho activity and stabilizing intercellular adhesion in epicardial mesothelial cells. Dev Biol 299: 489-504, 2006
32. Yang AH, Chen JY, Lin JK: Myofibroblastic conversion of mesothelial cells. Kidney Int 63: 1530-1539, 2003
33. Pollock C: Pathogenesis of peritoneal sclerosis. Int J Artif Organs 28: 90-96, 2005
34. Aguilera A, Aroeira LS, Ramirez-Huesca M, Perez-Lozano ML, Cir- ugeda A, Bajo MA, Del Peso G, Valenzuela-Fernandez A, Sanchez- Tomero JA, Lopez-Cabrera M, Selgas R: Effects of rapamycin on the epithelial-to-mesenchymal transition of human peritoneal mesothelial cells. Int J Artif Organs 28: 164-169, 2005
35. Yang J, Dai C, Liu Y: A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J Am Soc Nephrol 16: 68-78, 2005
36. Matsuoka T, Maeda Y, Matsuo K, Naiki Y, Tamai Y, Sakaguchi M, Hasegawa H, Funauchi M, Kanamaru A: Hepatocyte growth factor prevents peritoneal fibrosis in an animal model of encapsulating peritoneal sclerosis. J Nephrol 21: 64-73, 2008
37. Naiki Y, Matsuo K, Matsuoka T, Maeda Y: Possible role of hepatocyte growth factor in regeneration of human peritoneal mesothelial cells. int J Artif Organs 28: 141-149, 2005
38. Mizuno S, Matsumoto K, Nakamura T: Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int 59: 1304-1314, 2001
39. Inoue T, Okada H, Kobayashi T, Watanabe Y, Kanno Y, Kopp JB, Nishida T, Takigawa M, Ueno M, Nakamura T, Suzuki H: Hepatocyte growth factor counteracts transforming growth factor-1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice. FASEB J 17: 268-270, 2003
40. Rampino T, Cancarini G, Gregorini M, Guallini P, Maggio M, Ranghino A, Soccio G, Dal Canton A: Hepatocyte growth factor/scatter factor released during peritonitis is active on mesothelial cells. Am J Pathol 159: 1275-1285, 2001
41. Patel SR, Dressier GR: BMP7 signaling in renal development and disease. Trends Mol Med 11:512-518, 2005
42. Gould SE, Day M, Jones SS, Dorai H: BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells. Kidney Int 61: 51-60, 2002
43. Klahr S, Morrissey J, Hruska K, Wang S, Chen Q: New approaches to delay the progression of chronic renal failure. Kidney Int Suppl 80: 23-26, 2002
44. Simon M, Maresh JG, Harris SE, Hernandez JD, Arar M, Olson MS, Abboud HE: Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney. Am J Physiol 276: F382-F389, 1999
45. Vukicevic S, Basic V, Rogic D, Basic N, Shih MS, Shepard A, Jin D, Dattatreyamurty B, Jones W, Dorai H, Ryan S, Griffiths D, Maliakal J, Jelic M, Pastorcic M, Stavljenic A, Sampath TK: Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. J Clin Invest 102: 202-214, 1998
46. Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey J: Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 279: F130-F143, 2000
47. Do JY, Kim YL, Park JW, Cho KH, Kim TW, Yoon KW, Kim CD, Park SH, Han JH, Song IH: The effect of low glucose degradation product dialysis solution on epithelial-to-mesenchymal transition in continuous ambulatory peritoneal dialysis patients. Petit Dial lnt25[Suppl 3]: S22-S25, 2005
48. Jang WS, Kim JR, Sohn WJ, Seo JS, Ahn MW, Jang YS, Kim HK, Kim JR: Osteoinduction using recombinant bone morphogenic protein-7 gene. J Korean Orthop Assoc 39: 598-606, 2004
49. Park SH, Lee EG, Kim IS, Kim YJ, Cho DK, Kim YL: Effect of glucose degradation products on the peritoneal membrane in a chronic inflammatory infusion model of peritoneal dialysis in the rat. Perit Dial Int 24: 115-122, 2004