Ginseng treatment attenuates chronic cyclosporine nephropathy via reducing oxidative stress in an experimental mouse model

American Journal of Nephrology

Volumn 37, Issue 5, 2013, Pages 421-433

  Doh, Kyoung Chan ^a   Lim, Sun Woo ^a   Piao, Shang Guo ^a   Jin, Long ^a   Heo, Seong Beom ^a   Zheng, Yu Fen ^c   Bae, Soo Kyung ^b   Hwang, Gyu Hyun ^b   Min, Kyoung Il ^b   Chung, Byung Ha ^a   Yang, Chul Woo ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Apoptosis; Cyclosporine A; Inflammation; Korean red ginseng; Nephropathy; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CASPASE 3; CREATININE; CYCLOSPORIN; GINSENG EXTRACT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 17; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LIPOCORTIN 5; NITROGEN; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA1; UREA; CYTOKINE; NITRIC OXIDE SYNTHASE; TISSUE CULTURE MEDIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL INFILTRATION; CELL STRUCTURE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CULTURE MEDIUM; CYTOTOXICITY; DRUG EFFECT; ENZYME RELEASE; FLOW CYTOMETRY; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; INFLAMMATION; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DISORDER; MACROPHAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SODIUM RESTRICTION; TISSUE SECTION; UREA NITROGEN BLOOD LEVEL; URINALYSIS; DRUG MECHANISM; FIBROSING ALVEOLITIS; GINSENG; INTERSTITIAL NEPHRITIS; KIDNEY DISEASE; KIDNEY DYSFUNCTION;

ANIMALS; BIOLOGICAL MARKERS; CELL LINE; CYCLOSPORINE; HERB-DRUG INTERACTIONS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY DISEASES; MALE; MICE; OXIDATIVE STRESS; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; RANDOM ALLOCATION;

EID: 84876082185     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000349921     Document Type: Article

References (29)

1. Yoon HE, Yang CW: Established and newly proposed mechanisms of chronic cyclosporine nephropathy. Korean J Intern Med 2009; 24: 81-92
2. Capasso G, Di Gennaro CI, Della Ragione F, Manna C, Ciarcia R, Florio S, Perna A, Pollastro RM, Damiano S, Mazzoni O, Galletti P, Zappia V: In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats. Nephrol Dial Transplant 2008; 23: 1186-1195
3. Satyanarayana PS, Chopra K: Oxidative stress-mediated renal dysfunction by cyclosporine A in rats: Attenuation by trimetazidine. Ren Fail 2002; 24: 259-274
4. Tariq M, Morais C, Sobki S, Al Sulaiman M, Al Khader A: N-acetylcysteine attenuates cyclosporin- induced nephrotoxicity in rats. Nephrol Dial Transplant 1999; 14: 923-929
5. Jung NP, Jin SH: Studies on the physiological and biochemical effects of Korean ginseng. Korean J Ginseng Sci 1996; 20: 431-471
6. Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ, Shim I: Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci 2005; 97: 124-131
7. Choi YD, Xin ZC, Choi HK: Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res 1998; 10: 37- 43
8. Jeon BH, Kim CS, Kim HS, Park JB, Nam KY, Chang SJ: Effect of Korean red ginseng on blood pressure and nitric oxide production. Acta Pharmacol Sin 2000; 21: 1095-1100
9. Ryu JK, Lee T, Kim DJ, Park IS, Yoon SM, Lee HS, Song SU, Suh JK: Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats. Urology 2005; 65: 611-615
10. Voces J, Alvarez AI, Vila L, Ferrando A, Cabral de Oliveira C, Prieto JG: Effects of administration of the standardized Panax ginseng extract g115 on hepatic antioxidant function after exhaustive exercise. Comp Biochemistry Physiol C Pharmacol Toxicol Endocrinol 1999; 123: 175-184
11. Yoon M, Lee H, Jeong S, Kim JJ, Nicol CJ, Nam KW, Kim M, Cho BG, Oh GT: Peroxisome proliferator-activated receptor alpha is involved in the regulation of lipid metabolism by ginseng. Br J Pharmacol 2003; 138: 1295- 1302
12. Lim SW, Hyoung BJ, Piao SG, Doh KC, Chung BH, Yang CW: Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance. Transplantation 2012; 94: 218-225
13. Yang CW, Faulkner GR, Wahba IM, Christianson TA, Bagby GC, Jin DC, Abboud HE, Andoh TF, Bennett WM: Expression of apoptosis- related genes in chronic cyclosporine nephrotoxicity in mice. Am J Transplant 2002; 2: 391-399
14. Ghee JY, Han DH, Song HK, Kim WY, Kim SH, Yoon HE, Choi BS, Kim YS, Kim J, Yang CW: The role of macrophage in the pathogenesis of chronic cyclosporine-induced nephropathy. Nephrol Dial Transplant 2008; 23: 4061-4069
15. Hong CE, Lyu SY: Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes. Immune Netw 2011; 11: 42-49
16. Kang KS, Kim HY, Yamabe N, Nagai R, Yokozawa T: Protective effect of sun ginseng against diabetic renal damage. Biol Pharm Bull 2006; 29: 1678-1684
17. de Mattos AM, Olyaei AJ, Bennett WM: Nephrotoxicity of immunosuppressive drugs: Long-term consequences and challenges for the future. Am J Kidney Dis 2000; 35: 333-346
18. Sun BK, Li C, Lim SW, Jung JY, Lee SH, Kim IS, Kim YS, Kim J, Bang BK, Yang CW: Expression of transforming growth factor-betainducible gene-h3 in normal and cyclosporine- treated rat kidney. J Lab Clin Med 2004; 143: 175-183
19. Islam M, Burke JF, McGowan TA, Zhu Y, Dunn SR, McCue P, Kanalas J, Sharma K: Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction. Kidney Int 2001; 59: 498-506
20. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619
21. Kim EH LM, Kim IH, Pyo S, Choi KT, Rhee DK: Anti-apoptotic effects of red ginseng on oxidative stress induced by hydrogen peroxide in SK-N-SH cells. J Ginseng Res 2010; 34: 134-144
22. Lee Y KK, Bae HM, Lee YC, Choi SY: Protective effects of ginseng coffee against hydrogen peroxide-induced oxidative damage in L6 muscle cells. J Ginseng Res 2010; 34: 145-149
23. Park MS, Cho EJ, Lee SK, Lee EJ, Lee SD, Lee KH, Jeon BH: Korean red ginseng protects oxidative injury caused by lead poisoning. J Ginseng Res 2010; 34: 132-137
24. Im GJ, Chang JW, Choi J, Chae SW, Ko EJ, Jung HH: Protective effect of Korean red ginseng extract on cisplatin ototoxicity in HEI-OC1 auditory cells. Phytother Res 2010; 24: 614-621
25. Sung H, Jung Y-S, Cho Y-K: Beneficial effects of a combination of Korean red ginseng and highly active antiretroviral therapy in human immunodeficiency virus type 1-infected patients. Clin Vaccine Immunol 2009; 16: 1127- 1131
26. Vuksan V, Sung M-K, Sievenpiper J, Stavro PM, Jenkins A, Di Buono M, Lee K-S, Leiter L, Nam K, Arnason J, Choi M, Naeem A: Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis 2008; 18: 46-56
27. He N, Edeki T: The inhibitory effects of herbal components on CYP2C9 and CYP3A4 catalytic activities in human liver microsomes. Am J Ther 2004; 11: 206-212
28. Gurley B, Gardner S, Hubbard M, Williams DK, Gentry WB, Cui Y, Ang CYW: Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Clin Pharmacol Ther 2002; 72: 276-287
29. Gurley B, Gardner S, Hubbard M, Williams DK, Gentry WB, Cui Y, Ang CYW: Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba . Drugs Aging 2005; 22: 525-539 Health and Welfare Affairs