A role for superoxide in gentamicin-mediated nephropathy in rats

European Journal of Pharmacology

Volumn 450, Issue 1, 2002, Pages 67-76

  Cuzzocrea, Salvatore ^a   Mazzon, Emanuela ^a   Dugo, Laura ^a   Serraino, Ivana ^a   Di Paola, Rosanna ^a   Britti, Domenico ^b   De Sarro, Angela ^a   Pierpaoli, Simone ^c   Caputi, Achille P ^a   Masini, Emanuela ^c   Salvemini, Daniela ^d  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF TERAMO   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d MetaPhore Pharmaceuticals   (United States)

Author keywords

Compound M40403; Gentamicin; Superoxide anion; Superoxide dismutase mimetic

Indexed keywords

3 NITROTYROSINE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; GENTAMICIN; LITHIUM; MANGANESEDICHLORO(3,10,13,20,26 PENTAAZATETRACYCLO[20.3.1.0(4,9).0(14,19)] 1(26),22(23),24 HEXACOSATRIENE); NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SODIUM; SUPEROXIDE; 3-NITROTYROSINE; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; MANGANESE; ORGANOMETALLIC COMPOUND; OXIDIZING AGENT; SCAVENGER; SUPEROXIDE DISMUTASE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE NECROSIS; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION; URINE VOLUME; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; KIDNEY; KIDNEY CIRCULATION; KIDNEY FAILURE; METABOLISM; MOLECULAR MIMICRY; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMAL; ANTIBIOTICS, AMINOGLYCOSIDE; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; GENTAMICINS; KIDNEY; KIDNEY FAILURE; LIPID PEROXIDATION; MALE; MANGANESE; MOLECULAR MIMICRY; NEUTROPHIL INFILTRATION; ORGANOMETALLIC COMPOUNDS; OXIDANTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION; SUPEROXIDE DISMUTASE; SUPEROXIDES; TYROSINE; ANIMALS; ANTI-BACTERIAL AGENTS;

EID: 0037118909     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01749-1     Document Type: Article

References (46)

1. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats
2. Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study
3. Oxidant mechanisms in toxic acute renal failure
4. Increased nephrotoxicity of gentamicin in pyelonephritic rats
5. Comparison of cyclosporine nephrotoxicity with aminoglycoside nephrotoxicity
6. Inhibitors of poly(ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress
7. Inhibitors of poly(ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo
8. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat
9. Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration
10. Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury
11. Protective effects of M40403 a superoxide dismutase mimetic in a rodent model of colitis
12. Free radical damage to proteins: The influence of the relative localization of radical generation, antioxidants, and target proteins
13. Pinacidil-effects on function and perfusion of normal kidneys and renal xenografts
14. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions
15. Polymorphonuclear leukocyte-mediated cell and tissue injury: Oxygen metabolites and their relations to human disease
16. Oxygen free radicals in acute renal failure
17. Postanoxic formation of aldehydic lipid peroxidation products in human renal tubular cells
18. Role of free radicals and catalytic metal ions in human disease: An overview
19. Clinical and pathophysiologic aspects of aminoglycoside nephrotoxicity
20. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
21. Hydroxyl radical generation following ischaemia-reperfusion in cell-free perfused rat-kidney
22. Aminoglycoside toxicity - A review of clinical studies published between 1975 and 1982
23. Effect of N-acetylcysteine on gemtamicin-mediated nephropathy in rats
24. Free radicals and myocardial ischemia. The role of xanthine oxidase
25. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
26. Mechanisms for protective effects of free radical scavengers on gentamicin-mediated nephropathy in rats
27. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
28. Oxygen free radicals in ischemic acute renal failure in the rat
29. Effect of gentamicin on lipid peroxidation in rat renal cortex
30. Failure of inhibition of lipid peroxidation by vitamin E to protect against gentamicin nephrotoxicity in the rat
31. Reactive oxygen and DNA damage in mitochondria
32. Oxidative damage to mitochondrial DNA and its relationship to ageing
33. Synthesis, characterization and stability of manganese (II) C-substituted 1,4,7,10,13-Pentaazacyclopentadecane complexes exhibiting superoxide dismutase activity
34. Toward the rational design of superoxide dismutase mimics: Mechanistic studies for the elucidation of substituent effects on the catalysis activity of macrocyclic manganese (II) complexes
35. DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes
36. Nonpeptidyl mimetic of superoxide dismutase in clinical therapies for diseases
37. Synzymes: Potent non-peptidic agents against superoxide-driven tissue injury
38. M40403, a superoxide dismutase mimetic, ameliorates joint disease in a rat model of collagen-induced arthritis
39. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403
40. Effect of enzymatically generated reactive oxygen metabolites on the cyclic nucleotide content in isolated rat glomeruli
41. Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites
42. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly(ADP-ribose) synthetase by peroxynitrite
43. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle
44. Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats
45. Oxidant mechanisms in gentamicin nephrotoxicity
46. Phagocyte-generated oxygen metabolites and cellular injury