Wound-healing effect of ginsenoside Rd from leaves of Panax ginseng via cyclic AMP-dependent protein kinase pathway

European Journal of Pharmacology

Volumn 702, Issue 1-3, 2013, Pages 285-293

  Kim, Wang Kyun ^a,b   Song, Seung Yong ^a   Oh, Won Keun ^c   Kaewsuwan, Sireewan ^a,b,d   Tran, Tien Lam ^c   Kim, Won Serk ^e   Sung, Jong Hyuk ^a,b  

^a CHA University   (South Korea)

^b CHA Stem Cell Institute   (South Korea)

^c Chosun University   (South Korea)

^d PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^e School of Medicine   (South Korea)

Author keywords

Cyclic AMP dependent protein kinase; Ginsenoside Rd; Human dermal fibroblasts; Keratinocyte progenitor cells; Wound healing

Indexed keywords

COLLAGEN TYPE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GINSENOSIDE RD; HYDROGEN PEROXIDE; INTERSTITIAL COLLAGENASE; VIDARABINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIC AMP DEPENDENT PROTEIN KINASE PATHWAY; DOWN REGULATION; DRUG STRUCTURE; FEMALE; GENE EXPRESSION; GINSENG; HUMAN; HUMAN CELL; IN VIVO STUDY; KERATINOCYTE PROGENITOR CELL; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; STEM CELL; TISSUE REGENERATION; WOUND; WOUND HEALING;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; FIBROBLASTS; GINSENOSIDES; HUMANS; KERATINOCYTES; MATRIX METALLOPROTEINASE 1; MICE; MICE, HAIRLESS; PANAX; PHYTOTHERAPY; PLANT LEAVES; SIGNAL TRANSDUCTION; SKIN; STEM CELLS; WOUND HEALING;

EID: 84874622260     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.048     Document Type: Article

References (25)

1. A.S. Attele, J.A. Wu, and C.S. Yuan Ginseng pharmacology multiple constituents and multiple actions Biochem. Pharmacol. 58 1999 1685 1693
2. 2 by Caulobacter leidyia Biotechol. Lett. 28 2006 1121 1127
3. X. Chen Cardiovascular protection by ginsenosides and their nitric oxide releasing action Clin. Exp. Pharmacol. Physiol. 23 1996 728 732
4. 1 and Re from Panax ginseng by food microorganisms Biotechnol. Lett. 27 2005 765 771
5. 2, Rc and Rd isolated from Panax ginseng J. Gingseng Res. 34 2010 113 121
6. 1 down-regulates glucocorticoid receptor and displays synergistic effects with cAMP Steroids 63 1998 421 424
7. 1 by Rhizopus stolonifer and Curcularia lunata Biotechnol. Lett. 25 2003 339 344
8. C.N. Gillis Panax ginseng pharmacology: a nitric oxide link? Biochem. Pharmacol. 54 1997 1 8
9. S. Impey, K. Obrietan, and D.R. Storm Making new connections: role of ERK/MAP kinase signaling in neuronal plasticity Neuron 23 1999 11 14
10. T. Kanzaki, N. Morisaki, R. Shiina, and Y. Saito Role of transforming growth factor-b pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra Br. J. Pharmacol. 125 1998 255 262
11. 1 to pharmaceutically active minor ginsenoside Rd J. Microbiol. 43 2005 456 462
12. W.S. Kim, P.B. Park, S.H. Kim, and H.K. Sung, J.H. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors J. Dermatol. Sci. 53 2009 96 102
13. Y.G. Kim, M. Sumiyoski, M. Sakanaka, and Y. Kimura Effects of red ginseng extract on ultraviolet B-irradiated skin change in C57BL mice Phytother. Res. 22 2008 1423 1427
14. Y. Kimura, M. Sumiyoshi, K. Kawahira, and M. Sakanaka Effects of ginseng saponins isolated from Red Ginseng roots on burn wound healing in mice Br. J. Pharmacol. 148 2006 860 870
15. 1 protects huma HaCat keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2 J. Invest. Dermatol. 121 2003 607 613
16. J. Lee, E. Jung, J. Lee, S. Huh, J. Kim, M. Park, J. So, Y. Ham, K. Jung, C.G. Hyun, Y.S. Kim, and D. Park Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling J. Ethnopharmacol. 109 2007 29 34
17. S.A. Nag, J.J. Qin, W. Wang, M.H. Wang, H. Wang, and R. Zhang Ginsenosides as anticancer agents: in vitro and in vivo activities, structure-activity relationship, and molecular mechanisms of action Front. Pharmacol. 3 2012 1 18
18. 1 from ginseng root by high performance liquid chromatography Arch. Pharm. Res. 55 1982 7 12
19. C. Peyssonnaux, and A. Eychène The Raf/MEK/ERK pathway, new concepts of activation Biol. Cell 93 2001 53 62
20. 1 by β-glucosidase from Thermus caldophilus Biotechnol. Lett. 30 2008 713 716
21. P.J.S. Stork, and J.M. Schmitt Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation Trends Cell Biol. 12 2002 258 266
22. S.H. Sung, S.H. Park, S.Y. Song, S.J. Lee, H.W. Lee, S.H. Kim, M.A. Lee, I.S. Yoon, D.D. Kim, S. Kang, and J.H. Sung Epidermal regeneration by ent-16α, 17-dihydroxy-kauran-19-oic acid isolated from Siegesbeckia pubescens Cell Prolif. 44 2011 527 536
23. K. Wada, A. Nakajima, K. Katayama, C. Kudo, A. Shibuya, N. Kubota, Y. Terauchi, M. Tachibana, H. Miyoshi, Y. Kamisaki, T. Mayumi, T. Kadowaki, and R.S. Blumberg Peroxisome proliferator-activated receptor g-mediated regulation of neural stem cell proliferation and differentiation J. Biol. Chem. 281 2006 12673 12681
24. 1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway Brain Res. 1106 2006 91 98
25. 2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3beta via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells Chem. Biol. Interact. 195 2012 35 42