Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin

Journal of Ethnopharmacology

Volumn 145, Issue 1, 2013, Pages 233-240

  Liu, Zhi ^a   Li, Wei ^a   Li, Xiang ^b   Zhang, Ming ^c   Chen, Li ^c   Zheng, Yi Nan ^a   Sun, Guang Zhi ^a   Ruan, Chang Chun ^a  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c Basic Medical College   (China)

Author keywords

Antidiabetic; Malonyl ginsenosides; Panax ginseng; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; CHOLESTEROL; GINSENOSIDE; INSULIN; MALONYLGINSENOSIDE; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG STRUCTURE; GINSENG; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; RAT;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; GINSENOSIDES; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; MALE; PANAX; PANCREAS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR;

PANAX GINSENG; RATTUS;

EID: 84871263341     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.10.058     Document Type: Article

References (53)

1. S.L. Abbate, and J.D. Brunzell Pathophysiology of hyperlipidemia in diabetes mellitus Journal of Cardiovascular Pharmacology 16 1990 S1 S7
2. C. Abraira, J.A. Colwell, F.Q. Nuttall, C.T. Sawin, N.J. Nagel, J.P. Comstock, N.V. Emanuele, S.R. Levin, W. Henderson, and H.S. Lee Veterans affairs cooperative study on glycemic control and complications in type II diabetes (VA CSDM): results of the feasibility trial Diabetes Care 18 1995 1113 1123
3. M. Aragno, R. Mastrocola, M.G. Catalano, E. Brignardello, O. Danni, and G. Boccuzzi Oxidative stress impairs skeletal muscle repair in diabetic rats Diabetes 53 2004 1082 1088
4. A.S. Attele, Y.P. Zhou, J.T. Xie, J.A. Wu, L. Zhang, L. Dey, W. Pugh, P.A. Rue, K.S. Polonsky, and C.S. Yuan Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component Diabetes 51 2002 1851 1858
5. D.V.C. Awang The neglected Ginsenosides of North American Ginseng (Panax quinquefolius L.) Journal Herbs, Spices and Medicine Plants 7 2000 103 109
6. A. Aziz, and S. Wheatcroft Insulin resistance in type 2 diabetes and obesity: implications for endothelial function Expert Review of Cardiovascular Therapy 9 2011 403 407
7. M. Benwahhoud, H. Jouad, M. Eddouks, and B. Lyoussi Hypoglycemic effect of Suaeda fruticosa in streptozotocin-induced diabetic rats Journal of Ethnopharmacology 76 2001 35 38
8. W.C.S. Cho, W.S. Chung, S.K.W. Lee, A.W.N. Leung, C.H.K. Cheng, and K.K.M. Yue Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats European Journal of Pharmaceutical 550 2006 173 179
9. W.C. Chuang, H.K. Wu, S. Sheu, S.H. Chiou, H.C. Chang, and Y.P. Chen A comparative study on commercial samples of ginseng radix Planta Medicine 61 1995 459 465
10. M.B. Covington Traditional Chinese medicine in treatment diabetes Diabetes Spectrum 14 2001 154 159
11. L.R. De Souza, A.L. Jenkins, J.L. Sievenpiper, E. Jovanovski, D. Rahelic, and V. Vuksan Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: differential effects on postprandial glycemia in healthy individuals Journal of Ethnopharmacology 137 2011 245 250
12. R.A. Defronzo, and E. Ferrannini Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease Diabetes Care 14 1991 173 194
13. L. Dey, J.T. Xie, A. Wang, J. Wu, S.A. Maleckar, and C.S. Yuan Anti-hyperglycemic effects of ginseng: comparison between root and berry Phytomedicine 10 2003 600 605
14. J. El Hilaly, and B. Lyoussi Hypoglycemic effect of the lyophilized aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats Journal of Ethnopharmacology 80 2002 109 113
15. C.N. Gillis Panax ginseng pharmacology: a nitric oxide link? Biochemical Pharmacology 54 1997 1 8
16. D.Y. Kim, H.D. Yuan, I.K. Chung, and S.H. Chung Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells Journal of Agriculture Food Chemistry 57 2009 1532 1537
17. K. Kim, and H.Y. Kim Korean red ginseng stimulates insulin release from isolated rat pancreatic islets Journal of Ethnopharmacology 120 2008 190 195
18. 3 has a stimulatory effect on insulin signaling in L6 myotubes Biochemical and Biophysical Research Communications 389 2009 70 73
19. I. Kimura, N. Nakashima, Y. Sugihara, C. Fu-jun, and M. Kimura The antihyperglycaemic blend effect of traditional Chinese medicine byakko-ka- ninjin-to on alloxan and diabetic KK-CA(y) mice Phytotherapy Research 13 1999 484 488
20. R. Klein, B.E. Klein, S.E. Moss, and K.J. Cruickshanks Relationship of hyperglycemia to the long-term incidence and progression of diabetic retinopathy Archives of Internal Medicine 154 1994 2169 2178
21. 2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Medicine 72, 9-13.
22. M.S. Lee, J.T. Hwang, S.H. Kim, S. Yoon, M.S. Kim, H.J. Yang, and D.Y. Kwon Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism Journal of Ethnopharmacology 127 2010 771 776
23. 2 to lower plasma glucose in Wistar rats Clinical and Experimental Pharmacology and Physiology 33 2006 27 32
24. Z.Q. Liu Chemical insights into Ginseng as a resource for natural antioxidants Chemical Reviews 112 2012 3329 3355
25. W.L. Li, H.C. Zheng, J. Bukuru, and N. De Kimpe Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus Journal of Ethnopharmacology 92 2004 1 21
26. W. Li, M. Zhang, J. Gu, Z.J. Meng, L.C. Zhao, Y.N. Zheng, L. Chen, and G.L. Yang Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis Fitoterapia 83 2012 192 198
27. S.S. Liou, I.M. Liu, J.H. Hsu, Y.C. Wu, S.F. Hsu, and J.T. Chen Release of acetylcholine by Die-Huang-Wan to enhance insulin secretion for lowering plasma glucose in Wistar rats Autonomic Neuroscience 100 2002 21 26
28. Q.Z. Liu, D.J. Pettitt, R.L. Hanson, M.A. Charles, R. Klein, P.H. Bennett, and W.C. Knowler Glycated haemoglobin, plasma glucose and diabetic retinopathy: cross-sectional and prospective analyses Diabetologia 36 1993 428 432
29. Z. Liu, Y. Li, X. Li, C.C. Ruan, L.J. Wang, and G.Z. Sun The effects of dynamic changes of malonyl ginsenosides on evaluation and quality control of Panax ginseng C.A. Meyer Journal Pharmaceutical and Biomedical Analysis 64 2012 56 63
30. Z. Liu, L.J. Wang, X. Li, J.N. Hu, Y. Chen, C.C. Ruan, and G.Z. Sun Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice Phytotherapy Research 23 2009 1426 1430
31. Z.Q. Liu Chemical insights into ginseng as a resource for natural antioxidants Chemical Reviews 112 2012 3329 3355
32. Y. Ohkubo, H. Kishikawa, E. Araki, T. Miyata, S. Isami, S. Motoyoshi, Y. Kojima, N. Furuyoshi, and M. Shichiri Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study Diabetes Research and Clinical Practice 28 1995 103 117
33. M.J. Reed, K. Meszaros, L.J. Entes, M.D. Claypool, J.G. Pinkett, T.M. Gadbois, and G.M. Reaven A new rat model of type 2 diabetes, the fat-fed, streptozotocin-treated rat Metabolism 49 2000 1390 1394
34. V. Saini Molecular mechanisms of insulin resistance in type 2 diabetes mellitus World Journal of Diabetes 1 2010 68 75
35. J. Salas-Salvadó, M.Á. Martinez-González, M. Bulló, and E. Ros The role of diet in the prevention of type 2 diabetes Nutrition Metabolism and Cardiovascular Diseases 21 2011 B32 B48
36. J.E. Shaw, R.A. Sicree, and P.Z. Zimmet Global estimates of the prevalence of diabetes for 2010 and 2030 Diabetes Research and Clinical Practice 87 2010 4 14
37. J.S. Skyler Diabetes mellitus: pathogenesis and treatment strategies Journal of Medicine Chemistry 47 2004 4113 4177
38. R.P. Stolk, J.R. Vingerling, P.T. de Jong, I. Dielemans, A. Hofman, S.W. Lamberts, H.A. Pols, and D.E. Grobbee Retinopathy, glucose, and insulin in an elderly population: the Rotterdam study Diabetes 44 1995 11 15
39. G.Z. Sun, Z. Liu, X.G. Li, Y.N. Zheng, and J.Y. Wang Isolation and identification of two malonyl-ginsenosides from the fresh root of Panax ginseng Chinese Journal of Analytical Chemistry 33 2005 1783 1786
40. 4 from the root of Panax ginseng Chemical Journal of Chinese Universities 28 2007 1316 1318
41. T. Szkudelski The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas Physiological Research 50 2001 537 546
42. A.A. Tahrani, M.K. Piya, A. Kennedy, and A.H. Barnett Glycaemic control in type 2 diabetes: targets and new therapies Pharmacology and Therapeutics 125 2010 328 361
43. The Diabetes Control and Complications Trial Research Group The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus The New England Journal of Medicine 329 1993 977 986
44. U.S. Department of Health and Human Services, 2004. Diabetes: A national plan for action. pp. 19-22.
45. V. Vuksan, J.L. Sievenpiper, V.Y. Koo, T. Francis, U. Beljan-Zdravkovic, Z. Xu, and E. Vidgen American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus Archives of Internal Medicine 160 2000 1009 1013
46. V. Vuksan, L.A. Leiter, M.P. Stavro, R.G. Josse, J.L. Sievenpiper, Z. Xu, U. Beljan-Zdravkovic, and E. Vigden Similar postprandial glycemic reductions with escalation of dose and administration time of American Ginseng in type II diabetes Diabetes Care 23 2000 1221 1226
47. Wang, Y.T.; You, J.Y.; Yu, Y.; Qu, C.L.; Zhang, H.R.; Ding, L.; Zhang, H.Q.; Li, X.W.; 2008. Analysis of ginsenosides in Panax ginseng in high pressure microwave-assisted extraction. Food Chemistry 110, 161-167.
48. J.T. Xie, Y.P. Zhou, L. Dey, A.S. Attele, J.A. Wu, M. Gu, K.S. Polonsky, and C.S. Yuan Ginseng berry reduces blood glucose and body weight in db/db mice Phytomedicine 9 2002 254 258
49. J.T. Xie, C.Z. Wang, A. Wang, J. Wu, D. Basila, and C.S. Yuan Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng Acta Pharmacologica Sinica 26 2005 1104 1110
50. 1 in rats Diabetes 59 2010 2505 2512
51. G.Y. Yeh, D.M. Eisenberg, T.J. Kaptchuk, and R.S. Philips Systematic review of herbs and dietary supplements for glycemic control in diabetes Diabetes Care 26 2003 1277 1294
52. S.Q. Zhang, R.Z. Chen, H. Wu, and C.Z. Wang Ginsenoside extraction from Panax quinquefolium L. (American ginseng) root by using ultrahigh pressure Journal Pharmaceutical and Biomedical Analysis 41 2006 57 63
53. M. Zhang, X.Y. Lv, J. Li, Z.G. Xu, and L. Chen The characterization of high fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model Experimental Diabetes Research 2008 2008 704045