Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells

Biochemical and Biophysical Research Communications

Volumn 434, Issue 3, 2013, Pages 527-533

  Lee, Ko Eun ^a   Kim, Eun Young ^a   Kim, Chang Seong ^a   Choi, Joon Seok ^a   Bae, Eun Hui ^a   Ma, Seong Kwon ^a   Kim, Kyung Keun ^a   Lee, Jong Un ^a   Kim, Soo Wan ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Apoptosis; Gentamicin; Inflammation; MSP; Nf b

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; APOPTOSIS INHIBITOR; CASPASE 3; CYCLOOXYGENASE 2; CYTOPROTECTIVE AGENT; FLUORESCEIN ISOTHIOCYANATE; GENTAMICIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOCORTIN 5; MACROPHAGE ACTIVATING FACTOR; MACROPHAGE STIMULATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; RON RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; URINARY TRACT AGENT; ONCOPROTEIN; SCATTER FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE EPITHELIUM; MOLECULAR PATHOLOGY; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; STAINING; TRANSCRIPTION INITIATION; UPREGULATION; CELL LINE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

RATTUS;

APOPTOSIS; CELL LINE; EPITHELIAL CELLS; FLOW CYTOMETRY; GENTAMICINS; HEPATOCYTE GROWTH FACTOR; HUMANS; INFLAMMATION; KIDNEY TUBULES, PROXIMAL; PROTO-ONCOGENE PROTEINS;

MLCS; MLOWN;

EID: 84880462995     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.108     Document Type: Article

References (35)

1. H. Servais, A. Ortiz, O. Devuyst, S. Denamur, P.M. Tulkens, M.P. Mingeot-Leclercq, Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation, Apoptosis 13 (2008) 11-32.
2. S. Cuzzocrea, E. Mazzon, L. Dugo, I. Serraino, R. Di Paola, D. Britti, A. De Sarro, S. Pierpaoli, A. Caputi, E. Masini, D. Salvemini, A role for superoxide in gentamicin-mediated nephropathy in rats, Eur. J. Pharmacol. 450 (2002) 67-76.
3. E.P. Bottinger, M. Bitzer, TGF-beta signaling in renal disease, J. Am. Soc. Nephrol. 13 (2002) 2600-2610.
4. R. Sandoval, J. Leiser, B.A. Molitoris, Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells, J. Am. Soc. Nephrol. 9 (1998) 167-174.
5. H.D. Humes, D.A. Cieslinski, T.M. Coimbra, J.M. Messana, C. Galvao, Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure, J. Clin. Invest. 84 (1989) 1757-1761.
6. M. Flaquer, M. Franquesa, A. Vidal, N. Bolanos, J. Torras, N. Lloberas, I. Herrero-Fresneda, J.M. Grinyo, J.M. Cruzado, Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes, Diabetologia 55 (2012) 2059-2068.
7. X. Chen, Z. Chen, H. Wang, X. Xiong, X. Liu, C. Hu, Y. Han, Y. Lu, Z. Wu, Q. Zhang, Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats, Exp. Toxicol. Pathol. (2012), http://dx.doi.org/10.1016/j.etp.2012.03.003. [Epub ahead of print].
8. L.E. Donate, E. Gherardi, N. Srinivasan, R. Sowdhamini, S. Aparicio, T.L. Blundell, Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP), Protein Sci. 3 (1994) 2378-2394.
9. T. Rampino, C. Collesi, M. Gregorini, M. Maggio, G. Soccio, P. Guallini, A. Dal Canton, Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells, J. Am. Soc. Nephrol. 13 (2002) 649-657.
10. M.H. Wang, G.W. Cox, T. Yoshimura, L.A. Sheffler, A. Skeel, E.J. Leonard, Macrophage-stimulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages, J. Biol. Chem. 269 (1994) 14027-14031.
11. V. Cantaluppi, L. Biancone, G.M. Romanazzi, F. Figliolini, S. Beltramo, F. Galimi, M.G. Camboni, E. Deriu, P. Conaldi, A. Bottelli, V. Orlandi, M.B. Herrera, A. Pacitti, G.P. Segoloni, G. Camussi, Macrophage stimulating protein may promote tubular regeneration after acute injury, J. Am. Soc. Nephrol. 19 (2008) 1904-1918.
12. F. Xue, Y. Isaka, T. Takahara, R. Imamura, C. Suzuki, N. Ichimaru, P. Michieli, S. Takahara, HGF-MSP chimera protects kidneys from ischemia-reperfusion injury, Biochem. Biophys. Res. Commun. 363 (2007) 451-456.
13. C. Thery, C.D. Stern, Roles of kringle domain-containing serine proteases in epithelial-mesenchymal transitions during embryonic development, Acta Anat. (Basel) 156 (1996) 162-172.
14. M.H. Wang, F.M. Julian, R. Breathnach, P.J. Godowski, T. Takehara, W. Yoshikawa, M. Hagiya, E.J. Leonard, Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain, J. Biol. Chem. 272 (1997) 16999-17004.
15. N.M. Nikolaidis, J.K. Gray, D. Gurusamy, W. Fox, W.D. Stuart, N. Huber, S.E. Waltz, Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production, Shock 33 (2010) 197-204.
16. A.J. Cowin, N. Kallincos, N. Hatzirodos, J.G. Robertson, K.J. Pickering, J. Couper, D.A. Belford, Hepatocyte growth factor and macrophage-stimulating protein are upregulated during excisional wound repair in rats, Cell Tissue Res. 306 (2001) 239-250.
17. S. Brunelleschi, L. Penengo, L. Lavagno, C. Santoro, D. Colangelo, I. Viano, G. Gaudino, Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin, Br. J. Pharmacol. 134 (2001) 1285-1295.
18. T. Rampino, G. Soccio, M. Gregorini, C. Guidetti, M. Marasa, M. Maggio, V. Panichi, M. Migliori, C. Libetta, A. Dal Canton, Neutralization of macrophage-stimulating protein ameliorates renal injury in anti-thy 1 glomerulonephritis, J. Am. Soc. Nephrol. 18 (2007) 1486-1496.
19. C. Rosenau, D. Emery, B. Kaboord, M.W. Qoronfleh, Development of a high-throughput plate-based chemiluminescent transcription factor assay, J. Biomol. Screen. 9 (2004) 334-342.
20. L. Zamai, E. Falcieri, G. Marhefka, M. Vitale, Supravital exposure to propidium iodide identifies apoptotic cells in the absence of nucleosomal DNA fragmentation, Cytometry 23 (1996) 303-311.
21. M. Poljakovic, M.L. Svensson, C. Svanborg, K. Johansson, B. Larsson, K. Persson, Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney, Kidney Int. 59 (2001) 893-904.
22. T. Rampino, M. Gregorini, G. Soccio, M. Maggio, R. Rosso, P. Malvezzi, C. Collesi, A. Dal Canton, The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma, Am. J. Surg. Pathol. 27 (2003) 779-785.
23. E. Miller, Apoptosis measurement by annexin V staining, Methods Mol. Med. 88 (2004) 191-202.
24. J.K. Brunelle, A. Letai, Control of mitochondrial apoptosis by the Bcl-2 family, J. Cell Sci. 122 (2009) 437-441.
25. M. El Mouedden, G. Laurent, M.P. Mingeot-Leclercq, P.M. Tulkens, Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts, Toxicol. Sci. 56 (2000) 229-239.
26. E. Esposito, S. Cuzzocrea, The role of nitric oxide synthases in lung inflammation, Curr. Opin. Investig. Drugs 8 (2007) 899-909.
27. J.M. Ahn, S.J. You, Y.M. Lee, S.W. Oh, S.Y. Ahn, S. Kim, H.J. Chin, D.W. Chae, K.Y. Na, Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury, PLoS One 7 (2012) e48952.
28. X.M. Tong, J.C. Wang, Y. Shen, J.J. Xie, J.Y. Zhang, J. Jin, Inhibition of inflammatory mediators and related signaling pathways by macrophage-stimulating protein in rheumatoid arthritis synovial fibroblasts, Inflamm. Res. 60 (2011) 823-829.
29. L.E. Nee, T. McMorrow, E. Campbell, C. Slattery, M.P. Ryan, TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells, Kidney Int. 66 (2004) 1376-1386.
30. K.M. Ryan, M.K. Ernst, N.R. Rice, K.H. Vousden, Role of NF-kappaB in p53-mediated programmed cell death, Nature 404 (2000) 892-897.
31. H.M. Shen, V. Tergaonkar, NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy, Apoptosis 14 (2009) 348-363.
32. E.H. Bae, S. Cho, S.Y. Joo, S.K. Ma, S.H. Kim, J. Lee, S.W. Kim, 4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells, Nephrol. Dial. Transplant. 26 (2011) 3866-3873.
33. S. Shetty, J.B. Gladden, E.S. Henson, X. Hu, J. Villanueva, N. Haney, S.B. Gibson, Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines, Apoptosis 7 (2002) 413-420.
34. Y.C. Chen, C.H. Chen, Y.H. Hsu, T.H. Chen, Y.M. Sue, C.Y. Cheng, T.W. Chen, Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway, Eur. J. Pharmacol. 658 (2011) 213-218.
35. X. Gong, G. Celsi, K. Carlsson, S. Norgren, Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells, Ren. Fail. 34 (2012) 487-494.