Targeting DNA vaccines to myeloid cells using a small peptide

European Journal of Immunology

Volumn 45, Issue 1, 2015, Pages 82-88

  Ye, Chunting ^a   Choi, Jang Gi ^a   Abraham, Sojan ^a   Shankar, Premlata ^a   Manjunath, N ^a  

^a Texas Tech University Health Sciences Center El Paso   (United States)

Author keywords

Antigen targeting; Dendritic cells; DNA vaccine; Immune response; Rabies virus glycoprotein peptide

Indexed keywords

DNA VACCINE; GLYCOPROTEIN; NEUTRALIZING ANTIBODY; PROTAMINE; REAGENT; PEPTIDE; VIRAL PROTEIN; VIRUS ANTIGEN; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW CELL; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG TARGETING; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABIES VIRUS; T LYMPHOCYTE; VACCINIA; WEST NILE FLAVIVIRUS; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CYTOLOGY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFECTS; GENETIC ENGINEERING; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MOLECULAR GENETICS; SYNTHESIS; VACCINIA VIRUS; VIROLOGY; WEST NILE FEVER; WEST NILE VIRUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, VIRAL; DENDRITIC CELLS; GENETIC ENGINEERING; GLYCOPROTEINS; IMMUNIZATION; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PEPTIDES; RABIES VIRUS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, DNA; VACCINIA VIRUS; VIRAL PROTEINS; VIRAL VACCINES; WEST NILE FEVER; WEST NILE VIRUS;

EID: 84920972734     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201445010     Document Type: Article

References (32)

1. Bins, A. D., van den Berg, J. H., Oosterhuis, K. and Haanen, J. B., Recent advances towards the clinical application of DNA vaccines. Neth. J. Med. 2013. 71: 109-117.
2. Davis, B. S., Chang, G. J., Cropp, B., Roehrig, J. T., Martin, D. A., Mitchell, C. J., Bowen, R. et al., West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays. J. Virol. 2001. 75: 4040-4047.
3. Bergman, P. J., McKnight, J., Novosad, A., Charney, S., Farrelly, J., Craft, D., Wulderk, M. et al., Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial. Clin. Cancer Res. 2003. 9: 1284-1290.
4. Liu, M. A., DNA vaccines: an historical perspective and view to the future. Immunol. Rev. 2011. 239: 62-84.
5. Liu, M. A. and Ulmer, J. B., Human clinical trials of plasmid DNA vaccines. Adv. Genet. 2005. 55: 25-40.
6. + T cell immunity together with a dendritic cell targeted vaccine. Proc. Natl. Acad. Sci. USA 2008. 105: 2574-2579.
7. + T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J. Exp. Med. 2006. 203: 607-617.
8. Trumpfheller, C., Longhi, M. P., Caskey, M., Idoyaga, J., Bozzacco, L., Keler, T., Schlesinger, S. J. et al., Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity. J. Intern. Med. 2012. 271: 183-192.
9. Idoyaga, J., Cheong, C., Suda, K., Suda, N., Kim, J. Y., Lee, H., Park, C. G. et al., Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo. J. Immunol. 2008. 180: 3647-3650.
10. Idoyaga, J., Lubkin, A., Fiorese, C., Lahoud, M. H., Caminschi, I., Huang, Y., Rodriguez, A. et al., Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A. Proc. Natl. Acad. Sci. USA 2011. 108: 2384-2389.
11. + T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1. J. Immunol. 2006. 177: 2276-2284.
12. Bonifaz, L., Bonnyay, D., Mahnke, K., Rivera, M., Nussenzweig, M. C. and Steinman, R. M., Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med. 2002. 196: 1627-1638.
13. Bonifaz, L. C., Bonnyay, D. P., Charalambous, A., Darguste, D. I., Fujii, S., Soares, H., Brimnes, M. K. et al., In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 2004. 199: 815-824.
14. Stern, J. N., Keskin, D. B., Kato, Z., Waldner, H., Schallenberg, S., Anderson, A., von Boehmer, H. et al., Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc. Natl. Acad. Sci. USA 2010. 107: 17280-17285.
15. Hawiger, D., Masilamani, R. F., Bettelli, E., Kuchroo, V. K. and Nussenzweig, M. C., Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity 2004. 20: 695-705.
16. Tenbusch, M., Nchinda, G., Storcksdieck genannt Bonsmann, M., Temchura, V. and Uberla, K., Targeting the antigen encoded by adenoviral vectors to the DEC205 receptor modulates the cellular and humoral immune response. Int. Immunol. 2013. 25: 247-258.
17. Grossmann, C., Tenbusch, M., Nchinda, G., Temchura, V., Nabi, G., Stone, G. W., Kornbluth, R. S. et al., Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands. BMC Immunol. 2009. 10: 43.
18. Nchinda, G., Kuroiwa, J., Oks, M., Trumpfheller, C., Park, C. G., Huang, Y., Hannaman, D. et al., The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. J. Clin. Invest. 2008. 118: 1427-1436.
19. Demangel, C., Zhou, J., Choo, A. B., Shoebridge, G., Halliday, G. M. and Britton, W. J., Single chain antibody fragments for the selective targeting of antigens to dendritic cells. Mol. Immunol. 2005. 42: 979-985.
20. Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T. I., Donahoe, J. S., Courties, G., Lee, K. M. et al., Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat. Biotechnol. 2011. 29: 1005-1010.
21. Basha, G., Novobrantseva, T. I., Rosin, N., Tam, Y. Y., Hafez, I. M., Wong, M. K., Sugo, T. et al., Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol. Ther. 2011. 19: 2186-2200.
22. Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. et al., Rational design of cationic lipids for siRNA delivery. Nat. Biotechnol. 2010. 28: 172-176.
23. Love, K. T., Mahon, K. P., Levins, C. G., Whitehead, K. A., Querbes, W., Dorkin, J. R., Qin, J. et al., Lipid-like materials for low-dose, in vivo gene silencing. Proc. Natl. Acad. Sci. USA 2010. 107: 1864-1869.
24. Aouadi, M., Tesz, G. J., Nicoloro, S. M., Wang, M., Chouinard, M., Soto, E., Ostroff, G. R. et al., Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 2009. 458: 1180-1184.
25. Ye, C., Choi, J. G., Abraham, S., Wu, H., Diaz, D., Terreros, D., Shankar, P. et al., Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model. Proc. Natl. Acad. Sci. USA 2012. 109: 21052-21057.
26. Kim, S. S., Ye, C., Kumar, P., Chiu, I., Subramanya, S., Wu, H., Shankar, P. et al., Targeted delivery of siRNA to macrophages for anti-inflammatory treatment. Mol. Ther. 2010. 18: 993-1001.
27. Li, P., Liu, D., Miao, L., Liu, C., Sun, X., Liu, Y. and Zhang, N., A pH-sensitive multifunctional gene carrier assembled via layer-by-layer technique for efficient gene delivery. Int. J. Nanomedicine 2012. 7: 925-939.
28. Delgado, D., del Pozo-Rodriguez, A., Solinis, M. A., Aviles-Triqueros, M., Weber, B. H., Fernandez, E. and Gascon, A. R., Dextran and protamine-based solid lipid nanoparticles as potential vectors for the treatment of X-linked juvenile retinoschisis. Hum. Gene Ther. 2012. 23: 345-355.
29. Kumar, P., Wu, H., McBride, J. L., Jung, K. E., Kim, M. H., Davidson, B. L., Lee, S. K. et al., Transvascular delivery of small interfering RNA to the central nervous system. Nature 2007. 448: 39-43.
30. + T cell determinants to enable rational design and characterization of smallpox vaccines. J. Exp. Med. 2005. 201: 95-104.
31. Laouar, A., Manocha, M., Haridas, V. and Manjunath, N., Concurrent generation of effector and central memory CD8 T cells during vaccinia virus infection. PLoS One 2008. 3: e4089.
32. Ledgerwood, J. E., Pierson, T. C., Hubka, S. A., Desai, N., Rucker, S., Gordon, I. J., Enama, M. E. et al., A West Nile virus DNA vaccine utilizing a modified promoter induces neutralizing antibody in younger and older healthy adults in a phase I clinical trial. J. Infect. Dis. 2011. 203: 1396-1404.