-
1
-
-
77956938607
-
Mechanisms of vascular aging: New perspectives
-
Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci. 2010;65:1028-1041. doi:10.1093/gerona/glq113
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 1028-1041
-
-
Ungvari, Z.1
Kaley, G.2
De Cabo, R.3
Sonntag, W.E.4
Csiszar, A.5
-
2
-
-
84868497543
-
Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein
-
Yang K, Nie L, Huang Y, et al. Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein. Toxicol Lett. 2012;215:77-83. doi:10.1016/j.toxlet.2012.10.004
-
(2012)
Toxicol Lett.
, vol.215
, pp. 77-83
-
-
Yang, K.1
Nie, L.2
Huang, Y.3
-
3
-
-
79251528072
-
Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress
-
Yu M, Kim YJ, Kang DH. Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress. Clin J Am Soc Nephrol. 2011;6:30-39. doi:10.2215/ CJN.05340610
-
(2011)
Clin J Am Soc Nephrol.
, vol.6
, pp. 30-39
-
-
Yu, M.1
Kim, Y.J.2
Kang, D.H.3
-
4
-
-
84870741714
-
Klotho modulates the stress response in human senescent endothelial cells
-
Carracedo J, Buendía P, Merino A, et al. Klotho modulates the stress response in human senescent endothelial cells. Mech Ageing Dev. 2012;133:647-654. doi:10.1016/j.mad.2012.09.002
-
(2012)
Mech Ageing Dev.
, vol.133
, pp. 647-654
-
-
Carracedo, J.1
Buendía, P.2
Merino, A.3
-
5
-
-
70449715297
-
Vascular endothelial ageing, heartbeat after heartbeat
-
Thorin E, Thorin-Trescases N. Vascular endothelial ageing, heartbeat after heartbeat. Cardiovasc Res. 2009;84:24-32. doi:10.1093/cvr/cvp236
-
(2009)
Cardiovasc Res.
, vol.84
, pp. 24-32
-
-
Thorin, E.1
Thorin-Trescases, N.2
-
6
-
-
84896741055
-
Aging and chronic kidney disease: The impact on physical function and cognition
-
Anand S, Johansen KL, Kurella Tamura M. Aging and chronic kidney disease: The impact on physical function and cognition. J Gerontol A Biol Sci Med Sci. 2014;69:315-322. doi:10.1093/gerona/glt109
-
(2014)
J Gerontol A Biol Sci Med Sci.
, vol.69
, pp. 315-322
-
-
Anand, S.1
Johansen, K.L.2
Kurella Tamura, M.3
-
7
-
-
73249143062
-
Roles of oxidative stress and redox regulation in atherosclerosis
-
Kondo T, Hirose M, Kageyama K. Roles of oxidative stress and redox regulation in atherosclerosis. J Atheroscler Thromb. 2009;16:532-538. doi:10.5551/jat.1255
-
(2009)
J Atheroscler Thromb.
, vol.16
, pp. 532-538
-
-
Kondo, T.1
Hirose, M.2
Kageyama, K.3
-
8
-
-
0032493742
-
Age-dependent telomere shortening is slowed down by enrichment of intracellular Vitamin C via suppression of oxidative stress
-
Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci. 1998;63:935-948. doi:10.1016/S0024-3205(98)00351-8
-
(1998)
Life Sci.
, vol.63
, pp. 935-948
-
-
Furumoto, K.1
Inoue, E.2
Nagao, N.3
Hiyama, E.4
Miwa, N.5
-
9
-
-
70350586738
-
Carbamylated darbepoetin derivative prevents endothelial progenitor cell damage with no effect on angiogenesis
-
Ramirez R, Carracedo J, Nogueras S, et al. Carbamylated darbepoetin derivative prevents endothelial progenitor cell damage with no effect on angiogenesis. J Mol Cell Cardiol. 2009;47:781-788. doi:10.1016/j. yjmcc.2009.09.005
-
(2009)
J Mol Cell Cardiol.
, vol.47
, pp. 781-788
-
-
Ramirez, R.1
Carracedo, J.2
Nogueras, S.3
-
10
-
-
0030724491
-
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
-
Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45-51. doi:10.1038/36285
-
(1997)
Nature
, vol.390
, pp. 45-51
-
-
Kuro-O, M.1
Matsumura, Y.2
Aizawa, H.3
-
11
-
-
40149102029
-
Klotho as a regulator of oxidative stress and senescence
-
Kuro-o M. Klotho as a regulator of oxidative stress and senescence. Biol Chem. 2008;389:233-241. doi:10.1515/BC.2008.028
-
(2008)
Biol Chem.
, vol.389
, pp. 233-241
-
-
Kuro-O, M.1
-
12
-
-
0032489424
-
Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein
-
Shiraki-Iida T, Aizawa H, Matsumura Y, et al. Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 1998;424:6-10. doi:10.1016/S0014-5793(98) 00127-6
-
(1998)
FEBS Lett.
, vol.424
, pp. 6-10
-
-
Shiraki-Iida, T.1
Aizawa, H.2
Matsumura, Y.3
-
13
-
-
57749190558
-
Current understanding of klotho
-
Wang Y, Sun Z. Current understanding of klotho. Ageing Res Rev. 2009;8:43-51. doi:10.1016/j.arr.2008.10.002
-
(2009)
Ageing Res Rev.
, vol.8
, pp. 43-51
-
-
Wang, Y.1
Sun, Z.2
-
14
-
-
84880579414
-
Chronic kidney disease: A clinical model of premature aging
-
Stenvinkel P, Larsson TE. Chronic kidney disease: a clinical model of premature aging. Am J Kidney Dis. 2013;62:339-351. doi:10.1053/j. Ajkd.2012.11.051
-
(2013)
Am J Kidney Dis.
, vol.62
, pp. 339-351
-
-
Stenvinkel, P.1
Larsson, T.E.2
-
15
-
-
79959850992
-
Klotho and the aging process
-
Kuro-o M. Klotho and the aging process. Korean J Intern Med. 2011;26(2):113-22. doi:10.3904/kjim.2011.26.2.113
-
(2011)
Korean J Intern Med.
, vol.26
, Issue.2
, pp. 113-122
-
-
Kuro-O, M.1
-
16
-
-
84899482885
-
4-Phenylbutyric acid suppresses inflammation through regulation of endoplasmic reticulum stress of endothelial cells stimulated by uremic serum
-
Zeng W, Guo YH, Qi W, et al. 4-Phenylbutyric acid suppresses inflammation through regulation of endoplasmic reticulum stress of endothelial cells stimulated by uremic serum. Life Sciences. 2014;103(1):15-24. doi:10.1016/j.lfs.2014.03.007
-
(2014)
Life Sciences
, vol.103
, Issue.1
, pp. 15-24
-
-
Zeng, W.1
Guo, Y.H.2
Qi, W.3
-
17
-
-
13844318061
-
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice
-
Li SA, Watanabe M, Yamada H, Nagai A, Kinuta M, Takei K. Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct. 2004;29:91-99. doi:10.1247/ csf.29.91
-
(2004)
Cell Struct Funct.
, vol.29
, pp. 91-99
-
-
Li, S.A.1
Watanabe, M.2
Yamada, H.3
Nagai, A.4
Kinuta, M.5
Takei, K.6
-
18
-
-
79952281150
-
Klotho suppresses RIG-I-mediated senescenceassociated inflammation
-
Liu F, Wu S, Ren H, Gu J. Klotho suppresses RIG-I-mediated senescenceassociated inflammation. Nat Cell Biol. 2011;13:254-262. doi:10.1038/ ncb2167
-
(2011)
Nat Cell Biol.
, vol.13
, pp. 254-262
-
-
Liu, F.1
Wu, S.2
Ren, H.3
Gu, J.4
-
19
-
-
28844474827
-
Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
-
Ikushima M, Rakugi H, Ishikawa K, et al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun. 2006;339:827-832. doi:10.1016/j.bbrc.2005.11.094
-
(2006)
Biochem Biophys Res Commun.
, vol.339
, pp. 827-832
-
-
Ikushima, M.1
Rakugi, H.2
Ishikawa, K.3
-
20
-
-
79960144041
-
The inflammatory cytokines TWEAK and TNF? Reduce renal klotho expression through NFB
-
Moreno JA, Izquierdo MC, Sanchez-Niño MD, et al. The inflammatory cytokines TWEAK and TNF reduce renal klotho expression through NFB. J Am Soc Nephrol. 2011;22:1315-1325. doi:10.1681/ ASN.2010101073
-
(2011)
J Am Soc Nephrol.
, vol.22
, pp. 1315-1325
-
-
Moreno, J.A.1
Izquierdo, M.C.2
Sanchez-Niño, M.D.3
-
21
-
-
84879261404
-
Cellular senescence determines endothelial cell damage induced by uremia
-
Carracedo J, Buendía P, Merino A, et al. Cellular senescence determines endothelial cell damage induced by uremia. Exp Gerontol. 2013;48:766-773. doi:10.1016/j.exger.2013.04.004
-
(2013)
Exp Gerontol.
, vol.48
, pp. 766-773
-
-
Carracedo, J.1
Buendía, P.2
Merino, A.3
-
22
-
-
84863338125
-
Suppression of Klotho expression by proteinbound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation
-
Sun CY, Chang SC, Wu MS. Suppression of Klotho expression by proteinbound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int. 2012;81:640-650. doi:10.1038/ki.2011.445
-
(2012)
Kidney Int.
, vol.81
, pp. 640-650
-
-
Sun, C.Y.1
Chang, S.C.2
Wu, M.S.3
-
23
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone Klotho. Science. 2005;309:1829-1833. doi:10.1038/science. 1112766
-
(2005)
Science
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
24
-
-
80052101334
-
Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation
-
Zhao Y, Banerjee S, Dey N, et al. Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes. 2011;60:1907-1916. doi:10.2337/ db10-1262
-
(2011)
Diabetes
, vol.60
, pp. 1907-1916
-
-
Zhao, Y.1
Banerjee, S.2
Dey, N.3
-
25
-
-
80051518025
-
Plasma klotho and mortality risk in older community-dwelling adults
-
Semba RD, Cappola AR, Sun K, et al. Plasma klotho and mortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci. 2011;66:794-800. doi:10.1093/gerona/glr058
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 794-800
-
-
Semba, R.D.1
Cappola, A.R.2
Sun, K.3
-
26
-
-
79952279677
-
Klotho and kidney disease
-
Hu MC, Kuro-o M, Moe OW. Klotho and kidney disease. J Nephrol. 2010;23(16 Suppl):S136-S144
-
(2010)
J Nephrol.
, vol.23
, Issue.16
, pp. S136-S144
-
-
Hu, M.C.1
Kuro-O, M.2
Moe, O.W.3
-
27
-
-
78651408919
-
Klotho deficiency causes vascular calcification in chronic kidney disease
-
Hu MC, Shi M, Zhang J, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22:124-136. doi:10.1681/ASN.2009121311
-
(2011)
J Am Soc Nephrol.
, vol.22
, pp. 124-136
-
-
Hu, M.C.1
Shi, M.2
Zhang, J.3
-
28
-
-
84943010194
-
Endothelial dysfunction in chronic renal failure
-
Santoro D, Bellinghieri G, Conti G, et al. Endothelial dysfunction in chronic renal failure. J Ren Nutr. 2010;20(5 Suppl):S103-S108. doi:10.1053/j. jrn.2010.06.010
-
(2010)
J Ren Nutr.
, vol.20
, Issue.5
, pp. S103-S108
-
-
Santoro, D.1
Bellinghieri, G.2
Conti, G.3
-
29
-
-
78650684104
-
Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats
-
Adijiang A, Shimizu H, Higuchi Y, Nishijima F, Niwa T. Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats. J Ren Nutr. 2011;21:105-109. doi:10.1053/j. jrn.2010.10.020
-
(2011)
J Ren Nutr.
, vol.21
, pp. 105-109
-
-
Adijiang, A.1
Shimizu, H.2
Higuchi, Y.3
Nishijima, F.4
Niwa, T.5
-
30
-
-
79952346794
-
Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-B
-
Shimizu H, Bolati D, Adijiang A, et al. Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-B. Am J Nephrol. 2011;33:319-324. doi:10.1159/000324885
-
(2011)
Am J Nephrol.
, vol.33
, pp. 319-324
-
-
Shimizu, H.1
Bolati, D.2
Adijiang, A.3
-
31
-
-
34250163587
-
The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells
-
Dou L, Jourde-Chiche N, Faure V, et al. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J Thromb Haemost. 2007;5:1302-1308. doi:10.1111/j.1538-7836.2007.02540.x
-
(2007)
J Thromb Haemost.
, vol.5
, pp. 1302-1308
-
-
Dou, L.1
Jourde-Chiche, N.2
Faure, V.3
-
32
-
-
71549120440
-
Uremic toxicity, oxidative stress, and hemodialysis as renal replacement therapy
-
Himmelfarb J. Uremic toxicity, oxidative stress, and hemodialysis as renal replacement therapy. Semin Dial. 2009;22:636-643. doi:10.1111/j.1525-139X.2009.00659.x
-
(2009)
Semin Dial
, vol.22
, pp. 636-643
-
-
Himmelfarb, J.1
-
33
-
-
78649350746
-
The aging stress response
-
Haigis MC, Yankner BA. The aging stress response. Mol Cell. 2010;40:333-344. doi:10.1016/j.molcel.2010.10.002
-
(2010)
Mol Cell
, vol.40
, pp. 333-344
-
-
Haigis, M.C.1
Yankner, B.A.2
-
34
-
-
1342345219
-
Nuclear factor kappaB: A potential therapeutic target in atherosclerosis and thrombosis
-
Monaco C, Paleolog E. Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis. Cardiovasc Res. 2004;61:671-682. doi:10.1016/j.cardiores.2003.11.038
-
(2004)
Cardiovasc Res.
, vol.61
, pp. 671-682
-
-
Monaco, C.1
Paleolog, E.2
-
35
-
-
40849127117
-
Differential expression of proteins from cultured endothelial cells exposed to uremic versus normal serum
-
Carbó C, Arderiu G, Escolar G, et al. Differential expression of proteins from cultured endothelial cells exposed to uremic versus normal serum. Am J Kidney Dis. 2008;51:603-612. doi:10.1053/j.ajkd.2007. 11.029
-
(2008)
Am J Kidney Dis.
, vol.51
, pp. 603-612
-
-
Carbó, C.1
Arderiu, G.2
Escolar, G.3
-
36
-
-
77954203322
-
Recombinant human erythropoietin mitigates reductions in renal klotho expression
-
Sugiura H, Yoshida T, Mitobe M, Shiohira S, Nitta K, Tsuchiya K. Recombinant human erythropoietin mitigates reductions in renal klotho expression. Am J Nephrol. 2010;32:137-144. doi:10.1159/000.15864
-
(2010)
Am J Nephrol.
, vol.32
, pp. 137-144
-
-
Sugiura, H.1
Yoshida, T.2
Mitobe, M.3
Shiohira, S.4
Nitta, K.5
Tsuchiya, K.6
-
37
-
-
79952167540
-
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
-
Yoon HE, Ghee JY, Piao S, et al. Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant. 2011;26:800-813. doi:10.1093/ndt/gfq537
-
(2011)
Nephrol Dial Transplant
, vol.26
, pp. 800-813
-
-
Yoon, H.E.1
Ghee, J.Y.2
Piao, S.3
|