Klotho modulates the stress response in human senescent endothelial cells

Mechanisms of Ageing and Development

Volumn 133, Issue 11-12, 2012, Pages 647-654

  Carracedo, Julia ^a,b   Buendía, Paula ^a,b   Merino, Ana ^a,b,d   Madueño, Juan Antonio ^a,b   Peralbo, Esther ^a   Ortiz, Alberto ^b,c   Martín Malo, Alejandro ^a,b   Aljama, Pedro ^a,b   Rodríguez, Mariano ^a,b   Ramírez, Rafael ^a,b,e  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c Hospital UniversitarioFundación Jiménez Díaz   (Spain)

^d BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^e UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Cell senescence; Human endothelial cells; Klotho; Stress induced premature senescence

Indexed keywords

BETA GALACTOSIDASE; KLOTHO PROTEIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL AGING; CELL COUNT; CELL DIVISION; CELL POPULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM CELL; EXPOSURE; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRESS; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING;

AGING; ANIMALS; BETA-GALACTOSIDASE; CELL AGING; CELL PROLIFERATION; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLUCURONIDASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TELOMERE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84870741714     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2012.09.002     Document Type: Article

References (30)

1. Andrews N.C., Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Research 1991, 19:2499.
2. Chen Q.M., Prowse K.R., Tu V.C., Purdom S., Linskens M.H. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Experimental Cell Research 2001, 265:294-303.
3. Cristofalo V.J., Lorenzini A., Allen R.G., Torres C., Tresini M. Replicative senescence: a critical review. Mechanisms of Ageing and Development 2004, 125:827-848.
4. Hastings R., Qureshi M., Verma R., Lacy P.S., Williams B. Telomere attrition and accumulation of senescent cells in cultured human endothelial cells. Cell Proliferation 2004, 37:317-324.
5. Hayashi Y., Okino N., Kakuta Y., Shikanai T., Tani M., Narimatsu H., Ito M. Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. Journal of Biological Chemistry 2007, 282:30889-30900.
6. Ikushima M., Rakugi H., Ishikawa K., Maekawa Y., Yamamoto K., Ohta J., Chihara Y., Kida I., Ogihara T. Anti-apoptotic and anti-senescence effects of klotho on vascular endothelial cells. Biochemical and Biophysical Research Communications 2006, 339:827-832.
7. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Iida T., Nishikawa S., Nagai R., Nabeshima Y.I. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997, 390:45-51.
8. Kurosu H., Ogawa Y., Miyoshi M., Yamamoto M., Nandi A., Rosenblatt K.P., Baum M.G., Schiavi S., Hu M.C., Moe O.W., Kuro-o M. Regulation of fibroblast growth factor-23 signaling by klotho. Journal of Biological Chemistry 2006, 281:6120-6123.
9. 2+ channel to maintain endothelial integrity. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:19308-19313.
10. Levine E.M., Mueller S.N. Cultured vascular endothelial cells as a model system for the study of cellular senescence. International Review of Cytology. Supplement 1979, 10:67-76.
11. Li S.A., Watanabe M., Yamada H., Nagai A., Kinuta M., Takei K. Immunohistochemical localization of klotho protein in brain, kidney, and reproductive organs of mice. Cell Structure and Function 2004, 29:91-99.
12. Liu F., Wu S., Ren H., Gu J. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nature Cell Biology 2011, 13:254-262.
13. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 2001, 25:402-408.
14. Maekawa Y., Ohishi M., Ikushima M., Yamamoto K., Yasuda O., Oguro R., Yamamoto-Hanasaki H., Tatara Y., Takeya Y., Rakugi H. Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway. Geriatrics & Gerontology International 2011, 11:510-516.
15. Martin-Ventura J.L., Munoz-Garcia B., Egido J., Blanco-Colio L.M. Trail and vascular injury. Frontiers in Bioscience 2007, 12.:3656-3667.
16. Moreno J.A., Izquierdo M.C., Sanchez-Niño M.D., Suárez-Alvarez B., Lopez-Larrea C., Jakubowski A., Blanco J., Ramirez R., Selgas R., Ruiz-Ortega M., Egido J., Ortiz A., Sanz A.B. The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB. Journal of the American Society of Nephrology 2011, 22:1315-1325.
17. Nagai R., Saito Y., Ohyama Y., Aizawa H., Suga T., Nakamura T., Kurabayashi M., Kuro-o M. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cellular and Molecular Life Sciences 2000, 57:738-746.
18. Nogueras S., Merino A., Ojeda R., Carracedo J., Rodríguez M., Martín-Malo A., Ramírez R., Aljama P. Coupling of endothelial injury and repair. An analysis in vivo experimental model. American Journal of Physiology. Heart and Circulatory Physiology 2008, 294:708-713.
19. Ramírez R., Carracedo J., Jiménez R., Canela A., Herrera E., Aljama P., Blasco M.A. Massive telomere loss is an early event of DNA damage-induced apoptosis. Journal of Biological Chemistry 2003, 278:836-842.
20. Rakugi H., Matsukawa N., Ishikawa K., Yang J., Imai M., Ikushima M., Maekawa Y., Kida I., Miyazaki J., Ogihara T. Anti-oxidative effect of klotho on endothelial cells through cAMP activation. Endocrine 2007, 31:82-87.
21. Ruan W., Xu J.M., Li S.B., Yuan L.Q., Dai R.P. Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways. Cardiovascular Research 2012, 15:623-632.
22. Saito Y., Yamagishi T., Nakamura T., Ohyama Y., Aizawa H., Suga T., Matsumura Y., Masuda H., Kurabayashi M., Kuro-o M., Nabeshima Y., Nagai R. Klotho protein protects against endothelial dysfunction. Biochemical and Biophysical Research Communications 1998, 248:324-329.
23. Serrano M., Blasco M.A. Putting the stress on senescence. Current Opinion in Cell Biology 2001, 13:748-753.
24. Shiraki-Iida T., Aizawa H., Matsumura Y., Sekine S., Iida A., Anazawa H., Nagai R., Kuro-o M., Nabeshima Y. Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Letters 1998, 424:6-10.
25. Takahashi Y., Kuro-o M., Ishikawa F. Aging mechanisms. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:12407-12408.
26. Toussaint O., Dumont P., Dierick J.F., Pascal T., Frippiat C., Chainiaux F., Sluse F., Eliaers F., Remacle J. Stress-induced premature senescence. Essence of life, evolution, stress, and aging. Annals of the New York Academy of Sciences 2000, 908:85-98.
27. Witkowski J.M., Soroczyńska-Cybula M., Bryl E., Smoleńska Z., Jóźwik A. Klotho - a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. Journal of Immunology 2007, 178:771-777.
28. Zauli G., Secchiero P. The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology. Cytokine and Growth Factor Reviews 2006, 17:245-257.
29. Zhang J., Hui C., Su L., Xiaoyun W., Xi H., Yingchuan F. The association between telomere length and sensitivity to apoptosis of HUVEC. Advances in Experimental Medicine and Biology 2010, 664:47-53.
30. Zhou Z., Hu C.P., Wang C.J., Li T.T., Peng J., Li Y.J. Calcitonin gene-related peptide inhibits angiotensin II-induced endothelial progenitor cells senescence through up-regulation of klotho expression. Atherosclerosis 2010, 213:92-101.