Differential Expression of Proteins From Cultured Endothelial Cells Exposed to Uremic Versus Normal Serum

American Journal of Kidney Diseases

Volumn 51, Issue 4, 2008, Pages 603-612

  Carbó, Carla ^a   Arderiu, Gemma ^a   Escolar, Ginés ^a   Fusté, Berta ^a   Cases, Aleix ^a   Carrascal, Montserrat ^b   Abián, Joaquín ^b   Díaz Ricart, Maribel ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

Author keywords

Endothelial dysfunction; inflammation; oxidative stress; proteomics; SOD; uremia

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; ALDEHYDE REDUCTASE; GLUTATHIONE PEROXIDASE; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; VIMENTIN;

ADULT; AGED; ARTICLE; CELL CULTURE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FEMALE; HEMODIALYSIS; HEMOSTASIS; HUMAN; HUMAN TISSUE; ISOELECTRIC POINT; MALE; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEOMICS; SILVER STAINING; TWO DIMENSIONAL GEL ELECTROPHORESIS; UREMIA;

BLOOD PHYSIOLOGY; CELLS, CULTURED; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; ENDOTHELIAL CELLS; FEMALE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; PROTEIN BIOSYNTHESIS; UREMIA;

EID: 40849127117     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2007.11.029     Document Type: Article

References (41)

1. Gordge M.P., and Neild G.H. Platelet function in uraemia. Platelets 2 (1991) 115-123
2. Escolar G., Diaz-Ricart M., and Cases A. Uremic platelet dysfunction: Past and present. Curr Hematol Rep 4 (2005) 359-367
3. Huysmans K., Lins R.L., Daelemans R., et al. Hypertension and accelerated atherosclerosis in end stage renal disease. J Nephrol 11 (1998) 185-195
4. van Guldener C., Lambert J., Janssen M.J., et al. Endothelium-dependent vasodilatation and distensibility of large arteries in chronic haemodialysis patients. Nephrol Dial Transplant 12 (1997) 14-18
5. Aznar-Salatti J., Escolar G., Cases A., et al. Uraemic medium causes endothelial cell dysfunction characterized by an alteration of the properties of its subendothelial matrix. Nephrol Dial Transplant 10 (1995) 2199-2204
6. Serradell M., Diaz-Ricart M., Cases A., et al. Uremic medium disturbs the hemostatic balance of cultured human endothelial cells. Thromb Haemost 86 (2001) 1099-1105
7. Serradell M., Diaz-Ricart M., Cases A., et al. Uremic medium causes expression, redistribution and shedding of adhesion molecule in cultured endothelial cells. Haematologica 87 (2002) 1053-1061
8. Cines D.B., Pollak E.S., Buck C.A., et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91 (1998) 3527-3561
9. Morris S.T., and Jardine A.G. The vascular endothelium in chronic renal failure. J Nephrol 13 (2000) 96-105
10. Serradell M., Diaz-Ricart M., Cases A., et al. Uraemic medium accelerates proliferation but does not induce apoptosis of endothelial cells in culture. Nephrol Dial Transplant 18 (2003) 1079-1085
11. Jaffe E.A., Nachman R.L., Becker C.G., et al. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52 (1973) 2745-2756
12. Quero C., Colome N., Prieto M.R., et al. Determination of protein markers in human serum: Analysis of protein expression in toxic oil syndrome studies. Proteomics 4 (2004) 303-315
13. Shevchenko A., Wilm M., Vorm O., et al. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 68 (1996) 850-858
14. Gris J.C., Branger B., Vecina F., et al. Increased cardiovascular risk factors and features of endothelial activation and dysfunction in dialyzed uremic patients. Kidney Int 46 (1994) 807-813
15. Koyama H., Tabata T., Nishzawa Y., et al. Plasma endothelin levels in patients with uraemia. Lancet 1 (1989) 991-992
16. Passauer J., Bussemaker E., Range U., et al. Evidence in vivo showing increase of baseline nitric oxide generation and impairment of endothelium-dependent vasodilation in normotensive patients on chronic hemodialysis. J Am Soc Nephrol 11 (2000) 1726-1734
17. Price D.T., and Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med 107 (1999) 85-97
18. Fiuza C., Bustin M., Talwar S., et al. Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. Blood 101 (2003) 2652-2660
19. Ramana K.V., Bhatnagar A., and Srivastava S.K. Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J 18 (2004) 1209-1218
20. Dagia N.M., and Goetz D.J. A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1 beta- and TNF-alpha-induced ECAM expression and adhesion. Am J Physiol Cell Physiol 285 (2003) 813-822
21. Read M.A., Neish A.S., Luscinskas F.W., et al. The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity 2 (1995) 493-506
22. Goldberg A.L. Protein degradation and protection against misfolded or damaged proteins. Nature 426 (2003) 895-899
23. Elliott P.J., Zollner T.M., and Boehncke W.H. Proteasome inhibition: A new anti-inflammatory strategy. J Mol Med 81 (2003) 235-245
24. Reinstein E. The ubiquitin system for intracellular protein degradation involvement in human pathologies and therapeutic implications. Harefuah 143 (2004) 605-608 621, 620
25. Lin S.J., Shyue S.K., Hung Y.Y., et al. Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways. Arterioscler Thromb Vasc Biol 25 (2005) 334-340
26. Hernandez-Saavedra D., Zhou H., and McCord J.M. Anti-inflammatory properties of a chimeric recombinant superoxide dismutase: SOD2/3. Biomed Pharmacother 59 (2005) 204-208
27. Barnes P.J. Nuclear factor-kappa B. Int J Biochem Cell Biol 29 (1997) 867-870
28. Johnson F., and Giulivi C. Superoxide dismutases and their impact upon human health. Mol Aspects Med 26 (2005) 340-352
29. Himmelfarb J., Stenvinkel P., Ikizler T.A., et al. The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 62 (2002) 1524-1538
30. Canaud B., Cristol J., Morena M., et al. Imbalance of oxidants and antioxidants in haemodialysis patients. Blood Purif 17 (1999) 99-106
31. Vincent A.S., Lim B.G., Tan J., et al. Sulfite-mediated oxidative stress in kidney cells. Kidney Int 65 (2004) 393-402
32. Brigelius-Flohe R., Banning A., and Schnurr K. Selenium-dependent enzymes in endothelial cell function. Antioxid Redox Signal 5 (2003) 205-215
33. Himmelfarb J. Relevance of oxidative pathways in the pathophysiology of chronic kidney disease. Cardiol Clin 23 (2005) 319-330
34. Chang T.S., Cho C.S., Park S., et al. Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J Biol Chem 279 (2004) 41975-41984
35. Chacko G., Ling Q., and Hajjar K.A. Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta. J Biol Chem 273 (1998) 19840-19846
36. Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab 6 (2005) 27-36
37. Hotulainen P., Paunola E., Vartiainen M.K., et al. Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell 16 (2005) 649-664
38. Tsuruta D., and Jones J.C. The vimentin cytoskeleton regulates focal contact size and adhesion of endothelial cells subjected to shear stress. J Cell Sci 116 (2003) 4977-4984
39. Lee D.B., Jamgotchian N., Allen S.G., et al. Annexin A2 heterotetramer: Role in tight junction assembly. Am J Physiol Renal Physiol 287 (2004) 481-491
40. Koc M., Bihorac A., and Segal M.S. Circulating endothelial cells as potential markers of the state of the endothelium in hemodialysis patients. Am J Kidney Dis 42 (2003) 704-712
41. Rodriguez-Ayala E., Yao Q., Holmen C., et al. Imbalance between detached circulating endothelial cells and endothelial progenitor cells in chronic kidney disease. Blood Purif 24 (2005) 196-202