Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Kato, Shinichi ^a   Hayashi, Shusaku ^b   Kitahara, Yumeno ^a   Nagasawa, Koyo ^a   Aono, Hitomi ^a   Shibata, Junichiro ^a   Utsumi, Daichi ^a   Amagase, Kikuko ^a   Kadowaki, Makoto ^b  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOKINE; DAIKENCHUTO; FLUOROURACIL; HERBACEOUS AGENT; INTERLEUKIN 1BETA; SAIREI TO; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; INTERLEUKIN-1BETA (163-171); PEPTIDE FRAGMENT; SAIREI-TO; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CLINICAL EFFECTIVENESS; COLON CANCER; CONTROLLED STUDY; CRYPT CELL; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; ENZYME REPRESSION; HISTOCHEMISTRY; INTESTINE MUCOSA; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRADITIONAL MEDICINE; UPREGULATION; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; C57BL MOUSE; CHEMICALLY INDUCED; CHINESE MEDICINE; CYTOLOGY; DRUG EFFECTS; GENETICS; INTESTINE; JAPAN; METABOLISM; MUCOSITIS; PATHOLOGY;

MUS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BODY WEIGHT; CASPASE 3; CYTOKINES; DRUGS, CHINESE HERBAL; FLUOROURACIL; INTERLEUKIN-1BETA; INTESTINES; JAPAN; MALE; MEDICINE, KAMPO; MEDICINE, TRADITIONAL; MICE; MICE, INBRED C57BL; MUCOSITIS; PEPTIDE FRAGMENTS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84920774525     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116213     Document Type: Article

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