5-HT3 receptor antagonists ameliorate 5-fluorouracilinduced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells

British Journal of Pharmacology

Volumn 168, Issue 6, 2013, Pages 1388-1400

  Yasuda, M ^a   Kato, Shinichi ^a   Yamanaka, N ^a   Iimori, M ^a   Matsumoto, K ^b   Utsumi, D ^a   Kitahara, Y ^a   Amagase, K ^a   Horie, S ^b   Takeuchi, K ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b JOSAI INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

5 fluorouracil; 5 HT3 receptors; apoptosis; caspase 3; caspase 8; intestinal mucositis; ondansetron; ramosetron; TNF

Indexed keywords

CASPASE 3; CASPASE 8; FLUOROURACIL; INTERLEUKIN 1BETA; INTERLEUKIN 6; ONDANSETRON; PROTEIN BAX; PROTEIN BCL 2; RAMOSETRON; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL DESTRUCTION; CELL PROLIFERATION; CELL SHAPE; CONTROLLED STUDY; CRYPT CELL; CYTOKINE PRODUCTION; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVATION; HISTOLOGY; INTESTINAL MUCOSITIS; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; MALE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE; UPREGULATION; WEIGHT REDUCTION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZIMIDAZOLES; COLONIC NEOPLASMS; CYTOKINES; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUOROURACIL; GASTROINTESTINAL AGENTS; GENE EXPRESSION REGULATION; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MUCOSITIS; ONDANSETRON; SEROTONIN 5-HT3 RECEPTOR AGONISTS; SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS;

EID: 84874437013     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12019     Document Type: Article

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