Genetic underpinnings of white matter 'connectivity': Heritability, risk, and heterogeneity in schizophrenia

Schizophrenia Research

Volumn 161, Issue 1, 2015, Pages 50-60

  Voineskos, Aristotle N ^a,b,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Diffusion tensor imaging; Genetics; GWAS; Heritability; Quantitative trait; Schizophrenia; White matter

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 4; MESSENGER RNA; MICRORNA; MICRORNA 137; NEU DIFFERENTIATION FACTOR; UNCLASSIFIED DRUG;

BRAIN SIZE; DIFFUSION TENSOR IMAGING; FIRST DEGREE RELATIVE; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; HERITABILITY; HUMAN; MYELINATION; NERVE CELL NETWORK; NERVE GROWTH; NERVOUS SYSTEM DEVELOPMENT; NEUROIMAGING; OLIGODENDROGLIA; PENETRANCE; PERSONALIZED MEDICINE; QUANTITATIVE TRAIT LOCUS; REVIEW; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; WHITE MATTER; GENETIC ASSOCIATION STUDY; GENETICS; MYELINATED NERVE; PATHOLOGY; PHENOTYPE;

DIFFUSION TENSOR IMAGING; GENETIC ASSOCIATION STUDIES; HUMANS; NERVE FIBERS, MYELINATED; PHENOTYPE; QUANTITATIVE TRAIT LOCI; SCHIZOPHRENIA; WHITE MATTER;

EID: 84920647106     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.03.034     Document Type: Review

References (121)

1. Agartz I., Brown A.A., Rimol L.M., Hartberg C.B., Dale A.M., Melle I., Djurovic S., Andreassen O.A. Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia. Biol. Psychiatry 2011, 70(7):696-698.
2. Akil H., Brenner S., Kandel E., Kendler K.S., King M.C., Scolnick E., Watson J.D., Zoghbi H.Y. Medicine. The future of psychiatric research: genomes and neural circuits. Science 2010, 327(5973):1580-1581.
3. Baare W.F., Hulshoff Pol H.E., Boomsma D.I., Posthuma D., de Geus E.J., Schnack H.G., van Haren N.E., van Oel C.J., Kahn R.S. Quantitative genetic modeling of variation in human brain morphology. Cereb. Cortex 2001, 11(9):816-824.
4. Basser P.J., Mattiello J., LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys. J. 1994, 66(1):259-267.
5. Batouli S.A., Trollor J.N., Wen W., Sachdev P.S. The heritability of volumes of brain structures and its relationship to age: a review of twin and family studies. Ageing Res. Rev. 2013, 13C:1-9.
6. Batouli S.A., Sachdev P.S., Wen W., Wright M.J., Ames D., Trollor J.N. Heritability of brain volumes in older adults: the Older Australian Twins Study. Neurobiol. Aging 2014, 35(4):937. (e935-937 e918).
7. Bernstein B.E., Birney E., Dunham I., Green E.D., Gunter C., Snyder M. An integrated encyclopedia of DNA elements in the human genome. Nature 2012, 489(7414):57-74.
8. Bertisch H., Li D., Hoptman M.J., Delisi L.E. Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010, 153B(4):885-894.
9. Bigos K.L., Mattay V.S., Callicott J.H., Straub R.E., Vakkalanka R., Kolachana B., Hyde T.M., Lipska B.K., Kleinman J.E., Weinberger D.R. Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch. Gen. Psychiatry 2010, 67(9):939-945.
10. Birney E. The making of ENCODE: lessons for big-data projects. Nature 2012, 489(7414):49-51.
11. Bis J.C., DeCarli C., Smith A.V., van der Lijn F., Crivello F., Fornage M., Debette S., Shulman J.M., Schmidt H., Srikanth V., Schuur M., Yu L., Choi S.H., Sigurdsson S., Verhaaren B.F., DeStefano A.L., Lambert J.C., Jack C.R., Struchalin M., Stankovich J., Ibrahim-Verbaas C.A., Fleischman D., Zijdenbos A., den Heijer T., Mazoyer B., Coker L.H., Enzinger C., Danoy P., Amin N., Arfanakis K., van Buchem M.A., de Bruijn R.F., Beiser A., Dufouil C., Huang J., Cavalieri M., Thomson R., Niessen W.J., Chibnik L.B., Gislason G.K., Hofman A., Pikula A., Amouyel P., Freeman K.B., Phan T.G., Oostra B.A., Stein J.L., Medland S.E., Vasquez A.A., Hibar D.P., Wright M.J., Franke B., Martin N.G., Thompson P.M., Nalls M.A., Uitterlinden A.G., Au R., Elbaz A., Beare R.J., van Swieten J.C., Lopez O.L., Harris T.B., Chouraki V., Breteler M.M., De Jager P.L., Becker J.T., Vernooij M.W., Knopman D., Fazekas F., Wolf P.A., van der Lugt A., Gudnason V., Longstreth W.T., Brown M.A., Bennett D.A., van Duijn C.M., Mosley T.H., Schmidt R., Tzourio C., Launer L.J., Ikram M.A., Seshadri S. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat. Genet. 2012, 44(5):545-551.
12. Blokland G.A., de Zubicaray G.I., McMahon K.L., Wright M.J. Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies. Twin Res. Hum. Genet. 2012, 15(3):351-371.
13. Blokland G.A., CONSORTIUM, G., Petryshen T.L. The GENUS consortium: genetics of endophenotypes of neurofunction to understand schizophrenia. World Congress of Psychiatric Genetics, Boston, MA 2013.
14. Brans R.G., van Haren N.E., van Baal G.C., Schnack H.G., Kahn R.S., Hulshoff Pol H.E. Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Arch. Gen. Psychiatry 2008, 65(11):1259-1268.
15. Braskie M.N., Jahanshad N., Stein J.L., Barysheva M., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Ringman J.M., Toga A.W., Thompson P.M. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J. Neurosci. 2011, 31(18):6764-6770.
16. Braskie M.N., Jahanshad N., Stein J.L., Barysheva M., Johnson K., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Ringman J.M., Toga A.W., Thompson P.M. Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. J. Neurosci. 2012, 32(17):5964-5972.
17. Braskie M.N., Kohannim O., Jahanshad N., Chiang M.C., Barysheva M., Toga A.W., Ringman J.M., Montgomery G.W., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Thompson P.M. Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage 2013, 82:146-153.
18. Brouwer R.M., Mandl R.C., Peper J.S., van Baal G.C., Kahn R.S., Boomsma D.I., Hulshoff Pol H.E. Heritability of DTI and MTR in nine-year-old children. Neuroimage 2010, 53(3):1085-1092.
19. Callicott J.H., Feighery E.L., Mattay V.S., White M.G., Chen Q., Baranger D.A., Berman K.F., Lu B., Song H., Ming G.L., Weinberger D.R. DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity. J. Clin. Invest. 2013, 123(7):2961-2964.
20. Cannon D.M., Walshe M., Dempster E., Collier D.A., Marshall N., Bramon E., Murray R.M., McDonald C. The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives. Transl. Psychiatry 2012, 2:e167.
21. Chen S., Velardez M.O., Warot X., Yu Z.X., Miller S.J., Cros D., Corfas G. Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function. J. Neurosci. 2006, 26(12):3079-3086.
22. Chiang M.C., Avedissian C., Barysheva M., Toga A.W., McMahon K.L., de Zubicaray G.I., Wright M.J., Thompson P.M. Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture. Med. Image Comput. Comput. Assist. Interv. 2009, 12(Pt 2):506-513.
23. Chiang M.C., Barysheva M., Shattuck D.W., Lee A.D., Madsen S.K., Avedissian C., Klunder A.D., Toga A.W., McMahon K.L., de Zubicaray G.I., Wright M.J., Srivastava A., Balov N., Thompson P.M. Genetics of brain fiber architecture and intellectual performance. J. Neurosci. 2009, 29(7):2212-2224.
24. Chiang M.C., Barysheva M., Toga A.W., Medland S.E., Hansell N.K., James M.R., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Thompson P.M. BDNF gene effects on brain circuitry replicated in 455 twins. Neuroimage 2011, 55(2):448-454.
25. Chiang M.C., McMahon K.L., de Zubicaray G.I., Martin N.G., Hickie I., Toga A.W., Wright M.J., Thompson P.M. Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29. Neuroimage 2011, 54(3):2308-2317.
26. Chiang M.C., Barysheva M., McMahon K.L., de Zubicaray G.I., Johnson K., Montgomery G.W., Martin N.G., Toga A.W., Wright M.J., Shapshak P., Thompson P.M. Gene network effects on brain microstructure and intellectual performance identified in 472 twins. J. Neurosci. 2012, 32(25):8732-8745.
27. Clemm von Hohenberg C., Wigand M.C., Kubicki M., Leicht G., Giegling I., Karch S., Hartmann A.M., Konte B., Friedl M., Ballinger T., Eckbo R., Bouix S., Jager L., Shenton M.E., Rujescu D., Mulert C. CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study. J. Psychiatr. Res. 2013, 47(10):1349-1356.
28. Colantuoni C., Lipska B.K., Ye T., Hyde T.M., Tao R., Leek J.T., Colantuoni E.A., Elkahloun A.G., Herman M.M., Weinberger D.R., Kleinman J.E. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 2011, 478(7370):519-523.
29. Cosgaya J.M., Chan J.R., Shooter E.M. The neurotrophin receptor p75NTR as a positive modulator of myelination. Science 2002, 298(5596):1245-1248.
30. Cousijn H., Rijpkema M., Harteveld A., Harrison P.J., Fernandez G., Franke B., Arias-Vasquez A. Schizophrenia risk gene ZNF804A does not influence macroscopic brain structure: an MRI study in 892 volunteers. Mol. Psychiatry 2012, 17(12):1155-1157.
31. Davis K.L., Stewart D.G., Friedman J.I., Buchsbaum M., Harvey P.D., Hof P.R., Buxbaum J., Haroutunian V. White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch. Gen. Psychiatry 2003, 60(5):443-456.
32. Dietsche B., Backes H., Laneri D., Weikert T., Witt S.H., Rietschel M., Sommer J., Kircher T., Krug A. The impact of a CACNA1C gene polymorphism on learning and hippocampal formation in healthy individuals: a diffusion tensor imaging study. Neuroimage 2014, 89:256-261.
33. Emery B. Regulation of oligodendrocyte differentiation and myelination. Science 2010, 330(6005):779-782.
34. Esslinger C., Walter H., Kirsch P., Erk S., Schnell K., Arnold C., Haddad L., Mier D., Opitz von Boberfeld C., Raab K., Witt S.H., Rietschel M., Cichon S., Meyer-Lindenberg A. Neural mechanisms of a genome-wide supported psychosis variant. Science 2009, 324(5927):605.
35. Geng X., Prom-Wormley E.C., Perez J., Kubarych T., Styner M., Lin W., Neale M.C., Gilmore J.H. White matter heritability using diffusion tensor imaging in neonatal brains. Twin Res. Hum. Genet. 2012, 15(3):336-350.
36. Georgieva L., Moskvina V., Peirce T., Norton N., Bray N.J., Jones L., Holmans P., Macgregor S., Zammit S., Wilkinson J., Williams H., Nikolov I., Williams N., Ivanov D., Davis K.L., Haroutunian V., Buxbaum J.D., Craddock N., Kirov G., Owen M.J., O'Donovan M.C. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(33):12469-12474.
37. Gilmore J.H., Schmitt J.E., Knickmeyer R.C., Smith J.K., Lin W., Styner M., Gerig G., Neale M.C. Genetic and environmental contributions to neonatal brain structure: a twin study. Hum. Brain Mapp. 2010, 31(8):1174-1182.
38. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 2003, 160(4):636-645.
39. Green E.K., Grozeva D., Jones I., Jones L., Kirov G., Caesar S., Gordon-Smith K., Fraser C., Forty L., Russell E., Hamshere M.L., Moskvina V., Nikolov I., Farmer A., McGuffin P., Holmans P.A., Owen M.J., O'Donovan M.C., Craddock N. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol. Psychiatry 2010, 15(10):1016-1022.
40. Hakak Y., Walker J.R., Li C., Wong W.H., Davis K.L., Buxbaum J.D., Haroutunian V., Fienberg A.A. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(8):4746-4751.
41. Hashimoto R., Numakawa T., Ohnishi T., Kumamaru E., Yagasaki Y., Ishimoto T., Mori T., Nemoto K., Adachi N., Izumi A., Chiba S., Noguchi H., Suzuki T., Iwata N., Ozaki N., Taguchi T., Kamiya A., Kosuga A., Tatsumi M., Kamijima K., Weinberger D.R., Sawa A., Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum. Mol. Genet. 2006, 15(20):3024-3033.
42. Havik B., Le Hellard S., Rietschel M., Lybaek H., Djurovic S., Mattheisen M., Muhleisen T.W., Degenhardt F., Priebe L., Maier W., Breuer R., Schulze T.G., Agartz I., Melle I., Hansen T., Bramham C.R., Nothen M.M., Stevens B., Werge T., Andreassen O.A., Cichon S., Steen V.M. The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia. Biol. Psychiatry 2011, 70(1):35-42.
43. Hoptman M.J., Nierenberg J., Bertisch H.C., Catalano D., Ardekani B.A., Branch C.A., Delisi L.E. A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr. Res. 2008, 106(2-3):115-124.
44. Huang K.P., Huang F.L., Jager T., Li J., Reymann K.G., Balschun D. Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J. Neurosci. 2004, 24(47):10660-10669.
45. Hulshoff Pol H.E., Brans R.G., van Haren N.E., Schnack H.G., Langen M., Baare W.F., van Oel C.J., Kahn R.S. Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia. Biol. Psychiatry 2004, 55(2):126-130.
46. Insel T., Cuthbert B., Garvey M., Heinssen R., Pine D.S., Quinn K., Sanislow C., Wang P. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am. J. Psychiatry 2010, 167(7):748-751.
47. Jagannathan K., Calhoun V.D., Gelernter J., Stevens M.C., Liu J., Bolognani F., Windemuth A., Ruano G., Assaf M., Pearlson G.D. Genetic associations of brain structural networks in schizophrenia: a preliminary study. Biol. Psychiatry 2010, 68(7):657-666.
48. Jahanshad N., Lee A.D., Barysheva M., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Toga A.W., Thompson P.M. Genetic influences on brain asymmetry: a DTI study of 374 twins and siblings. Neuroimage 2010, 52(2):455-469.
49. Jahanshad N., Kohannim O., Hibar D.P., Stein J.L., McMahon K.L., de Zubicaray G.I., Medland S.E., Montgomery G.W., Whitfield J.B., Martin N.G., Wright M.J., Toga A.W., Thompson P.M. Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(14):E851-E859.
50. Jahanshad N., Kochunov P.V., Sprooten E., Mandl R.C., Nichols T.E., Almasy L., Blangero J., Brouwer R.M., Curran J.E., de Zubicaray G.I., Duggirala R., Fox P.T., Hong L.E., Landman B.A., Martin N.G., McMahon K.L., Medland S.E., Mitchell B.D., Olvera R.L., Peterson C.P., Starr J.M., Sussmann J.E., Toga A.W., Wardlaw J.M., Wright M.J., Hulshoff Pol H.E., Bastin M.E., McIntosh A.M., Deary I.J., Thompson P.M., Glahn D.C. Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. Neuroimage 2013, 81:455-469.
51. Jones D.K. Studying connections in the living human brain with diffusion MRI. Cortex 2008, 44(8):936-952.
52. Jones D.K., Williams S.C., Gasston D., Horsfield M.A., Simmons A., Howard R. Isotropic resolution diffusion tensor imaging with whole brain acquisition in a clinically acceptable time. Hum. Brain Mapp. 2002, 15(4):216-230.
53. Jones D.K., Symms M.R., Cercignani M., Howard R.J. The effect of filter size on VBM analyses of DT-MRI data. Neuroimage 2005, 26(2):546-554.
54. Judy J.T., Seifuddin F., Pirooznia M., Mahon P.B., Jancic D., Goes F.S., Schulze T., Cichon S., Noethen M., Rietschel M., Depaulo J.R., Potash J.B., Zandi P.P. Converging evidence for epistasis between ANK3 and potassium channel gene KCNQ2 in bipolar disorder. Front. Genet. 2013, 4:87.
55. Kennedy K.M., Rodrigue K.M., Land S.J., Raz N. BDNF Val66Met polymorphism influences age differences in microstructure of the corpus callosum. Front. Hum. Neurosci. 2009, 3:19.
56. Kim A.H., Parker E.K., Williamson V., McMichael G.O., Fanous A.H., Vladimirov V.I. Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137. Schizophr. Res. 2012, 141(1):60-64.
57. Kochunov P., Glahn D.C., Lancaster J.L., Winkler A.M., Smith S., Thompson P.M., Almasy L., Duggirala R., Fox P.T., Blangero J. Genetics of microstructure of cerebral white matter using diffusion tensor imaging. Neuroimage 2010, 53(3):1109-1116.
58. Kochunov P., Jahanshad N., Sprooten E., Nichols T., Mandl R., Almasy L., Booth T., Brouwer R.M., Curran J.E., de Zubicaray G., Dimitrova R., Duggirala R., Fox P., Hong E.J., Landman B.A., Lemaitre H., Lopez l, Martin N.G., McMahon K.L., Mitchell B., Olvera R.L., Peterson C.P., Starr J.M., Sussmann J., Toga A., Wardlaw J.M., Wright M.J., Wright S., Bastin M.E., McIntosh A., Boomsma D., Kahn R.S., den Braber A., de Geus E.J., Deary I.J., Hulshoff Pol H., Williamson D., Blangero J., van 't Ent D., Thompson P., Glahn D.C. Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: comparing meta and mega analytical approaches for data pooling. Neuroimage 2014, (in press).
59. Kohannim O., Jahanshad N., Braskie M.N., Stein J.L., Chiang M.C., Reese A.H., Hibar D.P., Toga A.W., McMahon K.L., de Zubicaray G.I., Medland S.E., Montgomery G.W., Martin N.G., Wright M.J., Thompson P.M. Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology 2012, 37(9):2012-2019.
60. Konrad A., Vucurevic G., Musso F., Stoeter P., Dahmen N., Winterer G. ErbB4 genotype predicts left frontotemporal structural connectivity in human brain. Neuropsychopharmacology 2009, 34(3):641-650.
61. Kuswanto C.N., Woon P.S., Zheng X.B., Qiu A., Sitoh Y.Y., Chan Y.H., Liu J., Williams H., Ong W.Y., Sim K. Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012, 159B(3):255-262.
62. Kwon E., Wang W., Tsai L.H. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Mol. Psychiatry 2013, 18(1):11-12.
63. Lencz T., Szeszko P.R., DeRosse P., Burdick K.E., Bromet E.J., Bilder R.M., Malhotra A.K. A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes. Neuropsychopharmacology 2010, 35(11):2284-2291.
64. Lett T.A., Chakavarty M.M., Felsky D., Brandl E.J., Tiwari A.K., Goncalves V.F., Rajji T.K., Daskalakis Z.J., Meltzer H.Y., Lieberman J.A., Lerch J.P., Mulsant B.H., Kennedy J.L., Voineskos A.N. The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia. Mol. Psychiatry 2013, 18(4):443-450.
65. Li M., Wang Y., Zheng X.B., Ikeda M., Iwata N., Luo X.J., Chong S.A., Lee J., Rietschel M., Zhang F., Muller-Myhsok B., Cichon S., Weinberger D.R., Mattheisen M., Schulze T.G., Martin N.G., Mitchell P.B., Schofield P.R., Liu J.J., Su B. Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility. Schizophr. Res. 2012, 142(1-3):200-205.
66. Li Y., Liu B., Hou B., Qin W., Wang D., Yu C., Jiang T. Less efficient information transfer in Cys-allele carriers of DISC1: a brain network study based on diffusion MRI. Cereb. Cortex 2013, 23(7):1715-1723.
67. Linke J., Witt S.H., King A.V., Nieratschker V., Poupon C., Gass A., Hennerici M.G., Rietschel M., Wessa M. Genome-wide supported risk variant for bipolar disorder alters anatomical connectivity in the human brain. Neuroimage 2012, 59(4):3288-3296.
68. Lopez L.M., Bastin M.E., Maniega S.M., Penke L., Davies G., Christoforou A., Valdes Hernandez M.C., Royle N.A., Tenesa A., Starr J.M., Porteous D.J., Wardlaw J.M., Deary I.J. A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity. Neurobiol. Aging 2012, 33(8):1847. (e1841-1814).
69. McIntosh A.M., Moorhead T.W., Job D., Lymer G.K., Munoz Maniega S., McKirdy J., Sussmann J.E., Baig B.J., Bastin M.E., Porteous D., Evans K.L., Johnstone E.C., Lawrie S.M., Hall J. The effects of a neuregulin 1 variant on white matter density and integrity. Mol. Psychiatry 2008, 13(11):1054-1059.
70. McTigue D.M., Tripathi R.B. The life, death, and replacement of oligodendrocytes in the adult CNS. J. Neurochem. 2008, 107(1):1-19.
71. Meyer-Lindenberg A., Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 2006, 7(10):818-827.
72. Montag C., Schoene-Bake J.C., Faber J., Reuter M., Weber B. Genetic variation on the BDNF gene is not associated with differences in white matter tracts in healthy humans measured by tract-based spatial statistics. Genes Brain Behav. 2010, 9(8):886-891.
73. Mothersill O., Morris D.W., Kelly S., Rose E.J., Fahey C., O'Brien C., Lyne R., Reilly R., Gill M., Corvin A.P., Donohoe G. Effects of MIR137 on fronto-amygdala functional connectivity. Neuroimage 2013, 90C:189-195.
74. O'Donovan M.C., Craddock N., Norton N., Williams H., Peirce T., Moskvina V., Nikolov I., Hamshere M., Carroll L., Georgieva L., Dwyer S., Holmans P., Marchini J.L., Spencer C.C., Howie B., Leung H.T., Hartmann A.M., Moller H.J., Morris D.W., Shi Y., Feng G., Hoffmann P., Propping P., Vasilescu C., Maier W., Rietschel M., Zammit S., Schumacher J., Quinn E.M., Schulze T.G., Williams N.M., Giegling I., Iwata N., Ikeda M., Darvasi A., Shifman S., He L., Duan J., Sanders A.R., Levinson D.F., Gejman P.V., Cichon S., Nothen M.M., Gill M., Corvin A., Rujescu D., Kirov G., Owen M.J., Buccola N.G., Mowry B.J., Freedman R., Amin F., Black D.W., Silverman J.M., Byerley W.F., Cloninger C.R. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet. 2008, 40(9):1053-1055.
75. O'Dushlaine C., Kenny E., Heron E., Donohoe G., Gill M., Morris D., Corvin A. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol. Psychiatry 2011, 16(3):286-292.
76. Ohi K., Hashimoto R., Yasuda Y., Nemoto K., Ohnishi T., Fukumoto M., Yamamori H., Umeda-Yano S., Okada T., Iwase M., Kazui H., Takeda M. Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia. PLoS ONE 2012, 7(1):e29780.
77. Pernet V., Joly S., Christ F., Dimou L., Schwab M.E. Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation. J. Neurosci. 2008, 28(29):7435-7444.
78. Pfefferbaum A., Sullivan E.V., Swan G.E., Carmelli D. Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiol. Aging 2000, 21(1):63-74.
79. Pfefferbaum A., Sullivan E.V., Carmelli D. Genetic regulation of regional microstructure of the corpus callosum in late life. Neuroreport 2001, 12(8):1677-1681.
80. Potkin S.G., Guffanti G., Lakatos A., Turner J.A., Kruggel F., Fallon J.H., Saykin A.J., Orro A., Lupoli S., Salvi E., Weiner M., Macciardi F. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS ONE 2009, 4(8):e6501.
81. Riley B., Thiselton D., Maher B.S., Bigdeli T., Wormley B., McMichael G.O., Fanous A.H., Vladimirov V., O'Neill F.A., Walsh D., Kendler K.S. Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol. Psychiatry 2010, 15(1):29-37.
82. Ripke S., O'Dushlaine C., Chambert K., Moran J.L., Kahler A.K., Akterin S., Bergen S.E., Collins A.L., Crowley J.J., Fromer M., Kim Y., Lee S.H., Magnusson P.K., Sanchez N., Stahl E.A., Williams S., Wray N.R., Xia K., Bettella F., Borglum A.D., Bulik-Sullivan B.K., Cormican P., Craddock N., de Leeuw C., Durmishi N., Gill M., Golimbet V., Hamshere M.L., Holmans P., Hougaard D.M., Kendler K.S., Lin K., Morris D.W., Mors O., Mortensen P.B., Neale B.M., O'Neill F.A., Owen M.J., Milovancevic M.P., Posthuma D., Powell J., Richards A.L., Riley B.P., Ruderfer D., Rujescu D., Sigurdsson E., Silagadze T., Smit A.B., Stefansson H., Steinberg S., Suvisaari J., Tosato S., Verhage M., Walters J.T., Levinson D.F., Gejman P.V., Laurent C., Mowry B.J., O'Donovan M.C., Pulver A.E., Schwab S.G., Wildenauer D.B., Dudbridge F., Shi J., Albus M., Alexander M., Campion D., Cohen D., Dikeos D., Duan J., Eichhammer P., Godard S., Hansen M., Lerer F.B., Liang K.Y., Maier W., Mallet J., Nertney D.A., Nestadt G., Norton N., Papadimitriou G.N., Ribble R., Sanders A.R., Silverman J.M., Walsh D., Williams N.M., Wormley B., Arranz M.J., Bakker S., Bender S., Bramon E., Collier D., Crespo-Facorro B., Hall J., Iyegbe C., Jablensky A., Kahn R.S., Kalaydjieva L., Lawrie S., Lewis C.M., Linszen D.H., Mata I., McIntosh A., Murray R.M., Ophoff R.A., Van Os J., Walshe M., Weisbrod M., Wiersma D., Donnelly P., Barroso I., Blackwell J.M., Brown M.A., Casas J.P., Corvin A.P., Deloukas P., Duncanson A., Jankowski J., Markus H.S., Mathew C.G., Palmer C.N., Plomin R., Rautanen A., Sawcer S.J., Trembath R.C., Viswanathan A.C., Wood N.W., Spencer C.C., Band G., Bellenguez C., Freeman C., Hellenthal G., Giannoulatou E., Pirinen M., Pearson R.D., Strange A., Su Z., Vukcevic D., Langford C., Hunt S.E., Edkins S., Gwilliam R., Blackburn H., Bumpstead S.J., Dronov S., Gillman M., Gray E., Hammond N., Jayakumar A., McCann O.T., Liddle J., Potter S.C., Ravindrarajah R., Ricketts M., Tashakkori-Ghanbaria A., Waller M.J., Weston P., Widaa S., Whittaker P., McCarthy M.I., Stefansson K., Scolnick E., Purcell S., McCarroll S.A., Sklar P., Hultman C.M., Sullivan P.F. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat. Genet. 2013, 45(10):1150-1159.
83. Rose E.J., Morris D.W., Fahey C., Robertson I.H., Greene C., O'Doherty J., Newell F.N., Garavan H., McGrath J., Bokde A., Tropea D., Gill M., Corvin A.P., Donohoe G. The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function. Twin Res. Hum. Genet. 2012, 15(3):296-303.
84. Rose E.J., Morris D.W., Hargreaves A., Fahey C., Greene C., Garavan H., Gill M., Corvin A., Donohoe G. Neural effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013, 162B(6):530-537.
85. Rose E.J., Hargreaves A., Morris D., Fahey C., Tropea D., Cummings E., Caltagirone C., Bossu P., Chiapponi C., Piras F., Spalletta G., Gill M., Corvin A., Donohoe G. Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style. Br. J. Psychiatry 2014, 204:115-121.
86. Roy K., Murtie J.C., El-Khodor B.F., Edgar N., Sardi S.P., Hooks B.M., Benoit-Marand M., Chen C., Moore H., O'Donnell P., Brunner D., Corfas G. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(19):8131-8136.
87. Scamvougeras A., Kigar D.L., Jones D., Weinberger D.R., Witelson S.F. Size of the human corpus callosum is genetically determined: an MRI study in mono and dizygotic twins. Neurosci. Lett. 2003, 338(2):91-94.
88. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium Genome-wide association study identifies five new schizophrenia loci. Nat. Genet. 2011, 43(10):969-976.
89. Segal D., Koschnick J.R., Slegers L.H., Hof P.R. Oligodendrocyte pathophysiology: a new view of schizophrenia. Int. J. Neuropsychopharmacol. 2007, 10(4):503-511.
90. Shen E.H., Overly C.C., Jones A.R. The Allen Human Brain Atlas: comprehensive gene expression mapping of the human brain. Trends Neurosci. 2012, 35(12):711-714.
91. Shenton M.E., Whitford T.J., Kubicki M. Structural neuroimaging in schizophrenia: from methods to insights to treatments. Dialogues Clin. Neurosci. 2010, 12(3):317-332.
92. Shifman S., Johannesson M., Bronstein M., Chen S.X., Collier D.A., Craddock N.J., Kendler K.S., Li T., O'Donovan M., O'Neill F.A., Owen M.J., Walsh D., Weinberger D.R., Sun C., Flint J., Darvasi A. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet. 2008, 4(2):e28.
93. Skudlarski P., Schretlen D.J., Thaker G.K., Stevens M.C., Keshavan M.S., Sweeney J.A., Tamminga C.A., Clementz B.A., O'Neil K., Pearlson G.D. Diffusion tensor imaging white matter endophenotypes in patients with schizophrenia or psychotic bipolar disorder and their relatives. Am. J. Psychiatry 2013, 170(8):886-898.
94. Sprooten E., Sussmann J.E., Moorhead T.W., Whalley H.C., Ffrench-Constant C., Blumberg H.P., Bastin M.E., Hall J., Lawrie S.M., McIntosh A.M. Association of white matter integrity with genetic variation in an exonic DISC1 SNP. Mol. Psychiatry 2011, 16(7):685. (688-689).
95. Sprooten E., McIntosh A.M., Lawrie S.M., Hall J., Sussmann J.E., Dahmen N., Konrad A., Bastin M.E., Winterer G. An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain. Magn. Reson. Imaging 2012, 30(10):1373-1380.
96. Stefansson H., Rujescu D., Cichon S., Pietilainen O.P., Ingason A., Steinberg S., Fossdal R., Sigurdsson E., Sigmundsson T., Buizer-Voskamp J.E., Hansen T., Jakobsen K.D., Muglia P., Francks C., Matthews P.M., Gylfason A., Halldorsson B.V., Gudbjartsson D., Thorgeirsson T.E., Sigurdsson A., Jonasdottir A., Jonasdottir A., Bjornsson A., Mattiasdottir S., Blondal T., Haraldsson M., Magnusdottir B.B., Giegling I., Moller H.J., Hartmann A., Shianna K.V., Ge D., Need A.C., Crombie C., Fraser G., Walker N., Lonnqvist J., Suvisaari J., Tuulio-Henriksson A., Paunio T., Toulopoulou T., Bramon E., Di Forti M., Murray R., Ruggeri M., Vassos E., Tosato S., Walshe M., Li T., Vasilescu C., Muhleisen T.W., Wang A.G., Ullum H., Djurovic S., Melle I., Olesen J., Kiemeney L.A., Franke B., Sabatti C., Freimer N.B., Gulcher J.R., Thorsteinsdottir U., Kong A., Andreassen O.A., Ophoff R.A., Georgi A., Rietschel M., Werge T., Petursson H., Goldstein D.B., Nothen M.M., Peltonen L., Collier D.A., St Clair D., Stefansson K. Large recurrent microdeletions associated with schizophrenia. Nature 2008, 455(7210):232-236.
97. Stefansson H., Ophoff R.A., Steinberg S., Andreassen O.A., Cichon S., Rujescu D., Werge T., Pietilainen O.P., Mors O., Mortensen P.B., Sigurdsson E., Gustafsson O., Nyegaard M., Tuulio-Henriksson A., Ingason A., Hansen T., Suvisaari J., Lonnqvist J., Paunio T., Borglum A.D., Hartmann A., Fink-Jensen A., Nordentoft M., Hougaard D., Norgaard-Pedersen B., Bottcher Y., Olesen J., Breuer R., Moller H.J., Giegling I., Rasmussen H.B., Timm S., Mattheisen M., Bitter I., Rethelyi J.M., Magnusdottir B.B., Sigmundsson T., Olason P., Masson G., Gulcher J.R., Haraldsson M., Fossdal R., Thorgeirsson T.E., Thorsteinsdottir U., Ruggeri M., Tosato S., Franke B., Strengman E., Kiemeney L.A., Melle I., Djurovic S., Abramova L., Kaleda V., Sanjuan J., de Frutos R., Bramon E., Vassos E., Fraser G., Ettinger U., Picchioni M., Walker N., Toulopoulou T., Need A.C., Ge D., Yoon J.L., Shianna K.V., Freimer N.B., Cantor R.M., Murray R., Kong A., Golimbet V., Carracedo A., Arango C., Costas J., Jonsson E.G., Terenius L., Agartz I., Petursson H., Nothen M.M., Rietschel M., Matthews P.M., Muglia P., Peltonen L., St Clair D., Goldstein D.B., Stefansson K., Collier D.A. Common variants conferring risk of schizophrenia. Nature 2009, 460(7256):744-747.
98. Stein J.L., Hibar D.P., Madsen S.K., Khamis M., McMahon K.L., de Zubicaray G.I., Hansell N.K., Montgomery G.W., Martin N.G., Wright M.J., Saykin A.J., Jack C.R., Weiner M.W., Toga A.W., Thompson P.M. Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search. Mol. Psychiatry 2011, 16(9):927-937. (881).
99. Stein J.L., Medland S.E., Vasquez A.A., Hibar D.P., Senstad R.E., Winkler A.M., Toro R., Appel K., Bartecek R., Bergmann O., Bernard M., Brown A.A., Cannon D.M., Chakravarty M.M., Christoforou A., Domin M., Grimm O., Hollinshead M., Holmes A.J., Homuth G., Hottenga J.J., Langan C., Lopez L.M., Hansell N.K., Hwang K.S., Kim S., Laje G., Lee P.H., Liu X., Loth E., Lourdusamy A., Mattingsdal M., Mohnke S., Maniega S.M., Nho K., Nugent A.C., O'Brien C., Papmeyer M., Putz B., Ramasamy A., Rasmussen J., Rijpkema M., Risacher S.L., Roddey J.C., Rose E.J., Ryten M., Shen L., Sprooten E., Strengman E., Teumer A., Trabzuni D., Turner J., van Eijk K., van Erp T.G., van Tol M.J., Wittfeld K., Wolf C., Woudstra S., Aleman A., Alhusaini S., Almasy L., Binder E.B., Brohawn D.G., Cantor R.M., Carless M.A., Corvin A., Czisch M., Curran J.E., Davies G., de Almeida M.A., Delanty N., Depondt C., Duggirala R., Dyer T.D., Erk S., Fagerness J., Fox P.T., Freimer N.B., Gill M., Goring H.H., Hagler D.J., Hoehn D., Holsboer F., Hoogman M., Hosten N., Jahanshad N., Johnson M.P., Kasperaviciute D., Kent J.W., Kochunov P., Lancaster J.L., Lawrie S.M., Liewald D.C., Mandl R., Matarin M., Mattheisen M., Meisenzahl E., Melle I., Moses E.K., Muhleisen T.W., Nauck M., Nothen M.M., Olvera R.L., Pandolfo M., Pike G.B., Puls R., Reinvang I., Renteria M.E., Rietschel M., Roffman J.L., Royle N.A., Rujescu D., Savitz J., Schnack H.G., Schnell K., Seiferth N., Smith C., Steen V.M., Valdes Hernandez M.C., Van den Heuvel M., van der Wee N.J., Van Haren N.E., Veltman J.A., Volzke H., Walker R., Westlye L.T., Whelan C.D., Agartz I., Boomsma D.I., Cavalleri G.L., Dale A.M., Djurovic S., Drevets W.C., Hagoort P., Hall J., Heinz A., Jack C.R., Foroud T.M., Le Hellard S., Macciardi F., Montgomery G.W., Poline J.B., Porteous D.J., Sisodiya S.M., Starr J.M., Sussmann J., Toga A.W., Veltman D.J., Walter H., Weiner M.W., Bis J.C., Ikram M.A., Smith A.V., Gudnason V., Tzourio C., Vernooij M.W., Launer L.J., DeCarli C., Seshadri S., Andreassen O.A., Apostolova L.G., Bastin M.E., Blangero J., Brunner H.G., Buckner R.L., Cichon S., Coppola G., de Zubicaray G.I., Deary I.J., Donohoe G., de Geus E.J., Espeseth T., Fernandez G., Glahn D.C., Grabe H.J., Hardy J., Hulshoff Pol H.E., Jenkinson M., Kahn R.S., McDonald C., McIntosh A.M., McMahon F.J., McMahon K.L., Meyer-Lindenberg A., Morris D.W., Muller-Myhsok B., Nichols T.E., Ophoff R.A., Paus T., Pausova Z., Penninx B.W., Potkin S.G., Samann P.G., Saykin A.J., Schumann G., Smoller J.W., Wardlaw J.M., Weale M.E., Martin N.G., Franke B., Wright M.J., Thompson P.M. Identification of common variants associated with human hippocampal and intracranial volumes. Nat. Genet. 2012, 44(5):552-561.
100. Terwisscha van Scheltinga A.F., Bakker S.C., van Haren N.E., Derks E.M., Buizer-Voskamp J.E., Boos H.B., Cahn W., Hulshoff Pol H.E., Ripke S., Ophoff R.A., Kahn R.S. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biol. Psychiatry 2013, 73(6):525-531.
101. Thomason M.E., Dougherty R.F., Colich N.L., Perry L.M., Rykhlevskaia E.I., Louro H.M., Hallmayer J.F., Waugh C.E., Bammer R., Glover G.H., Gotlib I.H. COMT genotype affects prefrontal white matter pathways in children and adolescents. Neuroimage 2010, 53(3):926-934.
102. Tost H., Lipska B.K., Vakkalanka R., Lemaitre H., Callicott J.H., Mattay V.S., Kleinman J.E., Marenco S., Weinberger D.R. No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression. Biol. Psychiatry 2010, 68(1):105-107.
103. van Erp T.G., Guella I., Vawter M.P., Turner J., Brown G.G., McCarthy G., Greve D.N., Glover G.H., Calhoun V.D., Lim K.O., Bustillo J.R., Belger A., Ford J.M., Mathalon D.H., Diaz M., Preda A., Nguyen D., Macciardi F., Potkin S.G. Schizophrenia miR-137 locus risk genotype is associated with dorsolateral prefrontal cortex hyperactivation. Biol. Psychiatry 2014, 75(5):398-405.
104. Voineskos A.N., Lerch J.P., Felsky D., Shaikh S., Rajji T.K., Miranda D., Lobaugh N.J., Mulsant B.H., Pollock B.G., Kennedy J.L. The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease. Arch. Gen. Psychiatry 2011, 68(2):198-206.
105. Voineskos A.N., Lerch J.P., Felsky D., Tiwari A., Rajji T.K., Miranda D., Lobaugh N.J., Pollock B.G., Mulsant B.H., Kennedy J.L. The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses. Neuropsychopharmacology 2011, 36(9):1871-1878.
106. Voineskos A.N., Lett T.A., Lerch J.P., Tiwari A.K., Ameis S.H., Rajji T.K., Muller D.J., Mulsant B.H., Kennedy J.L. Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders. PLoS ONE 2011, 6(6):e20982.
107. Voineskos A.N., Felsky D., Kovacevic N., Tiwari A.K., Zai C., Chakravarty M.M., Lobaugh N.J., Shenton M.E., Rajji T.K., Miranda D., Pollock B.G., Mulsant B.H., McIntosh A.R., Kennedy J.L. Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia. Cereb. Cortex 2013, 23(9):2044-2057.
108. Voineskos A.N., Foussias G., Lerch J., Felsky D., Remington G., Rajji T.K., Lobaugh N., Pollock B.G., Mulsant B.H. Neuroimaging evidence for the deficit subtype of schizophrenia. JAMA Psychiatry 2013, 70(5):472-480.
109. Wallace G.L., Eric Schmitt J., Lenroot R., Viding E., Ordaz S., Rosenthal M.A., Molloy E.A., Clasen L.S., Kendler K.S., Neale M.C., Giedd J.N. A pediatric twin study of brain morphometry. J. Child Psychol. Psychiatry 2006, 47(10):987-993.
110. Walters J.T., Rujescu D., Franke B., Giegling I., Vasquez A.A., Hargreaves A., Russo G., Morris D.W., Hoogman M., Da Costa A., Moskvina V., Fernandez G., Gill M., Corvin A., O'Donovan M.C., Donohoe G., Owen M.J. The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up. Am. J. Psychiatry 2013, 170(8):877-885.
111. Wang K.C., Kim J.A., Sivasankaran R., Segal R., He Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 2002, 420(6911):74-78.
112. Wang F., Jiang T., Sun Z., Teng S.L., Luo X., Zhu Z., Zang Y., Zhang H., Yue W., Qu M., Lu T., Hong N., Huang H., Blumberg H.P., Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. J. Psychiatry Neurosci. 2009, 34(3):181-186.
113. Wassink T.H., Epping E.A., Rudd D., Axelsen M., Ziebell S., Fleming F.W., Monson E., Ho B.C., Andreasen N.C. Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch. Gen. Psychiatry 2012, 69(9):885-892.
114. Wei Q., Kang Z., Diao F., Shan B., Li L., Zheng L., Guo X., Liu C., Zhang J., Zhao J. Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 36(1):122-127.
115. Wei Q., Kang Z., Diao F., Guidon A., Wu X., Zheng L., Li L., Guo X., Hu M., Zhang J., Liu C., Zhao J. No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study. Neurosci. Lett. 2013, 532:64-69.
116. White T., Andreasen N.C., Nopoulos P. Brain volumes and surface morphology in monozygotic twins. Cereb. Cortex 2002, 12(5):486-493.
117. Winterer G., Konrad A., Vucurevic G., Musso F., Stoeter P., Dahmen N. Association of 5' end neuregulin-1 (NRG1) gene variation with subcortical medial frontal microstructure in humans. Neuroimage 2008, 40(2):712-718.
118. Wirgenes K.V., Sonderby I.E., Haukvik U.K., Mattingsdal M., Tesli M., Athanasiu L., Sundet K., Rossberg J.I., Dale A.M., Brown A.A., Agartz I., Melle I., Djurovic S., Andreassen O.A. TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders. Transl. Psychiatry 2012, 2:e112.
119. Wood J.D., Bonath F., Kumar S., Ross C.A., Cunliffe V.T. Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. Hum. Mol. Genet. 2009, 18(3):391-404.
120. Yoon U., Fahim C., Perusse D., Evans A.C. Lateralized genetic and environmental influences on human brain morphology of 8-year-old twins. Neuroimage 2010, 53(3):1117-1125.
121. Zuliani R., Moorhead T.W., Bastin M.E., Johnstone E.C., Lawrie S.M., Brambilla P., O'Donovan M.C., Owen M.J., Hall J., McIntosh A.M. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Res. 2011, 191(2):133-137.