Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style

British Journal of Psychiatry

Volumn 204, Issue 2, 2014, Pages 115-121

  Rose, Emma Jane ^a,b   Hargreaves, April ^a   Morris, Derek ^a   Fahey, Ciara ^a   Tropea, Daniela ^a   Cummings, Elizabeth ^a   Caltagirone, Carlo ^c,d   Bossù, Paola ^c   Chiapponi, Chiara ^c   Piras, Fabrizio ^c   Spalletta, Gianfranco ^c   Gill, Michael ^a   Corvin, Aiden ^a   Donohoe, Gary ^a,e  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b RTI INTERNATIONAL   (United States)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ANTERIOR CINGULATE; ARTICLE; BRAIN; BRAIN SIZE; BRAIN STRUCTURE; COGNITION; CONTROLLED STUDY; CYCLIN M2 GENE; EDUCATIONAL STATUS; EYES TASK; FEMALE; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GRAY MATTER; GREY MATTER VOLUME; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL TASK; MIDDLE AGED; NERVOUS SYSTEM PARAMETERS; NEUROCOGNITION; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; SCHIZOPHRENIA; SELF SERVING BIAS; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL COGNITION; THEORY OF MIND; TISSUE STRUCTURE; VOXEL BASED MORPHOMETRY; WHITE MATTER; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; ANALYSIS OF VARIANCE; BRAIN; CASE-CONTROL STUDIES; CYCLINS; EMOTIONAL INTELLIGENCE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GYRUS CINGULI; HUMANS; INTERNAL-EXTERNAL CONTROL; IRELAND; ITALY; LINKAGE DISEQUILIBRIUM; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; ORGAN SIZE; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TEMPORAL LOBE; YOUNG ADULT;

EID: 84893527986     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.113.131359     Document Type: Article

References (48)

1. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990; 46: 229-41.
2. Owen MJ, O'Donovan MC, Gottesman II. Schizophrenia. In Psychiatric Genetics and Genomics (eds P McGuffin, MJ Owen, II Gottesman): 247-66. Oxford University Press, 2002.
3. Cardno AG, Gottesman II. Twin studies of schizophrenia: from bow-andarrow concordances to star wars Mx and functional genomics. Am J Med Genet 2000; 97: 12-7.
4. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60: 1187-92.
5. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 2008; 40: 1053-5.
6. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, et al. Common variants conferring risk of schizophrenia. Nature 2009; 460: 744-7.
7. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, et al. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 2011; 43: 969-76.
8. Aberg KA, Liu Y, Bukszár J, McClay JL, Khachane AN, Andreassen OA, et al. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry 2013; 70: 1-9.
9. Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genomewide analysis. Lancet 2013; 381: 1371-9.
10. Goytain A, Quamme GA. Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter. Physiol Genomics 2005; 22: 382-9.
11. Meyer TE, Verwoert GC, Hwang SJ, Glazer NL, Smith AV, van Rooij FJ, et al. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. PLoS Genet 2010; 6: e1001045.
12. Stuiver M, Lainez S, Will C, Terryn S, Gunzel D, Debaix H, et al. CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet 2011; 88: 333-43.
13. Tan HY, Callicott JH, Weinberger DR. Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? Mol Psychiatry 2008; 13: 233-8.
14. Gottesman, II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-45.
15. Walters JT, Owen MJ. Endophenotypes in psychiatric genetics. Mol Psychiatry 2007; 12: 886-90.
16. Allen DN, Strauss GP, Donohue B, van Kammen DP. Factor analytic support for social cognition as a separable cognitive domain in schizophrenia. Schizophr Res 2007; 93: 325-33.
17. Skuse DH, Gallagher L. Genetic influences on social cognition. Pediatr Res 2011; 69: 85R-91R.
18. Walter H, Schnell K, Erk S, Arnold C, Kirsch P, Esslinger C, et al. Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task. Mol Psychiatry 2011; 16: 462-70.
19. Hargreaves A, Morris DW, Rose E, Fahey C, Moore S, Cummings E, et al. ZNF804A and social cognition in patients with schizophrenia and healthy controls. Mol Psychiatry 2012; 17: 118-9.
20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). APA, 1994.
21. Wechsler D. Wechsler Adult Intelligence Scale (3rd edn) (WAIS-3). Harcourt Assessment, 1997.
22. Wechsler D. Wechsler Memory Scale: Manual (3rd edn). The Psychological Corporation, 1997.
23. Robbins TW, James M, Owen AM, Sahakian BJ, McInees L, Rabbitt P. Cambridge Neuropsychological Battery (CANTAB): a factor analytic study of a large sample of elderly volunteers. Dementia 1994; 5: 266-87.
24. Corcoran R, Mercer G, Frith CD. Schizophrenia, symptomology and social inference - investigating theory of mind in people with schizophrenia. Schizophr Res 1995; 17: 5-13.
25. Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The "Reading the Mind in the Eyes" test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001; 42: 241-51.
26. Kinderman P, Bentall RP. A new measure of causal locus: the internal, personal and situational attributions questionnaire. Pers Individ Dif 1996; 20: 261-4.
27. Rose EJ, Greene C, Kelly S, Morris DW, Robertson IH, Fahey C, et al. The NOS1 variant rs6490121 is associated with variation in prefrontal function and grey matter density in healthy individuals. Neuroimage 2012; 60: 614-22.
28. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). Biometrics Research, New York State Psychiatric Institute, 2002.
29. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). American Psychiatric Press, 1997.
30. Ashburner J, Friston KJ. Voxel-based morphometry - the methods. Neuroimage 2000; 11: 805-21.
31. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007; 38: 95-113.
32. Gallagher HL, Frith CD. Functional imaging of 'theory of mind'. Trends Cogn Sci 2003; 7: 77-83.
33. Cunningham WA, Zelazo PD. Attitudes and evaluations: a social cognitive neuroscience perspective. Trends Cogn Sci 2007; 11: 97-104.
34. Ochsner KN. The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond. Biol Psychiatry 2008; 64: 48-61.
35. Worsley KJ, Andermann M, Koulis T, MacDonald D, Evans AC. Detecting changes in nonisotropic images. Hum Brain Mapp 1999; 8: 98-101.
36. Hayasaka S, Phan KL, Liberzon I, Worsley KJ, Nichols TE. Nonstationary cluster-size inference with random field and permutation methods. Neuroimage 2004; 22: 676-87.
37. Bentall RP, Kinderman P, Kaney S. The self, attributional processes and abnormal beliefs: towards a model of persecutory delusions. Behav Res Ther 1994; 32: 331-41.
38. Candido CL, Romney DM. Attributional style in paranoid vs. depressed patients. Br J Med Psychol 1990; 63: 355-63.
39. Jolley S, Garety P, Bebbington P, Dunn G, Freeman D, Kuipers E, et al. Attributional style in psychosis-the role of affect and belief type. Behav Res Ther 2006; 44: 1597-607.
40. Seidel EM, Eickhoff SB, Kellermann T, Schneider F, Gur RC, Habel U, et al. Who is to blame? Neural correlates of causal attribution in social situations. Soc Neurosci 2010; 5: 335-50.
41. Cummings E, Donohoe G, McDonald C, Dinan TG, O'Neill FA, O'Callaghan E, et al. Clinical symptomatology and the psychosis risk gene ZNF804A. Schizophr Res 2010; 122: 273-5.
42. Beck AT. The Beck Depression Inventory - II. The Psychological Corporation, 1996.
43. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6: 278-96.
44. Giuliani NR, Drabant EM, Gross JJ. Anterior cingulate cortex volume and emotion regulation: is bigger better? Biol Psychol 2011; 86: 379-82.
45. Vasic N, Walter H, Hose A, Wolf RC. Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study. J Affect Disord 2008; 109: 107-16.
46. Yucel K, McKinnon MC, Chahal R, Taylor VH, Macdonald K, Joffe R, et al. Anterior cingulate volumes in never-treated patients with major depressive disorder. Neuropsychopharmacology 2008; 33: 3157-63.
47. Hill MJ, Jeffries AR, Dobson RJ, Price J, Bray NJ. Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Hum Mol Genet 2012; 21: 1018-24.
48. Rose EJ, Donohoe G. Brain vs. behavior: an effect size comparison of neuroimaging and cognitive studies of genetic risk for schizophrenia. Schizophr Bull 2013; 39: 518-26.