Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group

NeuroImage

Volumn 81, Issue , 2013, Pages 455-469

  Jahanshad, Neda ^a   Kochunov, Peter V ^b   Sprooten, Emma ^c,d   Mandl, René C ^e   Nichols, Thomas E ^f,g   Almasy, Laura ^h   Blangero, John ^h   Brouwer, Rachel M ^e   Curran, Joanne E ^h   de Zubicaray, Greig I ⁱ   Duggirala, Ravi ^h   Fox, Peter T ^j,m   Hong, L Elliot ^b   Landman, Bennett A ^k   Martin, Nicholas G ^l   McMahon, Katie L ⁱ   Medland, Sarah E ^l   Mitchell, Braxton D ^b   Olvera, Rene L ^j   Peterson, Charles P ^h   Starr, John M ^d   Sussmann, Jessika E ^d   Toga, Arthur W ^a   Wardlaw, Joanna M ^d   Wright, Margaret J ^l   Hulshoff Pol, Hilleke E ^e   Bastin, Mark E ^d   McIntosh, Andrew M ^d   Deary, Ian J ^d   Thompson, Paul M ^a   Glahn, David C ^c   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UNIVERSITY OF WARWICK   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

ⁱ UNIVERSITY OF QUEENSLAND   (Australia)

^j UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^k VANDERBILT UNIVERSITY   (United States)

^l QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^m VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

Diffusion Tensor Imaging (DTI); Heritability; Imaging genetics; Meta analysis; Multi site; Reliability

Indexed keywords

ACCESS TO INFORMATION; ADULT; AGED; AGING; ARTICLE; AUSTRALIA; BIPOLAR DISORDER; BRAIN REGION; CAUCASIAN; COGNITION; DATA ANALYSIS; DIFFUSION TENSOR IMAGING; ETHNIC DIFFERENCE; EUROPE; FEMALE; FRACTIONAL ANISOTROPY; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEREDITY; HERITABILITY; HISPANIC; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; INFORMATION PROCESSING; INTERNET; MAJOR CLINICAL STUDY; MALE; NORTH AMERICA; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PEDIGREE ANALYSIS; PILOT STUDY; PRIORITY JOURNAL; RELIABILITY; SCHIZOPHRENIA; TWINS; ADOLESCENT; ANISOTROPY; BRAIN; BRAIN MAPPING; MIDDLE AGED; REGISTER; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANISOTROPY; BRAIN; BRAIN MAPPING; DIFFUSION TENSOR IMAGING; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; PILOT PROJECTS; REGISTRIES; YOUNG ADULT;

EID: 84879725779     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2013.04.061     Document Type: Article

References (83)

1. Almasy L., Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 1998, 62:1198-1211.
2. Andersson J., Smith S., Jenkinson M. FNIRT - FMRIB's non-linear image registration tool In: Fourteenth Annual Meeting of the Organization for Human Brain Mapping - HBM 2008, vol. 14.
3. Amos C.I. Robust variance-components approach for assessing genetic linkage in pedigrees. Am. J. Hum. Genet. 1994, 54:535-543.
4. Barnes A., Isohanni M., Barnett J.H., Pietilainen O., Veijola J., Miettunen J., Paunio T., Tanskanen P., Ridler K., Suckling J., Bullmore E.T., Jones P.B., Murray G.K. Neuregulin-1 genotype is associated with structural differences in the normal human brain. NeuroImage 2012, 59:2057-2061.
5. Barysheva M., Jahanshad N., Foland-Ross L., Altshuler L.L., Thompson P.M. White matter microstructural abnormalities in bipolar disorder: a whole brain diffusion tensor imaging study. NeuroImage: Clinical 2013, (in press).
6. Basser P.J., Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J. Magn. Reson. B 1996, 111:209-219.
7. Basser P.J., Mattiello J., LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys. J. 1994, 66:259-267.
8. Bezdjian S., Baker L.A., Tuvblad C. Genetic and environmental influences on impulsivity: a meta-analysis of twin, family and adoption studies. Clin. Psychol. Rev. 2011, 31:1209-1223.
9. Bis J.C., DeCarli C., Smith A.V., van der Lijn F., Crivello F., Fornage M., Debette S., Shulman J.M., Schmidt H., Srikanth V., Schuur M., Yu L., Choi S.H., Sigurdsson S., Verhaaren B.F., DeStefano A.L., Lambert J.C., Jack C.R., Struchalin M., Stankovich J., Ibrahim-Verbaas C.A., Fleischman D., Zijdenbos A., den Heijer T., Mazoyer B., Coker L.H., Enzinger C., Danoy P., Amin N., Arfanakis K., van Buchem M.A., de Bruijn R.F., Beiser A., Dufouil C., Huang J., Cavalieri M., Thomson R., Niessen W.J., Chibnik L.B., Gislason G.K., Hofman A., Pikula A., Amouyel P., Freeman K.B., Phan T.G., Oostra B.A., Stein J.L., Medland S.E., Vasquez A.A., Hibar D.P., Wright M.J., Franke B., Martin N.G., Thompson P.M., Nalls M.A., Uitterlinden A.G., Au R., Elbaz A., Beare R.J., van Swieten J.C., Lopez O.L., Harris T.B., Chouraki V., Breteler M.M., De Jager P.L., Becker J.T., Vernooij M.W., Knopman D., Fazekas F., Wolf P.A., van der Lugt A., Gudnason V., Longstreth W.T., Brown M.A., Bennett D.A., van Duijn C.M., Mosley T.H., Schmidt R., Tzourio C., Launer L.J., Ikram M.A., Seshadri S. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat. Genet. 2012, 44:545-551.
10. Blangero J., Goring H.H., Kent J.W., Williams J.T., Peterson C.P., Almasy L., Dyer T.D. Quantitative trait nucleotide analysis using Bayesian model selection. Hum. Biol. 2005, 77:541-559.
11. Blokland G.A., de Zubicaray G.I., McMahon K.L., Wright M.J. Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies. Twin Res. Hum. Genet. 2012, 15:351-371.
12. Boos H.B., Mandl R.C., van Haren N.E., Cahn W., van Baal G.C., Kahn R.S., Hulshoff Pol H.E. Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings. Eur. Neuropsychopharmacol. 2013, 23:295-304.
13. Braskie M.N., Jahanshad N., Stein J.L., Barysheva M., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Ringman J.M., Toga A.W., Thompson P.M. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J. Neurosci. 2011, 31:6764-6770.
14. Braskie M.N., Ringman J.M., Thompson P.M. Neuroimaging measures as endophenotypes in Alzheimer's disease. Int. J. Alzheimers Dis. 2011, 2011:490140.
15. Braskie M.N., Jahanshad N., Stein J.L., Barysheva M., Johnson K., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Ringman J.M., Toga A.W., Thompson P.M. Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. J. Neurosci. 2012, 32:5964-5972.
16. Brouwer R.M., Mandl R.C., Peper J.S., van Baal G.C., Kahn R.S., Boomsma D.I., Hulshoff Pol H.E. Heritability of DTI and MTR in nine-year-old children. NeuroImage 2010, 53:1085-1092.
17. Carballedo A., Amico F., Ugwu I., Fagan A.J., Fahey C., Morris D., Meaney J.F., Leemans A., Frodl T. Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012, 159B:537-548.
18. Chen C.H., Gutierrez E.D., Thompson W., Panizzon M.S., Jernigan T.L., Eyler L.T., Fennema-Notestine C., Jak A.J., Neale M.C., Franz C.E., Lyons M.J., Grant M.D., Fischl B., Seidman L.J., Tsuang M.T., Kremen W.S., Dale A.M. Hierarchical genetic organization of human cortical surface area. Science 2012, 335:1634-1636.
19. Chiang M.C., Barysheva M., Shattuck D.W., Lee A.D., Madsen S.K., Avedissian C., Klunder A.D., Toga A.W., McMahon K.L., de Zubicaray G.I., Wright M.J., Srivastava A., Balov N., Thompson P.M. Genetics of brain fiber architecture and intellectual performance. J. Neurosci. 2009, 29:2212-2224.
20. Chiang M.C., Barysheva M., Toga A.W., Medland S.E., Hansell N.K., James M.R., McMahon K.L., de Zubicaray G.I., Martin N.G., Wright M.J., Thompson P.M. BDNF gene effects on brain circuitry replicated in 455 twins. NeuroImage 2011, 55:448-454.
21. Chiang M.C., McMahon K.L., de Zubicaray G.I., Martin N.G., Hickie I., Toga A.W., Wright M.J., Thompson P.M. Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29. NeuroImage 2011, 54:2308-2317.
22. Chiang M.C., Barysheva M., McMahon K.L., de Zubicaray G.I., Johnson K., Montgomery G.W., Martin N.G., Toga A.W., Wright M.J., Shapshak P., Thompson P.M. Gene network effects on brain microstructure and intellectual performance identified in 472 twins. J. Neurosci. 2012, 32:8732-8745.
23. Clark K.A., Nuechterlein K.H., Asarnow R.F., Hamilton L.S., Phillips O.R., Hageman N.S., Woods R.P., Alger J.R., Toga A.W., Narr K.L. Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia. J. Psychiatr. Res. 2011, 45:980-988.
24. Clerx L., Visser P.J., Verhey F., Aalten P. New MRI markers for Alzheimer's disease: a meta-analysis of diffusion tensor imaging and a comparison with medial temporal lobe measurements. J. Alzheimers Dis. 2012, 29:405-429.
25. de Zubicaray G.I., Chiang M.C., McMahon K.L., Shattuck D.W., Toga A.W., Martin N.G., Wright M.J., Thompson P.M. Meeting the challenges of neuroimaging genetics. Brain Imaging Behav. 2008, 2:258-263.
26. Deary I.J., Gow A.J., Taylor M.D., Corley J., Brett C., Wilson V., Campbell H., Whalley L.J., Visscher P.M., Porteous D.J., Starr J.M. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr. 2007, 7:28.
27. Deary I.J., Gow A.J., Pattie A., Starr J.M. Cohort profile: the Lothian Birth Cohorts of 1921 and 1936. Int. J. Epidemiol. 2012, 41:1576-1584.
28. Dinov I., Lozev K., Petrosyan P., Liu Z., Eggert P., Pierce J., Zamanyan A., Chakrapani S., Van Horn J., Parker D.S., Magsipoc R., Leung K., Gutman B., Woods R., Toga A. Neuroimaging study designs, computational analyses and data provenance using the LONI pipeline. PLoS One 2010, 5.
29. Gatt J.M., Korgaonkar M.S., Schofield P.R., Harris A., Clark C.R., Oakley K.L., Ram K., Michaelson H., Yap S., Stanners M., Wise V., Williams L.M. The TWIN-E project in emotional wellbeing: study protocol and preliminary heritability results across four MRI and DTI measures. Twin Res. Hum. Genet. 2012, 15:419-441.
30. Genovese C.R., Lazar N.A., Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage 2002, 15:870-878.
31. Glahn D.C., Thompson P.M., Blangero J. Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function. Hum. Brain Mapp. 2007, 28:488-501.
32. Glahn D.C., Winkler A.M., Kochunov P., Almasy L., Duggirala R., Carless M.A., Curran J.C., Olvera R.L., Laird A.R., Smith S.M., Beckmann C.F., Fox P.T., Blangero J. Genetic control over the resting brain. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:1223-1228.
33. Hasler G., Northoff G. Discovering imaging endophenotypes for major depression. Mol. Psychiatry 2011, 16:604-619.
34. Honea R.A., Vidoni E., Harsha A., Burns J.M. Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study. J. Alzheimers Dis. 2009, 18:553-564.
35. Ikram M.A., Fornage M., Smith A.V., Seshadri S., Schmidt R., Debette S., Vrooman H.A., Sigurdsson S., Ropele S., Taal H.R., Mook-Kanamori D.O., Coker L.H., Longstreth W.T., Niessen W.J., DeStefano A.L., Beiser A., Zijdenbos A.P., Struchalin M., Jack C.R., Rivadeneira F., Uitterlinden A.G., Knopman D.S., Hartikainen A.L., Pennell C.E., Thiering E., Steegers E.A., Hakonarson H., Heinrich J., Palmer L.J., Jarvelin M.R., McCarthy M.I., Grant S.F., St Pourcain B., Timpson N.J., Smith G.D., Sovio U., Nalls M.A., Au R., Hofman A., Gudnason H., van der Lugt A., Harris T.B., Meeks W.M., Vernooij M.W., van Buchem M.A., Catellier D., Jaddoe V.W., Gudnason V., Windham B.G., Wolf P.A., van Duijn C.M., Mosley T.H., Schmidt H., Launer L.J., Breteler M.M., DeCarli C. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat. Genet. 2012, 44:539-544.
36. Jahanshad N., Hibar D.P., Ryles A., Toga A.W., McMahon K.L., de Zubicaray G.I., Hansell N.K., Montgomery G.W., Martin N.G., Wright M.J., Thompson P.M. Discovery of genes that affect human brain connectivity: a genome-wide analysis of the connectome. Proc. IEEE Int. Symp. Biomed. Imaging 2012, 542-545.
37. Jahanshad N., Kohannim O., Hibar D.P., Stein J.L., McMahon K.L., de Zubicaray G.I., Medland S.E., Montgomery G.W., Whitfield J.B., Martin N.G., Wright M.J., Toga A.W., Thompson P.M. Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E851-E859.
38. Jahanshad N., Kohannim O., Toga A.W., McMahon K.L., de Zubicaray G.I., Hansell N.K., Montgomery G.W., Martin N.G., Wright M.J., Thompson P.M. Diffusion imaging protocol effects on genetic associations. Proc. IEEE Int. Symp. Biomed. Imaging 2012, 944-947.
39. Jahanshad N., Valcour V.G., Nir T.M., Kohannim O., Busovaca E., Nicolas K., Thompson P.M. Disrupted brain networks in the aging HIV+ population. Brain Connect. 2012, 2:335-344.
40. Jenkinson M., Bannister P., Brady M., Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. NeuroImage 2002, 17:825-841.
41. Karlsgodt K.H., Niendam T.A., Bearden C.E., Cannon T.D. White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol. Psychiatry 2009, 66:562-569.
42. Kochunov P., Lancaster J.L., Thompson P., Woods R., Mazziotta J., Hardies J., Fox P. Regional spatial normalization: toward an optimal target. J. Comput. Assist. Tomogr. 2001, 25:805-816.
43. Kochunov P., Lancaster J., Thompson P., Toga A.W., Brewer P., Hardies J., Fox P. An optimized individual target brain in the Talairach coordinate system. NeuroImage 2002, 17:922-927.
44. Kochunov P., Glahn D.C., Fox P.T., Lancaster J.L., Saleem K., Shelledy W., Zilles K., Thompson P.M., Coulon O., Mangin J.F., Blangero J., Rogers J. Genetics of primary cerebral gyrification: heritability of length, depth and area of primary sulci in an extended pedigree of Papio baboons. NeuroImage 2010, 53:1126-1134.
45. Kochunov P., Glahn D.C., Lancaster J., Winkler A., Karlsgodt K., Olvera R.L., Curran J.E., Carless M.A., Dyer T.D., Almasy L., Duggirala R., Fox P.T., Blangero J. Blood pressure and cerebral white matter share common genetic factors in Mexican Americans. Hypertension 2011, 57:330-335.
46. Kochunov P., Glahn D.C., Nichols T.E., Winkler A.M., Hong E.L., Holcomb H.H., Stein J.L., Thompson P.M., Curran J.E., Carless M.A., Olvera R.L., Johnson M.P., Cole S.A., Kochunov V., Kent J., Blangero J. Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. Front. Neurosci. 2011, 5:120.
47. Kochunov P., Glahn D.C., Rowland L.M., Olvera R.L., Winkler A., Yang Y.H., Sampath H., Carpenter W.T., Duggirala R., Curran J., Blangero J., Hong L.E. Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression. Biol. Psychiatry 2012, 10.1016/j.biopsych.2012.10.002.
48. Kohannim O., Jahanshad N., Braskie M.N., Stein J.L., Chiang M.C., Reese A.H., Hibar D.P., Toga A.W., McMahon K.L., de Zubicaray G.I., Medland S.E., Montgomery G.W., Martin N.G., Wright M.J., Thompson P.M. Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology 2012, 37:2012-2019.
49. Li M.D., Cheng R., Ma J.Z., Swan G.E. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 2003, 98:23-31.
50. Lopez L.M., Bastin M.E., Maniega S.M., Penke L., Davies G., Christoforou A., Valdes Hernandez M.C., Royle N.A., Tenesa A., Starr J.M., Porteous D.J., Wardlaw J.M., Deary I.J. A genome-wide search or genetic influences and biological pathways related to the brain's white matter integrity. Neurobiol. Aging 2012, 33(1847):e1841-1814.
51. Mahmood A., Bibat G., Zham A.L., Izbudak I., Farage L., Horska A., Mori S., Naidu S. White matter impairment in Rett syndrome: diffusion tensor imaging study with clinical correlations. Am. J. Neuroradiol. 2010, 31:295-299.
52. Malouff J.M., Rooke S.E., Schutte N.S. The heritability of human behavior: results of aggregating meta-analyses. Curr. Psychol. 2008, 27:153-161.
53. Mandl R.C., Schnack H.G., Luigjes J., van den Heuvel M.P., Cahn W., Kahn R.S., Hulshoff Pol H.E. Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophrenia. Schizophr. Bull. 2010, 36:778-787.
54. Mandl R.C., Rais M., van Baal G.C., van Haren N.E., Cahn W., Kahn R.S., Hulshoff Pol H.E. Altered white matter connectivity in never-medicated patients with schizophrenia. Hum. Brain Mapp. 2012, 10.1002/hbm.22075.
55. McIntosh A.M., Moorhead T.W., Job D., Lymer G.K., Munoz Maniega S., McKirdy J., Sussmann J.E., Baig B.J., Bastin M.E., Porteous D., Evans K.L., Johnstone E.C., Lawrie S.M., Hall J. The effects of a neuregulin 1 variant on white matter density and integrity. Mol. Psychiatry 2008, 13:1054-1059.
56. Mori S., Oishi K., Jiang H., Jiang L., Li X., Akhter K., Hua K., Faria A.V., Mahmood A., Woods R., Toga A.W., Pike G.B., Neto P.R., Evans A., Zhang J., Huang H., Miller M.I., van Zijl P., Mazziotta J. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. NeuroImage 2008, 40:570-582.
57. Nichols T., Hayasaka S. Controlling the familywise error rate in functional neuroimaging: a comparative review. Stat. Methods Med. Res. 2003, 12:419-446.
58. Olvera R.L., Bearden C.E., Velligan D.I., Almasy L., Carless M.A., Curran J.E., Williamson D.E., Duggirala R., Blangero J., Glahn D.C. Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011, 156B:561-568.
59. Penke L., Munoz Maniega S., Houlihan L.M., Murray C., Gow A.J., Clayden J.D., Bastin M.E., Wardlaw J.M., Deary I.J. White matter integrity in the splenium of the corpus callosum is related to successful cognitive aging and partly mediates the protective effect of an ancestral polymorphism in ADRB2. Behav. Genet. 2010, 40:146-156.
60. Penke L., Munoz Maniega S., Murray C., Gow A.J., Hernandez M.C., Clayden J.D., Starr J.M., Wardlaw J.M., Bastin M.E., Deary I.J. A general factor of brain white matter integrity predicts information processing speed in healthy older people. J. Neurosci. 2010, 30:7569-7574.
61. Smith S.M., Jenkinson M., Johansen-Berg H., Rueckert D., Nichols T.E., Mackay C.E., Watkins K.E., Ciccarelli O., Cader M.Z., Matthews P.M., Behrens T.E. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage 2006, 31:1487-1505.
62. Sprooten E., Sussmann J.E., Clugston A., Peel A., McKirdy J., Moorhead T.W., Anderson S., Shand A.J., Giles S., Bastin M.E., Hall J., Johnstone E.C., Lawrie S.M., McIntosh A.M. White matter integrity in individuals at high genetic risk of bipolar disorder. Biol. Psychiatry 2011, 70:350-356.
63. Sprooten E., Sussmann J.E., Moorhead T.W., Whalley H.C., Ffrench-Constant C., Blumberg H.P., Bastin M.E., Hall J., Lawrie S.M., McIntosh A.M. Association of white matter integrity with genetic variation in an exonic DISC1 SNP. Mol. Psychiatry 2011, 16(685):688-689.
64. Sprooten E., Fleming K.M., Thomson P.A., Bastin M.E., Whalley H.C., Hall J., Sussmann J.E., McKirdy J., Blackwood D., Lawrie S.M., McIntosh A.M. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. Psychiatry Res. 2013, 206:223-231.
65. Stein J.L., Medland S.E., Vasquez A.A., Hibar D.P., Senstad R.E., Winkler A.M., Toro R., Appel K., Bartecek R., Bergmann O., Bernard M., Brown A.A., Cannon D.M., Chakravarty M.M., Christoforou A., Domin M., Grimm O., Hollinshead M., Holmes A.J., Homuth G., Hottenga J.J., Langan C., Lopez L.M., Hansell N.K., Hwang K.S., Kim S., Laje G., Lee P.H., Liu X., Loth E., Lourdusamy A., Mattingsdal M., Mohnke S., Maniega S.M., Nho K., Nugent A.C., O'Brien C., Papmeyer M., Putz B., Ramasamy A., Rasmussen J., Rijpkema M., Risacher S.L., Roddey J.C., Rose E.J., Ryten M., Shen L., Sprooten E., Strengman E., Teumer A., Trabzuni D., Turner J., van Eijk K., van Erp T.G., van Tol M.J., Wittfeld K., Wolf C., Woudstra S., Aleman A., Alhusaini S., Almasy L., Binder E.B., Brohawn D.G., Cantor R.M., Carless M.A., Corvin A., Czisch M., Curran J.E., Davies G., de Almeida M.A., Delanty N., Depondt C., Duggirala R., Dyer T.D., Erk S., Fagerness J., Fox P.T., Freimer N.B., Gill M., Goring H.H., Hagler D.J., Hoehn D., Holsboer F., Hoogman M., Hosten N., Jahanshad N., Johnson M.P., Kasperaviciute D., Kent J.W., Kochunov P., Lancaster J.L., Lawrie S.M., Liewald D.C., Mandl R., Matarin M., Mattheisen M., Meisenzahl E., Melle I., Moses E.K., Muhleisen T.W., Nauck M., Nothen M.M., Olvera R.L., Pandolfo M., Pike G.B., Puls R., Reinvang I., Renteria M.E., Rietschel M., Roffman J.L., Royle N.A., Rujescu D., Savitz J., Schnack H.G., Schnell K., Seiferth N., Smith C., Steen V.M., Valdes Hernandez M.C., Van den Heuvel M., van der Wee N.J., Van Haren N.E., Veltman J.A., Volzke H., Walker R., Westlye L.T., Whelan C.D., Agartz I., Boomsma D.I., Cavalleri G.L., Dale A.M., Djurovic S., Drevets W.C., Hagoort P., Hall J., Heinz A., Jack C.R., Foroud T.M., Le Hellard S., Macciardi F., Montgomery G.W., Poline J.B., Porteous D.J., Sisodiya S.M., Starr J.M., Sussmann J., Toga A.W., Veltman D.J., Walter H., Weiner M.W., Bis J.C., Ikram M.A., Smith A.V., Gudnason V., Tzourio C., Vernooij M.W., Launer L.J., DeCarli C., Seshadri S., Andreassen O.A., Apostolova L.G., Bastin M.E., Blangero J., Brunner H.G., Buckner R.L., Cichon S., Coppola G., de Zubicaray G.I., Deary I.J., Donohoe G., de Geus E.J., Espeseth T., Fernandez G., Glahn D.C., Grabe H.J., Hardy J., Hulshoff Pol H.E., Jenkinson M., Kahn R.S., McDonald C., McIntosh A.M., McMahon F.J., McMahon K.L., Meyer-Lindenberg A., Morris D.W., Muller-Myhsok B., Nichols T.E., Ophoff R.A., Paus T., Pausova Z., Penninx B.W., Potkin S.G., Samann P.G., Saykin A.J., Schumann G., Smoller J.W., Wardlaw J.M., Weale M.E., Martin N.G., Franke B., Wright M.J., Thompson P.M. Identification of common variants associated with human hippocampal and intracranial volumes. Nat. Genet. 2012, 44:552-561.
66. Sullivan P.F., Kendler K.S., Neale M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 2003, 60:1187-1192.
67. Sutton A.J. Methods for Meta-analysis in Medical Research 2000, J. Wiley, Chichester; New York.
68. Taal H.R., St Pourcain B., Thiering E., Das S., Mook-Kanamori D.O., Warrington N.M., Kaakinen M., Kreiner-Moller E., Bradfield J.P., Freathy R.M., Geller F., Guxens M., Cousminer D.L., Kerkhof M., Timpson N.J., Ikram M.A., Beilin L.J., Bonnelykke K., Buxton J.L., Charoen P., Chawes B.L., Eriksson J., Evans D.M., Hofman A., Kemp J.P., Kim C.E., Klopp N., Lahti J., Lye S.J., McMahon G., Mentch F.D., Muller-Nurasyid M., O'Reilly P.F., Prokopenko I., Rivadeneira F., Steegers E.A., Sunyer J., Tiesler C., Yaghootkar H., Breteler M.M., Decarli C., Debette S., Fornage M., Gudnason V., Launer L.J., van der Lugt A., Mosley T.H., Seshadri S., Smith A.V., Vernooij M.W., Blakemore A.I., Chiavacci R.M., Feenstra B., Fernandez-Banet J., Grant S.F., Hartikainen A.L., van der Heijden A.J., Iniguez C., Lathrop M., McArdle W.L., Molgaard A., Newnham J.P., Palmer L.J., Palotie A., Pouta A., Ring S.M., Sovio U., Standl M., Uitterlinden A.G., Wichmann H.E., Vissing N.H., van Duijn C.M., McCarthy M.I., Koppelman G.H., Estivill X., Hattersley A.T., Melbye M., Bisgaard H., Pennell C.E., Widen E., Hakonarson H., Smith G.D., Heinrich J., Jarvelin M.R., Jaddoe V.W. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat. Genet. 2012, 44:532-538.
69. Teipel S.J., Reuter S., Stieltjes B., Acosta-Cabronero J., Ernemann U., Fellgiebel A., Filippi M., Frisoni G., Hentschel F., Jessen F., Kloppel S., Meindl T., Pouwels P.J., Hauenstein K.H., Hampel H. Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study. Psychiatry Res. 2011, 194:363-371.
70. Teipel S.J., Wegrzyn M., Meindl T., Frisoni G., Bokde A.L., Fellgiebel A., Filippi M., Hampel H., Kloppel S., Hauenstein K., Ewers M. Anatomical MRI and DTI in the diagnosis of Alzheimer's disease: a European multicenter study. J. Alzheimers Dis. JAD 2012, 31(Suppl 3):S33-47.
71. Thomason M.E., Thompson P.M. Diffusion imaging, white matter, and psychopathology. Annu. Rev. Clin. Psychol. 2011, 7:63-85.
72. Thompson P.M., Cannon T.D., Narr K.L., van Erp T., Poutanen V.P., Huttunen M., Lonnqvist J., Standertskjold-Nordenstam C.G., Kaprio J., Khaledy M., Dail R., Zoumalan C.I., Toga A.W. Genetic influences on brain structure. Nat. Neurosci. 2001, 4:1253-1258.
73. van den Heuvel M.P., van Soelen I.L., Stam C.J., Kahn R.S., Boomsma D.I., Hulshoff Pol H.E. Genetic control of functional brain network efficiency in children. Eur. Neuropsychopharmacol. 2013, 23:19-23.
74. Verweij K.J., Zietsch B.P., Lynskey M.T., Medland S.E., Neale M.C., Martin N.G., Boomsma D.I., Vink J.M. Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. Addiction 2010, 105:417-430.
75. Walker L., Curry M., Nayak A., Lange N., Pierpaoli C. A framework for the analysis of phantom data in multicenter diffusion tensor imaging studies. Hum. Brain Mapp. 2012, 10.1002/hbm.22081.
76. Wardlaw J.M., Bastin M.E., Valdes Hernandez M.C., Maniega S.M., Royle N.A., Morris Z., Clayden J.D., Sandeman E.M., Eadie E., Murray C., Starr J.M., Deary I.J. Brain aging, cognition in youth and old age and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol. Int. J. Stroke 2011, 6:547-559.
77. Weiner M.W., Veitch D.P., Aisen P.S., Beckett L.A., Cairns N.J., Green R.C., Harvey D., Jack C.R., Jagust W., Liu E., Morris J.C., Petersen R.C., Saykin A.J., Schmidt M.E., Shaw L., Siuciak J.A., Soares H., Toga A.W., Trojanowski J.Q. The Alzheimer's disease neuroimaging initiative: a review of papers published since its inception. Alzheimers Dement. 2012, 8:S1-S68.
78. Westlye E.T., Hodneland E., Haasz J., Espeseth T., Lundervold A., Lundervold A.J. Episodic memory of APOE epsilon4 carriers is correlated with fractional anisotropy, but not cortical thickness, in the medial temporal lobe. NeuroImage 2012, 63:507-516.
79. Winkler A.M., Kochunov P., Blangero J., Almasy L., Zilles K., Fox P.T., Duggirala R., Glahn D.C. Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. NeuroImage 2010, 53:1135-1146.
80. Zhan L., Jahanshad N., Ennis D.B., Jin Y., Bernstein M.A., Borowski B.J., Jack C.R., Toga A.W., Leow A.D., Thompson P.M. Angular versus spatial resolution trade-offs for diffusion imaging under time constraints. Hum. Brain Mapp. 2012, 10.1002/hbm.22094.
81. Zhu T., Hu R., Qiu X., Taylor M., Tso Y., Yiannoutsos C., Navia B., Mori S., Ekholm S., Schifitto G., Zhong J. Quantification of accuracy and precision of multi-center DTI measurements: a diffusion phantom and human brain study. NeuroImage 2011, 56:1398-1411.
82. Zuk O., Hechter E., Sunyaev S.R., Lander E.S. The mystery of missing heritability: genetic interactions create phantom heritability. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:1193-1198.
83. Zuliani R., Moorhead T.W., Bastin M.E., Johnstone E.C., Lawrie S.M., Brambilla P., O'Donovan M.C., Owen M.J., Hall J., McIntosh A.M. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Res. 2011, 191:133-137.