Heritability estimates for cognitive factors and brain white matter integrity as markers of schizophrenia

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 4, 2010, Pages 885-894

  Bertisch, Hilary ^a   Li, Dawei ^b   Hoptman, Matthew J ^a,c   DeLisi, Lynn E ^a,d  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cognition; DTI; Genetic; Neuroimaging

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BRAIN FUNCTION; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; EARLY DIAGNOSIS; FAMILY; FEMALE; FRONTAL CORTEX; HERITABILITY; HUMAN; IMAGE PROCESSING; LANGUAGE ABILITY; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; OCCIPITAL LOBE; PARIETAL LOBE; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; VERBAL MEMORY; VISUAL MEMORY; WHITE MATTER;

ADOLESCENT; ADULT; BRAIN; COGNITION; COHORT STUDIES; DIFFUSION TENSOR IMAGING; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; PSYCHOMETRICS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 77952727075     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31054     Document Type: Article

References (66)

1. Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211. (Pubitemid 28199022)
2. Antila M, Tuulio-Henriksson A, Kieseppa T, Soronen P, Palo OM, Paunio T, Haukka J, Partonen T, Lonnqvist J. 2007. Heritability of cognitive functions in families with bipolar disorder.AmJ Med Genet Part B 144B: 802-808.
3. Ardekani BA, Braun M, Hutton BF, KannoI, Iida H. 1995. A fully automatic multimodality image registration algorithm. J Comput Assist Tomogr 19:615-623.
4. Ardekani BA, Nierenberg J, Hoptman MJ, Javitt DC, Lim KO. 2003. MRI study of white matter diffusion anisotropy in schizophrenia. Neuro-Report 14:2025-2029.
5. Aron AR, Poldrack RA. 2005. The cognitive neuroscience of response inhibition: Relevance for genetic research in attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1285-1292.
6. Aukes MF, Alizadeh BZ, Sitskoorn MM, Elten JP, Sinke RJ, Kemner C, Ophoff RA, Kahn RS. 2008. Finding suitable phenotypes for genetic studies of schizophrenia: Heritability and segregation analysis. Biol Psychiatry 64:128-136.
7. Baare WFS, Hulshoff Pol HE, Boomsma DI, Posthuma D, de Geus EJC, Schnack HG, van Haren NEM, van Oel CJ, Kahn RS. 2001. Quantitative genetic modeling of variation in human brain morpohology. Cereb Cortex 11:816-824.
8. Banerjee TD, Middleton F, Faraone SV. 2007. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr 96:1269-1274.
9. Baron-Cohen S. 2004. Autism: Research into causes and intervention. Pediatr Rehabil 7:73-78.
10. Baudewig J, Dechent P, Merboldt KD, Frahm J. 2003. Thresholding in correlational analyses of magnetic resonance functional neuroimaging. Magn Reson Imaging 21:1121-1130. (Pubitemid 38199717)
11. Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc B Met 57:289-300.
12. Bertisch HC, Fava J, Kattan A, DeLisi LE. 2008. Preliminary neurosychological findings in individuals at high genetic risk for schizophrenia. Early Interv Psychiatry 2:45-49.
13. CannonTD, Thompson PM, van Erp TG, Huttunen M, Lonnqvist J, Kaprio J, Toga AW. 2006. Mapping heritability and molecular genetic associations with cortical features using probabilistic brain atlases: Methods and applications to schizophrenia. Neuroinformatics 4:5-19.
14. Cheverud JM, Buikstra JE, Twitchell E. 1979. Relationships between nonmetric skeletal traits and cranial size and shape. AmJ Phys Anthropol 50:191-198.
15. Chiang MC, Barysheva M, Shattuck DW, Lee AD, Madsen SK, Avedissian C, Klunder AD, Toga AW, McMahon KL, deZubicaray GI, Wright MJ, Srivastava A, Balov N, Thompson PM. 2009. Genetics of brain fiber architecture and intellectual performance. J Neuroscience 29:2212-2224.
16. Cohen MJ. 1997. Children's memory scale. San Antonio: The Psychological Corporation.
17. Delis DC, Kramer JH, Kaplan E, Ober BA. 1987. California verbal learning test, adult version. San Antonio, TX: The Psychological Corporation.
18. Delis DC, Kramer JH, Kaplan E, Ober BA. 1994. California verbal learning test, children's version. San Antonio, TX: The Psychological Corporation.
19. DeLisi LE, Goldin LR, Hamovit JR, Maxwell ME, Kurtz D, Gershon ES. 1986. A family study of the association of increased ventricular size with schizophrenia. Arch Gen Psychiatry 43:148-153.
20. DeLisi LE, Szulc KU, Bertisch H, Majcher M, Brown K, Bappal A, Branch CA, Ardekani BA. 2006. Early detection of schizophrenia by diffusion weighted imaging. Psychiatry Res 148:61-66.
21. Dunn LM, Dunn LM. 1997. Peabody picture vocabulary test 3rd edition. Circle Pines, Minnesota: American Guidance Service.
22. Ellison-Wright I, Bullmore E. 2009. Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophr Res 108:3-10.
23. Giubilei F, Medda E, Fagnani C, Bianchi V, De Carolis A, Salvetti M, Sepe-Monti M, StaziM. 2008. Heritability of neurocognitive functioning in the elderly: Evidence from an Italian twin study. Age Ageing 37:640-646.
24. Glahn DC, Thompson PM, Blangero J. 2007. Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function. Hum Brain Mapp 28:488-501. (Pubitemid 46849366)
25. Golden CJ. 1978a. Stroop color and word test. Chicago, IL: Stoelting Co. Golden CJ. 1978b. Stroop color and word test: A manual for clinical and experimental uses. Chicago, IL: Skoelting; pp. 1-32.
26. Goldman AL, Pezawas L, Matay VS, Fischl B, Verchinski BA, Zoltick B, Weinberger DR, Meyer-Lindenberg A. 2008. Heritability of brain morphology related to schizophrenia: A large scale automated magnetic resonance imaging segmentation study. Biol Psychiatry 5:475-483. (Pubitemid 351227357)
27. Goldman AL, Pezawas L, Doz P, Mattay VS, Fischl B, Verchinski BA, Chen A, Weinberger DR, Meyer-Lindenberg A. 2009. Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Arch Gen Psychiatry 66:467-477.
28. Gottesman I, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160:636-645. (Pubitemid 41079594)
29. Greenwood PM, Parasuraman R. 2003. Normal genetic variation, cognition and aging. Behav Cogn Neuroci Rev 2:278-306.
30. Greenwood TA, Braff DL, Light GA, Cadenhead K, Calkins ME, Dobie DJ, Freedman R, Green MF, Gur RE, Gur RC, Mintz J, Nuechterlein KH, Olincy A, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Schork NJ. 2007. Initial heritability analyses of endophenotypic measures for schizophrenia. Arch Gen Psychiatry 64:1242-1250.
31. Gur RE, Calkins ME, Gur RC, Horan WP, Nuechterlein KH, Seidman LJ, Stone WS. 2007a. The Consortium on the Genetics of Schizophrenia: Neurocognitive endophenotypes. Schizophr Bull 3:49-68. (Pubitemid 46026259)
32. Gur RE, Nimgaonkar WL, Almasy L, Calkins ME, Ragland JD, Pogue-Geile MF, Kanes S, Blangero J, Gur RC. 2007b. Neurocognitive endophenotypes in a multiplex multigenerational study of schizophrenia. Am J Psychiatry 164:813-819. (Pubitemid 46808537)
33. Heydebrand G. 2006. Cognitive deficits in the families of patients with schizophrenia. Curr Opin Psychiatry 19:277-281. (Pubitemid 44309485)
34. Hoff AL, Svetina C, Maurizio AM, Crow TJ, Spokes K, DeLisi LE. 2005. Familial cognitive deficits in schizophrenia. Am J Med Genet Part B 133B:43-49.
35. Hoptman MJ, Nierenberg J, Bertisch HC, Catalano D, Ardekani BA, Branch CA, Delisi LE. 2008. A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr Res 106:115-124.
36. Kanaan RA, Shergill SS, Barker G, Catani M, Ng VW, Howard R, et al. 2006. Tract-specific anisotropy measurements in diffusion tensor imaging. Psychiatry Res 14:73-82. (Pubitemid 43269991)
37. Kaplan EF, Goodglass H, Weintraub S. 1983. Boston naming test 2nd edition. San Antonio, TX: The Psychological Corporation.
38. Konigsberg LW, Kohn LAP, Cheverud JM. 1993. Cranial deformation and nonmetric trait variation. Am J Phys Anthropol 90:35-48.
39. Kremen WS, Xian H, Eisen SA, Tsuang MT, Jacobsen KC, Eaves LJ, Lyons MJ. 2007. Genetics of verbal working memory process: A twin study of middle-aged men. Neuropsychology 21:569-580. (Pubitemid 47488799)
40. Kubicki M, Park H, Westin CF, Nestor PG, Mulkern RV, Maier SE, et al. 2005. DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity. NeuroImage 26:1109-1118. (Pubitemid 40806489)
41. Lee JH. 2003. Genetic evidence for cognitive reserve: Variations in memory and related cognitive functions. J Clin Exp Neuropsychol 25: 594-613.
42. Lenroot RK, Schmitt J, Ordaz SJ, Wallace GL, Neale MC, Lerch JP, Kendler KS, Evans AC, Giedd JN. 2007. Differences in genetic and environmental influences on the human cerebral cortex associated with development during childhood and adolescence. Hum Brain Mapp 30:163-174.
43. Liu Y, Liang M, Zhou Y, He Y, Hao Y, Song M, Yu C, Liu H, Liu Z, Jiang T. 2008. Disrupted small-world networks in schizophrenia. Brain 131: 945-961.
44. Loo SK, Smalle SL. 2008. Preliminary report of familial clustering of EEG measures in ADHD. Am J Med Genet Part B 147B:107-109.
45. McGue M, Bouchard TJ. 1998. Genetic and environmental influences on human behavioral differences. Annu Rev Neurosci 21:1-24. (Pubitemid 28150656)
46. Nurnberger JI Jr, Blehar MC, Kaurmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T. 1994. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51:849-859; discussion 863-864
47. Otsu N. 1979. A threshold selection method from gray-level histograms. IEEE Trans Systems Man Cybernetics 9:63-66.
48. Owen MJ, O'Donovan MC, Harrison PJ. 2005. Schizophrenia: A genetic disorder of the synapse? BMJ 330:158-159.
49. Pfefferbaum A, Sullivan EV, Carmelli D. 2001. Genetic regulation of regional microstructure of the corpus callosum in late life. NeuroReport 12:1677-1681. (Pubitemid 32521485)
50. Plomin R, Craig I. 2001. Genetics, environment and cognitive abilities: A review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling. Br J Psychiatry Suppl 40:s41-s48. (Pubitemid 32273181)
51. Reitan RM. 1969. Manual for administration of neuropsychological test batteries for adults and children. Author, Indianapolis, IN.
52. Reveley AM, Reveley MA, Clifford CA, Murray RM. 1982. Cerebral ventricular size in twins discordant for schizophrenia. Lancet 6:540-541.
53. Rommelse NNJ, Altink ME, Martin NC, Buschgens CJM, Bultelaar JK, Sergeant JA, Oosterlaan J. 2008. Neuropsychological measures probably facilitate heritability of ADHD. Arch Clin Neuropsychiatry 23:579-591.
54. Santangelo SL, Tsatsanis K. 2005. What is known about autism: Genes, brain and behavior. Am J Pharmacogenomics 5:7192.
55. SAS Institute, Inc. 2001. SAS Version 8.2.SAS Institute, Inc. Cary, NC.
56. Ségonne F, Dale AM, Busa E, Glessner M, Salvolini U, Hahn HK, Fischl B. 2004. A hybrid approach to the skull-stripping problem in MRI. Neuro-Image 22:1060-1075. (Pubitemid 38829195)
57. Smit DJ, Stam CJ, Posthuma D, Boomsma DI, De Geus EJ. 2008. Heritability of "small-world" networks in the brain: Agraph theoretical analysis of resting-state EEG functional connectivity. Hum Brain Mapp 29:1368-1378.
58. Spreen O, Strauss E. 1991. A Compendium of neuropsychological tests, Administration, norms, and commentary. New York: Oxford University Press.
59. Strogatz SH. 2001. Exploring complex networks. Nature 410:268-276.
60. Styner M, Lieberman JA, McClure RK, Weinberger DR, Jones DW, Gerig G. 2005. Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. Proc Natl Acad Sci USA 102:4872-4877. (Pubitemid 40471546)
61. Tiffin J. 1968. Purdue Pegboard Test. Chicago: Scientific Research Associates.
62. Van Haren NE, Bakker SC, Kahn RS. 2008. Genes and structural brain imaging in schizophrenia. Curr Opin Psychiatry 21:161-167. (Pubitemid 351339871)
63. Wechsler D. 1997a. Wechsler adult intelligence scale 3rd edition. San Antonio, TX: The Psychological Corporation.
64. Wechsler D. 1997b. Wechsler memory scale. San Antonio, TX: The Psychological Corporation.
65. Wechsler D. 2003. Wechsler intelligence scale for children-fourth edition technical and interpretive manual. San Antonio, TX: The Psychological Corporation.
66. Wilkinson GS. 1993. The wide range achievement test. Wilmington, DE: Wide Range, Inc.